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The map label for this gene is hutH [H]

Identifier: 119776517

GI number: 119776517

Start: 4012189

End: 4013745

Strand: Direct

Name: hutH [H]

Synonym: Sama_3385

Alternate gene names: 119776517

Gene position: 4012189-4013745 (Clockwise)

Preceding gene: 119776516

Following gene: 119776518

Centisome position: 93.17

GC content: 59.67

Gene sequence:

>1557_bases
ATGACTAACCAATCAACTGAAATGAAAGAGACTGTTAAGTTTGGCTACGGCGCACTGACCATAGAGCAGGTAGTCGCCAT
CGCCAAAGGCGCCAGGGTTGAACTCAGACGCGACCAGGAATACGTGGAATACATCCAGCGCGGCGCCCGCTTTATCGACA
GTCTGCTGGCCGAAGAAGGCGTAGTGTACGGCGTAACCACAGGTTACGGCGACTCCTGCACTGTGACAGTAGGGCTGGAT
CTGGTGCACGAACTGCCGCTGCACCTGTCGCGCTTCCACGGCTGTGGCATGGGCCGCGAGCTTACGCCAATGCAGTCCCG
CGCCGTCATGGCCTGCCGCTTGAACTCTCTGGCCATCGGCAAGTCCGGGGTCAGCTTCGAATTGCTCGAGCGCATCGAAA
CCCTGATTAATGAAGACATCTGCCCGGTTATCCCGGAAGAAGGCTCGGTGGGCGCCAGCGGCGATTTGACTCCGCTGTCT
TATCTGGCCGGCGTGCTGATAGGCGAGCGTGACGTGTTTTATCGCGGCGGCCGCCTGCCCAGCAGTGAAGTGTTCCAGAA
GCTGAATATCACCCCGCTGAAGCTGCGCCCGAAAGAGGGTCTGGCACTGATGAACGGCACAGCGGTGATGACGGCACTGG
CTTGTCTTGCATATGACAGAGCAGACTACCTGACCCGTCTGTCCTCACGCATCACCGCCATGGCATCCTTGACCCTCAAA
GGCAACTCCAACCATTTCGACGACATCCTGTTTGCCGCCAAGCCCCACCCGGGTCAGAGTCGGGTAGCCAGCTGGATCCG
TGATGACCTCAATCACCACGAGCATCCCCGCAACTCTGACCGCTTGCAGGATAGATATTCCATCCGCTGCGCGCCCCATA
TCATAGGCGTGCTGGCCGATGCCCAGCCAATGTTGCGCCAGTTTATTGAGAACGAACTTAACAGCGCCAACGACAACCCG
ATTGTGGATGGCGAGGGCGAGCACATCCTCCACGGTGGCCACTTCTACGGCGGCCATATCGCCTTTGCCATGGACAGCCT
CAAGAATCTGGTGGCCAACATCAGCGACCTGATTGACCGCCAGATGGCGCTGGTGATGGATCCCAAGTTTAACAATGGCT
TGCCAGCGAATCTCTCCGGCGCCGAAGGTGCCCGTCGCCCCATCAATCACGGCTTCAAGGCGGTGCAGATTGGCGTATCG
GCTTGGACCGCCGAAGCGCTCAAACTCACTATGCCTGCCAGCGTGTTTTCCCGTTCTACCGAGTGCCACAACCAGGACAA
GGTCAGCATGGGCACCATTGCCGCCCGTGACTGTTTGCGGGTGCTGGAGCTGACTGAGCAGGTGGCTGCCGCTGCGCTGC
TGGCGATGACCCAGGGTATGCGCCTGCGCATCCGTCAGGGCGAGCTGTGTGAGTCGTCACTAACCGCTTCGGTTGCCAAA
ACCCTGGCCCAGGTCAGCGAGGCTTGCCCGCTGGTGACAGAAGACAGGCCACTCGAAGCCACGCTGCGCCAGACGCTGGC
ACGCATTCAGGCCGGTGAGTGGGAGGTGTGTCGATGA

Upstream 100 bases:

>100_bases
TACGCCCGCAAAGAGCCACTGCAGTGGTTCAACTTTTTCGATTTTTGGCGCCGCGGCCAATAAGGCTTTAGGCCCGGGCA
GACGCCACAGGAACGGTAAA

Downstream 100 bases:

>100_bases
AATCTCTGCTTCACGCCGAGACAGAAATCATCATTCCCTTCCACGATGTGGATCCGATGCAGATCACCTGGCACGGTAAC
TACCTGCGTTACTTCGAGAT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MTNQSTEMKETVKFGYGALTIEQVVAIAKGARVELRRDQEYVEYIQRGARFIDSLLAEEGVVYGVTTGYGDSCTVTVGLD
LVHELPLHLSRFHGCGMGRELTPMQSRAVMACRLNSLAIGKSGVSFELLERIETLINEDICPVIPEEGSVGASGDLTPLS
YLAGVLIGERDVFYRGGRLPSSEVFQKLNITPLKLRPKEGLALMNGTAVMTALACLAYDRADYLTRLSSRITAMASLTLK
GNSNHFDDILFAAKPHPGQSRVASWIRDDLNHHEHPRNSDRLQDRYSIRCAPHIIGVLADAQPMLRQFIENELNSANDNP
IVDGEGEHILHGGHFYGGHIAFAMDSLKNLVANISDLIDRQMALVMDPKFNNGLPANLSGAEGARRPINHGFKAVQIGVS
AWTAEALKLTMPASVFSRSTECHNQDKVSMGTIAARDCLRVLELTEQVAAAALLAMTQGMRLRIRQGELCESSLTASVAK
TLAQVSEACPLVTEDRPLEATLRQTLARIQAGEWEVCR

Sequences:

>Translated_518_residues
MTNQSTEMKETVKFGYGALTIEQVVAIAKGARVELRRDQEYVEYIQRGARFIDSLLAEEGVVYGVTTGYGDSCTVTVGLD
LVHELPLHLSRFHGCGMGRELTPMQSRAVMACRLNSLAIGKSGVSFELLERIETLINEDICPVIPEEGSVGASGDLTPLS
YLAGVLIGERDVFYRGGRLPSSEVFQKLNITPLKLRPKEGLALMNGTAVMTALACLAYDRADYLTRLSSRITAMASLTLK
GNSNHFDDILFAAKPHPGQSRVASWIRDDLNHHEHPRNSDRLQDRYSIRCAPHIIGVLADAQPMLRQFIENELNSANDNP
IVDGEGEHILHGGHFYGGHIAFAMDSLKNLVANISDLIDRQMALVMDPKFNNGLPANLSGAEGARRPINHGFKAVQIGVS
AWTAEALKLTMPASVFSRSTECHNQDKVSMGTIAARDCLRVLELTEQVAAAALLAMTQGMRLRIRQGELCESSLTASVAK
TLAQVSEACPLVTEDRPLEATLRQTLARIQAGEWEVCR
>Mature_517_residues
TNQSTEMKETVKFGYGALTIEQVVAIAKGARVELRRDQEYVEYIQRGARFIDSLLAEEGVVYGVTTGYGDSCTVTVGLDL
VHELPLHLSRFHGCGMGRELTPMQSRAVMACRLNSLAIGKSGVSFELLERIETLINEDICPVIPEEGSVGASGDLTPLSY
LAGVLIGERDVFYRGGRLPSSEVFQKLNITPLKLRPKEGLALMNGTAVMTALACLAYDRADYLTRLSSRITAMASLTLKG
NSNHFDDILFAAKPHPGQSRVASWIRDDLNHHEHPRNSDRLQDRYSIRCAPHIIGVLADAQPMLRQFIENELNSANDNPI
VDGEGEHILHGGHFYGGHIAFAMDSLKNLVANISDLIDRQMALVMDPKFNNGLPANLSGAEGARRPINHGFKAVQIGVSA
WTAEALKLTMPASVFSRSTECHNQDKVSMGTIAARDCLRVLELTEQVAAAALLAMTQGMRLRIRQGELCESSLTASVAKT
LAQVSEACPLVTEDRPLEATLRQTLARIQAGEWEVCR

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=470, Percent_Identity=36.5957446808511, Blast_Score=288, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI17567831, Length=508, Percent_Identity=34.8425196850394, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56652; Mature: 56520

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQSTEMKETVKFGYGALTIEQVVAIAKGARVELRRDQEYVEYIQRGARFIDSLLAEEG
CCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCC
VVYGVTTGYGDSCTVTVGLDLVHELPLHLSRFHGCGMGRELTPMQSRAVMACRLNSLAIG
EEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHEEC
KSGVSFELLERIETLINEDICPVIPEEGSVGASGDLTPLSYLAGVLIGERDVFYRGGRLP
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHEEECCCCC
SSEVFQKLNITPLKLRPKEGLALMNGTAVMTALACLAYDRADYLTRLSSRITAMASLTLK
HHHHHHHCCCCEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
GNSNHFDDILFAAKPHPGQSRVASWIRDDLNHHEHPRNSDRLQDRYSIRCAPHIIGVLAD
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEHHHHHHHHHC
AQPMLRQFIENELNSANDNPIVDGEGEHILHGGHFYGGHIAFAMDSLKNLVANISDLIDR
CHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCEEECCHHHHHHHHHHHHHHHHHHHHHH
QMALVMDPKFNNGLPANLSGAEGARRPINHGFKAVQIGVSAWTAEALKLTMPASVFSRST
HHHEEECCCCCCCCCCCCCCCCCCCCCHHCCCEEEEEEHHHHHHHHHHEECCHHHHHCCH
ECHNQDKVSMGTIAARDCLRVLELTEQVAAAALLAMTQGMRLRIRQGELCESSLTASVAK
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHH
TLAQVSEACPLVTEDRPLEATLRQTLARIQAGEWEVCR
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TNQSTEMKETVKFGYGALTIEQVVAIAKGARVELRRDQEYVEYIQRGARFIDSLLAEEG
CCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCC
VVYGVTTGYGDSCTVTVGLDLVHELPLHLSRFHGCGMGRELTPMQSRAVMACRLNSLAIG
EEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHEEC
KSGVSFELLERIETLINEDICPVIPEEGSVGASGDLTPLSYLAGVLIGERDVFYRGGRLP
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHEEECCCCC
SSEVFQKLNITPLKLRPKEGLALMNGTAVMTALACLAYDRADYLTRLSSRITAMASLTLK
HHHHHHHCCCCEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
GNSNHFDDILFAAKPHPGQSRVASWIRDDLNHHEHPRNSDRLQDRYSIRCAPHIIGVLAD
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEHHHHHHHHHC
AQPMLRQFIENELNSANDNPIVDGEGEHILHGGHFYGGHIAFAMDSLKNLVANISDLIDR
CHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCEEECCHHHHHHHHHHHHHHHHHHHHHH
QMALVMDPKFNNGLPANLSGAEGARRPINHGFKAVQIGVSAWTAEALKLTMPASVFSRST
HHHEEECCCCCCCCCCCCCCCCCCCCCHHCCCEEEEEEHHHHHHHHHHEECCHHHHHCCH
ECHNQDKVSMGTIAARDCLRVLELTEQVAAAALLAMTQGMRLRIRQGELCESSLTASVAK
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHH
TLAQVSEACPLVTEDRPLEATLRQTLARIQAGEWEVCR
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA