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The map label for this gene is ldh [H]

Identifier: 119775202

GI number: 119775202

Start: 2503088

End: 2504122

Strand: Direct

Name: ldh [H]

Synonym: Sama_2067

Alternate gene names: 119775202

Gene position: 2503088-2504122 (Clockwise)

Preceding gene: 119775200

Following gene: 119775203

Centisome position: 58.13

GC content: 55.36

Gene sequence:

>1035_bases
GTGGCTGTATTCAATCATGTATCTTATGACGAACATGAACAGGTTGTTTTCTGTCATGACAAAGAGAGTGGCCTGAAGGC
AATTATTGCCGTGCACAATACCAATCTGGGCCCTGCGGTGGGTGGTTGCCGTATGTGGAACTACCAGTCTGACGAAGAAG
CGCTGAACGACGTACTTCGCCTCTCCCGCGGCATGACCTATAAAAATGCCCTCGCCGGCCTGACCATGGGTGGTGGCAAG
TCAGTGATCATTGCCGATCCCAAGACCCAGGACAGAGAAGCCCTGTTCCGTGCCTTTGGCCGCTTTATCAATACCCTGGG
TGGCAAGTATTATTCCGCTGAAGACGTGGGCACCACCACGGCCGACATCATGATTGCCCACCAGGAGACCCCTTACATGG
CCGGTCTGGAAGGCAAGAGTGGCGACCCATCCCCTTTCACTGCCCTGGGGACTTTCCTTGGGATCAAAGCTGCCGTTAAA
CATCAGCGCGGTCTCGACAGCCTCAAGGGGCTGAAAATCGCCGTTCAGGGCGTGGGCCACGTTGGCTACTACCTGTGTAA
GCACCTGCACGAAGAAGGCGCAGAACTTATCGTGACAGACATTCATCAGGCATCTCTGGACAAGGTTGCCACCGAGTTTG
GTGCGGCTGTTGTTGCCCCACAGGACATCTACTCTCAGGACGTTGATATCTATGCTCCTTGCGCCCTGGGAGCCACCATT
AACGACGCTACTCTGCCACTGCTCAAGGCCAAGATTGTGGCCGGTTGTGCCAACAACCAGCTGGCCGAGCCACGTCACGG
CCAGATGCTGAAAGACATGGGTATCCTCTACGCCCCTGACTACGTAATTAACGCTGGCGGTATCATCAACGTGTCGTTCG
AAAACGACTACGATGCAGCCAGGTCCACTGCCAAAGTGGAGAAGATTTACGACACCCTGCTGACCATCTTTACTGCCGCA
GACGAGCAGAACCGCACCACAGGTGCCGTTGCCGACGAAATGGCCCGCGCCATTATCGACGCCGCCCGTAAGTAA

Upstream 100 bases:

>100_bases
CTTTGTTGAGAGTATCCCTAAATGCTATGGTTCGGCAATAAATATAACGACCGCAGGTAGCCGCCTGCGGCTTTTTATTA
GCAATGCGGAGATCTGCAAC

Downstream 100 bases:

>100_bases
TTCAGCCAATTCAAAACACAGGGAAACCATTTCGGTTTCCCTTTTTTGTGCCTGCATTTTGTCATCTTTCGCCGGTAAGA
TTTTTTTCAGATTAAATTTA

Product: leucine dehydrogenase

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MAVFNHVSYDEHEQVVFCHDKESGLKAIIAVHNTNLGPAVGGCRMWNYQSDEEALNDVLRLSRGMTYKNALAGLTMGGGK
SVIIADPKTQDREALFRAFGRFINTLGGKYYSAEDVGTTTADIMIAHQETPYMAGLEGKSGDPSPFTALGTFLGIKAAVK
HQRGLDSLKGLKIAVQGVGHVGYYLCKHLHEEGAELIVTDIHQASLDKVATEFGAAVVAPQDIYSQDVDIYAPCALGATI
NDATLPLLKAKIVAGCANNQLAEPRHGQMLKDMGILYAPDYVINAGGIINVSFENDYDAARSTAKVEKIYDTLLTIFTAA
DEQNRTTGAVADEMARAIIDAARK

Sequences:

>Translated_344_residues
MAVFNHVSYDEHEQVVFCHDKESGLKAIIAVHNTNLGPAVGGCRMWNYQSDEEALNDVLRLSRGMTYKNALAGLTMGGGK
SVIIADPKTQDREALFRAFGRFINTLGGKYYSAEDVGTTTADIMIAHQETPYMAGLEGKSGDPSPFTALGTFLGIKAAVK
HQRGLDSLKGLKIAVQGVGHVGYYLCKHLHEEGAELIVTDIHQASLDKVATEFGAAVVAPQDIYSQDVDIYAPCALGATI
NDATLPLLKAKIVAGCANNQLAEPRHGQMLKDMGILYAPDYVINAGGIINVSFENDYDAARSTAKVEKIYDTLLTIFTAA
DEQNRTTGAVADEMARAIIDAARK
>Mature_343_residues
AVFNHVSYDEHEQVVFCHDKESGLKAIIAVHNTNLGPAVGGCRMWNYQSDEEALNDVLRLSRGMTYKNALAGLTMGGGKS
VIIADPKTQDREALFRAFGRFINTLGGKYYSAEDVGTTTADIMIAHQETPYMAGLEGKSGDPSPFTALGTFLGIKAAVKH
QRGLDSLKGLKIAVQGVGHVGYYLCKHLHEEGAELIVTDIHQASLDKVATEFGAAVVAPQDIYSQDVDIYAPCALGATIN
DATLPLLKAKIVAGCANNQLAEPRHGQMLKDMGILYAPDYVINAGGIINVSFENDYDAARSTAKVEKIYDTLLTIFTAAD
EQNRTTGAVADEMARAIIDAARK

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=343, Percent_Identity=24.7813411078717, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4885281, Length=334, Percent_Identity=24.251497005988, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 36998; Mature: 36867

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVFNHVSYDEHEQVVFCHDKESGLKAIIAVHNTNLGPAVGGCRMWNYQSDEEALNDVLR
CCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHH
LSRGMTYKNALAGLTMGGGKSVIIADPKTQDREALFRAFGRFINTLGGKYYSAEDVGTTT
HHCCCCHHHHHHCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCE
ADIMIAHQETPYMAGLEGKSGDPSPFTALGTFLGIKAAVKHQRGLDSLKGLKIAVQGVGH
EEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEECCHH
VGYYLCKHLHEEGAELIVTDIHQASLDKVATEFGAAVVAPQDIYSQDVDIYAPCALGATI
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCEEECCHHHHHCCCCEEECEECCCCC
NDATLPLLKAKIVAGCANNQLAEPRHGQMLKDMGILYAPDYVINAGGIINVSFENDYDAA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCEECCCEEEECCCEEEEEECCCHHHH
RSTAKVEKIYDTLLTIFTAADEQNRTTGAVADEMARAIIDAARK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVFNHVSYDEHEQVVFCHDKESGLKAIIAVHNTNLGPAVGGCRMWNYQSDEEALNDVLR
CCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHH
LSRGMTYKNALAGLTMGGGKSVIIADPKTQDREALFRAFGRFINTLGGKYYSAEDVGTTT
HHCCCCHHHHHHCEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCE
ADIMIAHQETPYMAGLEGKSGDPSPFTALGTFLGIKAAVKHQRGLDSLKGLKIAVQGVGH
EEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEECCHH
VGYYLCKHLHEEGAELIVTDIHQASLDKVATEFGAAVVAPQDIYSQDVDIYAPCALGATI
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCEEECCHHHHHCCCCEEECEECCCCC
NDATLPLLKAKIVAGCANNQLAEPRHGQMLKDMGILYAPDYVINAGGIINVSFENDYDAA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCEECCCEEEECCCEEEEEECCCHHHH
RSTAKVEKIYDTLLTIFTAADEQNRTTGAVADEMARAIIDAARK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3069133; 1400267 [H]