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The map label for this gene is ywlC [H]

Identifier: 119776125

GI number: 119776125

Start: 3566298

End: 3567245

Strand: Direct

Name: ywlC [H]

Synonym: Sama_2993

Alternate gene names: 119776125

Gene position: 3566298-3567245 (Clockwise)

Preceding gene: 119776123

Following gene: 119776128

Centisome position: 82.82

GC content: 60.34

Gene sequence:

>948_bases
ATGGCGCAAATCACCGACCAAATTTCCCTTGCCGTGGCTGCCCTTAACCGGGGTGAGCTGGTGGCTATGCCCACAGAGAC
CGTGTATGGCCTTGCCGCCGATGCGGGCAACGCGGATGCCGTCGCCAAGGTATTTGCCTTGAAGGGGCGTCCGGCGACCA
ATCCGCTGATTGTGCATGTGGCCGACGCAAGCTGGATTAATGACTGGGCCAGCGACGTGGGACAGGACGCCGAGGCGCTG
ATGGCAGCGTTTTGGCCCGGGCCACTGACTCTGGTTCTGCCTGCCAAGACCTATGTATCCCGTGCTGTCACCGCCGGGCA
GAATACGGTTGCCCTGAGAATGCCGGCTCATCCCCAGGCGCTTGCCTTGCTGAAGGATTTTGGCCGCGCCCTGGTAGCCC
CCTCGGCCAACAAGTACATGTCCATCAGCCCCACCAGCAGCGACCATGTGGCGCGCCAGTTTGCCGGTGATGAACTGCTT
ATTCTGGAAGGTGGCAACTGCAGGGTGGGGCTTGAATCCACCATAGTGGCGCTGCTTCCCGGTGATGAACCCAGATTACT
GCGCCCGGGCATGGTATCAGTTGCCAGTATCGAAGCCGTGCTTGGCCGCCCGGTTGCTCAGCAAAGCGGTGGCGTGGTGG
CCCCCGGGCAGCACCACAAGCATTATTCCCCCGGCTTACCCTGCTACCGATATGGCGCAGAATCTGATGTCAGCCACTTG
CTCCAGGCCAATGACATCGGCTGGATTTTCTGCGGCAATGCAGTACCAGTAGCCGGAAAAGCCATAGAGCTCGGCGCAGA
CCCCGATGCCTATGCCCAGGGGCTCTACGATGCCTTGTATCAGCTCGACCACGAAACCCTCAGTGCGATTTATATCGCCG
AGCCGCCACACAGCAGTGAATGGCAAGCCGTGCAAAACCGTCTTGAACGTGCAGCCAAGCCACGCTAA

Upstream 100 bases:

>100_bases
CCCGGACAAAGGCAAAGCCATTCATCATGGAGAGCCAGTTTCGGCTTGACTGATTCTGGTCAAATTTTTACCATACGCGG
CCAGTTTTTCAGAGGTGCGT

Downstream 100 bases:

>100_bases
AAAGCAGCTGTAAAAATTACCTGTAAAAAAGGGGCCCTGCGGCCCCTTTTTTGTATTCACAACAGTGGACTAATAAATGG
ATGGCTATTTGGGCAATTCG

Product: SUA5/YciO/YrdC family translation initiation protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MAQITDQISLAVAALNRGELVAMPTETVYGLAADAGNADAVAKVFALKGRPATNPLIVHVADASWINDWASDVGQDAEAL
MAAFWPGPLTLVLPAKTYVSRAVTAGQNTVALRMPAHPQALALLKDFGRALVAPSANKYMSISPTSSDHVARQFAGDELL
ILEGGNCRVGLESTIVALLPGDEPRLLRPGMVSVASIEAVLGRPVAQQSGGVVAPGQHHKHYSPGLPCYRYGAESDVSHL
LQANDIGWIFCGNAVPVAGKAIELGADPDAYAQGLYDALYQLDHETLSAIYIAEPPHSSEWQAVQNRLERAAKPR

Sequences:

>Translated_315_residues
MAQITDQISLAVAALNRGELVAMPTETVYGLAADAGNADAVAKVFALKGRPATNPLIVHVADASWINDWASDVGQDAEAL
MAAFWPGPLTLVLPAKTYVSRAVTAGQNTVALRMPAHPQALALLKDFGRALVAPSANKYMSISPTSSDHVARQFAGDELL
ILEGGNCRVGLESTIVALLPGDEPRLLRPGMVSVASIEAVLGRPVAQQSGGVVAPGQHHKHYSPGLPCYRYGAESDVSHL
LQANDIGWIFCGNAVPVAGKAIELGADPDAYAQGLYDALYQLDHETLSAIYIAEPPHSSEWQAVQNRLERAAKPR
>Mature_314_residues
AQITDQISLAVAALNRGELVAMPTETVYGLAADAGNADAVAKVFALKGRPATNPLIVHVADASWINDWASDVGQDAEALM
AAFWPGPLTLVLPAKTYVSRAVTAGQNTVALRMPAHPQALALLKDFGRALVAPSANKYMSISPTSSDHVARQFAGDELLI
LEGGNCRVGLESTIVALLPGDEPRLLRPGMVSVASIEAVLGRPVAQQSGGVVAPGQHHKHYSPGLPCYRYGAESDVSHLL
QANDIGWIFCGNAVPVAGKAIELGADPDAYAQGLYDALYQLDHETLSAIYIAEPPHSSEWQAVQNRLERAAKPR

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Escherichia coli, GI2367210, Length=151, Percent_Identity=31.7880794701987, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537239, Length=189, Percent_Identity=30.1587301587302, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321269, Length=232, Percent_Identity=35.7758620689655, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 33296; Mature: 33165

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQITDQISLAVAALNRGELVAMPTETVYGLAADAGNADAVAKVFALKGRPATNPLIVHV
CCCCHHHHHEEEEECCCCCEEEECCHHHEEEECCCCCHHHHHHHHEECCCCCCCCEEEEE
ADASWINDWASDVGQDAEALMAAFWPGPLTLVLPAKTYVSRAVTAGQNTVALRMPAHPQA
ECCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCEEEEEECCCHHH
LALLKDFGRALVAPSANKYMSISPTSSDHVARQFAGDELLILEGGNCRVGLESTIVALLP
HHHHHHHHHEEECCCCCCEEEECCCCCHHHHHHHCCCEEEEEECCCEEEECCCEEEEEEC
GDEPRLLRPGMVSVASIEAVLGRPVAQQSGGVVAPGQHHKHYSPGLPCYRYGAESDVSHL
CCCCCEECCCCHHHHHHHHHHCCCCHHHCCCEECCCCCCCCCCCCCCCEECCCHHHHHHH
LQANDIGWIFCGNAVPVAGKAIELGADPDAYAQGLYDALYQLDHETLSAIYIAEPPHSSE
HHCCCCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCH
WQAVQNRLERAAKPR
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
AQITDQISLAVAALNRGELVAMPTETVYGLAADAGNADAVAKVFALKGRPATNPLIVHV
CCCHHHHHEEEEECCCCCEEEECCHHHEEEECCCCCHHHHHHHHEECCCCCCCCEEEEE
ADASWINDWASDVGQDAEALMAAFWPGPLTLVLPAKTYVSRAVTAGQNTVALRMPAHPQA
ECCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCEEEEEECCCHHH
LALLKDFGRALVAPSANKYMSISPTSSDHVARQFAGDELLILEGGNCRVGLESTIVALLP
HHHHHHHHHEEECCCCCCEEEECCCCCHHHHHHHCCCEEEEEECCCEEEECCCEEEEEEC
GDEPRLLRPGMVSVASIEAVLGRPVAQQSGGVVAPGQHHKHYSPGLPCYRYGAESDVSHL
CCCCCEECCCCHHHHHHHHHHCCCCHHHCCCEECCCCCCCCCCCCCCCEECCCHHHHHHH
LQANDIGWIFCGNAVPVAGKAIELGADPDAYAQGLYDALYQLDHETLSAIYIAEPPHSSE
HHCCCCCEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCH
WQAVQNRLERAAKPR
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]