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The map label for this gene is ilvA [H]

Identifier: 119896791

GI number: 119896791

Start: 537808

End: 539328

Strand: Reverse

Name: ilvA [H]

Synonym: azo0500

Alternate gene names: 119896791

Gene position: 539328-537808 (Counterclockwise)

Preceding gene: 119896792

Following gene: 119896790

Centisome position: 12.32

GC content: 67.19

Gene sequence:

>1521_bases
ATGACTTCCGCCAGTCCCGATTACCTGGAACGCATCCTCAACGCCCAAGTCTATGATCTTGCGGTGGAAACCCCGCTCGA
TCTGGCGACCAACCTGTCGGCGCGGAGCGGTAACCGGATCTACCTGAAGCGCGAGGACATGCAGCCGGTGTTCAGCTTCA
AGCTGCGCGGCGCGTACAACAAGATGGCCAACCTGTCGCCGCAGGCGCTGCAGCGCGGCGTCATCTGCGCTTCGGCCGGC
AACCACGCCCAGGGCGTCGCGCTGTCGGCGCAGAAGCTGGGGGTGCGCGCGGTGATCGTGATGCCGACGACGACGCCGCA
GATCAAGATCGACGCGGTGCGCAGCCGCGGCGGCGAGGTGGTGCTGGCGGGCGAGTCCTATTCCGACGCGTACGCGCACG
CGCTGGAGCTGGAAAAAGCGGAAAAGCTCACCTTCGTCCATCCCTACGACGACCCCGACGTGATCGCCGGCCAGGGCACC
ATCGGCATGGAAATCCTGCGCGCGCATGCGAAGCCGATCCACGCGATCTTCTGCGCCGTCGGCGGCGGCGGCCTGATCGC
CGGGGTCGCGGCCTACGTCAAGCGCTTGCGCCCCGAGACCCGCATCATCGGCGTCGAATCCGAGGGCGCCGCGGCCATGA
CCGAATCGCTCGCGCGGGGCGAGCGCGTCAGCCTCGAGCAGGTAGCGCTCTTTGCGGACGGCACTGCGGTCAAGCAGGTG
GGCGGCGAAACCTTCCGCCTGTGCCAGCAATACGTCGATGAAATGATCGTGGTCGACAACGACGCGATCTGCGCGGCGAT
CAAGGACGTTTTCGAAGACACCCGCTCCATCCTCGAACCCTCGGGCGCCCTCGCGGTGGCCGGTGCAAAGGAGTACGCAC
GGCGCCACCAGCTCAGCGACCGCAGCCTGGTCGCGGTCGCGTCCGGCGCGAACATGAACTTCGACCGCCTGCGCTTCGTC
GCCGAGCGCGCGGAGCTCGGCGAACAGCGCGAGGCCGTGCTTGCGGTCACCATTCCGGAGCAGCCCGGCTCGTTCCGCAA
GTTCATCAACATCCTGGGCAACCGCGACATCACCGAGTTCAACTACCGCTACGCCGACAGCGAGCGCGCCCACATCTTCG
TCGGGGTCACGGTGCGCAGCCGCGACGAGGCCACCCGGCTGGTGGAGATGCTCGGCCAGCACGACCTGCCGGCGCTCGAC
CTCACCGACGACGAACTCGCCAAGTCGCACGTGCGCTACATGGTCGGCGGACGCGCGCCGCAGGTGGCCAACGAGCTGGT
ATACCGCTTCGTGTTTCCGGAGCGCCCGGGCGCGCTGCTCAACTTCCTGTCCAACCTGCGCTCGGACTGGAACATCAGCC
TGTTCCACTATCGCAACCACGGCGCGGATTTCGGCCGCGTGCTGGTGGGCATGCAGGTGCCGCCCCAGGACATCGACGCG
TTCGAGGCCTTCCTGCAGCGCCTCGGCTACGAATACGCCGCGGAAACGGAAAACCCGGCCTACCGGCTGTTCCTGGCCTG
A

Upstream 100 bases:

>100_bases
CCCGCCAAGCCCGTCCCCTGCCTGGCAGCCGGCATCGCCCTTGCTGGGGTTGCGCCCCGGCTGCTAACCTCGTCTCCTTT
GCCGCGCCCGTCCTTCTGCC

Downstream 100 bases:

>100_bases
CGGTGACGTATGCCGCGCCGGGTTGAGCCCGGCGCTTGAAGAGGCACTACTTTTGTAATAAAAAGAACAGGCGCCGTCCG
GTAGTTTTCAGGGCCGTTCA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MTSASPDYLERILNAQVYDLAVETPLDLATNLSARSGNRIYLKREDMQPVFSFKLRGAYNKMANLSPQALQRGVICASAG
NHAQGVALSAQKLGVRAVIVMPTTTPQIKIDAVRSRGGEVVLAGESYSDAYAHALELEKAEKLTFVHPYDDPDVIAGQGT
IGMEILRAHAKPIHAIFCAVGGGGLIAGVAAYVKRLRPETRIIGVESEGAAAMTESLARGERVSLEQVALFADGTAVKQV
GGETFRLCQQYVDEMIVVDNDAICAAIKDVFEDTRSILEPSGALAVAGAKEYARRHQLSDRSLVAVASGANMNFDRLRFV
AERAELGEQREAVLAVTIPEQPGSFRKFINILGNRDITEFNYRYADSERAHIFVGVTVRSRDEATRLVEMLGQHDLPALD
LTDDELAKSHVRYMVGGRAPQVANELVYRFVFPERPGALLNFLSNLRSDWNISLFHYRNHGADFGRVLVGMQVPPQDIDA
FEAFLQRLGYEYAAETENPAYRLFLA

Sequences:

>Translated_506_residues
MTSASPDYLERILNAQVYDLAVETPLDLATNLSARSGNRIYLKREDMQPVFSFKLRGAYNKMANLSPQALQRGVICASAG
NHAQGVALSAQKLGVRAVIVMPTTTPQIKIDAVRSRGGEVVLAGESYSDAYAHALELEKAEKLTFVHPYDDPDVIAGQGT
IGMEILRAHAKPIHAIFCAVGGGGLIAGVAAYVKRLRPETRIIGVESEGAAAMTESLARGERVSLEQVALFADGTAVKQV
GGETFRLCQQYVDEMIVVDNDAICAAIKDVFEDTRSILEPSGALAVAGAKEYARRHQLSDRSLVAVASGANMNFDRLRFV
AERAELGEQREAVLAVTIPEQPGSFRKFINILGNRDITEFNYRYADSERAHIFVGVTVRSRDEATRLVEMLGQHDLPALD
LTDDELAKSHVRYMVGGRAPQVANELVYRFVFPERPGALLNFLSNLRSDWNISLFHYRNHGADFGRVLVGMQVPPQDIDA
FEAFLQRLGYEYAAETENPAYRLFLA
>Mature_505_residues
TSASPDYLERILNAQVYDLAVETPLDLATNLSARSGNRIYLKREDMQPVFSFKLRGAYNKMANLSPQALQRGVICASAGN
HAQGVALSAQKLGVRAVIVMPTTTPQIKIDAVRSRGGEVVLAGESYSDAYAHALELEKAEKLTFVHPYDDPDVIAGQGTI
GMEILRAHAKPIHAIFCAVGGGGLIAGVAAYVKRLRPETRIIGVESEGAAAMTESLARGERVSLEQVALFADGTAVKQVG
GETFRLCQQYVDEMIVVDNDAICAAIKDVFEDTRSILEPSGALAVAGAKEYARRHQLSDRSLVAVASGANMNFDRLRFVA
ERAELGEQREAVLAVTIPEQPGSFRKFINILGNRDITEFNYRYADSERAHIFVGVTVRSRDEATRLVEMLGQHDLPALDL
TDDELAKSHVRYMVGGRAPQVANELVYRFVFPERPGALLNFLSNLRSDWNISLFHYRNHGADFGRVLVGMQVPPQDIDAF
EAFLQRLGYEYAAETENPAYRLFLA

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=307, Percent_Identity=30.6188925081433, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI33469958, Length=315, Percent_Identity=30.7936507936508, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI19923959, Length=320, Percent_Identity=28.75, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI1790207, Length=501, Percent_Identity=54.4910179640719, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI1789505, Length=295, Percent_Identity=36.9491525423729, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71991565, Length=364, Percent_Identity=34.0659340659341, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17537387, Length=314, Percent_Identity=36.3057324840764, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17508781, Length=275, Percent_Identity=30.5454545454545, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320930, Length=519, Percent_Identity=50.2890173410405, Blast_Score=485, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6322631, Length=294, Percent_Identity=33.6734693877551, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6319788, Length=284, Percent_Identity=26.4084507042254, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322024, Length=156, Percent_Identity=26.9230769230769, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21355833, Length=329, Percent_Identity=33.434650455927, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24645328, Length=252, Percent_Identity=32.1428571428571, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55565; Mature: 55434

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSASPDYLERILNAQVYDLAVETPLDLATNLSARSGNRIYLKREDMQPVFSFKLRGAYN
CCCCCHHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCEEEEEECCCCHHHHEEECCHHH
KMANLSPQALQRGVICASAGNHAQGVALSAQKLGVRAVIVMPTTTPQIKIDAVRSRGGEV
HHCCCCHHHHHCCEEEECCCCCCCCEEEEHHHCCEEEEEEECCCCCCEEEEEECCCCCEE
VLAGESYSDAYAHALELEKAEKLTFVHPYDDPDVIAGQGTIGMEILRAHAKPIHAIFCAV
EEECCCCCHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCHHHHHHHHHCCCEEEEEEEE
GGGGLIAGVAAYVKRLRPETRIIGVESEGAAAMTESLARGERVSLEQVALFADGTAVKQV
CCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHEEEEECCHHHHHH
GGETFRLCQQYVDEMIVVDNDAICAAIKDVFEDTRSILEPSGALAVAGAKEYARRHQLSD
CCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHCCCC
RSLVAVASGANMNFDRLRFVAERAELGEQREAVLAVTIPEQPGSFRKFINILGNRDITEF
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEC
NYRYADSERAHIFVGVTVRSRDEATRLVEMLGQHDLPALDLTDDELAKSHVRYMVGGRAP
EEEECCCCCCEEEEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCH
QVANELVYRFVFPERPGALLNFLSNLRSDWNISLFHYRNHGADFGRVLVGMQVPPQDIDA
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCHHEEEECCCCCCHHHH
FEAFLQRLGYEYAAETENPAYRLFLA
HHHHHHHCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
TSASPDYLERILNAQVYDLAVETPLDLATNLSARSGNRIYLKREDMQPVFSFKLRGAYN
CCCCHHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCCEEEEEECCCCHHHHEEECCHHH
KMANLSPQALQRGVICASAGNHAQGVALSAQKLGVRAVIVMPTTTPQIKIDAVRSRGGEV
HHCCCCHHHHHCCEEEECCCCCCCCEEEEHHHCCEEEEEEECCCCCCEEEEEECCCCCEE
VLAGESYSDAYAHALELEKAEKLTFVHPYDDPDVIAGQGTIGMEILRAHAKPIHAIFCAV
EEECCCCCHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCHHHHHHHHHCCCEEEEEEEE
GGGGLIAGVAAYVKRLRPETRIIGVESEGAAAMTESLARGERVSLEQVALFADGTAVKQV
CCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHEEEEECCHHHHHH
GGETFRLCQQYVDEMIVVDNDAICAAIKDVFEDTRSILEPSGALAVAGAKEYARRHQLSD
CCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHCCCC
RSLVAVASGANMNFDRLRFVAERAELGEQREAVLAVTIPEQPGSFRKFINILGNRDITEF
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEC
NYRYADSERAHIFVGVTVRSRDEATRLVEMLGQHDLPALDLTDDELAKSHVRYMVGGRAP
EEEECCCCCCEEEEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCH
QVANELVYRFVFPERPGALLNFLSNLRSDWNISLFHYRNHGADFGRVLVGMQVPPQDIDA
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCHHEEEECCCCCCHHHH
FEAFLQRLGYEYAAETENPAYRLFLA
HHHHHHHCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA