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The map label for this gene is prlC [H]

Identifier: 119776678

GI number: 119776678

Start: 4177877

End: 4179913

Strand: Direct

Name: prlC [H]

Synonym: Sama_3546

Alternate gene names: 119776678

Gene position: 4177877-4179913 (Clockwise)

Preceding gene: 119776673

Following gene: 119776679

Centisome position: 97.02

GC content: 56.5

Gene sequence:

>2037_bases
ATGACCAATCCACTGCTTGCGGCCAACGCGCTGCCCCCCTTTTCGGCCATCAAGCCAGAGCATATTCAGCCAGCGGTCGA
GCAGGCCATAGACCACTGCCGGGCAGAAATTGCACGGGTACTGGAACGTGGTGATTTCAGCTGGCAGGGACTGGTTGCGC
CCCTGGAGGAAGCTGACGATCGCCTCAGCAAACTTTGGTCACCGGTATCGCACATGAACTCAGTGCTCAGCACAGAAGCA
TGGCGCGCGGCCCACGACGCTTGCCTGCCGCTTCTGTCTGAGTATGGCACCTTTGTGGGCCAGCATCAGGGGCTGTATCA
GGCCTATAAAACCCTTAAAAATTCTGATGAATTTCAAGGTCTGTCCAAGGCGCAGCAACAGGTGATTGACCATGCCCTGC
GAGACTTTGAACTCTCGGGTATTGGCTTGGATGACGACAAAAAGGCCCGTTATGGCGAAATAGTCAAACGCCTGTCGGAA
CTGTCGAGCAGCTTCTCCAATCAGGTGTTGGATGCCACCCACGCCTGGCAGAAGCTCATCACCGATGAGTCCGAACTTAA
GGGTCTGCCTGAATCGGCCCTTGCTGCAGCACGCGCCATGGCAGAAGAAAAAGGCGAGCAGGGGTATCTGTTCACCCTCG
ACTTCCCATCGTATTTGCCTGTGATGATGTACAGCGAAAACCGTGAACTGCGCCAGGAGTGCTACACCGCCTTCGTGACC
CGCGCCTCGGATCAGGGCCCCAACGCCGGTGAATTTGACAATGGCCCCTTGATGGAAGAGTTGCTGGCGCTGCGCCACGA
GCTGGCCACCCTGCTCGGTTTCGACAGCTTTGCCCACAAGTCGCTGGCCACCAAGATGGCCGAAACACCGGGCCAGGTTA
TCAGCTTCCTGAATGAGCTGGCCCTGCACTCTCGTCCACAGGCCAAACAGGAGCTGGATGAGCTCAAGGCCTTCGCCGCG
AAAGAATATGGCCAAACCGACCTCAAGGCATGGGATTTAAGCTTTTACGCCGAAAAACTCAAACAGCACAGATACGAAAT
TTCCCAGGAAGAACTGCGCCCTTACTTTCCCGAAAACAAGGTACTGAGCGGCCTCTTCCACACGGTAGAGCGTCTCTTTG
GCATGAAGATAGTCGAGCAGCAGGAATTTGACCGCTGGCATAAGGACGTGCGCTTCTTCCACATTATGGACAGCGAAGGC
GAGCACAGAGGCAGCTTCTATCTGGATCTCTACGCCCGCAGCGGTAAACGCGGCGGCGCCTGGATGGACGAGTGCCGGGT
TCGTCGTCAAACCCCCGATGGGCTGCAAAAACCCGTGGCTTACCTCACCTGTAACTTCAATGGTCCCGTGGGCAATAAAC
CAGCGCTCTTTACCCATGACGAAGTGGTTACCCTGTTCCATGAGTTTGGCCATGGCATCCACCATATGCTGACCAAGGTA
GAGGTAGGCGGTGTATCCGGTATCAATGGTGTGCCCTGGGATGCCGTGGAGCTGCCAAGCCAGTTCCTCGAGAATTGGTG
CTGGGAAGAAGCAGCCCTCGGCGAAATCTCCGGCCACTACGAAACCGGCGAGCCGCTGCCCAAGGCCATGCTGGACAAGA
TGTTGGCGGCCAAAAATTTCCAATCCGCCATGATGATGGTGCGCCAGCTGGAGTTTTCGCTGTTCGATTTCCGCCTGCAC
CTGGAATACAACGGCGAAGACGGTGCCCGCATTCAGGAAACTCTGGACGAAGTGCGTCAGCAGGTGGCCGTGGTGATCCC
CCCCAGCTTTAATCGCTTCCAGCACAGCTTCTCCCATATTTTTGCCGGGGGATATGCCGCAGGTTACTACAGCTACAAGT
GGGCCGAAGTACTGTCGGCCGATGCCTTCTCGCGGTTTGAAGCTGAAGGTATCTTTAATCCAGATACGGGGCGCGACTTC
CTTACCCATATCCTTGAGATGGGTGGCAGCGAAGAGCCCATGGAACTGTTCCGCCGCTTCATGGGCCGGGAGCCCAATAC
AGATGCGCTACTGCGCCACAGCGGCATTCAGCACTGA

Upstream 100 bases:

>100_bases
ATCCGGCGCCAGCCCTTATGTATGCTCCATGGCCCAGGCCGCAACTGCTTTGCAAAACCTGCTTTGCACGACACTATTTG
CACGATAATAAGGGATCTCC

Downstream 100 bases:

>100_bases
GATTGATTTCATCTTAAAGGCGCTTCGGCGCCTTTTTTATTACTCCGACAGGAAGGCCTTGTGGCTACACTGACAGTTGC
CCGCTGGTAGGACCTCTGTT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MTNPLLAANALPPFSAIKPEHIQPAVEQAIDHCRAEIARVLERGDFSWQGLVAPLEEADDRLSKLWSPVSHMNSVLSTEA
WRAAHDACLPLLSEYGTFVGQHQGLYQAYKTLKNSDEFQGLSKAQQQVIDHALRDFELSGIGLDDDKKARYGEIVKRLSE
LSSSFSNQVLDATHAWQKLITDESELKGLPESALAAARAMAEEKGEQGYLFTLDFPSYLPVMMYSENRELRQECYTAFVT
RASDQGPNAGEFDNGPLMEELLALRHELATLLGFDSFAHKSLATKMAETPGQVISFLNELALHSRPQAKQELDELKAFAA
KEYGQTDLKAWDLSFYAEKLKQHRYEISQEELRPYFPENKVLSGLFHTVERLFGMKIVEQQEFDRWHKDVRFFHIMDSEG
EHRGSFYLDLYARSGKRGGAWMDECRVRRQTPDGLQKPVAYLTCNFNGPVGNKPALFTHDEVVTLFHEFGHGIHHMLTKV
EVGGVSGINGVPWDAVELPSQFLENWCWEEAALGEISGHYETGEPLPKAMLDKMLAAKNFQSAMMMVRQLEFSLFDFRLH
LEYNGEDGARIQETLDEVRQQVAVVIPPSFNRFQHSFSHIFAGGYAAGYYSYKWAEVLSADAFSRFEAEGIFNPDTGRDF
LTHILEMGGSEEPMELFRRFMGREPNTDALLRHSGIQH

Sequences:

>Translated_678_residues
MTNPLLAANALPPFSAIKPEHIQPAVEQAIDHCRAEIARVLERGDFSWQGLVAPLEEADDRLSKLWSPVSHMNSVLSTEA
WRAAHDACLPLLSEYGTFVGQHQGLYQAYKTLKNSDEFQGLSKAQQQVIDHALRDFELSGIGLDDDKKARYGEIVKRLSE
LSSSFSNQVLDATHAWQKLITDESELKGLPESALAAARAMAEEKGEQGYLFTLDFPSYLPVMMYSENRELRQECYTAFVT
RASDQGPNAGEFDNGPLMEELLALRHELATLLGFDSFAHKSLATKMAETPGQVISFLNELALHSRPQAKQELDELKAFAA
KEYGQTDLKAWDLSFYAEKLKQHRYEISQEELRPYFPENKVLSGLFHTVERLFGMKIVEQQEFDRWHKDVRFFHIMDSEG
EHRGSFYLDLYARSGKRGGAWMDECRVRRQTPDGLQKPVAYLTCNFNGPVGNKPALFTHDEVVTLFHEFGHGIHHMLTKV
EVGGVSGINGVPWDAVELPSQFLENWCWEEAALGEISGHYETGEPLPKAMLDKMLAAKNFQSAMMMVRQLEFSLFDFRLH
LEYNGEDGARIQETLDEVRQQVAVVIPPSFNRFQHSFSHIFAGGYAAGYYSYKWAEVLSADAFSRFEAEGIFNPDTGRDF
LTHILEMGGSEEPMELFRRFMGREPNTDALLRHSGIQH
>Mature_677_residues
TNPLLAANALPPFSAIKPEHIQPAVEQAIDHCRAEIARVLERGDFSWQGLVAPLEEADDRLSKLWSPVSHMNSVLSTEAW
RAAHDACLPLLSEYGTFVGQHQGLYQAYKTLKNSDEFQGLSKAQQQVIDHALRDFELSGIGLDDDKKARYGEIVKRLSEL
SSSFSNQVLDATHAWQKLITDESELKGLPESALAAARAMAEEKGEQGYLFTLDFPSYLPVMMYSENRELRQECYTAFVTR
ASDQGPNAGEFDNGPLMEELLALRHELATLLGFDSFAHKSLATKMAETPGQVISFLNELALHSRPQAKQELDELKAFAAK
EYGQTDLKAWDLSFYAEKLKQHRYEISQEELRPYFPENKVLSGLFHTVERLFGMKIVEQQEFDRWHKDVRFFHIMDSEGE
HRGSFYLDLYARSGKRGGAWMDECRVRRQTPDGLQKPVAYLTCNFNGPVGNKPALFTHDEVVTLFHEFGHGIHHMLTKVE
VGGVSGINGVPWDAVELPSQFLENWCWEEAALGEISGHYETGEPLPKAMLDKMLAAKNFQSAMMMVRQLEFSLFDFRLHL
EYNGEDGARIQETLDEVRQQVAVVIPPSFNRFQHSFSHIFAGGYAAGYYSYKWAEVLSADAFSRFEAEGIFNPDTGRDFL
THILEMGGSEEPMELFRRFMGREPNTDALLRHSGIQH

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=596, Percent_Identity=33.0536912751678, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI14149738, Length=671, Percent_Identity=29.5081967213115, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI156105687, Length=670, Percent_Identity=26.1194029850746, Blast_Score=181, Evalue=3e-45,
Organism=Escherichia coli, GI1789913, Length=679, Percent_Identity=63.6229749631811, Blast_Score=900, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=690, Percent_Identity=31.0144927536232, Blast_Score=299, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI71999758, Length=572, Percent_Identity=27.6223776223776, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI32565901, Length=592, Percent_Identity=23.9864864864865, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6319793, Length=686, Percent_Identity=27.4052478134111, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6322715, Length=700, Percent_Identity=24.5714285714286, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21356111, Length=695, Percent_Identity=27.1942446043165, Blast_Score=236, Evalue=6e-62,
Organism=Drosophila melanogaster, GI20129717, Length=598, Percent_Identity=25.4180602006689, Blast_Score=171, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76853; Mature: 76722

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLAANALPPFSAIKPEHIQPAVEQAIDHCRAEIARVLERGDFSWQGLVAPLEEADD
CCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
RLSKLWSPVSHMNSVLSTEAWRAAHDACLPLLSEYGTFVGQHQGLYQAYKTLKNSDEFQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LSKAQQQVIDHALRDFELSGIGLDDDKKARYGEIVKRLSELSSSFSNQVLDATHAWQKLI
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDESELKGLPESALAAARAMAEEKGEQGYLFTLDFPSYLPVMMYSENRELRQECYTAFVT
CCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHHH
RASDQGPNAGEFDNGPLMEELLALRHELATLLGFDSFAHKSLATKMAETPGQVISFLNEL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ALHSRPQAKQELDELKAFAAKEYGQTDLKAWDLSFYAEKLKQHRYEISQEELRPYFPENK
HHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHH
VLSGLFHTVERLFGMKIVEQQEFDRWHKDVRFFHIMDSEGEHRGSFYLDLYARSGKRGGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCEEEEEEECCCCCCCC
WMDECRVRRQTPDGLQKPVAYLTCNFNGPVGNKPALFTHDEVVTLFHEFGHGIHHMLTKV
CHHHHHHHCCCCCHHHCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHCHHHHHHHHHH
EVGGVSGINGVPWDAVELPSQFLENWCWEEAALGEISGHYETGEPLPKAMLDKMLAAKNF
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
QSAMMMVRQLEFSLFDFRLHLEYNGEDGARIQETLDEVRQQVAVVIPPSFNRFQHSFSHI
HHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHH
FAGGYAAGYYSYKWAEVLSADAFSRFEAEGIFNPDTGRDFLTHILEMGGSEEPMELFRRF
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
MGREPNTDALLRHSGIQH
HCCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
TNPLLAANALPPFSAIKPEHIQPAVEQAIDHCRAEIARVLERGDFSWQGLVAPLEEADD
CCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
RLSKLWSPVSHMNSVLSTEAWRAAHDACLPLLSEYGTFVGQHQGLYQAYKTLKNSDEFQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LSKAQQQVIDHALRDFELSGIGLDDDKKARYGEIVKRLSELSSSFSNQVLDATHAWQKLI
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TDESELKGLPESALAAARAMAEEKGEQGYLFTLDFPSYLPVMMYSENRELRQECYTAFVT
CCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCHHHHHHHHHHHHH
RASDQGPNAGEFDNGPLMEELLALRHELATLLGFDSFAHKSLATKMAETPGQVISFLNEL
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ALHSRPQAKQELDELKAFAAKEYGQTDLKAWDLSFYAEKLKQHRYEISQEELRPYFPENK
HHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHH
VLSGLFHTVERLFGMKIVEQQEFDRWHKDVRFFHIMDSEGEHRGSFYLDLYARSGKRGGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCEEEEEEECCCCCCCC
WMDECRVRRQTPDGLQKPVAYLTCNFNGPVGNKPALFTHDEVVTLFHEFGHGIHHMLTKV
CHHHHHHHCCCCCHHHCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHCHHHHHHHHHH
EVGGVSGINGVPWDAVELPSQFLENWCWEEAALGEISGHYETGEPLPKAMLDKMLAAKNF
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
QSAMMMVRQLEFSLFDFRLHLEYNGEDGARIQETLDEVRQQVAVVIPPSFNRFQHSFSHI
HHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHH
FAGGYAAGYYSYKWAEVLSADAFSRFEAEGIFNPDTGRDFLTHILEMGGSEEPMELFRRF
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
MGREPNTDALLRHSGIQH
HCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]