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The map label for this gene is pyrD

Identifier: 119774730

GI number: 119774730

Start: 1945662

End: 1946681

Strand: Direct

Name: pyrD

Synonym: Sama_1593

Alternate gene names: 119774730

Gene position: 1945662-1946681 (Clockwise)

Preceding gene: 119774729

Following gene: 119774731

Centisome position: 45.18

GC content: 46.86

Gene sequence:

>1020_bases
ATGTTTTACAAAATCGCGCAGTCTATCATGTTCCAAATGGATCCTGAGCGAGCCCACAACCTGGCCATTGGCAGCCTCAA
GCGAACCGCTAACACACCTATGACGGCGTTTTATGCTCAGTGCATTGCACCTAAACCTGTGACTTGCATGGGGATCATCT
TTCCAAACCCTGTTGGGCTTGCCGCAGGTCTGGATAAAGACGGTGAGGCCATTGATGCCTTCCACGCCATGGGTTTTGGA
CATGTGGAAGTAGGGACAGTGACACCGCGTCCACAGCCTGGCAACGATCTGCCGCGTTTGTTCCGGTTAAAGCCGGCCAA
GGGCATCATCAACCGCATGGGTTTTAACAATAAGGGCGTGGATAATCTGGTCGCGAACCTTAAGGCAAAGAAAACCGATA
TTCTGGTCGGTGTGAATATTGGTAAAAACAAAGATACACCGGTGGAAGAGGGTAAAAACGATTACCTCATCTGTATGGAT
AAGGTGTATCCCCATGCGGCCTATATTGCCGTGAATATTTCATCTCCCAACACGCCGGGTTTACGCACCCTGCAGTATGG
CGATCTATTGGATGATCTCCTGTCGTCGCTTAAAGCCAAGCAAACTGAGCTGGCTGAGCAGCATGGCAAATATGTGCCCA
TTGCACTTAAAATTGCACCGGATCTGACCGATGAAGAAATTGCCAGTATTGCGACATCCTTAATCAAAAACCAATTTGAT
GCGGCAATTGCCACCAATACGACCTTGAGCCGTGATGGTGTTTCAGGATTGGCCAATGCAAATGAAACTGGTGGTCTATC
AGGTAAGCCATTAACTGAATTATCGACCAAGGTGATCAAAAAATTGGCCGCCGAATTAAAAGGTGAGATCCCAATTATTG
GTGTGGGTGGGATCAATTCATCTCAGGATGCACTGGCTAAATTTGATGCAGGTGCCACGCTTGTTCAAATATATTCAGGC
TTTATCTATCAGGGTCCGAAATTAATAAAAGACATAGTGGCTTCTTATAGCGCAAAATAA

Upstream 100 bases:

>100_bases
TTTTTTTGGCCAAAAACACGGTGCTGCTGTACACTGTGCGCCTTACCCTGCAGGCAGCCTGGCCTTAGAACAAACAAACA
TTAAAATCCAAGGAGATCCA

Downstream 100 bases:

>100_bases
CAACAAAAGGATCGCGAAAGCGATCCTTTTTTCTTTTATTAGATCTGGTTTGATCGAAAATTGATCTGATTGATCTAACT
AACGTGTTGTTAAGTAAGTC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MFYKIAQSIMFQMDPERAHNLAIGSLKRTANTPMTAFYAQCIAPKPVTCMGIIFPNPVGLAAGLDKDGEAIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGVDNLVANLKAKKTDILVGVNIGKNKDTPVEEGKNDYLICMD
KVYPHAAYIAVNISSPNTPGLRTLQYGDLLDDLLSSLKAKQTELAEQHGKYVPIALKIAPDLTDEEIASIATSLIKNQFD
AAIATNTTLSRDGVSGLANANETGGLSGKPLTELSTKVIKKLAAELKGEIPIIGVGGINSSQDALAKFDAGATLVQIYSG
FIYQGPKLIKDIVASYSAK

Sequences:

>Translated_339_residues
MFYKIAQSIMFQMDPERAHNLAIGSLKRTANTPMTAFYAQCIAPKPVTCMGIIFPNPVGLAAGLDKDGEAIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGVDNLVANLKAKKTDILVGVNIGKNKDTPVEEGKNDYLICMD
KVYPHAAYIAVNISSPNTPGLRTLQYGDLLDDLLSSLKAKQTELAEQHGKYVPIALKIAPDLTDEEIASIATSLIKNQFD
AAIATNTTLSRDGVSGLANANETGGLSGKPLTELSTKVIKKLAAELKGEIPIIGVGGINSSQDALAKFDAGATLVQIYSG
FIYQGPKLIKDIVASYSAK
>Mature_339_residues
MFYKIAQSIMFQMDPERAHNLAIGSLKRTANTPMTAFYAQCIAPKPVTCMGIIFPNPVGLAAGLDKDGEAIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGVDNLVANLKAKKTDILVGVNIGKNKDTPVEEGKNDYLICMD
KVYPHAAYIAVNISSPNTPGLRTLQYGDLLDDLLSSLKAKQTELAEQHGKYVPIALKIAPDLTDEEIASIATSLIKNQFD
AAIATNTTLSRDGVSGLANANETGGLSGKPLTELSTKVIKKLAAELKGEIPIIGVGGINSSQDALAKFDAGATLVQIYSG
FIYQGPKLIKDIVASYSAK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=329, Percent_Identity=42.8571428571429, Blast_Score=241, Evalue=9e-64,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=62.4624624624625, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17509475, Length=347, Percent_Identity=41.2103746397695, Blast_Score=233, Evalue=8e-62,
Organism=Drosophila melanogaster, GI281361352, Length=331, Percent_Identity=41.0876132930514, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI17137316, Length=331, Percent_Identity=41.0876132930514, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_SHEAM (A1S5Z4)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_927470.1
- ProteinModelPortal:   A1S5Z4
- SMR:   A1S5Z4
- STRING:   A1S5Z4
- GeneID:   4603845
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_1593
- NMPDR:   fig|326297.7.peg.1505
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- PhylomeDB:   A1S5Z4
- ProtClustDB:   PRK05286
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36183; Mature: 36183

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYKIAQSIMFQMDPERAHNLAIGSLKRTANTPMTAFYAQCIAPKPVTCMGIIFPNPVGL
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCCC
AAGLDKDGEAIDAFHAMGFGHVEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGV
CCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHCCCCHHHHHHHCCCCCCCH
DNLVANLKAKKTDILVGVNIGKNKDTPVEEGKNDYLICMDKVYPHAAYIAVNISSPNTPG
HHHHHHHHCCCCEEEEEEECCCCCCCCHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCC
LRTLQYGDLLDDLLSSLKAKQTELAEQHGKYVPIALKIAPDLTDEEIASIATSLIKNQFD
CEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
AAIATNTTLSRDGVSGLANANETGGLSGKPLTELSTKVIKKLAAELKGEIPIIGVGGINS
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
SQDALAKFDAGATLVQIYSGFIYQGPKLIKDIVASYSAK
CHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFYKIAQSIMFQMDPERAHNLAIGSLKRTANTPMTAFYAQCIAPKPVTCMGIIFPNPVGL
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCCC
AAGLDKDGEAIDAFHAMGFGHVEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGV
CCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHCCCCHHHHHHHCCCCCCCH
DNLVANLKAKKTDILVGVNIGKNKDTPVEEGKNDYLICMDKVYPHAAYIAVNISSPNTPG
HHHHHHHHCCCCEEEEEEECCCCCCCCHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCC
LRTLQYGDLLDDLLSSLKAKQTELAEQHGKYVPIALKIAPDLTDEEIASIATSLIKNQFD
CEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
AAIATNTTLSRDGVSGLANANETGGLSGKPLTELSTKVIKKLAAELKGEIPIIGVGGINS
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
SQDALAKFDAGATLVQIYSGFIYQGPKLIKDIVASYSAK
CHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA