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The map label for this gene is ttcA

Identifier: 119774936

GI number: 119774936

Start: 2192916

End: 2193875

Strand: Direct

Name: ttcA

Synonym: Sama_1801

Alternate gene names: 119774936

Gene position: 2192916-2193875 (Clockwise)

Preceding gene: 119774935

Following gene: 119774939

Centisome position: 50.93

GC content: 51.15

Gene sequence:

>960_bases
ATGTCAGATGTAGTGCAAGACGAACTTTCCAAGAAACAAACTACCCGCCTCAACAAACTTCAAAAGCGACTTCGCCGCGA
AGTTGGCAGCGCTATTGCTGATTACAACATGATTGAAGAAGGTGACAGAGTCATGTGCTGTCTGTCCGGTGGCAAAGACA
GCTATGCCATGCTGGATATTCTGATCAATCTGCAGCAACGTGCCCCTGTTTCTTTTGAAATTGTGGCCGTTAACCTGGAT
CAGAAGCAGCCAGGCTTCCCTGAGCATGTGCTGCCTGCCTACCTTGAGACCCTGGGTGTGCCTTTTCATATTCTTGAGAA
AGACACTTATTCCATCGTTAAAGACAAGATCCCGGAAGGCAAGACCACCTGTTCTTTGTGTTCACGCCTGCGTCGAGGCA
CCCTGTATGGATTTGCCCAGCGGATTGGTGCCACCAAAATTGCTTTGGGGCACCACAGGGACGACATTATTGAGACCCTG
TTCCTGAACATGTTCTATGGCGGCAAAATGAAAGCCATGCCGCCCAAGCTGTTGTCGGACGATGGTGCCAACGTGGTTAT
CCGCCCCCTCGCCTATTGCCGCGAAAAAGACATTGCCGAGTATGCCGAGCTGAAGCAGTTCCCCATTATTCCCTGTAACC
TCTGTGGATCTCAGGAAAACCTCAAGCGTGCTGCGGTAAAAGACATGCTTAAGCAGTGGGACCGTCAGCATCCTGGTCGT
ATTGAAACCATCTTTACTGCCATGCAGAATACTGCACCTTCCCAGGGCGTCGACCGCGAGCAATTCGACTTTGTCTCGCT
CAAACAGGATCCCAACGCGGAATTTCGCGGTGATGTAGCAGAAGCTGATTTGCCCGCCTTTGACTTTATGGACACGGCAA
ACAGTGGTCATATCAATCTGGACGATGCCAGCAAACGTCAGGGCACCCGCATCGATGTGGTATCGACCTTTACCCCCTGA

Upstream 100 bases:

>100_bases
ATGGATATAAATCACCGCTTCAGGAAGGCTAACGCTTTACCCTAAGCCGCTAAGCTGGAATAATACGCGCCCTGAAACCT
AGGTTACCGGGCGCTTTTTT

Downstream 100 bases:

>100_bases
TAGCTGACATTCCCTCCAAACTAACTGGGGAATGTGACATTAAAACACGCAAAAAAGCCCGCGTTAAGCGGGCTTTTTCA
TGGGACATCATCAGCAAATT

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSDVVQDELSKKQTTRLNKLQKRLRREVGSAIADYNMIEEGDRVMCCLSGGKDSYAMLDILINLQQRAPVSFEIVAVNLD
QKQPGFPEHVLPAYLETLGVPFHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETL
FLNMFYGGKMKAMPPKLLSDDGANVVIRPLAYCREKDIAEYAELKQFPIIPCNLCGSQENLKRAAVKDMLKQWDRQHPGR
IETIFTAMQNTAPSQGVDREQFDFVSLKQDPNAEFRGDVAEADLPAFDFMDTANSGHINLDDASKRQGTRIDVVSTFTP

Sequences:

>Translated_319_residues
MSDVVQDELSKKQTTRLNKLQKRLRREVGSAIADYNMIEEGDRVMCCLSGGKDSYAMLDILINLQQRAPVSFEIVAVNLD
QKQPGFPEHVLPAYLETLGVPFHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETL
FLNMFYGGKMKAMPPKLLSDDGANVVIRPLAYCREKDIAEYAELKQFPIIPCNLCGSQENLKRAAVKDMLKQWDRQHPGR
IETIFTAMQNTAPSQGVDREQFDFVSLKQDPNAEFRGDVAEADLPAFDFMDTANSGHINLDDASKRQGTRIDVVSTFTP
>Mature_318_residues
SDVVQDELSKKQTTRLNKLQKRLRREVGSAIADYNMIEEGDRVMCCLSGGKDSYAMLDILINLQQRAPVSFEIVAVNLDQ
KQPGFPEHVLPAYLETLGVPFHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLF
LNMFYGGKMKAMPPKLLSDDGANVVIRPLAYCREKDIAEYAELKQFPIIPCNLCGSQENLKRAAVKDMLKQWDRQHPGRI
ETIFTAMQNTAPSQGVDREQFDFVSLKQDPNAEFRGDVAEADLPAFDFMDTANSGHINLDDASKRQGTRIDVVSTFTP

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=273, Percent_Identity=69.5970695970696, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI193211090, Length=232, Percent_Identity=33.6206896551724, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17540090, Length=241, Percent_Identity=26.9709543568465, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651972, Length=234, Percent_Identity=27.3504273504274, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_SHEAM (A1S6K0)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927676.1
- ProteinModelPortal:   A1S6K0
- SMR:   A1S6K0
- STRING:   A1S6K0
- GeneID:   4604051
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1801
- NMPDR:   fig|326297.7.peg.1695
- eggNOG:   COG0037
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- PhylomeDB:   A1S6K0
- ProtClustDB:   PRK10696
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 35847; Mature: 35716

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVVQDELSKKQTTRLNKLQKRLRREVGSAIADYNMIEEGDRVMCCLSGGKDSYAMLDI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
LINLQQRAPVSFEIVAVNLDQKQPGFPEHVLPAYLETLGVPFHILEKDTYSIVKDKIPEG
HHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCC
KTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMFYGGKMKAMPPKLLSD
CHHHHHHHHHHHCHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHCC
DGANVVIRPLAYCREKDIAEYAELKQFPIIPCNLCGSQENLKRAAVKDMLKQWDRQHPGR
CCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCH
IETIFTAMQNTAPSQGVDREQFDFVSLKQDPNAEFRGDVAEADLPAFDFMDTANSGHINL
HHHHHHHHHHCCCCCCCCHHHCCEEEECCCCCCCCCCCCHHCCCCCHHHHHCCCCCEEEC
DDASKRQGTRIDVVSTFTP
CCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
SDVVQDELSKKQTTRLNKLQKRLRREVGSAIADYNMIEEGDRVMCCLSGGKDSYAMLDI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
LINLQQRAPVSFEIVAVNLDQKQPGFPEHVLPAYLETLGVPFHILEKDTYSIVKDKIPEG
HHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCC
KTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMFYGGKMKAMPPKLLSD
CHHHHHHHHHHHCHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHCC
DGANVVIRPLAYCREKDIAEYAELKQFPIIPCNLCGSQENLKRAAVKDMLKQWDRQHPGR
CCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCH
IETIFTAMQNTAPSQGVDREQFDFVSLKQDPNAEFRGDVAEADLPAFDFMDTANSGHINL
HHHHHHHHHHCCCCCCCCHHHCCEEEECCCCCCCCCCCCHHCCCCCHHHHHCCCCCEEEC
DDASKRQGTRIDVVSTFTP
CCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA