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The map label for this gene is 119775160

Identifier: 119775160

GI number: 119775160

Start: 2460445

End: 2462355

Strand: Reverse

Name: 119775160

Synonym: Sama_2025

Alternate gene names: NA

Gene position: 2462355-2460445 (Counterclockwise)

Preceding gene: 119775161

Following gene: 119775158

Centisome position: 57.18

GC content: 45.58

Gene sequence:

>1911_bases
ATGAAGAAGTTTCTGTTAAGCCTTACCGCAGTTACCTGCATGGCATCACAGCCACTCTATGCGGAGCCAGTGACTGCGCA
GTCACAAGCCGTGAGCACTATTGAAGCCTTTTCTACTGCGCCTCTTATTCGCAGTGTTGCTGTTTCAAGCGACGGAACCA
AAGTAGCCATCATCCGGGCCACGTCGAAGGAAGGTGACTATGTGATTGAAATCCGCGACACGAGCAAACTCGATGCCCAA
CCAATCGTTTTGGGAGCAAATCGTATGATGGTTTCGGGTGTCGTGTGGCTTAACAATGACAAGATTGGCGTAATGTTCCG
TCAGATCTTGAAAGATGGTGCCAGAAGGTATTGGGTAAACCGATTTGCAATTACCGATGCAGATGGGAAAGGAGATTGGT
TAATTCCGTTTCAAAACAATCCCCGCGCAGGTTTTTCTATCCTGAATACCTTGCCTGATAACAAGGATGAAATCCTGGTT
GAAACCGACCTGAACAACAACTACAAGCCTGATGTTGTCCGTTTTAACGTAAATAATGGTCGCACAGTCTCAGTTCTTCG
AGGCAGTGACAAAATTTCTGGTGGTTATATCTCAGATGCAGATGGTGATGTACGCGCTGCGACAGGCTGGAATTTGTCAG
ACAATGCCATCGACCTTTATGCCAGAGCGAAGGGCGATAGTGACTGGAAGCTCGTGAAACAGATTTCACCCAAATCCAGA
GAAAGTTACAGCTTTATCGGCTTTTCAAAGGAAAATCCCGATGAAATTTATGTCAACGCCAACCAAGGGCAGGACAAAAC
CGGAATCTACCTTTACAACATTAAAACGGGCCAGTATTCCGAACGTCTATTCGGTTTGGAAAACGTCGATGCGGATGGCG
TGATCCAGAAAAAAGACGGTAGCTTGGTTGGATTTGGTTATTCAGCAAAATGGCCTCAGCGCTATCTTACCGATGCCAAT
GAACAAGCAATTTATGATGGATTGGATAAACTGTTTGAAGGCAAGTTTGTTTCCATTATTAGCCGTTCTAATGATGACTC
AGTCATGGTGGTCAGTGCGTCATCCGACAAGGATCCTGGGACTTATTACCTTGTTTTAAACAAAAGTAAAATTGAAACCA
TCGGCAGTAAGTTGCCCTTTGTCGACCAAGAAAAACTTGGTAGCGTCAAATACATCTCTTACAAAGCCCGTGATGGCCGT
AAAGTCTACGCATATGTCACTCTTCCAAAAGGAAAAGGACCGTTTCCTGCGGTAGTATTGCCACATGGTGGCCCTTGGGT
TCGAGACACAATCGTATTTGACGATTGGGCGCAATTACTGGCTTCCAATGGTTATGTTGTTATCCAGCCCAACTACCGAG
GTTCAACCGGTTATGGTATCGAGCACTGGACTGCGGGTGACAACAATTGGGGCCTGAAAATGCAGGACGACCTTGATGAT
GCTGCCATGTATCTGGTTGAAAAAGGACTGGCCACCAAGGACAAGTTGGCCATGTTTGGTTGGAGTTATGGTGGTTACGC
CGCTTTCGCCGCGTCAATGCGCGATAATAACATTTACCAGTGTACTGTTGCCGGAGCGGGTGTCAGCGATTTAAGTAAAA
TCAATGCAACCTTGAACGAAAATCGGTTCTTAAGCCGTCTGCAACGTCCAACAATCACGGGTGTTTCACCTCTTTCACAG
GTTGAGAAAGTCAATGTGCCAATACTCGTGGTACACGGTGATATCGATGGACGTGTGCCAGTTGCCCACAGCCGTGAGTT
TGTAGAAAAACTCAAGGATTTGAAAAAGGATCATAAATACGTTGAGCTGGTGGACGCTGATCACTTTTCAGACACTTTGT
TTTATGAACATAAAATGGCGTTTTACTCAGAACTTATTGATTGGTTAGACAATAAGTGCGGTCTGAAGTAA

Upstream 100 bases:

>100_bases
GATGTTCAACAAATGCTGAACATGATTATGAGTAAACGATGAAAAATGGCCCTGCGGGGCCATTTTTTTCGAAAGGAATT
ACAGAATTAAGGACGGTTAA

Downstream 100 bases:

