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The map label for this gene is pepD [H]

Identifier: 119775651

GI number: 119775651

Start: 3026955

End: 3028415

Strand: Direct

Name: pepD [H]

Synonym: Sama_2519

Alternate gene names: 119775651

Gene position: 3026955-3028415 (Clockwise)

Preceding gene: 119775646

Following gene: 119775653

Centisome position: 70.29

GC content: 57.02

Gene sequence:

>1461_bases
GTGACTGCTATTAATCAGCTCTACCCTCAGCCTCTGTGGCAGTGGTTCGAACAAATCTGTGCCATTCCCCATCCTTCAAA
ACACGAAGCGGCCCTGAGCCAGCACATTCAGGCATGGGCCCGCGATAAAGGCCTGCCAGTGGTTGAAGATAAAGTCGGCA
ACCTGATCATCCGTAAAGCCGCCACTCCCGGCATGGAAAACCGCAAGACTGTGGTTATTCAGGCGCACATCGACATGGTG
CCGCAGAAGAACAACGACAAGGTACACGACTTTACCAAAGACCCCATTGAAGCCTATGTGGATGGTGAGTGGGTAAAAGC
CCGTGGCACTACCCTTGGCTCAGACAACGGCATTGGTATGGCGTCGGCCCTGGCAATCCTCGGCAGCGATGACATTCCCC
ACGGCCCACTGGAAGTGCTGCTGACCATCGATGAAGAAGCCGGTATGACCGGCGCCTTCGGCCTGGAAGCCGGTTATCTG
GATGCCGAAATTCTGATCAACACAGATTCTGAGCAGGAAGGCGAGATTTACATGGGCTGCGCCGGTGGCGTAGACGCTGA
AATCACCCTGCCCATGGTATGGGAAGCCCCGGCCGAAGGTTACAAGAGCTTCGCGCTGAACCTGTCTGGTCTCAAGGGTG
GTCACTCAGGGGTGAACATTCACCTTGGCCGTGGCAATGCCAACAAGCTGCTGGCCCGTTTCCTGTTTGAAAACGTCGAA
GCCCTGCAACTGGAGCTGGCCGATTTCAACGGCGGCTCACTGCGTAACGCCATTCCCCGAGAAGCTGGCCTGACCCTGAT
GGTACCGGCCGAGCACGAGCAAGGCTTGAAAGACGCCGTCAGTGCCTTCGAAGCTTTGGTGCGTGAAGAGCTGGCCATTG
CCGATCCCGGCGCCGTACTGACCCTGACCGAAGTGGCCGAGCCCAAGCGGGTGATGAGCGAGCATAGCCAAAACACCTTT
ATCGACCTGCTGAACGCCTGCCCCAACGGCGTTATGCGCATGAGCGATGAAGTGGCCGGCGTTACCGAGACTTCGCTCAA
CGTGGGCGTTATTACCACCAGCGAGCAGGATGTGAAAATCCTCTGCCTGATCCGCTCACTGATTGACTCAGGCCGCACCC
AGGTTGAAGGCATGCTGATTGCGCTGTCTAACCTCGCTGGCGCAGAAATCGAGCTCTCCGGCGCTTACCCGGGCTGGAAG
CCAGACAACAGCTCGCCTGTGATGGCCATCGTGCGTGAAACCTATCAGGACATCTACAACAAGGAGCCGGTGATCATGGT
TATCCACGCTGGTCTCGAATGTGGCCTGTTCAAGAAGCCCTATCCCGAGATGGACATGGTTTCCATTGGCCCCACCATCC
GCTTCCCACACAGCCCCGATGAGATGGTGAACATCGAAACCGTGGGTCAGTACTGGCAGCTGCTGCTGGCAGTGCTTGAG
CGTATTCCTGAAAAAGCTTGA

Upstream 100 bases:

>100_bases
AGGGATGTTTGCCCATCCACCCGGGACGCACACTGTGGTAAACTCGGCGCAATCAGGGGCGCACAGCGCCCAGTCATGAC
AAAAAAGCCGGGAGTATTCC

Downstream 100 bases:

>100_bases
GCGCATTCCTGAAAAAGCTTGAGCGCATTCCTGAAAAGGCCTGAGCCGTAAATAAATCCAGTTAAAAGGGCGACACTTCA
GTCGCCCTTTTCTTTATCTA

Product: Xaa-His dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTAINQLYPQPLWQWFEQICAIPHPSKHEAALSQHIQAWARDKGLPVVEDKVGNLIIRKAATPGMENRKTVVIQAHIDMV
PQKNNDKVHDFTKDPIEAYVDGEWVKARGTTLGSDNGIGMASALAILGSDDIPHGPLEVLLTIDEEAGMTGAFGLEAGYL
DAEILINTDSEQEGEIYMGCAGGVDAEITLPMVWEAPAEGYKSFALNLSGLKGGHSGVNIHLGRGNANKLLARFLFENVE
ALQLELADFNGGSLRNAIPREAGLTLMVPAEHEQGLKDAVSAFEALVREELAIADPGAVLTLTEVAEPKRVMSEHSQNTF
IDLLNACPNGVMRMSDEVAGVTETSLNVGVITTSEQDVKILCLIRSLIDSGRTQVEGMLIALSNLAGAEIELSGAYPGWK
PDNSSPVMAIVRETYQDIYNKEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRFPHSPDEMVNIETVGQYWQLLLAVLE
RIPEKA

Sequences:

>Translated_486_residues
MTAINQLYPQPLWQWFEQICAIPHPSKHEAALSQHIQAWARDKGLPVVEDKVGNLIIRKAATPGMENRKTVVIQAHIDMV
PQKNNDKVHDFTKDPIEAYVDGEWVKARGTTLGSDNGIGMASALAILGSDDIPHGPLEVLLTIDEEAGMTGAFGLEAGYL
DAEILINTDSEQEGEIYMGCAGGVDAEITLPMVWEAPAEGYKSFALNLSGLKGGHSGVNIHLGRGNANKLLARFLFENVE
ALQLELADFNGGSLRNAIPREAGLTLMVPAEHEQGLKDAVSAFEALVREELAIADPGAVLTLTEVAEPKRVMSEHSQNTF
IDLLNACPNGVMRMSDEVAGVTETSLNVGVITTSEQDVKILCLIRSLIDSGRTQVEGMLIALSNLAGAEIELSGAYPGWK
PDNSSPVMAIVRETYQDIYNKEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRFPHSPDEMVNIETVGQYWQLLLAVLE
RIPEKA
>Mature_485_residues
TAINQLYPQPLWQWFEQICAIPHPSKHEAALSQHIQAWARDKGLPVVEDKVGNLIIRKAATPGMENRKTVVIQAHIDMVP
QKNNDKVHDFTKDPIEAYVDGEWVKARGTTLGSDNGIGMASALAILGSDDIPHGPLEVLLTIDEEAGMTGAFGLEAGYLD
AEILINTDSEQEGEIYMGCAGGVDAEITLPMVWEAPAEGYKSFALNLSGLKGGHSGVNIHLGRGNANKLLARFLFENVEA
LQLELADFNGGSLRNAIPREAGLTLMVPAEHEQGLKDAVSAFEALVREELAIADPGAVLTLTEVAEPKRVMSEHSQNTFI
DLLNACPNGVMRMSDEVAGVTETSLNVGVITTSEQDVKILCLIRSLIDSGRTQVEGMLIALSNLAGAEIELSGAYPGWKP
DNSSPVMAIVRETYQDIYNKEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRFPHSPDEMVNIETVGQYWQLLLAVLER
IPEKA

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=485, Percent_Identity=62.680412371134, Blast_Score=625, Evalue=1e-180,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52793; Mature: 52662

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAINQLYPQPLWQWFEQICAIPHPSKHEAALSQHIQAWARDKGLPVVEDKVGNLIIRKA
CCCHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEC
ATPGMENRKTVVIQAHIDMVPQKNNDKVHDFTKDPIEAYVDGEWVKARGTTLGSDNGIGM
CCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCCCH
ASALAILGSDDIPHGPLEVLLTIDEEAGMTGAFGLEAGYLDAEILINTDSEQEGEIYMGC
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCEECCCCCCCCCEEEEEECCCCCCCCEEEEE
AGGVDAEITLPMVWEAPAEGYKSFALNLSGLKGGHSGVNIHLGRGNANKLLARFLFENVE
CCCCCCEEEEEEEECCCHHCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCC
ALQLELADFNGGSLRNAIPREAGLTLMVPAEHEQGLKDAVSAFEALVREELAIADPGAVL
EEEEEEECCCCCCHHCCCCHHCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHCCCCCCEE
TLTEVAEPKRVMSEHSQNTFIDLLNACPNGVMRMSDEVAGVTETSLNVGVITTSEQDVKI
EEHHHCCHHHHHHHCCCHHHHHHHHHCCCCHHHHCHHHCCCEECCCEEEEEECCCCCHHH
LCLIRSLIDSGRTQVEGMLIALSNLAGAEIELSGAYPGWKPDNSSPVMAIVRETYQDIYN
HHHHHHHHHCCCHHHHEEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
KEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRFPHSPDEMVNIETVGQYWQLLLAVLE
CCCEEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCEEEHHHHHHHHHHHHHHHH
RIPEKA
HCCCCC
>Mature Secondary Structure 
TAINQLYPQPLWQWFEQICAIPHPSKHEAALSQHIQAWARDKGLPVVEDKVGNLIIRKA
CCHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEC
ATPGMENRKTVVIQAHIDMVPQKNNDKVHDFTKDPIEAYVDGEWVKARGTTLGSDNGIGM
CCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCCCCCCH
ASALAILGSDDIPHGPLEVLLTIDEEAGMTGAFGLEAGYLDAEILINTDSEQEGEIYMGC
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCEECCCCCCCCCEEEEEECCCCCCCCEEEEE
AGGVDAEITLPMVWEAPAEGYKSFALNLSGLKGGHSGVNIHLGRGNANKLLARFLFENVE
CCCCCCEEEEEEEECCCHHCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCC
ALQLELADFNGGSLRNAIPREAGLTLMVPAEHEQGLKDAVSAFEALVREELAIADPGAVL
EEEEEEECCCCCCHHCCCCHHCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHCCCCCCEE
TLTEVAEPKRVMSEHSQNTFIDLLNACPNGVMRMSDEVAGVTETSLNVGVITTSEQDVKI
EEHHHCCHHHHHHHCCCHHHHHHHHHCCCCHHHHCHHHCCCEECCCEEEEEECCCCCHHH
LCLIRSLIDSGRTQVEGMLIALSNLAGAEIELSGAYPGWKPDNSSPVMAIVRETYQDIYN
HHHHHHHHHCCCHHHHEEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
KEPVIMVIHAGLECGLFKKPYPEMDMVSIGPTIRFPHSPDEMVNIETVGQYWQLLLAVLE
CCCEEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCEEEHHHHHHHHHHHHHHHH
RIPEKA
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]