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The map label for this gene is adhc1 [H]

Identifier: 119775841

GI number: 119775841

Start: 3241154

End: 3242200

Strand: Direct

Name: adhc1 [H]

Synonym: Sama_2709

Alternate gene names: 119775841

Gene position: 3241154-3242200 (Clockwise)

Preceding gene: 119775840

Following gene: 119775844

Centisome position: 75.27

GC content: 55.3

Gene sequence:

>1047_bases
ATGAAAACCATTGGATACGCAGCCCAATCTGCATTAAGCCCCTTAGCACCATACGAATACACATGCCGTGAGCTAAGGGA
GGATGACGTTGCCATTGAAATACTCTACAGCGGCGTGTGCCACAGCGATTTACACACAGTGAAAAACGACTGGGGGTGGA
CAGTTTATCCCACGGTACCCGGGCACGAGATTGTTGGCCGTGTCGTCGACATTGGCGCCAGCGTCACTCAGTTCAGGATT
GGTGACAATGTCGCCGTAGGCTGCATGGTCGACAGCTGTCAGACCTGTTCTCACTGCCACAGTGGTGAAGAGCAATTCTG
CGAGCAGGGATTTACCCAAACCTATAACAGCGCCGAAAGGCACAGCGGGGAAATCACCAAAGGGGGTTACGCCAGACACA
TAGTCGTGCGGCAGGAGTTTGTACTCCAGATCCCGCCATCTCTGGATCTTGCCAGGGCTGCCCCACTGCTGTGTGCCGGT
ATTACCACCTACTCGCCTCTGAGAACCTGGCAGGTCGGCCCGGGCAGCCGTGTGGCGGTAATTGGCATGGGCGGTCTCGG
TCATATGGCAATTAAACTGGCCGTCGCAATGGGTGCACATGTCACCGTCATCAGCCGCACTGCTGACAAACGCGCGGATG
CCATGCAACTGGGCGCCAATGAGTTTCTCATTTCAAGTGAGACAGAGAGTATGCAGCAGGCAGCAAACCGCTTTGAGCTC
ATCCTGGATACCATTCCGGTAAAACACGACGTGACGCCTTACATGCCCTTGCTCAAGGTCGATGGCACCCTGACCCTGGT
GGGCCAGGTGGGCCCGATGGCAGAAGTGAATACCGTGCCCATGATCATGGGACGCAGGCGCATTGCCGCCTCCCTGATTG
GCGGAATCGCCGAAACACAGGAGATGCTGGACTTTTGTGCCCGGATGAACATCTTGCCCGAGGTTGAAATGATCACCATG
GAGCAGATAAACGACGCATTCGAGCGGCTTGAAAAGTCAGACGTACACTACCGTTTTGTCATCGATATGCAGGCGTCCAG
GTTCTGA

Upstream 100 bases:

>100_bases
TGTAGCGCAGGCGGATGCGTGCAAAACGCCAGGCATTTACCCCGGCCCACTGTGGGCCGGTGATGAGTCCCATAACGAGA
GTTACCCATCTGGAGACATG

Downstream 100 bases:

>100_bases
TGTATCAAAAAAAGAGGCTCAGTTCAGAGCCTCTTTTTCTATGACTAATTCGATGTCTTTGGCATCGGTTAACCAGGCGC
AGTCGCCCGGTAGCCTGCCA

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKTIGYAAQSALSPLAPYEYTCRELREDDVAIEILYSGVCHSDLHTVKNDWGWTVYPTVPGHEIVGRVVDIGASVTQFRI
GDNVAVGCMVDSCQTCSHCHSGEEQFCEQGFTQTYNSAERHSGEITKGGYARHIVVRQEFVLQIPPSLDLARAAPLLCAG
ITTYSPLRTWQVGPGSRVAVIGMGGLGHMAIKLAVAMGAHVTVISRTADKRADAMQLGANEFLISSETESMQQAANRFEL
ILDTIPVKHDVTPYMPLLKVDGTLTLVGQVGPMAEVNTVPMIMGRRRIAASLIGGIAETQEMLDFCARMNILPEVEMITM
EQINDAFERLEKSDVHYRFVIDMQASRF

Sequences:

>Translated_348_residues
MKTIGYAAQSALSPLAPYEYTCRELREDDVAIEILYSGVCHSDLHTVKNDWGWTVYPTVPGHEIVGRVVDIGASVTQFRI
GDNVAVGCMVDSCQTCSHCHSGEEQFCEQGFTQTYNSAERHSGEITKGGYARHIVVRQEFVLQIPPSLDLARAAPLLCAG
ITTYSPLRTWQVGPGSRVAVIGMGGLGHMAIKLAVAMGAHVTVISRTADKRADAMQLGANEFLISSETESMQQAANRFEL
ILDTIPVKHDVTPYMPLLKVDGTLTLVGQVGPMAEVNTVPMIMGRRRIAASLIGGIAETQEMLDFCARMNILPEVEMITM
EQINDAFERLEKSDVHYRFVIDMQASRF
>Mature_348_residues
MKTIGYAAQSALSPLAPYEYTCRELREDDVAIEILYSGVCHSDLHTVKNDWGWTVYPTVPGHEIVGRVVDIGASVTQFRI
GDNVAVGCMVDSCQTCSHCHSGEEQFCEQGFTQTYNSAERHSGEITKGGYARHIVVRQEFVLQIPPSLDLARAAPLLCAG
ITTYSPLRTWQVGPGSRVAVIGMGGLGHMAIKLAVAMGAHVTVISRTADKRADAMQLGANEFLISSETESMQQAANRFEL
ILDTIPVKHDVTPYMPLLKVDGTLTLVGQVGPMAEVNTVPMIMGRRRIAASLIGGIAETQEMLDFCARMNILPEVEMITM
EQINDAFERLEKSDVHYRFVIDMQASRF

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=361, Percent_Identity=25.7617728531856, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI34577061, Length=338, Percent_Identity=25.4437869822485, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI71565154, Length=245, Percent_Identity=28.9795918367347, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI156523966, Length=233, Percent_Identity=26.6094420600858, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4501939, Length=356, Percent_Identity=22.752808988764, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI71743840, Length=221, Percent_Identity=26.2443438914027, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI262073058, Length=221, Percent_Identity=26.2443438914027, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI71565152, Length=234, Percent_Identity=26.4957264957265, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786518, Length=344, Percent_Identity=52.3255813953488, Blast_Score=323, Evalue=9e-90,
Organism=Escherichia coli, GI87082401, Length=338, Percent_Identity=36.3905325443787, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI87081918, Length=329, Percent_Identity=26.7477203647416, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788407, Length=252, Percent_Identity=30.5555555555556, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788073, Length=269, Percent_Identity=25.6505576208178, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082125, Length=317, Percent_Identity=22.7129337539432, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI226510992, Length=251, Percent_Identity=26.2948207171315, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790045, Length=191, Percent_Identity=29.8429319371728, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788075, Length=260, Percent_Identity=23.4615384615385, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786552, Length=377, Percent_Identity=23.6074270557029, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1786825, Length=191, Percent_Identity=26.7015706806283, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=340, Percent_Identity=27.6470588235294, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17562584, Length=352, Percent_Identity=27.5568181818182, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562582, Length=325, Percent_Identity=28.9230769230769, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=360, Percent_Identity=26.3888888888889, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=362, Percent_Identity=26.5193370165746, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=334, Percent_Identity=26.6467065868263, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=341, Percent_Identity=24.633431085044, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=196, Percent_Identity=29.0816326530612, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=329, Percent_Identity=35.258358662614, Blast_Score=178, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6319949, Length=332, Percent_Identity=34.3373493975904, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319621, Length=336, Percent_Identity=30.6547619047619, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6323961, Length=325, Percent_Identity=29.8461538461538, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=29.9694189602446, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324486, Length=325, Percent_Identity=29.5384615384615, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=27.5204359673025, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=337, Percent_Identity=24.6290801186944, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737897, Length=230, Percent_Identity=27.3913043478261, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737895, Length=359, Percent_Identity=25.0696378830084, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137530, Length=217, Percent_Identity=27.6497695852535, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 38197; Mature: 38197

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIGYAAQSALSPLAPYEYTCRELREDDVAIEILYSGVCHSDLHTVKNDWGWTVYPTVP
CCCCHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCEEEECCCC
GHEIVGRVVDIGASVTQFRIGDNVAVGCMVDSCQTCSHCHSGEEQFCEQGFTQTYNSAER
CHHHHHHHHHCCCCEEEEECCCCEEEEEEEHHHHHHHHHCCCHHHHHHCCHHHHCCCHHH
HSGEITKGGYARHIVVRQEFVLQIPPSLDLARAAPLLCAGITTYSPLRTWQVGPGSRVAV
CCCCCCCCCCEEEEEEEEEEEEECCCCCCHHHHCHHHHCCCCCCCCCEEEECCCCCEEEE
IGMGGLGHMAIKLAVAMGAHVTVISRTADKRADAMQLGANEFLISSETESMQQAANRFEL
EEECCHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
ILDTIPVKHDVTPYMPLLKVDGTLTLVGQVGPMAEVNTVPMIMGRRRIAASLIGGIAETQ
HHHCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EMLDFCARMNILPEVEMITMEQINDAFERLEKSDVHYRFVIDMQASRF
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
>Mature Secondary Structure
MKTIGYAAQSALSPLAPYEYTCRELREDDVAIEILYSGVCHSDLHTVKNDWGWTVYPTVP
CCCCHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCEEEECCCC
GHEIVGRVVDIGASVTQFRIGDNVAVGCMVDSCQTCSHCHSGEEQFCEQGFTQTYNSAER
CHHHHHHHHHCCCCEEEEECCCCEEEEEEEHHHHHHHHHCCCHHHHHHCCHHHHCCCHHH
HSGEITKGGYARHIVVRQEFVLQIPPSLDLARAAPLLCAGITTYSPLRTWQVGPGSRVAV
CCCCCCCCCCEEEEEEEEEEEEECCCCCCHHHHCHHHHCCCCCCCCCEEEECCCCCEEEE
IGMGGLGHMAIKLAVAMGAHVTVISRTADKRADAMQLGANEFLISSETESMQQAANRFEL
EEECCHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
ILDTIPVKHDVTPYMPLLKVDGTLTLVGQVGPMAEVNTVPMIMGRRRIAASLIGGIAETQ
HHHCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EMLDFCARMNILPEVEMITMEQINDAFERLEKSDVHYRFVIDMQASRF
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]