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The map label for this gene is serS

Identifier: 119774911

GI number: 119774911

Start: 2171156

End: 2172442

Strand: Direct

Name: serS

Synonym: Sama_1776

Alternate gene names: 119774911

Gene position: 2171156-2172442 (Clockwise)

Preceding gene: 119774910

Following gene: 119774912

Centisome position: 50.42

GC content: 52.68

Gene sequence:

>1287_bases
ATGTTAGATACCAAATATCTCCGTAATGAACTGGAATTCACCAAAGAGCGTCTGGCCGCACGCGGCTTCGCGCTGGACAT
CGATCATCTCAAAGCGCTGGAAGAAAAGCGCAAGTCGCTGCAGGTCGCCACTGAAGAGCTGCAGGCCAGTCGCAACGCAA
TTTCCAAATCCATCGGTCAGGCAAAGTCCCGTGGTGAAGACGTCGCGCCCATCATGGCTCAGGTAGGTAACCTGGGTACC
GAGCTTGAGGCCAAAAAAATCGAATTGGCAGCGCTGCTGGAAGAAATCAACGCCATTGCCATGTCAGTGCCCAACCTGCC
TGATGAGTCAGTGCCTGTTGGGAAAGACGAAAGTGAAAACGTTGAAATTCGCCGTTGGGGCGAGCCACGCAGCTTTGATT
TTGCAGTTAAAGATCATGTGGATCTGGGTGAAACCCTGGGTGGTTTGGATTTCAAGAGCGCGGTTAAGATCACCGGCTCA
CGCTTTATCGTTATGAAAGGCCAGATTGCCCGCATGCACCGCGCACTGGCGCAGTTTATGCTGGATCTGCATACCATTGA
GCACGGTTATACTGAGGCCTATGTGCCTTTGCTGGTAAACACAGACAGTTTACTGGGTACTGGTCAGTTACCCAAGTTCA
GTGAAGACCTGTTCAACCTCAAGCCTGCGACCGAAGAAGGTCAGGCACTGAGCCTGATCCCAACGGCAGAAGTACCAGTG
ACCAACCTGGTGCGTGATACCATCCTTGATGAGGCCGACCTGCCTATCAAGATTACCGCACACACGGCATGCTTCCGCTC
CGAAGCCGGTTCATACGGTAAAGATACCCGTGGTCTTATCCGTCAGCACCAGTTCGACAAAGTGGAAATGGTGCAGATAG
TTAAGCCCGAAAACTCCATGGATGCCCTTGAGCAAATGGTTGGCCACGCCGAAAACGTACTGAAAAAGCTGGGTCTGCCA
TACCGCACAGTGGTGCTTTGCACCGGCGACATGGGCTTTGGTGCCGCCAAGACCTACGACATTGAAGTATGGCTGCCTGC
GCAGAACACCTATCGTGAAATCTCTTCGTGCTCTAACGTGAAGGATTTCCAGGCCCGCCGTATGCAAGCCCGCTATCGCA
GCAAAGAAGACAACAAGCCTGCACTGGTTCACACCCTCAATGGTTCAGGTCTTGCGGTAGGTCGTACTCTGGTAGCGATT
CTGGAGAACTATCAGAATGCCGATGGTACAGTTACCGTGCCTGAAGCCCTGCGCCCATATATGGGTGGTATTGAGCAACT
CGGTTAA

Upstream 100 bases:

>100_bases
CGAGCCTGAATGTGCTTCTGAACCTGATACTTTGCCTGACCGTGGTGTATCTAGGGCAGCAGCTGATTTATTCCCGCGTT
TAACTTATAAGACAACAAGT

Downstream 100 bases:

>100_bases
TAACAAGACACTATTTTTCAAGGTTATATGGATAACGGTCAACGCTACTTACGTTGGCTTTCATACGTGGCAGTGATAGC
GGTGTTTGTCGGTATCATGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLDTKYLRNELEFTKERLAARGFALDIDHLKALEEKRKSLQVATEELQASRNAISKSIGQAKSRGEDVAPIMAQVGNLGT
ELEAKKIELAALLEEINAIAMSVPNLPDESVPVGKDESENVEIRRWGEPRSFDFAVKDHVDLGETLGGLDFKSAVKITGS
RFIVMKGQIARMHRALAQFMLDLHTIEHGYTEAYVPLLVNTDSLLGTGQLPKFSEDLFNLKPATEEGQALSLIPTAEVPV
TNLVRDTILDEADLPIKITAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPENSMDALEQMVGHAENVLKKLGLP
YRTVVLCTGDMGFGAAKTYDIEVWLPAQNTYREISSCSNVKDFQARRMQARYRSKEDNKPALVHTLNGSGLAVGRTLVAI
LENYQNADGTVTVPEALRPYMGGIEQLG

Sequences:

