Click here to switch to the map view.

The map label for this gene is nrdA [H]

Identifier: 119774863

GI number: 119774863

Start: 2113784

End: 2116132

Strand: Reverse

Name: nrdA [H]

Synonym: Sama_1728

Alternate gene names: 119774863

Gene position: 2116132-2113784 (Counterclockwise)

Preceding gene: 119774864

Following gene: 119774862

Centisome position: 49.14

GC content: 51.47

Gene sequence:

>2349_bases
ATGGCACGATTGTTTACATGGATATGTAGGGCAATACCAATCTATAAAGGCCTATCTTCAATGAATAGCAACATGACAGT
CACAAAACGCAGTGGCGAACGCGAGCAGATCGATCTCGACAAAATCCATCGCGTGGTTACCTGGGCCGCCAAGGGCTTAA
AAAATGTTTCCGTTTCTGAAGTAGAACTGCGTTCGCACCTGCAGTTTTTTGAAGGCATCCCTACCGAAGCCATCCACGAA
ACCATTATTAAAGCTGCTGCGGATCTGATCTCTCCCGAGTCTCCAGATTATCAGTTCCTGGCCGCCCGTTTGGCTGTATT
CCATCTTCGCAAGAAGGCCTTTGGCCAGTTCGAGCCGCCTAAGCTGTATGATCACGTGGTCAAGCTGGTCGAGATGGGCA
AGTATGACCGCCACATCCTCGAAGACTACACCAAAGAAGAACTGGACGTTTTAGACAGCTACATAGACCACTGGCGCGAT
ATGAATTTCTCATACGCCGCCGTGAAGCAGCTGGAAGGCAAATACCTGGTTCAAAACCGTGTCACTCACGAAGTGTACGA
GAGCGCCCAGTTCCTCTACATCCTGGTTGCAGCCTGCTTGTTTGCCGGTTATCCAAAAGAGACCCGTCTGAAGTATGTAA
AAGACTTCTATGATGCAGTATCTACCTTCAAGATTTCGCTGCCTACACCCATCATGTCCGGTGTACGTACTCCTACCCGC
CAGTTCAGCTCCTGCGTACTGATTGAGTGTGGTGACAGCCTGGATTCTATCAACGCCACTGCCTCTTCCATCGTGAAGTA
CGTGAGTCAGCGCGCCGGTATCGGCGTGAATGCAGGCCGTATCCGCGCCCTGGGCAGCCCAATCCGTGGCGGTGAAGCGT
TCCATACTGGCTGTCTGCCTTTCTATAAGTATTTCCAGACTGCGGTGAAGTCCTGCTCTCAGGGCGGTGTGCGTGGCGGC
GCGGCAACGCTGTTCTATCCAATTTGGCACCTGGAAGTAGAGTCGCTGCTGGTGCTGAAGAATAACCGCGGCGTTGAAGA
CAACCGTATCCGGCATCTGGACTATGGCGTACAGCTGAACAAACTCATGTATCAGCGCCTGATCAAGGGTGAGAACATCA
CCCTGTTCAGCCCGTCAGACGTGCCCGGCCTGTACGATGCCTTCTTTGAAAATCAGGATGAATTCGAGCGCCTGTACACC
AAGTACGAGCAAGAACCGAGCATCCGTAAAAAGTCGCTTAAGGCCGTTGAACTGTTCTCATTGATGATGCAGGAACGTGC
CTCAACCGGTCGTATCTATGTGCAGAACGTGGATCACTGCAACACCCACAGCCCATTTGACTCAAGCGTTGCCCCTATCC
GCCAGTCAAACCTGTGTCTGGAAATTGCACTGCCAACCAAACCACTGGACAGCGTGGACGATACCAATGGTGAAATCGCA
CTCTGTACTCTGTCAGCACTGAATTTGGGTGCCATCGAGAACCTTGAAGAACTCGAAGGTTTGTCAGACCTCGCGGTACG
TGCTCTCGATAGCCTGCTGGACTATCAGGACTACCCCATCAAGGCAGCCAAGCTTGGCTCCATGAACCGTCGTACCCTGG
GTATTGGTGTGATTAACTTTGCCAACTACCTGGCTAAAAACGGCAAAAAATATTCAGATGGCAGTGCCAACAACCTGACC
CACAAGACATTCGAAGCTATTCAGTTCAACCTGCTGAAAGCCTCGATGAATCTGGCAAAGGAAAAAGGCGCCTGTCCGGC
GTTCCATGAGACGACTTACTCTCAGGGTATTCTGCCAATCGACACCTATAAGCGCGATCTGGACAAGATTTGCGATGAGC
CGCTGCATCTGGATTGGGAAGGACTGCGTGCCGATATCAAGCACTACGGCCTGCGTAACTCTACCCTGTCAGCACTGATG
CCGTCAGAGACTTCTTCTCAGATCTCCAATGCCACCAACGGTATCGAGCCACCCCGTGGTCTGATTTCGGTGAAAGCCAG
TAAAGACGGTCAGCTCAAGCAAGTCGTGCCTGACTTTGATGAATTGCGCAACGCGTACGAATTGCTGTGGCAAATGCCGT
CAAACGACGGTTACCTGCAATTGGTTGGCATTATGCAGAAGTTTGTGGATCAGGCGATTTCTGCCAACACCAACTATGAC
CCCGCCAAGTTCGAGGGTCGTAAGGTACCAATGCAGCTGCTGCTTAAAGATCTACTTACCGCATACAAACTGGGCCTCAA
AACCCTCTACTACCATAACACCCGTGATGGTGCGACCGATCAGCATGATGACATTGCTGTGGTTGAAAAAGAGGACGACG
GCTGCGCCGGTGGTGCCTGTAAGATTTAA

