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The map label for this gene is iorA [H]

Identifier: 119896313

GI number: 119896313

Start: 23470

End: 23928

Strand: Direct

Name: iorA [H]

Synonym: azo0021

Alternate gene names: 119896313

Gene position: 23470-23928 (Clockwise)

Preceding gene: 119896311

Following gene: 119896314

Centisome position: 0.54

GC content: 69.06

Gene sequence:

>459_bases
ATGACCCGCTTCACCCTCAACGGCAAGCCGGTGGAAACCGCCTTGCCCGACGACACCCCGCTGCTGTGGGTCCTGCGCGA
CGGACTCGACCAGACCGGCACCAAGTTCGGCTGCGGCATGGGCCTGTGCGGCGCCTGCACCGTGCATCTGGACGGCCAGC
CGATCCGTTCCTGTTCCACGCCGCTGTCGGCCGCCGCCGGCAAGAAGATCACCACCATCGAGGGCGTCGGCAAGGCCCGC
GTCGGCGCCGCGGTGCAGAAGGCGTGGCAGAAGCTCGACGTGGTGCAGTGCGGTTACTGCCAGTCGGGCCAGATCATGTC
CGCCACCGCGCTGCTCACCGCCAACCCCAAGCCCACCGACGCCGACATCGACGCCGCGATGGGCGGAAACATCTGCCGCT
GCGCCACCTATGTGCGCATCCGCGCCGCCATCCACGAAGCCGCCAAGAGCCTGGCGTAA

Upstream 100 bases:

>100_bases
AAGCTGAACGTCATTTCAGTGCGGCAGCCATGACGACCGCACACACCCCCGGCCCCAACCGAATCCGAACGACCCCCGTC
CCAATCTCCAGGAGACGCCG

Downstream 100 bases:

>100_bases
GGAGCGCACGATGAAGATGCAGATCACCAACGTGTCGCGCCGCGACTTCCTCAAGGCCGGCGCCGGCCTCACGCTGTCGG
TCAGCCTGCCAGGCGCGGTA

Product: isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTRFTLNGKPVETALPDDTPLLWVLRDGLDQTGTKFGCGMGLCGACTVHLDGQPIRSCSTPLSAAAGKKITTIEGVGKAR
VGAAVQKAWQKLDVVQCGYCQSGQIMSATALLTANPKPTDADIDAAMGGNICRCATYVRIRAAIHEAAKSLA

Sequences:

>Translated_152_residues
MTRFTLNGKPVETALPDDTPLLWVLRDGLDQTGTKFGCGMGLCGACTVHLDGQPIRSCSTPLSAAAGKKITTIEGVGKAR
VGAAVQKAWQKLDVVQCGYCQSGQIMSATALLTANPKPTDADIDAAMGGNICRCATYVRIRAAIHEAAKSLA
>Mature_151_residues
TRFTLNGKPVETALPDDTPLLWVLRDGLDQTGTKFGCGMGLCGACTVHLDGQPIRSCSTPLSAAAGKKITTIEGVGKARV
GAAVQKAWQKLDVVQCGYCQSGQIMSATALLTANPKPTDADIDAAMGGNICRCATYVRIRAAIHEAAKSLA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=86, Percent_Identity=37.2093023255814, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI91823271, Length=146, Percent_Identity=38.3561643835616, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1786480, Length=160, Percent_Identity=40.625, Blast_Score=106, Evalue=6e-25,
Organism=Escherichia coli, GI1789232, Length=150, Percent_Identity=40.6666666666667, Blast_Score=93, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17540638, Length=157, Percent_Identity=41.4012738853503, Blast_Score=106, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17539860, Length=153, Percent_Identity=35.9477124183007, Blast_Score=96, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI32566215, Length=153, Percent_Identity=36.6013071895425, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17737937, Length=161, Percent_Identity=37.2670807453416, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24647199, Length=160, Percent_Identity=39.375, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24647193, Length=165, Percent_Identity=38.7878787878788, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24647201, Length=160, Percent_Identity=36.25, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24647197, Length=165, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647195, Length=165, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 15836; Mature: 15705

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRFTLNGKPVETALPDDTPLLWVLRDGLDQTGTKFGCGMGLCGACTVHLDGQPIRSCST
CCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
PLSAAAGKKITTIEGVGKARVGAAVQKAWQKLDVVQCGYCQSGQIMSATALLTANPKPTD
CCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCC
ADIDAAMGGNICRCATYVRIRAAIHEAAKSLA
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRFTLNGKPVETALPDDTPLLWVLRDGLDQTGTKFGCGMGLCGACTVHLDGQPIRSCST
CEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
PLSAAAGKKITTIEGVGKARVGAAVQKAWQKLDVVQCGYCQSGQIMSATALLTANPKPTD
CCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCC
ADIDAAMGGNICRCATYVRIRAAIHEAAKSLA
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]