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The map label for this gene is hpt [H]

Identifier: 119773908

GI number: 119773908

Start: 954860

End: 955390

Strand: Direct

Name: hpt [H]

Synonym: Sama_0771

Alternate gene names: 119773908

Gene position: 954860-955390 (Clockwise)

Preceding gene: 119773907

Following gene: 119773909

Centisome position: 22.17

GC content: 52.17

Gene sequence:

>531_bases
ATGAAACACACCATCGAAGAGATGATCTCGGCCGCCGAGATTGACCAGAAACTCAATGAACTGGCCGAGCGTATCAACGC
CCACTATGAAAACAGCGAACGACTGCTGATGGTAGGCTTGCTCAAGGGATCCGCGGTCTTTATGGCTGACCTGTGTCGCC
GTATCAAAGGCCATGTGGAAATCGACTTTATGTGCGTTTCCAGCTATGGCAATGCCATGTCCAGTTCCCGCGATGTGAAG
ATCCTCAAAGACGTGCAGTCAGATATCGCCGATCGTGATGTGCTTATCGTTGAAGATCTTATTGATTCGGGCAACACCCT
GTCCAAGGTGCGCGAACTGCTGCTGGTGCGTGAGCCAAAGAGCCTGGCCCTGTGCACCCTGCTGGATAAGCCGGAGCGCC
GTGAAGTAAATGTGCATGTGGACTTTGTCGGCTTTACCATTCCAGACGAGTTCATCGTTGGCTACGGTATCGACTATGCC
GAGAAGTACCGTAACCTGCCTTATATCGCCAAGGTGATCCCGCAGGAATAA

Upstream 100 bases:

>100_bases
GCACGAATTCTTGACCATTTGGGCGTAGCCCACAGCCTGACCAAGCGCTGGGGTTATGGTGGCGAAGGCGCCACACAAGC
TTCTGATAATTGAGAGTATT

Downstream 100 bases:

>100_bases
GCGGGCCTGGGGTGAAGTCGGGGGCTGTGGCCCCCGCTTTTGTTTAAGGTATCAAATCAATTGAGTTTTAAATTCAGGTT
CAGCGAGGGGAAGCAATGAC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MKHTIEEMISAAEIDQKLNELAERINAHYENSERLLMVGLLKGSAVFMADLCRRIKGHVEIDFMCVSSYGNAMSSSRDVK
ILKDVQSDIADRDVLIVEDLIDSGNTLSKVRELLLVREPKSLALCTLLDKPERREVNVHVDFVGFTIPDEFIVGYGIDYA
EKYRNLPYIAKVIPQE

Sequences:

>Translated_176_residues
MKHTIEEMISAAEIDQKLNELAERINAHYENSERLLMVGLLKGSAVFMADLCRRIKGHVEIDFMCVSSYGNAMSSSRDVK
ILKDVQSDIADRDVLIVEDLIDSGNTLSKVRELLLVREPKSLALCTLLDKPERREVNVHVDFVGFTIPDEFIVGYGIDYA
EKYRNLPYIAKVIPQE
>Mature_176_residues
MKHTIEEMISAAEIDQKLNELAERINAHYENSERLLMVGLLKGSAVFMADLCRRIKGHVEIDFMCVSSYGNAMSSSRDVK
ILKDVQSDIADRDVLIVEDLIDSGNTLSKVRELLLVREPKSLALCTLLDKPERREVNVHVDFVGFTIPDEFIVGYGIDYA
EKYRNLPYIAKVIPQE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=150, Percent_Identity=36, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI9910262, Length=145, Percent_Identity=31.7241379310345, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI87081689, Length=174, Percent_Identity=65.5172413793103, Blast_Score=239, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17510817, Length=175, Percent_Identity=33.1428571428571, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19973; Mature: 19973

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTIEEMISAAEIDQKLNELAERINAHYENSERLLMVGLLKGSAVFMADLCRRIKGHVE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCE
IDFMCVSSYGNAMSSSRDVKILKDVQSDIADRDVLIVEDLIDSGNTLSKVRELLLVREPK
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHCCCCHHHHHHHHHHHCCCC
SLALCTLLDKPERREVNVHVDFVGFTIPDEFIVGYGIDYAEKYRNLPYIAKVIPQE
HHEEEHHCCCCCCCEEEEEEEEEEEECCCHHHEECCCCHHHHHCCCCHHHHCCCCC
>Mature Secondary Structure
MKHTIEEMISAAEIDQKLNELAERINAHYENSERLLMVGLLKGSAVFMADLCRRIKGHVE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCE
IDFMCVSSYGNAMSSSRDVKILKDVQSDIADRDVLIVEDLIDSGNTLSKVRELLLVREPK
EEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHCCCCHHHHHHHHHHHCCCC
SLALCTLLDKPERREVNVHVDFVGFTIPDEFIVGYGIDYAEKYRNLPYIAKVIPQE
HHEEEHHCCCCCCCEEEEEEEEEEEECCCHHHEECCCCHHHHHCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]