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The map label for this gene is ffh [H]

Identifier: 119774025

GI number: 119774025

Start: 1076533

End: 1077906

Strand: Direct

Name: ffh [H]

Synonym: Sama_0888

Alternate gene names: 119774025

Gene position: 1076533-1077906 (Clockwise)

Preceding gene: 119774022

Following gene: 119774026

Centisome position: 25.0

GC content: 55.09

Gene sequence:

>1374_bases
ATGTTTGAGAACCTGACCGACAGACTGTCGCGTACGCTGAAGACCATCAGCGGTCGCGGTCGCTTAACGGAAGACAACAT
TAAAGACACCCTGCGGGAAGTCCGTATGGCGCTCCTTGAGGCCGATGTGGCCTTGCCGGTTGTCCGTGAATTTGTGAACG
CCGTTAAAGAGCGCGCAGTGGGCCAGGACGTGGCCAAGAGCCTGACGCCCGGTCAGGTGTTTGTCAAAATCGTTCAAAGC
GAGCTTGAAAAGGCGATGGGTGAGGCCAACGAGGCCCTGAATCTTGCCGCCCAGCCCCCGGCTGTGATCATGATGGCAGG
TCTACAGGGTGCGGGTAAAACCACCTCTGTGGCCAAGTTGTCCAAATTCCTGCGTACCCGTCAGAAAAAATCTGTACTGG
TGGTCAGTGCCGACGTTTACCGCCCTGCGGCAATCAAGCAGCTCGAAACCCTGGCCAAAGAAGTGGAAGTGGAATTCTTC
CCCTCCGATGTGAGCCAAAAGCCCATCGACATCGCCAATGCGGCTATTTCGCACGCCAAGCTGAAATTCATTGATGTAGT
GATCCTCGATACCGCGGGCCGATTGCACGTCGATGAAGCCATGATGGATGAAATCAAGGCACTGCATGCAGCAGTCAAGC
CTATCGAAACGCTGTTCGTGGTAGACGCCATGACGGGTCAGGATGCAGCCAACACCGCCAAGGCCTTTAACGAGGCGCTG
CCGTTGACTGGTGTGGTACTGACCAAGGTGGACGGTGATGCCCGCGGTGGTGCGGCGTTGTCTATCCGCCACATTACTGG
CAAGCCCATTAAGTTCCTCGGTGTCGGCGAAAAGACAGATGCGCTGGAGCCATTCCACCCTGACCGTGTAGCCTCGCGCA
TCCTTGGCATGGGTGACGTACTTTCCCTGATTGAGCAGGTAGAGCGCGGCGTTGATAAAGAAAAAGCCATGAAGCTGGCC
TCCAAGGTCAAATCGGGTGGCAATTTCGACCTCGAAGACTTCCGCGAGCAGCTGCAGCAGATGAAAAACATGGGCGGCAT
GATGGGACTGCTGGAAAAATTGCCCGGCGTTGGTCAGCTGCCACCGGAAGCCATGGCACAAATTCAGGATGGTAAAATGA
CCCGCCAAATGGAGGCTATTATTAACTCCATGACACCGGGCGAACGTCAGAATCCTGATATCATCAAGGGCTCCCGCAAG
CGTCGCATTGCAGCGGGTAGTGGCACACAAATTCAAGACGTTAACCGTCTGCTTAAGCAGTTCACCCAGATGCAGAAAAT
GATGAAGAAGATGTCTTCCAAGGGTGGAATGCAGAAAATGATGCGCGCCATGGGTGGTATGATGCCCGGCGGCATGAAGC
TTCCCGGGCGTTAA

Upstream 100 bases:

>100_bases
TGCTCGGCATCCATACAGGCAAGCGGACAGGTAGCATAAACCGCAGGCATCGCTATAATACAAGCCCACATTTGACATTA
TTAAAGGTTTGCACAGGACG

Downstream 100 bases:

>100_bases
GCCCGGACTCAATGCAGCCGTAAAATTGGCCACTTTCGGTTGCATTCGCCTGAAACTCAGGTAAAATTCTCCGGCTTTCT
TGCTGGGACTCTTCTGCGAA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFENLTDRLSRTLKTISGRGRLTEDNIKDTLREVRMALLEADVALPVVREFVNAVKERAVGQDVAKSLTPGQVFVKIVQS
ELEKAMGEANEALNLAAQPPAVIMMAGLQGAGKTTSVAKLSKFLRTRQKKSVLVVSADVYRPAAIKQLETLAKEVEVEFF
PSDVSQKPIDIANAAISHAKLKFIDVVILDTAGRLHVDEAMMDEIKALHAAVKPIETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDVLSLIEQVERGVDKEKAMKLA
SKVKSGGNFDLEDFREQLQQMKNMGGMMGLLEKLPGVGQLPPEAMAQIQDGKMTRQMEAIINSMTPGERQNPDIIKGSRK
RRIAAGSGTQIQDVNRLLKQFTQMQKMMKKMSSKGGMQKMMRAMGGMMPGGMKLPGR

Sequences:

>Translated_457_residues
MFENLTDRLSRTLKTISGRGRLTEDNIKDTLREVRMALLEADVALPVVREFVNAVKERAVGQDVAKSLTPGQVFVKIVQS
ELEKAMGEANEALNLAAQPPAVIMMAGLQGAGKTTSVAKLSKFLRTRQKKSVLVVSADVYRPAAIKQLETLAKEVEVEFF
PSDVSQKPIDIANAAISHAKLKFIDVVILDTAGRLHVDEAMMDEIKALHAAVKPIETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDVLSLIEQVERGVDKEKAMKLA
SKVKSGGNFDLEDFREQLQQMKNMGGMMGLLEKLPGVGQLPPEAMAQIQDGKMTRQMEAIINSMTPGERQNPDIIKGSRK
RRIAAGSGTQIQDVNRLLKQFTQMQKMMKKMSSKGGMQKMMRAMGGMMPGGMKLPGR
>Mature_457_residues
MFENLTDRLSRTLKTISGRGRLTEDNIKDTLREVRMALLEADVALPVVREFVNAVKERAVGQDVAKSLTPGQVFVKIVQS
ELEKAMGEANEALNLAAQPPAVIMMAGLQGAGKTTSVAKLSKFLRTRQKKSVLVVSADVYRPAAIKQLETLAKEVEVEFF
PSDVSQKPIDIANAAISHAKLKFIDVVILDTAGRLHVDEAMMDEIKALHAAVKPIETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDVLSLIEQVERGVDKEKAMKLA
SKVKSGGNFDLEDFREQLQQMKNMGGMMGLLEKLPGVGQLPPEAMAQIQDGKMTRQMEAIINSMTPGERQNPDIIKGSRK
RRIAAGSGTQIQDVNRLLKQFTQMQKMMKKMSSKGGMQKMMRAMGGMMPGGMKLPGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=448, Percent_Identity=32.5892857142857, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI226371618, Length=390, Percent_Identity=33.0769230769231, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI295424842, Length=314, Percent_Identity=27.0700636942675, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI23308697, Length=314, Percent_Identity=27.0700636942675, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=36.875, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1788963, Length=457, Percent_Identity=77.4617067833698, Blast_Score=683, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=33.5849056603774, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=423, Percent_Identity=29.5508274231678, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=34.8837209302326, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=443, Percent_Identity=33.4085778781038, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320498, Length=314, Percent_Identity=27.3885350318471, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17647949, Length=448, Percent_Identity=31.6964285714286, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=30, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49701; Mature: 49701

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTDRLSRTLKTISGRGRLTEDNIKDTLREVRMALLEADVALPVVREFVNAVKERAV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQDVAKSLTPGQVFVKIVQSELEKAMGEANEALNLAAQPPAVIMMAGLQGAGKTTSVAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHH
SKFLRTRQKKSVLVVSADVYRPAAIKQLETLAKEVEVEFFPSDVSQKPIDIANAAISHAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHH
LKFIDVVILDTAGRLHVDEAMMDEIKALHAAVKPIETLFVVDAMTGQDAANTAKAFNEAL
HHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEQVERGVDKEKAMKLASKVKSGGNFDLEDFREQLQQMKNMGGMMGLLEKLPGVGQL
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
PPEAMAQIQDGKMTRQMEAIINSMTPGERQNPDIIKGSRKRRIAAGSGTQIQDVNRLLKQ
CHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHH
FTQMQKMMKKMSSKGGMQKMMRAMGGMMPGGMKLPGR
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MFENLTDRLSRTLKTISGRGRLTEDNIKDTLREVRMALLEADVALPVVREFVNAVKERAV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQDVAKSLTPGQVFVKIVQSELEKAMGEANEALNLAAQPPAVIMMAGLQGAGKTTSVAKL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHH
SKFLRTRQKKSVLVVSADVYRPAAIKQLETLAKEVEVEFFPSDVSQKPIDIANAAISHAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHH
LKFIDVVILDTAGRLHVDEAMMDEIKALHAAVKPIETLFVVDAMTGQDAANTAKAFNEAL
HHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEQVERGVDKEKAMKLASKVKSGGNFDLEDFREQLQQMKNMGGMMGLLEKLPGVGQL
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
PPEAMAQIQDGKMTRQMEAIINSMTPGERQNPDIIKGSRKRRIAAGSGTQIQDVNRLLKQ
CHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHH
FTQMQKMMKKMSSKGGMQKMMRAMGGMMPGGMKLPGR
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]