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The map label for this gene is fadA2 [H]

Identifier: 119896760

GI number: 119896760

Start: 506636

End: 507868

Strand: Direct

Name: fadA2 [H]

Synonym: azo0469

Alternate gene names: 119896760

Gene position: 506636-507868 (Clockwise)

Preceding gene: 119896759

Following gene: 119896761

Centisome position: 11.58

GC content: 70.97

Gene sequence:

>1233_bases
ATGCGTGGCACCGAAAGACACGAGGAGAACAGACACATGAGCACACAGATCCAGGACGCCTACATCGTTGCCGCGGTGCG
CACCCCGGTGGCCAAGCGCAATGGCGCTTTCCGCCATGTCCGCCCGGACGACATGCTGGCGCATGTGCTGCGCGCGGTCG
TGGCCCAGGTGCCGGCGCTCGACGCCGGCGAGATCGGCGACGTGATCACCGGCTGCGCGATGCCGGAAGCCGAGCAGGGC
ATGAATGTGGCGCGCATCGGGCTGCTGCTGGCCGGGCTGCCGGAGCGGGTGCCGGGCGTCACCCTCAACCGCTTCTGCGC
CTCCAGCCTGCAGGCGGTGGCCGATGCCGCCAACCGCATCCGCCTCGGCGAAGCCGACGTGATGATCGCCGCCGGCACCG
AGAGCATGAGCGCGATGCCGCAGATCATGGGCAACAAGGTCAGCCTCAATCCCGAGATCTTCGCCCGCCAGGAAAACATC
GACATCGCCTACGGCATGGGGCTCACCGCCGAGAAAGTGGCCGAAGAGTGGAAAGTCAGCCGCGCCGACCAGGACGCCTT
CGCGCTGCAGTCGCACCAGCGCGCCAGCGCCGCGATCGCCGATGGCAGCTTCGGCGACGAGATCGCGCCCTACACCGTGC
GCAGCCACCTGCCGGGCGAAGGCGGCACCGTGCGGATTGCCGAGCGCATCGTCGACACCGATGAAGGGCCGCGCGCCGAC
GCCACGCTGGAAGCGCTCGCCAGGCTCAAGCCGGTGTTCGCCGCGCGCGGCTCGGTCACCGCCGGCAACAGCTCGCAGAT
GTCCGACGGCGCCGGTGCGGTGCTGCTGATGAGCGAGACCGCGCTGCAACGCTACGGCGTGACGCCGCTTGCGCGCTTTC
GCAGCTATGCGGTGGCGGGCGTGCCGCCGCGGGTGATGGGGATCGGGCCGGTCGAAGCGATCCCGCGCGCGCTGCGGCTG
GCGGGCCTCGGGCTGGATGCGCTCGACCGCATCGAACTCAACGAGGCCTTCGCCGCGCAGGCGCTGGCCGTCATCCGCAC
GCTCGGGCTCGACCCGGCGCGGGTCAATCCGCAGGGCGGCGCGATTGCGCTCGGCCATCCGCTCGGCGCCACCGGCGCCA
TCCGCACCGCCACGCTGATGCGCGCGATGCGGCAGGGCGGCGTGCGCCACGGGATGATCACCATGTGCGTCGGCACCGGC
ATGGGCGCGGCCGCGATCTTCGAACGCGTATAG

Upstream 100 bases:

>100_bases
AGGGGTGGGGCGTTTGTGGAGAGGGCGAGGACTGTCCGAGGGCGCGTAGCGAACGAGTTCGGCAGCCCTCGGAGCAAATG
CCCCGCCTGGGGCTGCAACC

Downstream 100 bases:

>100_bases
GCGGCGCGGGCCGCTAAACTTCCGGCTCTGGGCGGCGCCGCGGGTGCGCCGCCGCAACCCCCTGGAGCCCCCCGAGATGG
CCGATACCGTATTGCTCGAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MRGTERHEENRHMSTQIQDAYIVAAVRTPVAKRNGAFRHVRPDDMLAHVLRAVVAQVPALDAGEIGDVITGCAMPEAEQG
MNVARIGLLLAGLPERVPGVTLNRFCASSLQAVADAANRIRLGEADVMIAAGTESMSAMPQIMGNKVSLNPEIFARQENI
DIAYGMGLTAEKVAEEWKVSRADQDAFALQSHQRASAAIADGSFGDEIAPYTVRSHLPGEGGTVRIAERIVDTDEGPRAD
ATLEALARLKPVFAARGSVTAGNSSQMSDGAGAVLLMSETALQRYGVTPLARFRSYAVAGVPPRVMGIGPVEAIPRALRL
AGLGLDALDRIELNEAFAAQALAVIRTLGLDPARVNPQGGAIALGHPLGATGAIRTATLMRAMRQGGVRHGMITMCVGTG
MGAAAIFERV

Sequences:

>Translated_410_residues
MRGTERHEENRHMSTQIQDAYIVAAVRTPVAKRNGAFRHVRPDDMLAHVLRAVVAQVPALDAGEIGDVITGCAMPEAEQG
MNVARIGLLLAGLPERVPGVTLNRFCASSLQAVADAANRIRLGEADVMIAAGTESMSAMPQIMGNKVSLNPEIFARQENI
DIAYGMGLTAEKVAEEWKVSRADQDAFALQSHQRASAAIADGSFGDEIAPYTVRSHLPGEGGTVRIAERIVDTDEGPRAD
ATLEALARLKPVFAARGSVTAGNSSQMSDGAGAVLLMSETALQRYGVTPLARFRSYAVAGVPPRVMGIGPVEAIPRALRL
AGLGLDALDRIELNEAFAAQALAVIRTLGLDPARVNPQGGAIALGHPLGATGAIRTATLMRAMRQGGVRHGMITMCVGTG
MGAAAIFERV
>Mature_410_residues
MRGTERHEENRHMSTQIQDAYIVAAVRTPVAKRNGAFRHVRPDDMLAHVLRAVVAQVPALDAGEIGDVITGCAMPEAEQG
MNVARIGLLLAGLPERVPGVTLNRFCASSLQAVADAANRIRLGEADVMIAAGTESMSAMPQIMGNKVSLNPEIFARQENI
DIAYGMGLTAEKVAEEWKVSRADQDAFALQSHQRASAAIADGSFGDEIAPYTVRSHLPGEGGTVRIAERIVDTDEGPRAD
ATLEALARLKPVFAARGSVTAGNSSQMSDGAGAVLLMSETALQRYGVTPLARFRSYAVAGVPPRVMGIGPVEAIPRALRL
AGLGLDALDRIELNEAFAAQALAVIRTLGLDPARVNPQGGAIALGHPLGATGAIRTATLMRAMRQGGVRHGMITMCVGTG
MGAAAIFERV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=44.8979591836735, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=38.3084577114428, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI148539872, Length=405, Percent_Identity=38.5185185185185, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI4557237, Length=420, Percent_Identity=33.5714285714286, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4504327, Length=440, Percent_Identity=30.9090909090909, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI194353979, Length=245, Percent_Identity=35.5102040816327, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=44.7941888619855, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=44.25, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=42.0792079207921, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=41.6256157635468, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=32.3943661971831, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=404, Percent_Identity=36.6336633663366, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=403, Percent_Identity=32.0099255583127, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI25147385, Length=409, Percent_Identity=30.3178484107579, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=435, Percent_Identity=30.3448275862069, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=26.75, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=415, Percent_Identity=40.4819277108434, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=34.3980343980344, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655093, Length=406, Percent_Identity=38.9162561576355, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=34.8039215686275, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24640423, Length=418, Percent_Identity=32.7751196172249, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI17137578, Length=438, Percent_Identity=30.365296803653, Blast_Score=170, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 43122; Mature: 43122

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGTERHEENRHMSTQIQDAYIVAAVRTPVAKRNGAFRHVRPDDMLAHVLRAVVAQVPAL
CCCCCCCHHHHHHHHHHHHHEEEEEHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
DAGEIGDVITGCAMPEAEQGMNVARIGLLLAGLPERVPGVTLNRFCASSLQAVADAANRI
CCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHE
RLGEADVMIAAGTESMSAMPQIMGNKVSLNPEIFARQENIDIAYGMGLTAEKVAEEWKVS
EECCCCEEEEECCHHHHHHHHHHCCEEECCHHHEEECCCCEEEECCCCCHHHHHHHHHHC
RADQDAFALQSHQRASAAIADGSFGDEIAPYTVRSHLPGEGGTVRIAERIVDTDEGPRAD
CCCCHHHHHHHHHHHHHEECCCCCCCCCCCEEHHCCCCCCCCEEEHHHHHHCCCCCCCCH
ATLEALARLKPVFAARGSVTAGNSSQMSDGAGAVLLMSETALQRYGVTPLARFRSYAVAG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHHHCCC
VPPRVMGIGPVEAIPRALRLAGLGLDALDRIELNEAFAAQALAVIRTLGLDPARVNPQGG
CCCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
AIALGHPLGATGAIRTATLMRAMRQGGVRHGMITMCVGTGMGAAAIFERV
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure
MRGTERHEENRHMSTQIQDAYIVAAVRTPVAKRNGAFRHVRPDDMLAHVLRAVVAQVPAL
CCCCCCCHHHHHHHHHHHHHEEEEEHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
DAGEIGDVITGCAMPEAEQGMNVARIGLLLAGLPERVPGVTLNRFCASSLQAVADAANRI
CCCHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHE
RLGEADVMIAAGTESMSAMPQIMGNKVSLNPEIFARQENIDIAYGMGLTAEKVAEEWKVS
EECCCCEEEEECCHHHHHHHHHHCCEEECCHHHEEECCCCEEEECCCCCHHHHHHHHHHC
RADQDAFALQSHQRASAAIADGSFGDEIAPYTVRSHLPGEGGTVRIAERIVDTDEGPRAD
CCCCHHHHHHHHHHHHHEECCCCCCCCCCCEEHHCCCCCCCCEEEHHHHHHCCCCCCCCH
ATLEALARLKPVFAARGSVTAGNSSQMSDGAGAVLLMSETALQRYGVTPLARFRSYAVAG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHHHCCC
VPPRVMGIGPVEAIPRALRLAGLGLDALDRIELNEAFAAQALAVIRTLGLDPARVNPQGG
CCCHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
AIALGHPLGATGAIRTATLMRAMRQGGVRHGMITMCVGTGMGAAAIFERV
EEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]