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The map label for this gene is glmU

Identifier: 119776774

GI number: 119776774

Start: 4292739

End: 4294103

Strand: Reverse

Name: glmU

Synonym: Sama_3642

Alternate gene names: 119776774

Gene position: 4294103-4292739 (Counterclockwise)

Preceding gene: 119776775

Following gene: 119776773

Centisome position: 99.72

GC content: 58.39

Gene sequence:

>1365_bases
ATGTCACTCAATGTTGTCATTCTCGCCGCCGGAAAAGGCACCCGCATGCGCTCAGACCTGCCCAAGGTGCTGCACAGCGT
CGCCCACAAACCCATGGTTCAGCACGTGATAGACACGGCACGCGAGCTCAATGCCGATAACATCAATCTGGTGTATGGCT
ATGGCGGCGAACTGCTTAAAGCCAAGCTGGGCGAGCAGCCGCTGAATTTTGTGCTGCAGGCCGAGCAGCTGGGTACCGGC
CACGCGGTAGCACAGGCGATTGATCACATCAACGACGAGGATACAGTGCTGGTGCTCTACGGCGATGTGCCACTGACCCG
CAAGGAAACCTTGGAAGCCCTGCTGGCTGCCCGCCAACCCGATGGCGTCGCCGTGCTGACGGTGCATCTGGATAACCCCA
CCGGCTATGGCCGCATGGTGCGTGAGGGCGGAAAAGTTGTTGGCATCGTCGAGCAGAAGGATGCCAGTCCGGAGCAGCTC
AAGATTAATGAAATCAACAGCGGCATCATGGCGCTGCCGGGCAAGCGCCTCAAAGCCTGGCTTGGTCGCCTCGAGAACAA
CAACGCCCAGGGCGAGTTTTACCTCACCGACGTGATTGCCATGGCCCACGCCGATGGTGTGGCCATTGATACCGCCCATC
CCGCCAATCCCATCGAGACCGAAGGCGCCAACAACCGGGTGCAGCTGGCGGCACTGGAGCGAGCTTATCAGGCGCGCCGT
GCCGAAGAGCTGATGCTTGCAGGCGCCAACCTGCGCGACCCTGCCCGTATCGATATTCGCGGTGACGTGACTGTGGGCAT
GGACGTGATGATTGATGTGAACGTGATTTTTGAAGGTACGGTCAAGCTTGGTAATAACGTTACCATCGGTGCCGGTGCGA
TCCTGATTGACTGCGACATTGCCGACAACGCCGACATTAAACCTTACAGCATTATTGAAGGTGCCAAACTGGGCGATAGC
GCCAGTGCCGGCCCCTTCGCCCGTCTGCGCCCCGGCGCCGAGCTGCACAAAGATGCCCACATTGGCAACTTTGTCGAAAT
GAAGAAAGCCGTGCTCGGTGAAGGCTCCAAGGCCGGGCATCTGGCATACCTCGGCGATGCCGAAATAGGCAAAGGCGTGA
ACATAGGTGCCGGTACCATCACCTGTAACTACGATGGCGCCAACAAACACCTCACCGTAATTGAAGACAATGTCTTTGTT
GGCAGCGATACCCAACTGGTGGCGCCAGTGGTAATCCGTAAAGGTGCGACCCTGGGCGCCGGCTCTACCGTGACCCACGA
AGTGGGTGAAAACGAGCTGGTGATCACCCGGGTGAAGCAGCGCCATATTCAGGGTTGGCAACGTCCGGTGAAAAAGCCCA
AGTAA

Upstream 100 bases:

>100_bases
TTTTTTATTGGGCAAAAATAACCTGTCCTCTTCTGCACAGCGGTGAATTTTAGGCGGCCATCGGGTACACTTGCGCCAGA
TAAAAGATAAGGGACCTCCT

Downstream 100 bases:

>100_bases
TCGACTTCTTATTGAAAAGCGGCGCATTTGCGCCGCTTTTTTGTTTTCACACCAATGCTTTTGTGAGTGCCATCACCAGC
AATTGTAAATTACCGTAAAG

Product: UDP-N-acetylglucosamine diphosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSLNVVILAAGKGTRMRSDLPKVLHSVAHKPMVQHVIDTARELNADNINLVYGYGGELLKAKLGEQPLNFVLQAEQLGTG
HAVAQAIDHINDEDTVLVLYGDVPLTRKETLEALLAARQPDGVAVLTVHLDNPTGYGRMVREGGKVVGIVEQKDASPEQL
KINEINSGIMALPGKRLKAWLGRLENNNAQGEFYLTDVIAMAHADGVAIDTAHPANPIETEGANNRVQLAALERAYQARR
AEELMLAGANLRDPARIDIRGDVTVGMDVMIDVNVIFEGTVKLGNNVTIGAGAILIDCDIADNADIKPYSIIEGAKLGDS
ASAGPFARLRPGAELHKDAHIGNFVEMKKAVLGEGSKAGHLAYLGDAEIGKGVNIGAGTITCNYDGANKHLTVIEDNVFV
GSDTQLVAPVVIRKGATLGAGSTVTHEVGENELVITRVKQRHIQGWQRPVKKPK

Sequences:

>Translated_454_residues
MSLNVVILAAGKGTRMRSDLPKVLHSVAHKPMVQHVIDTARELNADNINLVYGYGGELLKAKLGEQPLNFVLQAEQLGTG
HAVAQAIDHINDEDTVLVLYGDVPLTRKETLEALLAARQPDGVAVLTVHLDNPTGYGRMVREGGKVVGIVEQKDASPEQL
KINEINSGIMALPGKRLKAWLGRLENNNAQGEFYLTDVIAMAHADGVAIDTAHPANPIETEGANNRVQLAALERAYQARR
AEELMLAGANLRDPARIDIRGDVTVGMDVMIDVNVIFEGTVKLGNNVTIGAGAILIDCDIADNADIKPYSIIEGAKLGDS
ASAGPFARLRPGAELHKDAHIGNFVEMKKAVLGEGSKAGHLAYLGDAEIGKGVNIGAGTITCNYDGANKHLTVIEDNVFV
GSDTQLVAPVVIRKGATLGAGSTVTHEVGENELVITRVKQRHIQGWQRPVKKPK
>Mature_453_residues
SLNVVILAAGKGTRMRSDLPKVLHSVAHKPMVQHVIDTARELNADNINLVYGYGGELLKAKLGEQPLNFVLQAEQLGTGH
AVAQAIDHINDEDTVLVLYGDVPLTRKETLEALLAARQPDGVAVLTVHLDNPTGYGRMVREGGKVVGIVEQKDASPEQLK
INEINSGIMALPGKRLKAWLGRLENNNAQGEFYLTDVIAMAHADGVAIDTAHPANPIETEGANNRVQLAALERAYQARRA
EELMLAGANLRDPARIDIRGDVTVGMDVMIDVNVIFEGTVKLGNNVTIGAGAILIDCDIADNADIKPYSIIEGAKLGDSA
SAGPFARLRPGAELHKDAHIGNFVEMKKAVLGEGSKAGHLAYLGDAEIGKGVNIGAGTITCNYDGANKHLTVIEDNVFVG
SDTQLVAPVVIRKGATLGAGSTVTHEVGENELVITRVKQRHIQGWQRPVKKPK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=61.8625277161863, Blast_Score=561, Evalue=1e-161,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_SHEAM (A1SBT8)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_929514.1
- ProteinModelPortal:   A1SBT8
- SMR:   A1SBT8
- STRING:   A1SBT8
- GeneID:   4605889
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_3642
- NMPDR:   fig|326297.7.peg.3431
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   A1SBT8
- ProtClustDB:   CLSK907802
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48452; Mature: 48321

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 360-360 BINDING 73-73 BINDING 137-137 BINDING 151-151 BINDING 166-166 BINDING 384-384 BINDING 402-402 BINDING 420-420 BINDING 437-437

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNVVILAAGKGTRMRSDLPKVLHSVAHKPMVQHVIDTARELNADNINLVYGYGGELLK
CCEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
AKLGEQPLNFVLQAEQLGTGHAVAQAIDHINDEDTVLVLYGDVPLTRKETLEALLAARQP
HHCCCCCHHEEEEHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCC
DGVAVLTVHLDNPTGYGRMVREGGKVVGIVEQKDASPEQLKINEINSGIMALPGKRLKAW
CCEEEEEEEECCCCCCHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCEEECCCHHHHHH
LGRLENNNAQGEFYLTDVIAMAHADGVAIDTAHPANPIETEGANNRVQLAALERAYQARR
HHHHCCCCCCCEEEEEEEHHHHCCCCEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHH
AEELMLAGANLRDPARIDIRGDVTVGMDVMIDVNVIFEGTVKLGNNVTIGAGAILIDCDI
HHHHEEECCCCCCCCEEEEECCEEECEEEEEEEEEEEEEEEEECCEEEEECCEEEEEEEC
ADNADIKPYSIIEGAKLGDSASAGPFARLRPGAELHKDAHIGNFVEMKKAVLGEGSKAGH
CCCCCCCCEEEECCCCCCCCCCCCCCHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCE
LAYLGDAEIGKGVNIGAGTITCNYDGANKHLTVIEDNVFVGSDTQLVAPVVIRKGATLGA
EEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCEEECCCCCEEEHHHEECCCCCCC
GSTVTHEVGENELVITRVKQRHIQGWQRPVKKPK
CCCEEEECCCCCEEEEHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLNVVILAAGKGTRMRSDLPKVLHSVAHKPMVQHVIDTARELNADNINLVYGYGGELLK
CEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
AKLGEQPLNFVLQAEQLGTGHAVAQAIDHINDEDTVLVLYGDVPLTRKETLEALLAARQP
HHCCCCCHHEEEEHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCC
DGVAVLTVHLDNPTGYGRMVREGGKVVGIVEQKDASPEQLKINEINSGIMALPGKRLKAW
CCEEEEEEEECCCCCCHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCEEECCCHHHHHH
LGRLENNNAQGEFYLTDVIAMAHADGVAIDTAHPANPIETEGANNRVQLAALERAYQARR
HHHHCCCCCCCEEEEEEEHHHHCCCCEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHH
AEELMLAGANLRDPARIDIRGDVTVGMDVMIDVNVIFEGTVKLGNNVTIGAGAILIDCDI
HHHHEEECCCCCCCCEEEEECCEEECEEEEEEEEEEEEEEEEECCEEEEECCEEEEEEEC
ADNADIKPYSIIEGAKLGDSASAGPFARLRPGAELHKDAHIGNFVEMKKAVLGEGSKAGH
CCCCCCCCEEEECCCCCCCCCCCCCCHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCE
LAYLGDAEIGKGVNIGAGTITCNYDGANKHLTVIEDNVFVGSDTQLVAPVVIRKGATLGA
EEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCEEECCCCCEEEHHHEECCCCCCC
GSTVTHEVGENELVITRVKQRHIQGWQRPVKKPK
CCCEEEECCCCCEEEEHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA