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The map label for this gene is gltR [H]

Identifier: 119896322

GI number: 119896322

Start: 31735

End: 32625

Strand: Reverse

Name: gltR [H]

Synonym: azo0030

Alternate gene names: 119896322

Gene position: 32625-31735 (Counterclockwise)

Preceding gene: 119896324

Following gene: 119896320

Centisome position: 0.75

GC content: 72.28

Gene sequence:

>891_bases
ATGCTGTCGCCCACCCGCTTCAATCCCCAGCTGCTCCGCTATTTCCGCGCCGTGGTGGAGCAGGGCAGCCTCAGCGCCGC
ATCGCGCCAGCTCAACTGCGTGCCGTCCAACGTATCGGCGCGGCTGCGTCAGCTGGAGGAGCAACTGGGCAGCGTGCTGC
TGGAGCGCAACGGACCGCAGTTCACGCTGACCGCTGCCGGCGAGCGCCTGCTGCCGCACGCGCGCCAGCTCGACGCGCTG
TGTTCGGCGGCGTGGAACAGCGTGCATCTGGATACCCTGCAGGGGCGCCTGCGGCTGGGGTCGATGGAAACCACCGCGGC
GATGCGGCTGCCGGACGTGCTGGCGCGCTTCCATCGCCATGCGCCGCGGGTGGAGGTGGAGCTGGAAACCGGCACCAGCG
CCACGCTGATCGAGCGCGTGCTGGGCCACGAGCTGGACGCGGCGCTGGTGGCGGGGCCGCTGGAGCATCCTCGCCTGCTG
GCCAACGAGGTGTGGCGCGAAGAACTGCGGCTGGTGGTGCCGCCCGGCGAGCCGGCGCCGGCGCCCGGTACCGAGGTGAG
CCTGATCGCCTTTCCGGAGGGCTGCCATTACCGCGCCCGCTTGTTCACCCATGCGCGCGATTGCGGCTGGCGGGTGCGCG
GCCAGCAGAGCTATGCCTCGGTGGAGGCGATCATCGGCTGTGTGGGTGCCGGACTCGGACTCGGCGTGCTGCCGGCCAGC
CTGCTCGCCGCCCATCCGCGCGGGCGACAGGTGGCGAGCCATCCGCTGCCGCCCTCGCTGGCGGTGTCGCCCACGGTGCT
GGTGCGACGCCGCGTGGCCGAGCCCCATCCTGCGCTCGACGCGTGGGTGGAAGTGCTGCTGGGCGGCGCCAGCGGGACCC
AGACGCAATGA

Upstream 100 bases:

>100_bases
GGGATGGGGCCGGCGGGTCGGATTCCACTGTAGCCCAGGATGGGAGGTGACTGTGAGTGAAAAGTAGTATTCTTTATTTT
CACTAATGGAGAAAGACGCC

Downstream 100 bases:

>100_bases
CGCCGCGGCGAGGCGCGGCGTCATTGCGGTAGCGCTGCGGCCTGCGCCGCCCGCCGCGTCAGCGCTTTTCGGGGGCCGGG
GTTTGCTCCGGCACGTAGGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MLSPTRFNPQLLRYFRAVVEQGSLSAASRQLNCVPSNVSARLRQLEEQLGSVLLERNGPQFTLTAAGERLLPHARQLDAL
CSAAWNSVHLDTLQGRLRLGSMETTAAMRLPDVLARFHRHAPRVEVELETGTSATLIERVLGHELDAALVAGPLEHPRLL
ANEVWREELRLVVPPGEPAPAPGTEVSLIAFPEGCHYRARLFTHARDCGWRVRGQQSYASVEAIIGCVGAGLGLGVLPAS
LLAAHPRGRQVASHPLPPSLAVSPTVLVRRRVAEPHPALDAWVEVLLGGASGTQTQ

Sequences:

>Translated_296_residues
MLSPTRFNPQLLRYFRAVVEQGSLSAASRQLNCVPSNVSARLRQLEEQLGSVLLERNGPQFTLTAAGERLLPHARQLDAL
CSAAWNSVHLDTLQGRLRLGSMETTAAMRLPDVLARFHRHAPRVEVELETGTSATLIERVLGHELDAALVAGPLEHPRLL
ANEVWREELRLVVPPGEPAPAPGTEVSLIAFPEGCHYRARLFTHARDCGWRVRGQQSYASVEAIIGCVGAGLGLGVLPAS
LLAAHPRGRQVASHPLPPSLAVSPTVLVRRRVAEPHPALDAWVEVLLGGASGTQTQ
>Mature_296_residues
MLSPTRFNPQLLRYFRAVVEQGSLSAASRQLNCVPSNVSARLRQLEEQLGSVLLERNGPQFTLTAAGERLLPHARQLDAL
CSAAWNSVHLDTLQGRLRLGSMETTAAMRLPDVLARFHRHAPRVEVELETGTSATLIERVLGHELDAALVAGPLEHPRLL
ANEVWREELRLVVPPGEPAPAPGTEVSLIAFPEGCHYRARLFTHARDCGWRVRGQQSYASVEAIIGCVGAGLGLGVLPAS
LLAAHPRGRQVASHPLPPSLAVSPTVLVRRRVAEPHPALDAWVEVLLGGASGTQTQ

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787806, Length=278, Percent_Identity=35.9712230215827, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI87082132, Length=240, Percent_Identity=31.6666666666667, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787601, Length=198, Percent_Identity=27.7777777777778, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790208, Length=249, Percent_Identity=27.3092369477912, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI157672245, Length=169, Percent_Identity=29.585798816568, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693105, Length=287, Percent_Identity=24.7386759581882, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788481, Length=182, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788297, Length=251, Percent_Identity=25.8964143426295, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081904, Length=173, Percent_Identity=30.635838150289, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787879, Length=247, Percent_Identity=29.1497975708502, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788626, Length=244, Percent_Identity=25, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790399, Length=242, Percent_Identity=23.1404958677686, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32019; Mature: 32019

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSPTRFNPQLLRYFRAVVEQGSLSAASRQLNCVPSNVSARLRQLEEQLGSVLLERNGPQ
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCE
FTLTAAGERLLPHARQLDALCSAAWNSVHLDTLQGRLRLGSMETTAAMRLPDVLARFHRH
EEEECCCCHHCHHHHHHHHHHHHHCCCEEHHHHHCHHEECCCHHHHHHHHHHHHHHHHHC
APRVEVELETGTSATLIERVLGHELDAALVAGPLEHPRLLANEVWREELRLVVPPGEPAP
CCCEEEEEECCCHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHCEEEECCCCCCC
APGTEVSLIAFPEGCHYRARLFTHARDCGWRVRGQQSYASVEAIIGCVGAGLGLGVLPAS
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCCCHHHHHHH
LLAAHPRGRQVASHPLPPSLAVSPTVLVRRRVAEPHPALDAWVEVLLGGASGTQTQ
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLSPTRFNPQLLRYFRAVVEQGSLSAASRQLNCVPSNVSARLRQLEEQLGSVLLERNGPQ
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCE
FTLTAAGERLLPHARQLDALCSAAWNSVHLDTLQGRLRLGSMETTAAMRLPDVLARFHRH
EEEECCCCHHCHHHHHHHHHHHHHCCCEEHHHHHCHHEECCCHHHHHHHHHHHHHHHHHC
APRVEVELETGTSATLIERVLGHELDAALVAGPLEHPRLLANEVWREELRLVVPPGEPAP
CCCEEEEEECCCHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHCEEEECCCCCCC
APGTEVSLIAFPEGCHYRARLFTHARDCGWRVRGQQSYASVEAIIGCVGAGLGLGVLPAS
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCCCHHHHHHH
LLAAHPRGRQVASHPLPPSLAVSPTVLVRRRVAEPHPALDAWVEVLLGGASGTQTQ
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]