Upstream 100 bases:

>100_bases
AATAAGCACCATATCTTGTGTATTGGTAGCAATCAGACACACTAGAGGTGTCCACCCCGAAACGCTTGTTGTGCCAGTAC
AAAGCGCTGGTTCGGGGCGC

Downstream 100 bases:

>100_bases
CACAGGCAAATACAAGGAAATTTGGTGTTAACAGGGGGCTTTGCCCCCTTTTACCGGAATAGAGAAATCATGGCTTACAC
TACTTTTTGTCAAACTCCCA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Protein B1; Ribonucleoside-diphosphate reductase 1 R1 subunit; Ribonucleotide reductase 1 [H]

Number of amino acids: Translated: 782; Mature: 781

Protein sequence:

>782_residues
MARLFTWICRAIPIYKGLSSMNSNMTVTKRSGEREQIDLDKIHRVVTWAAKGLKNVSVSEVELRSHLQFFEGIPTEAIHE
TIIKAAADLISPESPDYQFLAARLAVFHLRKKAFGQFEPPKLYDHVVKLVEMGKYDRHILEDYTKEELDVLDSYIDHWRD
MNFSYAAVKQLEGKYLVQNRVTHEVYESAQFLYILVAACLFAGYPKETRLKYVKDFYDAVSTFKISLPTPIMSGVRTPTR
QFSSCVLIECGDSLDSINATASSIVKYVSQRAGIGVNAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGG
AATLFYPIWHLEVESLLVLKNNRGVEDNRIRHLDYGVQLNKLMYQRLIKGENITLFSPSDVPGLYDAFFENQDEFERLYT
KYEQEPSIRKKSLKAVELFSLMMQERASTGRIYVQNVDHCNTHSPFDSSVAPIRQSNLCLEIALPTKPLDSVDDTNGEIA
LCTLSALNLGAIENLEELEGLSDLAVRALDSLLDYQDYPIKAAKLGSMNRRTLGIGVINFANYLAKNGKKYSDGSANNLT
HKTFEAIQFNLLKASMNLAKEKGACPAFHETTYSQGILPIDTYKRDLDKICDEPLHLDWEGLRADIKHYGLRNSTLSALM
PSETSSQISNATNGIEPPRGLISVKASKDGQLKQVVPDFDELRNAYELLWQMPSNDGYLQLVGIMQKFVDQAISANTNYD
PAKFEGRKVPMQLLLKDLLTAYKLGLKTLYYHNTRDGATDQHDDIAVVEKEDDGCAGGACKI

Sequences:

>Translated_782_residues
MARLFTWICRAIPIYKGLSSMNSNMTVTKRSGEREQIDLDKIHRVVTWAAKGLKNVSVSEVELRSHLQFFEGIPTEAIHE
TIIKAAADLISPESPDYQFLAARLAVFHLRKKAFGQFEPPKLYDHVVKLVEMGKYDRHILEDYTKEELDVLDSYIDHWRD
MNFSYAAVKQLEGKYLVQNRVTHEVYESAQFLYILVAACLFAGYPKETRLKYVKDFYDAVSTFKISLPTPIMSGVRTPTR
QFSSCVLIECGDSLDSINATASSIVKYVSQRAGIGVNAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGG
AATLFYPIWHLEVESLLVLKNNRGVEDNRIRHLDYGVQLNKLMYQRLIKGENITLFSPSDVPGLYDAFFENQDEFERLYT
KYEQEPSIRKKSLKAVELFSLMMQERASTGRIYVQNVDHCNTHSPFDSSVAPIRQSNLCLEIALPTKPLDSVDDTNGEIA
LCTLSALNLGAIENLEELEGLSDLAVRALDSLLDYQDYPIKAAKLGSMNRRTLGIGVINFANYLAKNGKKYSDGSANNLT
HKTFEAIQFNLLKASMNLAKEKGACPAFHETTYSQGILPIDTYKRDLDKICDEPLHLDWEGLRADIKHYGLRNSTLSALM
PSETSSQISNATNGIEPPRGLISVKASKDGQLKQVVPDFDELRNAYELLWQMPSNDGYLQLVGIMQKFVDQAISANTNYD
PAKFEGRKVPMQLLLKDLLTAYKLGLKTLYYHNTRDGATDQHDDIAVVEKEDDGCAGGACKI
>Mature_781_residues
ARLFTWICRAIPIYKGLSSMNSNMTVTKRSGEREQIDLDKIHRVVTWAAKGLKNVSVSEVELRSHLQFFEGIPTEAIHET
IIKAAADLISPESPDYQFLAARLAVFHLRKKAFGQFEPPKLYDHVVKLVEMGKYDRHILEDYTKEELDVLDSYIDHWRDM
NFSYAAVKQLEGKYLVQNRVTHEVYESAQFLYILVAACLFAGYPKETRLKYVKDFYDAVSTFKISLPTPIMSGVRTPTRQ
FSSCVLIECGDSLDSINATASSIVKYVSQRAGIGVNAGRIRALGSPIRGGEAFHTGCLPFYKYFQTAVKSCSQGGVRGGA
ATLFYPIWHLEVESLLVLKNNRGVEDNRIRHLDYGVQLNKLMYQRLIKGENITLFSPSDVPGLYDAFFENQDEFERLYTK
YEQEPSIRKKSLKAVELFSLMMQERASTGRIYVQNVDHCNTHSPFDSSVAPIRQSNLCLEIALPTKPLDSVDDTNGEIAL
CTLSALNLGAIENLEELEGLSDLAVRALDSLLDYQDYPIKAAKLGSMNRRTLGIGVINFANYLAKNGKKYSDGSANNLTH
KTFEAIQFNLLKASMNLAKEKGACPAFHETTYSQGILPIDTYKRDLDKICDEPLHLDWEGLRADIKHYGLRNSTLSALMP
SETSSQISNATNGIEPPRGLISVKASKDGQLKQVVPDFDELRNAYELLWQMPSNDGYLQLVGIMQKFVDQAISANTNYDP
AKFEGRKVPMQLLLKDLLTAYKLGLKTLYYHNTRDGATDQHDDIAVVEKEDDGCAGGACKI

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=783, Percent_Identity=27.7139208173691, Blast_Score=245, Evalue=1e-64,
Organism=Escherichia coli, GI2367133, Length=762, Percent_Identity=81.1023622047244, Blast_Score=1313, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=645, Percent_Identity=24.6511627906977, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17555242, Length=818, Percent_Identity=26.2836185819071, Blast_Score=237, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6320914, Length=785, Percent_Identity=28.2802547770701, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6322123, Length=785, Percent_Identity=28.0254777070064, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI17352481, Length=800, Percent_Identity=27.875, Blast_Score=247, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 87786; Mature: 87655

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLFTWICRAIPIYKGLSSMNSNMTVTKRSGEREQIDLDKIHRVVTWAAKGLKNVSVSE
CHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
VELRSHLQFFEGIPTEAIHETIIKAAADLISPESPDYQFLAARLAVFHLRKKAFGQFEPP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCH
KLYDHVVKLVEMGKYDRHILEDYTKEELDVLDSYIDHWRDMNFSYAAVKQLEGKYLVQNR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHH
VTHEVYESAQFLYILVAACLFAGYPKETRLKYVKDFYDAVSTFKISLPTPIMSGVRTPTR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEECCCHHHHCCCCCHH
QFSSCVLIECGDSLDSINATASSIVKYVSQRAGIGVNAGRIRALGSPIRGGEAFHTGCLP
HHCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHH
FYKYFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNRGVEDNRIRHLDYGVQLN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEHEEEEECCCCCCCCCEEEECCCCHHH
KLMYQRLIKGENITLFSPSDVPGLYDAFFENQDEFERLYTKYEQEPSIRKKSLKAVELFS
HHHHHHHHCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LMMQERASTGRIYVQNVDHCNTHSPFDSSVAPIRQSNLCLEIALPTKPLDSVDDTNGEIA
HHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEE
LCTLSALNLGAIENLEELEGLSDLAVRALDSLLDYQDYPIKAAKLGSMNRRTLGIGVINF
EEEECHHCCHHHCCHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEHHHHH
ANYLAKNGKKYSDGSANNLTHKTFEAIQFNLLKASMNLAKEKGACPAFHETTYSQGILPI
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEH
DTYKRDLDKICDEPLHLDWEGLRADIKHYGLRNSTLSALMPSETSSQISNATNGIEPPRG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHCCCCCCCCCC
LISVKASKDGQLKQVVPDFDELRNAYELLWQMPSNDGYLQLVGIMQKFVDQAISANTNYD
EEEEECCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PAKFEGRKVPMQLLLKDLLTAYKLGLKTLYYHNTRDGATDQHDDIAVVEKEDDGCAGGAC
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEEECCCCCCCCCC
KI
CC
>Mature Secondary Structure 
ARLFTWICRAIPIYKGLSSMNSNMTVTKRSGEREQIDLDKIHRVVTWAAKGLKNVSVSE
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHH
VELRSHLQFFEGIPTEAIHETIIKAAADLISPESPDYQFLAARLAVFHLRKKAFGQFEPP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCH
KLYDHVVKLVEMGKYDRHILEDYTKEELDVLDSYIDHWRDMNFSYAAVKQLEGKYLVQNR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHH
VTHEVYESAQFLYILVAACLFAGYPKETRLKYVKDFYDAVSTFKISLPTPIMSGVRTPTR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEECCCHHHHCCCCCHH
QFSSCVLIECGDSLDSINATASSIVKYVSQRAGIGVNAGRIRALGSPIRGGEAFHTGCLP
HHCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHH
FYKYFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNRGVEDNRIRHLDYGVQLN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEHEEEEECCCCCCCCCEEEECCCCHHH
KLMYQRLIKGENITLFSPSDVPGLYDAFFENQDEFERLYTKYEQEPSIRKKSLKAVELFS
HHHHHHHHCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LMMQERASTGRIYVQNVDHCNTHSPFDSSVAPIRQSNLCLEIALPTKPLDSVDDTNGEIA
HHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEE
LCTLSALNLGAIENLEELEGLSDLAVRALDSLLDYQDYPIKAAKLGSMNRRTLGIGVINF
EEEECHHCCHHHCCHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEHHHHH
ANYLAKNGKKYSDGSANNLTHKTFEAIQFNLLKASMNLAKEKGACPAFHETTYSQGILPI
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEH
DTYKRDLDKICDEPLHLDWEGLRADIKHYGLRNSTLSALMPSETSSQISNATNGIEPPRG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHCCCCCCCCCC
LISVKASKDGQLKQVVPDFDELRNAYELLWQMPSNDGYLQLVGIMQKFVDQAISANTNYD
EEEEECCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
PAKFEGRKVPMQLLLKDLLTAYKLGLKTLYYHNTRDGATDQHDDIAVVEKEDDGCAGGAC
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEEECCCCCCCCCC
KI
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6087316; 3287341; 9205837; 9278503; 3894026; 2663852; 8702814; 8052308; 9309223; 10493864 [H]