>100_bases
CACAATAACTCTGATAAAAGCCCGGCAATTGCCGGGCTTTTTGATGCAAGAGCATTACACATAGTGTTCAGACACAATCA
CACTTTTTGATCATGGTGAT

Product: prolyl oligopeptidase family protein

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MKKFLLSLTAVTCMASQPLYAEPVTAQSQAVSTIEAFSTAPLIRSVAVSSDGTKVAIIRATSKEGDYVIEIRDTSKLDAQ
PIVLGANRMMVSGVVWLNNDKIGVMFRQILKDGARRYWVNRFAITDADGKGDWLIPFQNNPRAGFSILNTLPDNKDEILV
ETDLNNNYKPDVVRFNVNNGRTVSVLRGSDKISGGYISDADGDVRAATGWNLSDNAIDLYARAKGDSDWKLVKQISPKSR
ESYSFIGFSKENPDEIYVNANQGQDKTGIYLYNIKTGQYSERLFGLENVDADGVIQKKDGSLVGFGYSAKWPQRYLTDAN
EQAIYDGLDKLFEGKFVSIISRSNDDSVMVVSASSDKDPGTYYLVLNKSKIETIGSKLPFVDQEKLGSVKYISYKARDGR
KVYAYVTLPKGKGPFPAVVLPHGGPWVRDTIVFDDWAQLLASNGYVVIQPNYRGSTGYGIEHWTAGDNNWGLKMQDDLDD
AAMYLVEKGLATKDKLAMFGWSYGGYAAFAASMRDNNIYQCTVAGAGVSDLSKINATLNENRFLSRLQRPTITGVSPLSQ
VEKVNVPILVVHGDIDGRVPVAHSREFVEKLKDLKKDHKYVELVDADHFSDTLFYEHKMAFYSELIDWLDNKCGLK

Sequences:

>Translated_636_residues
MKKFLLSLTAVTCMASQPLYAEPVTAQSQAVSTIEAFSTAPLIRSVAVSSDGTKVAIIRATSKEGDYVIEIRDTSKLDAQ
PIVLGANRMMVSGVVWLNNDKIGVMFRQILKDGARRYWVNRFAITDADGKGDWLIPFQNNPRAGFSILNTLPDNKDEILV
ETDLNNNYKPDVVRFNVNNGRTVSVLRGSDKISGGYISDADGDVRAATGWNLSDNAIDLYARAKGDSDWKLVKQISPKSR
ESYSFIGFSKENPDEIYVNANQGQDKTGIYLYNIKTGQYSERLFGLENVDADGVIQKKDGSLVGFGYSAKWPQRYLTDAN
EQAIYDGLDKLFEGKFVSIISRSNDDSVMVVSASSDKDPGTYYLVLNKSKIETIGSKLPFVDQEKLGSVKYISYKARDGR
KVYAYVTLPKGKGPFPAVVLPHGGPWVRDTIVFDDWAQLLASNGYVVIQPNYRGSTGYGIEHWTAGDNNWGLKMQDDLDD
AAMYLVEKGLATKDKLAMFGWSYGGYAAFAASMRDNNIYQCTVAGAGVSDLSKINATLNENRFLSRLQRPTITGVSPLSQ
VEKVNVPILVVHGDIDGRVPVAHSREFVEKLKDLKKDHKYVELVDADHFSDTLFYEHKMAFYSELIDWLDNKCGLK
>Mature_636_residues
MKKFLLSLTAVTCMASQPLYAEPVTAQSQAVSTIEAFSTAPLIRSVAVSSDGTKVAIIRATSKEGDYVIEIRDTSKLDAQ
PIVLGANRMMVSGVVWLNNDKIGVMFRQILKDGARRYWVNRFAITDADGKGDWLIPFQNNPRAGFSILNTLPDNKDEILV
ETDLNNNYKPDVVRFNVNNGRTVSVLRGSDKISGGYISDADGDVRAATGWNLSDNAIDLYARAKGDSDWKLVKQISPKSR
ESYSFIGFSKENPDEIYVNANQGQDKTGIYLYNIKTGQYSERLFGLENVDADGVIQKKDGSLVGFGYSAKWPQRYLTDAN
EQAIYDGLDKLFEGKFVSIISRSNDDSVMVVSASSDKDPGTYYLVLNKSKIETIGSKLPFVDQEKLGSVKYISYKARDGR
KVYAYVTLPKGKGPFPAVVLPHGGPWVRDTIVFDDWAQLLASNGYVVIQPNYRGSTGYGIEHWTAGDNNWGLKMQDDLDD
AAMYLVEKGLATKDKLAMFGWSYGGYAAFAASMRDNNIYQCTVAGAGVSDLSKINATLNENRFLSRLQRPTITGVSPLSQ
VEKVNVPILVVHGDIDGRVPVAHSREFVEKLKDLKKDHKYVELVDADHFSDTLFYEHKMAFYSELIDWLDNKCGLK