>Translated_428_residues
MLDTKYLRNELEFTKERLAARGFALDIDHLKALEEKRKSLQVATEELQASRNAISKSIGQAKSRGEDVAPIMAQVGNLGT
ELEAKKIELAALLEEINAIAMSVPNLPDESVPVGKDESENVEIRRWGEPRSFDFAVKDHVDLGETLGGLDFKSAVKITGS
RFIVMKGQIARMHRALAQFMLDLHTIEHGYTEAYVPLLVNTDSLLGTGQLPKFSEDLFNLKPATEEGQALSLIPTAEVPV
TNLVRDTILDEADLPIKITAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPENSMDALEQMVGHAENVLKKLGLP
YRTVVLCTGDMGFGAAKTYDIEVWLPAQNTYREISSCSNVKDFQARRMQARYRSKEDNKPALVHTLNGSGLAVGRTLVAI
LENYQNADGTVTVPEALRPYMGGIEQLG
>Mature_428_residues
MLDTKYLRNELEFTKERLAARGFALDIDHLKALEEKRKSLQVATEELQASRNAISKSIGQAKSRGEDVAPIMAQVGNLGT
ELEAKKIELAALLEEINAIAMSVPNLPDESVPVGKDESENVEIRRWGEPRSFDFAVKDHVDLGETLGGLDFKSAVKITGS
RFIVMKGQIARMHRALAQFMLDLHTIEHGYTEAYVPLLVNTDSLLGTGQLPKFSEDLFNLKPATEEGQALSLIPTAEVPV
TNLVRDTILDEADLPIKITAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPENSMDALEQMVGHAENVLKKLGLP
YRTVVLCTGDMGFGAAKTYDIEVWLPAQNTYREISSCSNVKDFQARRMQARYRSKEDNKPALVHTLNGSGLAVGRTLVAI
LENYQNADGTVTVPEALRPYMGGIEQLG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=364, Percent_Identity=35.989010989011, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI8923421, Length=400, Percent_Identity=31, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI225579074, Length=403, Percent_Identity=30.272952853598, Blast_Score=185, Evalue=9e-47,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=71.1627906976744, Blast_Score=642, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=435, Percent_Identity=31.4942528735632, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=328, Percent_Identity=29.5731707317073, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=398, Percent_Identity=32.4120603015075, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6321799, Length=392, Percent_Identity=30.6122448979592, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24581334, Length=347, Percent_Identity=34.8703170028818, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17737985, Length=327, Percent_Identity=31.8042813455657, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_SHEAM (A1S6H5)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927651.1
- ProteinModelPortal:   A1S6H5
- SMR:   A1S6H5
- STRING:   A1S6H5
- GeneID:   4604026
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1776
- NMPDR:   fig|326297.7.peg.1676
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   A1S6H5
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47281; Mature: 47281

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 289-289 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTKYLRNELEFTKERLAARGFALDIDHLKALEEKRKSLQVATEELQASRNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKSRGEDVAPIMAQVGNLGTELEAKKIELAALLEEINAIAMSVPNLPDESVPVGKDESEN
HHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEIRRWGEPRSFDFAVKDHVDLGETLGGLDFKSAVKITGSRFIVMKGQIARMHRALAQFM
EEEEECCCCCCCCEEECCCCCHHHHHCCCCHHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTIEHGYTEAYVPLLVNTDSLLGTGQLPKFSEDLFNLKPATEEGQALSLIPTAEVPV
HHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEECCCCCCH
TNLVRDTILDEADLPIKITAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPENSM
HHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHH
DALEQMVGHAENVLKKLGLPYRTVVLCTGDMGFGAAKTYDIEVWLPAQNTYREISSCSNV
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHHCCC
KDFQARRMQARYRSKEDNKPALVHTLNGSGLAVGRTLVAILENYQNADGTVTVPEALRPY
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHH
MGGIEQLG
HHHHHHCC
>Mature Secondary Structure
MLDTKYLRNELEFTKERLAARGFALDIDHLKALEEKRKSLQVATEELQASRNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKSRGEDVAPIMAQVGNLGTELEAKKIELAALLEEINAIAMSVPNLPDESVPVGKDESEN
HHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEIRRWGEPRSFDFAVKDHVDLGETLGGLDFKSAVKITGSRFIVMKGQIARMHRALAQFM
EEEEECCCCCCCCEEECCCCCHHHHHCCCCHHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTIEHGYTEAYVPLLVNTDSLLGTGQLPKFSEDLFNLKPATEEGQALSLIPTAEVPV
HHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEECCCCCCH
TNLVRDTILDEADLPIKITAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPENSM
HHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHH
DALEQMVGHAENVLKKLGLPYRTVVLCTGDMGFGAAKTYDIEVWLPAQNTYREISSCSNV
HHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHHCCC
KDFQARRMQARYRSKEDNKPALVHTLNGSGLAVGRTLVAILENYQNADGTVTVPEALRPY
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHH
MGGIEQLG
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA