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The map label for this gene is phoR [H]

Identifier: 119896457

GI number: 119896457

Start: 181446

End: 182717

Strand: Direct

Name: phoR [H]

Synonym: azo0165

Alternate gene names: 119896457

Gene position: 181446-182717 (Clockwise)

Preceding gene: 119896456

Following gene: 119896466

Centisome position: 4.15

GC content: 67.45

Gene sequence:

>1272_bases
GTGGCCGGACTCGCCGCGCTTGTCGGCGGCAGCCTTGCGGCCCTGCTGGCTGCGCTCGTGGGGCTGCTGGCGGCCGGCTG
GTACCACCTCGTCAACCTGTACCGGCTCGTGCAATGGACGCGCGAACCCGTCGGCACCCCGCTGCCACGCGCCGCCGGAA
CCTGGGGCAAGGTATTCGCCGACATGAGCCGGCGCTCGCGTCTTGCCTACGACATGCGCGAGCGGCTGGCGGCAACGCTG
GATCGCTTTCGCGACGCCAGTCAGGCAATGCCGGACGGGGTGATGTACCTCGCCGAAAGCGACACGATCGAATGGATGAA
CCTGAAGGCCGAGCAGCATTTCGGACTCGACCACACGCGCGACATCGGCGCGCCGGTGACCAATCTGGTCCGCCAGCCGG
CCTTCGTGCAGTACCTGCATGGCGGACATTACGAAGAGTCGCTCGTGCTGCCCTCGACCCGCCCGGGCGGACTCACGCTG
CAGGTCCAGGTGATTCCGTTCGGCGATGGTCAGAAAATGGTGCTGTCGCGTGACATTTCGCAGCTGGAGCGGCTGGAAAC
CATGCGGCAGGACTTCGTCGCCAATGTGTCGCACGAGTTGCGGACGCCACTGACGGTTGTCGGCGGCTTTCTCGAGACCC
TGATCGACGGCGCGGGCGATTTCGAGCCGGACGACGTGCAACGCTACCTCCGGCTCGCGCTCGAACAGTCGAACCGGATG
CGTCACCTGATCGAGGACTTGCTGACGCTGTCCGCGCTCGAGACCGGCGCGCCGGCACCTGCCGAAGAAAGGGTCGGGGT
GGCGACGCTGGTGCGGGACGTCTATGCCGAGGCCGAGGCGCTGTCGTCTGGGCGTCATCAGCTCAGCCTGGTGCTCGACA
CCGACGCGGTGCTGCTGGGCAGCCACAAGGAACTGCGCAGCGCATTCGCCAACCTCTGCAGCAACGCCGTGCGCTACACG
CCGGACGGGGGCAGGATCGAAGTCGGCTGGCGGCAGGACGACGCCGGTGGCGAATTCTGGGTGCGCGACGACGGCATCGG
CATCGATGCCCAGCACATTCCGCGTCTGACCGAACGCTTCTACCGCGTCGACCGCGGCCGCTCACGCGAAACCGGTGGTA
CCGGGCTGGGGCTGGCCATCGTCAAGCACATCCTCACGCGCCACCAGGCCGAACTGCACGTGGTGAGCACCCCTGGCGCC
GGCAGCCGCTTCAGCGTGCGTTTTCCGCGCGCGCGGCTTATGCAACCGAAGGCGGCAGCGCTTCGAAGCTGA

Upstream 100 bases:

>100_bases
ACACGCTGAGCCGTCGTCAGCGTTCTTCGGAGTTCACACCATCCGTTCCACCACCTACATCTGGACCGGCGCACTGTCCC
TGCTGCTCGCGCTGCTGGCC

Downstream 100 bases:

>100_bases
CCTGATCGAAGTTCGCCCCGCGCAGCACCAGTTGTTCGAGCCGGACCTGGCTGGACTTGCCCTCGACGTGGATTTCGATG
ACCGCGCTCGGGTGGTACCA

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MAGLAALVGGSLAALLAALVGLLAAGWYHLVNLYRLVQWTREPVGTPLPRAAGTWGKVFADMSRRSRLAYDMRERLAATL
DRFRDASQAMPDGVMYLAESDTIEWMNLKAEQHFGLDHTRDIGAPVTNLVRQPAFVQYLHGGHYEESLVLPSTRPGGLTL
QVQVIPFGDGQKMVLSRDISQLERLETMRQDFVANVSHELRTPLTVVGGFLETLIDGAGDFEPDDVQRYLRLALEQSNRM
RHLIEDLLTLSALETGAPAPAEERVGVATLVRDVYAEAEALSSGRHQLSLVLDTDAVLLGSHKELRSAFANLCSNAVRYT
PDGGRIEVGWRQDDAGGEFWVRDDGIGIDAQHIPRLTERFYRVDRGRSRETGGTGLGLAIVKHILTRHQAELHVVSTPGA
GSRFSVRFPRARLMQPKAAALRS

Sequences:

>Translated_423_residues
MAGLAALVGGSLAALLAALVGLLAAGWYHLVNLYRLVQWTREPVGTPLPRAAGTWGKVFADMSRRSRLAYDMRERLAATL
DRFRDASQAMPDGVMYLAESDTIEWMNLKAEQHFGLDHTRDIGAPVTNLVRQPAFVQYLHGGHYEESLVLPSTRPGGLTL
QVQVIPFGDGQKMVLSRDISQLERLETMRQDFVANVSHELRTPLTVVGGFLETLIDGAGDFEPDDVQRYLRLALEQSNRM
RHLIEDLLTLSALETGAPAPAEERVGVATLVRDVYAEAEALSSGRHQLSLVLDTDAVLLGSHKELRSAFANLCSNAVRYT
PDGGRIEVGWRQDDAGGEFWVRDDGIGIDAQHIPRLTERFYRVDRGRSRETGGTGLGLAIVKHILTRHQAELHVVSTPGA
GSRFSVRFPRARLMQPKAAALRS
>Mature_422_residues
AGLAALVGGSLAALLAALVGLLAAGWYHLVNLYRLVQWTREPVGTPLPRAAGTWGKVFADMSRRSRLAYDMRERLAATLD
RFRDASQAMPDGVMYLAESDTIEWMNLKAEQHFGLDHTRDIGAPVTNLVRQPAFVQYLHGGHYEESLVLPSTRPGGLTLQ
VQVIPFGDGQKMVLSRDISQLERLETMRQDFVANVSHELRTPLTVVGGFLETLIDGAGDFEPDDVQRYLRLALEQSNRMR
HLIEDLLTLSALETGAPAPAEERVGVATLVRDVYAEAEALSSGRHQLSLVLDTDAVLLGSHKELRSAFANLCSNAVRYTP
DGGRIEVGWRQDDAGGEFWVRDDGIGIDAQHIPRLTERFYRVDRGRSRETGGTGLGLAIVKHILTRHQAELHVVSTPGAG
SRFSVRFPRARLMQPKAAALRS

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=406, Percent_Identity=39.1625615763547, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1788393, Length=260, Percent_Identity=32.3076923076923, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786783, Length=253, Percent_Identity=34.3873517786561, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI145693157, Length=222, Percent_Identity=33.7837837837838, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=31.6239316239316, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=392, Percent_Identity=25.5102040816327, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081816, Length=244, Percent_Identity=31.5573770491803, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=26.8398268398268, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=30.7359307359307, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI48994928, Length=381, Percent_Identity=24.9343832020997, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790861, Length=236, Percent_Identity=30.0847457627119, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=29.957805907173, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790551, Length=226, Percent_Identity=32.3008849557522, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789403, Length=204, Percent_Identity=30.8823529411765, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46602; Mature: 46471

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00626 RCC1_2 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLAALVGGSLAALLAALVGLLAAGWYHLVNLYRLVQWTREPVGTPLPRAAGTWGKVFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
DMSRRSRLAYDMRERLAATLDRFRDASQAMPDGVMYLAESDTIEWMNLKAEQHFGLDHTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCHHHHCCCCCCH
DIGAPVTNLVRQPAFVQYLHGGHYEESLVLPSTRPGGLTLQVQVIPFGDGQKMVLSRDIS
HCCCHHHHHHHCCHHHHHHHCCCCCCCEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHH
QLERLETMRQDFVANVSHELRTPLTVVGGFLETLIDGAGDFEPDDVQRYLRLALEQSNRM
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
RHLIEDLLTLSALETGAPAPAEERVGVATLVRDVYAEAEALSSGRHQLSLVLDTDAVLLG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCEEEEC
SHKELRSAFANLCSNAVRYTPDGGRIEVGWRQDDAGGEFWVRDDGIGIDAQHIPRLTERF
CHHHHHHHHHHHHHCCEEECCCCCEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHH
YRVDRGRSRETGGTGLGLAIVKHILTRHQAELHVVSTPGAGSRFSVRFPRARLMQPKAAA
HHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCHHHHCCCHHHH
LRS
HCC
>Mature Secondary Structure 
AGLAALVGGSLAALLAALVGLLAAGWYHLVNLYRLVQWTREPVGTPLPRAAGTWGKVFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
DMSRRSRLAYDMRERLAATLDRFRDASQAMPDGVMYLAESDTIEWMNLKAEQHFGLDHTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCHHHHCCCCCCH
DIGAPVTNLVRQPAFVQYLHGGHYEESLVLPSTRPGGLTLQVQVIPFGDGQKMVLSRDIS
HCCCHHHHHHHCCHHHHHHHCCCCCCCEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHH
QLERLETMRQDFVANVSHELRTPLTVVGGFLETLIDGAGDFEPDDVQRYLRLALEQSNRM
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
RHLIEDLLTLSALETGAPAPAEERVGVATLVRDVYAEAEALSSGRHQLSLVLDTDAVLLG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCEEEEC
SHKELRSAFANLCSNAVRYTPDGGRIEVGWRQDDAGGEFWVRDDGIGIDAQHIPRLTERF
CHHHHHHHHHHHHHCCEEECCCCCEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHH
YRVDRGRSRETGGTGLGLAIVKHILTRHQAELHVVSTPGAGSRFSVRFPRARLMQPKAAA
HHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCHHHHCCCHHHH
LRS
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]