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Caenorhabditis elegans, GI25144537, Length=430, Percent_Identity=28.8372093023256, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144540, Length=410, Percent_Identity=29.7560975609756, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144543, Length=339, Percent_Identity=29.7935103244838, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17552908, Length=194, Percent_Identity=31.9587628865979, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI25149159, Length=257, Percent_Identity=26.4591439688716, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508017, Length=225, Percent_Identity=28.8888888888889, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17508019, Length=225, Percent_Identity=28.8888888888889, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 70592; Mature: 70592

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFLLSLTAVTCMASQPLYAEPVTAQSQAVSTIEAFSTAPLIRSVAVSSDGTKVAIIRA
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEE
TSKEGDYVIEIRDTSKLDAQPIVLGANRMMVSGVVWLNNDKIGVMFRQILKDGARRYWVN
ECCCCCEEEEEECCCCCCCCEEEEECCEEEEEEEEEECCCCHHHHHHHHHHHCHHEEEEE
RFAITDADGKGDWLIPFQNNPRAGFSILNTLPDNKDEILVETDLNNNYKPDVVRFNVNNG
EEEEECCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEECCCC
RTVSVLRGSDKISGGYISDADGDVRAATGWNLSDNAIDLYARAKGDSDWKLVKQISPKSR
CEEEEEECCCCCCCCEEECCCCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHCCCCCC
ESYSFIGFSKENPDEIYVNANQGQDKTGIYLYNIKTGQYSERLFGLENVDADGVIQKKDG
CCEEEEEECCCCCCEEEEECCCCCCCCCEEEEEEECCCHHHHHCCCCCCCCCCEEEECCC
SLVGFGYSAKWPQRYLTDANEQAIYDGLDKLFEGKFVSIISRSNDDSVMVVSASSDKDPG
CEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCC
TYYLVLNKSKIETIGSKLPFVDQEKLGSVKYISYKARDGRKVYAYVTLPKGKGPFPAVVL
EEEEEEECCHHHHHHCCCCCCCHHHCCCEEEEEEECCCCCEEEEEEEECCCCCCCCEEEE
PHGGPWVRDTIVFDDWAQLLASNGYVVIQPNYRGSTGYGIEHWTAGDNNWGLKMQDDLDD
CCCCCCEEEEEEHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCCEEECCCCHH
AAMYLVEKGLATKDKLAMFGWSYGGYAAFAASMRDNNIYQCTVAGAGVSDLSKINATLNE
HHHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHCCH
NRFLSRLQRPTITGVSPLSQVEKVNVPILVVHGDIDGRVPVAHSREFVEKLKDLKKDHKY
HHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCE
VELVDADHFSDTLFYEHKMAFYSELIDWLDNKCGLK
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKFLLSLTAVTCMASQPLYAEPVTAQSQAVSTIEAFSTAPLIRSVAVSSDGTKVAIIRA
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEE
TSKEGDYVIEIRDTSKLDAQPIVLGANRMMVSGVVWLNNDKIGVMFRQILKDGARRYWVN
ECCCCCEEEEEECCCCCCCCEEEEECCEEEEEEEEEECCCCHHHHHHHHHHHCHHEEEEE
RFAITDADGKGDWLIPFQNNPRAGFSILNTLPDNKDEILVETDLNNNYKPDVVRFNVNNG
EEEEECCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEECCCC
RTVSVLRGSDKISGGYISDADGDVRAATGWNLSDNAIDLYARAKGDSDWKLVKQISPKSR
CEEEEEECCCCCCCCEEECCCCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHCCCCCC
ESYSFIGFSKENPDEIYVNANQGQDKTGIYLYNIKTGQYSERLFGLENVDADGVIQKKDG
CCEEEEEECCCCCCEEEEECCCCCCCCCEEEEEEECCCHHHHHCCCCCCCCCCEEEECCC
SLVGFGYSAKWPQRYLTDANEQAIYDGLDKLFEGKFVSIISRSNDDSVMVVSASSDKDPG
CEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCC
TYYLVLNKSKIETIGSKLPFVDQEKLGSVKYISYKARDGRKVYAYVTLPKGKGPFPAVVL
EEEEEEECCHHHHHHCCCCCCCHHHCCCEEEEEEECCCCCEEEEEEEECCCCCCCCEEEE
PHGGPWVRDTIVFDDWAQLLASNGYVVIQPNYRGSTGYGIEHWTAGDNNWGLKMQDDLDD
CCCCCCEEEEEEHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCCEEECCCCHH
AAMYLVEKGLATKDKLAMFGWSYGGYAAFAASMRDNNIYQCTVAGAGVSDLSKINATLNE
HHHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHCCH
NRFLSRLQRPTITGVSPLSQVEKVNVPILVVHGDIDGRVPVAHSREFVEKLKDLKKDHKY
HHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCE
VELVDADHFSDTLFYEHKMAFYSELIDWLDNKCGLK
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]