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The map label for this gene is hisA

Identifier: 119775081

GI number: 119775081

Start: 2374027

End: 2374764

Strand: Direct

Name: hisA

Synonym: Sama_1946

Alternate gene names: 119775081

Gene position: 2374027-2374764 (Clockwise)

Preceding gene: 119775080

Following gene: 119775082

Centisome position: 55.13

GC content: 55.69

Gene sequence:

>738_bases
ATGATCATTCCTGCAATTGACCTTATCGATGGTCAGGTGGTGCGCCTGTTTCAGGGCGATTACGCCAAAAAGACCGAATT
TTCACTGGACCCCAAGAACCAGCTGCTGAGTTATCAGCAGGATGGCGCTGCACTCTTGCACCTTGTTGATCTAACCGGCG
CTAAAGATCCGGACAAAAGGCAAACCAAGTTAATCGAAGAGATTGCGGCCAGTTTGTCCACCCCGCTGCAAGTCGGCGGC
GGCATTCGCAGCGCTGCAGACGTGGATGCCCTGCTGAATGCGGGCGTTGCCCGGGTGGTTATCGGCTCGCTGGCTGTCAA
ATCACCTGAGGTAGTACTGCGCCTTTTTGATAAGTATGGCGGCGATGCCATTTGTCTTGCCCTTGACGTCAATATAGATG
CCGACGGCAACAAGATGGTGGCGGTTCACGGCTGGCAACAGGGCGGCGGCAAGTCGCTGGAATCCTTGGTGGATACCTTT
ATGCCCGCAGGCCTTAAACATGCACTGGTGACCGACATCAGCCGCGATGGCACCATGACCGGCGCCAATACAGCCCTTTA
CTGTGAACTGGCCGAGCGCTTCAACGAGGTACAGTGGCAGGCCAGTGGCGGCGTGGCGACCCTTGATGACGTAAAGGCCG
TCAAAACCTCTGGTGCCAGTGGTATCATTATCGGTAAGGCGCTGCTAACCGGCGTGTTCAGTGCAAAGGAGGCAATTGCA
TGCTGGCCAAACGTATAG

Upstream 100 bases:

>100_bases
GCGCCAAAATCCTCAGGAATTTTCTGGCAATCACCCTGGCCGACCTGGGGCTTGATGACCATTTTCGAGCGCAATCACAT
GCTGGCACCTTGGAGCAATC

Downstream 100 bases:

>100_bases
TGCCTTGCCTGGATGTGAAAGACGGCAAAGTGGTTAAGGGCGTGCAATTTCGTAACCACGAGATTGTCGGCGATATAGTG
CCGCTTGCTGCCCGCTACGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MIIPAIDLIDGQVVRLFQGDYAKKTEFSLDPKNQLLSYQQDGAALLHLVDLTGAKDPDKRQTKLIEEIAASLSTPLQVGG
GIRSAADVDALLNAGVARVVIGSLAVKSPEVVLRLFDKYGGDAICLALDVNIDADGNKMVAVHGWQQGGGKSLESLVDTF
MPAGLKHALVTDISRDGTMTGANTALYCELAERFNEVQWQASGGVATLDDVKAVKTSGASGIIIGKALLTGVFSAKEAIA
CWPNV

Sequences:

>Translated_245_residues
MIIPAIDLIDGQVVRLFQGDYAKKTEFSLDPKNQLLSYQQDGAALLHLVDLTGAKDPDKRQTKLIEEIAASLSTPLQVGG
GIRSAADVDALLNAGVARVVIGSLAVKSPEVVLRLFDKYGGDAICLALDVNIDADGNKMVAVHGWQQGGGKSLESLVDTF
MPAGLKHALVTDISRDGTMTGANTALYCELAERFNEVQWQASGGVATLDDVKAVKTSGASGIIIGKALLTGVFSAKEAIA
CWPNV
>Mature_245_residues
MIIPAIDLIDGQVVRLFQGDYAKKTEFSLDPKNQLLSYQQDGAALLHLVDLTGAKDPDKRQTKLIEEIAASLSTPLQVGG
GIRSAADVDALLNAGVARVVIGSLAVKSPEVVLRLFDKYGGDAICLALDVNIDADGNKMVAVHGWQQGGGKSLESLVDTF
MPAGLKHALVTDISRDGTMTGANTALYCELAERFNEVQWQASGGVATLDDVKAVKTSGASGIIIGKALLTGVFSAKEAIA
CWPNV

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=58.6065573770492, Blast_Score=295, Evalue=2e-81,
Organism=Escherichia coli, GI1788336, Length=216, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_SHEAM (A1S6Z5)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927821.1
- ProteinModelPortal:   A1S6Z5
- STRING:   A1S6Z5
- GeneID:   4604196
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1946
- NMPDR:   fig|326297.7.peg.1828
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   A1S6Z5
- ProtClustDB:   PRK00748
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25764; Mature: 25764

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: ACT_SITE 7-7 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPAIDLIDGQVVRLFQGDYAKKTEFSLDPKNQLLSYQQDGAALLHLVDLTGAKDPDKR
CCCCCEECCCCCEEEEECCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCCHH
QTKLIEEIAASLSTPLQVGGGIRSAADVDALLNAGVARVVIGSLAVKSPEVVLRLFDKYG
HHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCC
GDAICLALDVNIDADGNKMVAVHGWQQGGGKSLESLVDTFMPAGLKHALVTDISRDGTMT
CCEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCC
GANTALYCELAERFNEVQWQASGGVATLDDVKAVKTSGASGIIIGKALLTGVFSAKEAIA
CCCCEEEHHHHHHHHHEEEECCCCEEEHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEE
CWPNV
CCCCC
>Mature Secondary Structure
MIIPAIDLIDGQVVRLFQGDYAKKTEFSLDPKNQLLSYQQDGAALLHLVDLTGAKDPDKR
CCCCCEECCCCCEEEEECCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCCCHH
QTKLIEEIAASLSTPLQVGGGIRSAADVDALLNAGVARVVIGSLAVKSPEVVLRLFDKYG
HHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCC
GDAICLALDVNIDADGNKMVAVHGWQQGGGKSLESLVDTFMPAGLKHALVTDISRDGTMT
CCEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCC
GANTALYCELAERFNEVQWQASGGVATLDDVKAVKTSGASGIIIGKALLTGVFSAKEAIA
CCCCEEEHHHHHHHHHEEEECCCCEEEHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEE
CWPNV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA