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The map label for this gene is folP [H]

Identifier: 119774092

GI number: 119774092

Start: 1155159

End: 1155998

Strand: Direct

Name: folP [H]

Synonym: Sama_0955

Alternate gene names: 119774092

Gene position: 1155159-1155998 (Clockwise)

Preceding gene: 119774091

Following gene: 119774093

Centisome position: 26.83

GC content: 53.69

Gene sequence:

>840_bases
GTGTTTACGCTAACTGCCAGAGAGAAAACCCTCGACCTGAGCCGCCCCGTGGTGATGGGGATTTTGAATGTGACTCCGGA
TTCATTTTCCGACGGAGGCCAATTCGCCGCTTTTGAACGTGCCTGTGAACATGCTGACCAGTTGGTAACAGAAGGCGCGG
CCATCATCGACATCGGTGGCGAGTCTACCCGCCCCGGCGCTGCCGAGGTATCGCTGGATGAAGAGATCAGCCGCGTCATC
CCGCTGGTAGAGTATGTCAGCAAGACACATGATGTATGGGTGTCAGTGGATACCAGTAAAGCCGGAGTGATGAGTGAAGC
CGCCAAGGCAGGTGCCCACTTAATCAATGATGTGCGTGCGCTGATGGAGCCGGGAGCGCTTGAAGCAGCCGCGGTTTCGG
GATTAGCCGTATGCTTGATGCATATGCAGGGTCAGCCGCGCACCATGCAGCAAAATCCGGAATATGACAATTTAATAGAA
GATGTATGCACGTTTTTTGAACATCGTATTGCTGCCTGTGTTGACGCGGGGATCCCACGGGCGCAGATTATCCTTGATCC
CGGTTTTGGATTCGGTAAAACAGTTTCGCACAACTATGAGCTGCTCGCCCGATTTGCAGAGTTTGAGCGATTTGGTTTAC
CGCTGCTGGCAGGCTTGTCCCGAAAGAGCATGCTTGGCAATTTGCTTGGCCGTGATGCAACTTCGCGTCTTGCTGGCAGT
CTTGCTGGTGCCTTATTGTCGGCGCAGCAGGGCGCAAACATAATCAGGGTGCATGATGTCGCAGAGACGATAGATGTCCT
CAAGGTGCTTGAGGCCACCCGGGAATATAAACACCTGTAA

Upstream 100 bases:

>100_bases
CTGAACCCTGATGAACCTGTGATCAAACATTGATAGTGCTTAGCGATTGATGTTACTTAGAAAACCCCGAACCCGGGGTT
TTCTTGTTTAAGGAGTATCC

Downstream 100 bases:

>100_bases
TGATATTGGAGCAGGGACCAACAAACGCTCTTCAGTGAGTGTGGATGTGAATGGGGTAGAGAGTGTCACAACGTAAATTT
TTTGGAACTGACGGGATCCG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MFTLTAREKTLDLSRPVVMGILNVTPDSFSDGGQFAAFERACEHADQLVTEGAAIIDIGGESTRPGAAEVSLDEEISRVI
PLVEYVSKTHDVWVSVDTSKAGVMSEAAKAGAHLINDVRALMEPGALEAAAVSGLAVCLMHMQGQPRTMQQNPEYDNLIE
DVCTFFEHRIAACVDAGIPRAQIILDPGFGFGKTVSHNYELLARFAEFERFGLPLLAGLSRKSMLGNLLGRDATSRLAGS
LAGALLSAQQGANIIRVHDVAETIDVLKVLEATREYKHL

Sequences:

>Translated_279_residues
MFTLTAREKTLDLSRPVVMGILNVTPDSFSDGGQFAAFERACEHADQLVTEGAAIIDIGGESTRPGAAEVSLDEEISRVI
PLVEYVSKTHDVWVSVDTSKAGVMSEAAKAGAHLINDVRALMEPGALEAAAVSGLAVCLMHMQGQPRTMQQNPEYDNLIE
DVCTFFEHRIAACVDAGIPRAQIILDPGFGFGKTVSHNYELLARFAEFERFGLPLLAGLSRKSMLGNLLGRDATSRLAGS
LAGALLSAQQGANIIRVHDVAETIDVLKVLEATREYKHL
>Mature_279_residues
MFTLTAREKTLDLSRPVVMGILNVTPDSFSDGGQFAAFERACEHADQLVTEGAAIIDIGGESTRPGAAEVSLDEEISRVI
PLVEYVSKTHDVWVSVDTSKAGVMSEAAKAGAHLINDVRALMEPGALEAAAVSGLAVCLMHMQGQPRTMQQNPEYDNLIE
DVCTFFEHRIAACVDAGIPRAQIILDPGFGFGKTVSHNYELLARFAEFERFGLPLLAGLSRKSMLGNLLGRDATSRLAGS
LAGALLSAQQGANIIRVHDVAETIDVLKVLEATREYKHL

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=276, Percent_Identity=59.7826086956522, Blast_Score=348, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6324073, Length=337, Percent_Identity=28.486646884273, Blast_Score=128, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30005; Mature: 30005

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTLTAREKTLDLSRPVVMGILNVTPDSFSDGGQFAAFERACEHADQLVTEGAAIIDIGG
CEEECCCHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECC
ESTRPGAAEVSLDEEISRVIPLVEYVSKTHDVWVSVDTSKAGVMSEAAKAGAHLINDVRA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LMEPGALEAAAVSGLAVCLMHMQGQPRTMQQNPEYDNLIEDVCTFFEHRIAACVDAGIPR
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
AQIILDPGFGFGKTVSHNYELLARFAEFERFGLPLLAGLSRKSMLGNLLGRDATSRLAGS
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCCHHHHHHHH
LAGALLSAQQGANIIRVHDVAETIDVLKVLEATREYKHL
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFTLTAREKTLDLSRPVVMGILNVTPDSFSDGGQFAAFERACEHADQLVTEGAAIIDIGG
CEEECCCHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECC
ESTRPGAAEVSLDEEISRVIPLVEYVSKTHDVWVSVDTSKAGVMSEAAKAGAHLINDVRA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LMEPGALEAAAVSGLAVCLMHMQGQPRTMQQNPEYDNLIEDVCTFFEHRIAACVDAGIPR
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
AQIILDPGFGFGKTVSHNYELLARFAEFERFGLPLLAGLSRKSMLGNLLGRDATSRLAGS
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCCHHHHHHHH
LAGALLSAQQGANIIRVHDVAETIDVLKVLEATREYKHL
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]