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The map label for this gene is galE [H]

Identifier: 119775359

GI number: 119775359

Start: 2687868

End: 2688878

Strand: Direct

Name: galE [H]

Synonym: Sama_2224

Alternate gene names: 119775359

Gene position: 2687868-2688878 (Clockwise)

Preceding gene: 119775358

Following gene: 119775360

Centisome position: 62.42

GC content: 55.29

Gene sequence:

>1011_bases
ATGACGATTTTGGTGACCGGCGGTGCCGGCTACATTGGAACCCACACAGTGGTGGCCCTGCAGCAGGCTGGTATGGAGGT
GCTGGTTCTTGACAATCTCTCCAACGCATGTGTCGAAGCACTGAACCGGGTCGAACAGATCACGGGGCAGGCGGTGCCCT
TTGTGCAAGGGGATATTCTCGATAAGCCCCTGCTGATGAAAATCTTTATGGATAACGACATTGAGGCGGTGATCCACTTC
GCCGGCCTCAAGGCAGTGGGGGAATCGGTTGCTCAGCCGCTGCGCTATTACGAAAACAATGTCACCGGTACCCTGGTGCT
TTGCCAGGTGATGGCCGAATTTAACGTGAAGCAGCTGGTGTTTTCTTCTTCAGCCACCGTGTATGGCGATCCCGCCAGTC
TGCCCATCACCGAAGACTTTCCCACAGGGGCAACCAATCCCTATGGCCAGTCCAAGCTGATGGTGGAACACATTTTGGCT
GATTTGCACCATTCAGATCCCAGCTGGAATATCGCCCGCCTGCGTTATTTCAATCCCGTGGGTGCCCATGAAAGCGGGCT
GATTGGCGAAGATCCCAATGACATCCCCAACAACCTGATGCCCTTTATCAGCCAGGTTGCCGTGGGCAAACGGGAAAAAT
TGTCGATTTTTGGCAATGACTACCCTACCCACGATGGCACGGGGGTGCGGGATTATATCCACGTGGTAGACCTGGCAGAC
GGACATTTGAAAGCCCTTGAAAAGCTGAGAACCCAACCCGGTCTGGTTACCTACAACCTGGGCACAGGTCAGGGCTACAG
CGTACTGGATATGGTCAAGGCCTTTGAAAAAGCCTCAGGCAAAGCCGTGCCCTATGAAATAGCCCCACGACGCCCCGGCG
ACATCGCCGCCTGTTATGCTGATCCCGGCAAAGCCACCAAAGAACTGGGCTGGAAAGCAAAGCTCTCTGTGGATGAGATG
GCCGCCAGCAGCTGGCGCTGGCAGTCCGGCAATCCCAACGGTTACCGATAA

Upstream 100 bases:

>100_bases
GTTATATGCAGGCCAATGTGGAATACGCGCTGCGTCACCCCGAGCTTGGTAAGGAATTTGCCAAGTATTTGAAGCAACTG
GTTAAAGGACTCAACTAAGG

Downstream 100 bases:

>100_bases
GATTCAGGCCCTTCGGGGCCTTTTGCCTATGAAAGAGAACATTAATTTAAGTCGCCGCCGACTCTTCAGTCGCCGCAAGG
ACAACGCCCTGCGGCCACCC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTILVTGGAGYIGTHTVVALQQAGMEVLVLDNLSNACVEALNRVEQITGQAVPFVQGDILDKPLLMKIFMDNDIEAVIHF
AGLKAVGESVAQPLRYYENNVTGTLVLCQVMAEFNVKQLVFSSSATVYGDPASLPITEDFPTGATNPYGQSKLMVEHILA
DLHHSDPSWNIARLRYFNPVGAHESGLIGEDPNDIPNNLMPFISQVAVGKREKLSIFGNDYPTHDGTGVRDYIHVVDLAD
GHLKALEKLRTQPGLVTYNLGTGQGYSVLDMVKAFEKASGKAVPYEIAPRRPGDIAACYADPGKATKELGWKAKLSVDEM
AASSWRWQSGNPNGYR

Sequences:

>Translated_336_residues
MTILVTGGAGYIGTHTVVALQQAGMEVLVLDNLSNACVEALNRVEQITGQAVPFVQGDILDKPLLMKIFMDNDIEAVIHF
AGLKAVGESVAQPLRYYENNVTGTLVLCQVMAEFNVKQLVFSSSATVYGDPASLPITEDFPTGATNPYGQSKLMVEHILA
DLHHSDPSWNIARLRYFNPVGAHESGLIGEDPNDIPNNLMPFISQVAVGKREKLSIFGNDYPTHDGTGVRDYIHVVDLAD
GHLKALEKLRTQPGLVTYNLGTGQGYSVLDMVKAFEKASGKAVPYEIAPRRPGDIAACYADPGKATKELGWKAKLSVDEM
AASSWRWQSGNPNGYR
>Mature_335_residues
TILVTGGAGYIGTHTVVALQQAGMEVLVLDNLSNACVEALNRVEQITGQAVPFVQGDILDKPLLMKIFMDNDIEAVIHFA
GLKAVGESVAQPLRYYENNVTGTLVLCQVMAEFNVKQLVFSSSATVYGDPASLPITEDFPTGATNPYGQSKLMVEHILAD
LHHSDPSWNIARLRYFNPVGAHESGLIGEDPNDIPNNLMPFISQVAVGKREKLSIFGNDYPTHDGTGVRDYIHVVDLADG
HLKALEKLRTQPGLVTYNLGTGQGYSVLDMVKAFEKASGKAVPYEIAPRRPGDIAACYADPGKATKELGWKAKLSVDEMA
ASSWRWQSGNPNGYR

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=59.1176470588235, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=59.1176470588235, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=59.1176470588235, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI7657641, Length=347, Percent_Identity=27.6657060518732, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI42516563, Length=323, Percent_Identity=24.1486068111455, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=60.1190476190476, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1788353, Length=361, Percent_Identity=26.5927977839335, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI48994969, Length=360, Percent_Identity=25.5555555555556, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790049, Length=283, Percent_Identity=27.208480565371, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=54.4927536231884, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=54.178674351585, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17568069, Length=341, Percent_Identity=25.8064516129032, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=53.0612244897959, Blast_Score=372, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19923002, Length=343, Percent_Identity=60.3498542274053, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI21356223, Length=322, Percent_Identity=24.8447204968944, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36461; Mature: 36330

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVTGGAGYIGTHTVVALQQAGMEVLVLDNLSNACVEALNRVEQITGQAVPFVQGDIL
CEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
DKPLLMKIFMDNDIEAVIHFAGLKAVGESVAQPLRYYENNVTGTLVLCQVMAEFNVKQLV
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHH
FSSSATVYGDPASLPITEDFPTGATNPYGQSKLMVEHILADLHHSDPSWNIARLRYFNPV
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
GAHESGLIGEDPNDIPNNLMPFISQVAVGKREKLSIFGNDYPTHDGTGVRDYIHVVDLAD
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHEEEEECCC
GHLKALEKLRTQPGLVTYNLGTGQGYSVLDMVKAFEKASGKAVPYEIAPRRPGDIAACYA
HHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEC
DPGKATKELGWKAKLSVDEMAASSWRWQSGNPNGYR
CCCCHHHHCCCEEECCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TILVTGGAGYIGTHTVVALQQAGMEVLVLDNLSNACVEALNRVEQITGQAVPFVQGDIL
EEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
DKPLLMKIFMDNDIEAVIHFAGLKAVGESVAQPLRYYENNVTGTLVLCQVMAEFNVKQLV
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHH
FSSSATVYGDPASLPITEDFPTGATNPYGQSKLMVEHILADLHHSDPSWNIARLRYFNPV
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
GAHESGLIGEDPNDIPNNLMPFISQVAVGKREKLSIFGNDYPTHDGTGVRDYIHVVDLAD
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHEEEEECCC
GHLKALEKLRTQPGLVTYNLGTGQGYSVLDMVKAFEKASGKAVPYEIAPRRPGDIAACYA
HHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEC
DPGKATKELGWKAKLSVDEMAASSWRWQSGNPNGYR
CCCCHHHHCCCEEECCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]