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The map label for this gene is ykoW [H]

Identifier: 119774143

GI number: 119774143

Start: 1217777

End: 1219261

Strand: Direct

Name: ykoW [H]

Synonym: Sama_1006

Alternate gene names: 119774143

Gene position: 1217777-1219261 (Clockwise)

Preceding gene: 119774142

Following gene: 119774146

Centisome position: 28.28

GC content: 52.93

Gene sequence:

>1485_bases
ATGGTTTATCTGATTGCCTTCCTGGCTGCCTGCTTATTCTTACTGGCGTGGCTTTGGTATCGCTACTCGCGCAGTACTGA
GTTGTTTCTTCATCGTCTTACGCAGGAGTTGCTCAGTAAAGGCGAGCAGCGCCAGCCCCTGATGTTGACTGATATCCCTG
AGTCTTTTTCAGCCCTGGTTCAGGCGATTCAGCATGTATTGCTGCATACACCGTTGCATACCACCAAGGATAAGCTTACC
GGCTTGCCCAATCGGGTTGGTTTCAAGCGGGCCATTACCCACTCCATGCCGCTCACATCCGGCACCCTGGTATTAATAGA
TCTCTATCGTTTCCGCTACGTAAACGATCTGTTCGGTTTCGCTTTTGGCGATACCCTGCTGCAATTATTTGCCGACCGTT
TACGTTTAATGCCGAAAAAGCCCCGCCAGATGGCGCGCATGAATGGCGATGAATTTTTGCTCTATTTCGACACCTGTCTG
GACGAAAAAGGGCTGTTGGAGATTAAGCAACTGTTGCAGCAGCCCTTCAGTATTCAGGACACCCCTGTCTCGGTCAGATT
ACAAATGGGGTATGTGCAACTGGCACAGCACCATGCAGATGTCAGCCAAATGCTCAGGCGCGCCGATCTGGCACTTAAGC
GTGCCCGCAGCGACAAAGATATGCTGGCGGCTTATCAACAGGACGACGATATCAGTCAACGTCGTGAACTTTTTATTATC
AACAGCTTGCCAAAGGCGTTGGCGCATAATCAATTGTATCTGGTATACCAGCCCAAAGAATCGCTGCACCACGGTGGCTG
TGAGCAGGTCGAGGCGCTTATCCGTTGGGAACATCCTGATCTGGGATTGATATCTCCCGCCGAGTTTATTCCGCTGGCAG
AATATGCGGGAATGATCGATTTGGTCAGTGCCTGGGCACTGGAGCAAGTGTTGATGCAGCAGGTGCGCTGGCGCGCCGAA
GGCATACATATTAGGGTGGCGGTGAATCTGTCGGTGGAGGATATGCAGGAAGGCAATCTGCCCACGATGGTACAGGCAGC
GCTGGCGCGTTATCAGCTGCCCGGTGAGGTCTTGGCGCTGGAAATCACTGAAAGTACCCTGATGTCCAATTTGGCCCGCG
CCACTGAAAATATCGTCAAGCTCAGGGAAATGGGGGTGAAGGTCGCCATTGATGACTTTGGCACAGGTCACTCTTCACTG
GCCTACCTCAAAGACTTGCCTGCTGATGAGGTGAAAATCGACCGTGCGTTCCTCGATGGCATCATGGAACAAGAGCGTGC
ACGCAATATTATGACCACCAGCATCCAGCTGGCCAAGCGCCTTGGTTTTGAGGTGACGGTTGAGGGCGTGGAATCCGATG
CCCTTCGCAAAATGTTGGCTGCCATGGGCGCCGATAATATTCAGGGGCAATATTTCGCCAGGCCGATGCGGGCATTGGAG
CTGGAAATGGACCTGCGGCGGCTTGGCATTGCCAGACGTGCCTGA

Upstream 100 bases:

>100_bases
CAAGTTACGAGTAATACGGGCCGGGGCAGGGGTCACTCTGCCATGGATCAGGCCCCGTTCTATTCTCAAGCTAAGGAGGC
GCAGTGTTAAGGTCTAGCCC

Downstream 100 bases:

>100_bases
TTAAGCTTCCAGTAAGCTTGCCATCAGTTGTGCTGGCATGGGGGTGAGTTGGCGTTGCTGGTTCAAACAGACCATTTCGA
TATAGCCGCTCACAGCCGGA

Product: cyclic nucleotide phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MVYLIAFLAACLFLLAWLWYRYSRSTELFLHRLTQELLSKGEQRQPLMLTDIPESFSALVQAIQHVLLHTPLHTTKDKLT
GLPNRVGFKRAITHSMPLTSGTLVLIDLYRFRYVNDLFGFAFGDTLLQLFADRLRLMPKKPRQMARMNGDEFLLYFDTCL
DEKGLLEIKQLLQQPFSIQDTPVSVRLQMGYVQLAQHHADVSQMLRRADLALKRARSDKDMLAAYQQDDDISQRRELFII
NSLPKALAHNQLYLVYQPKESLHHGGCEQVEALIRWEHPDLGLISPAEFIPLAEYAGMIDLVSAWALEQVLMQQVRWRAE
GIHIRVAVNLSVEDMQEGNLPTMVQAALARYQLPGEVLALEITESTLMSNLARATENIVKLREMGVKVAIDDFGTGHSSL
AYLKDLPADEVKIDRAFLDGIMEQERARNIMTTSIQLAKRLGFEVTVEGVESDALRKMLAAMGADNIQGQYFARPMRALE
LEMDLRRLGIARRA

Sequences:

>Translated_494_residues
MVYLIAFLAACLFLLAWLWYRYSRSTELFLHRLTQELLSKGEQRQPLMLTDIPESFSALVQAIQHVLLHTPLHTTKDKLT
GLPNRVGFKRAITHSMPLTSGTLVLIDLYRFRYVNDLFGFAFGDTLLQLFADRLRLMPKKPRQMARMNGDEFLLYFDTCL
DEKGLLEIKQLLQQPFSIQDTPVSVRLQMGYVQLAQHHADVSQMLRRADLALKRARSDKDMLAAYQQDDDISQRRELFII
NSLPKALAHNQLYLVYQPKESLHHGGCEQVEALIRWEHPDLGLISPAEFIPLAEYAGMIDLVSAWALEQVLMQQVRWRAE
GIHIRVAVNLSVEDMQEGNLPTMVQAALARYQLPGEVLALEITESTLMSNLARATENIVKLREMGVKVAIDDFGTGHSSL
AYLKDLPADEVKIDRAFLDGIMEQERARNIMTTSIQLAKRLGFEVTVEGVESDALRKMLAAMGADNIQGQYFARPMRALE
LEMDLRRLGIARRA
>Mature_494_residues
MVYLIAFLAACLFLLAWLWYRYSRSTELFLHRLTQELLSKGEQRQPLMLTDIPESFSALVQAIQHVLLHTPLHTTKDKLT
GLPNRVGFKRAITHSMPLTSGTLVLIDLYRFRYVNDLFGFAFGDTLLQLFADRLRLMPKKPRQMARMNGDEFLLYFDTCL
DEKGLLEIKQLLQQPFSIQDTPVSVRLQMGYVQLAQHHADVSQMLRRADLALKRARSDKDMLAAYQQDDDISQRRELFII
NSLPKALAHNQLYLVYQPKESLHHGGCEQVEALIRWEHPDLGLISPAEFIPLAEYAGMIDLVSAWALEQVLMQQVRWRAE
GIHIRVAVNLSVEDMQEGNLPTMVQAALARYQLPGEVLALEITESTLMSNLARATENIVKLREMGVKVAIDDFGTGHSSL
AYLKDLPADEVKIDRAFLDGIMEQERARNIMTTSIQLAKRLGFEVTVEGVESDALRKMLAAMGADNIQGQYFARPMRALE
LEMDLRRLGIARRA

Specific function: Probable signaling protein whose physiological role is not yet known [H]

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=481, Percent_Identity=30.977130977131, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI87081921, Length=441, Percent_Identity=30.1587301587302, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1788849, Length=273, Percent_Identity=31.5018315018315, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1790496, Length=234, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI226510982, Length=235, Percent_Identity=32.7659574468085, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87081845, Length=256, Percent_Identity=33.203125, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI87081743, Length=234, Percent_Identity=29.4871794871795, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1788502, Length=241, Percent_Identity=31.1203319502075, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786507, Length=234, Percent_Identity=27.7777777777778, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081980, Length=234, Percent_Identity=31.1965811965812, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI87082096, Length=245, Percent_Identity=29.3877551020408, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787055, Length=244, Percent_Identity=28.6885245901639, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788956, Length=208, Percent_Identity=28.3653846153846, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 56278; Mature: 56278

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYLIAFLAACLFLLAWLWYRYSRSTELFLHRLTQELLSKGEQRQPLMLTDIPESFSALV
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHH
QAIQHVLLHTPLHTTKDKLTGLPNRVGFKRAITHSMPLTSGTLVLIDLYRFRYVNDLFGF
HHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
AFGDTLLQLFADRLRLMPKKPRQMARMNGDEFLLYFDTCLDEKGLLEIKQLLQQPFSIQD
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHHHCCCCCCC
TPVSVRLQMGYVQLAQHHADVSQMLRRADLALKRARSDKDMLAAYQQDDDISQRRELFII
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHEEEE
NSLPKALAHNQLYLVYQPKESLHHGGCEQVEALIRWEHPDLGLISPAEFIPLAEYAGMID
HHHHHHHCCCCEEEEECCHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHH
LVSAWALEQVLMQQVRWRAEGIHIRVAVNLSVEDMQEGNLPTMVQAALARYQLPGEVLAL
HHHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHCCCCCHHHHHHHHHHHCCCCCEEEE
EITESTLMSNLARATENIVKLREMGVKVAIDDFGTGHSSLAYLKDLPADEVKIDRAFLDG
EEHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHH
IMEQERARNIMTTSIQLAKRLGFEVTVEGVESDALRKMLAAMGADNIQGQYFARPMRALE
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LEMDLRRLGIARRA
HHHHHHHHCHHCCC
>Mature Secondary Structure
MVYLIAFLAACLFLLAWLWYRYSRSTELFLHRLTQELLSKGEQRQPLMLTDIPESFSALV
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHH
QAIQHVLLHTPLHTTKDKLTGLPNRVGFKRAITHSMPLTSGTLVLIDLYRFRYVNDLFGF
HHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
AFGDTLLQLFADRLRLMPKKPRQMARMNGDEFLLYFDTCLDEKGLLEIKQLLQQPFSIQD
HHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHHHCCCCCCC
TPVSVRLQMGYVQLAQHHADVSQMLRRADLALKRARSDKDMLAAYQQDDDISQRRELFII
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHEEEE
NSLPKALAHNQLYLVYQPKESLHHGGCEQVEALIRWEHPDLGLISPAEFIPLAEYAGMID
HHHHHHHCCCCEEEEECCHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHH
LVSAWALEQVLMQQVRWRAEGIHIRVAVNLSVEDMQEGNLPTMVQAALARYQLPGEVLAL
HHHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHCCCCCHHHHHHHHHHHCCCCCEEEE
EITESTLMSNLARATENIVKLREMGVKVAIDDFGTGHSSLAYLKDLPADEVKIDRAFLDG
EEHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHH
IMEQERARNIMTTSIQLAKRLGFEVTVEGVESDALRKMLAAMGADNIQGQYFARPMRALE
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LEMDLRRLGIARRA
HHHHHHHHCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 11728710 [H]