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The map label for this gene is gmk [H]

Identifier: 119773407

GI number: 119773407

Start: 305313

End: 305936

Strand: Reverse

Name: gmk [H]

Synonym: Sama_0266

Alternate gene names: 119773407

Gene position: 305936-305313 (Counterclockwise)

Preceding gene: 119773413

Following gene: 119773406

Centisome position: 7.1

GC content: 53.37

Gene sequence:

>624_bases
ATGAGCACTCGTGGAAATCTTTTTATCGTATCGGCCCCCAGCGGTGCCGGAAAGTCTTCGCTGATATCAGCCCTGCTGAA
AGATAAACCCGCCGACAAGCAGGTTTCTGTGTCTCACACTACCCGCAAACCGCGTCCGGGCGAAGAAAACGGCGTGCATT
ATCACTTTGTCAGCGTGGATGAATTTAAAGCGCTGATCGCGCAGGATGCTTTTTTTGAGTGGGCCGAAGTCTTTGGCAAC
TTTTATGGCACCTCACGCCTTACGGTGCAGGCAACTCTGGAGCGCGGCATCGATGTGTTTTTGGATATCGACTGGCAAGG
CGCCCAGCAGGTGAAAAAACTCATGCCAGAGGCCATGGGGATTTTTATTCTGCCACCGAGCCGTGAAGAGCTGGAGCGCC
GCCTTATTGGCCGCGGCCAGGACAGTGATGAAGTGATTGCTTCACGCATGGCACAGGCCGTGTCTGAAATGTCCCATTAC
ACTGAATATGAGTATGTTATCGTTAACGATAACTTTGATGAGGCCCTGGCCGATTTGCAGGCTATCATCCGTGCGGGGCG
CTTAACCTGCGCTGGTCAAGCCCGCACCCACGGTGATATGCTTAAGGGTCTGTTGGCAGACTGA

Upstream 100 bases:

>100_bases
CGCAGAAGGCAGCAGCGGGAATATAATAGTCGGCTTATTCTTGTATTTTGACGGGCCAACATCCGGGCCCGGCGACCAGC
CAGAGCGGAAAAGCCAACTG

Downstream 100 bases:

>100_bases
CTGCCTTAGTGTACACTTTTGCGTCATTTTTTTACTGGACCGGTGCATTTACCGGCTAAATTTGGGAGTTCCACTACATG
GCTCGCGTAACTGTAGAAGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSTRGNLFIVSAPSGAGKSSLISALLKDKPADKQVSVSHTTRKPRPGEENGVHYHFVSVDEFKALIAQDAFFEWAEVFGN
FYGTSRLTVQATLERGIDVFLDIDWQGAQQVKKLMPEAMGIFILPPSREELERRLIGRGQDSDEVIASRMAQAVSEMSHY
TEYEYVIVNDNFDEALADLQAIIRAGRLTCAGQARTHGDMLKGLLAD

Sequences:

>Translated_207_residues
MSTRGNLFIVSAPSGAGKSSLISALLKDKPADKQVSVSHTTRKPRPGEENGVHYHFVSVDEFKALIAQDAFFEWAEVFGN
FYGTSRLTVQATLERGIDVFLDIDWQGAQQVKKLMPEAMGIFILPPSREELERRLIGRGQDSDEVIASRMAQAVSEMSHY
TEYEYVIVNDNFDEALADLQAIIRAGRLTCAGQARTHGDMLKGLLAD
>Mature_206_residues
STRGNLFIVSAPSGAGKSSLISALLKDKPADKQVSVSHTTRKPRPGEENGVHYHFVSVDEFKALIAQDAFFEWAEVFGNF
YGTSRLTVQATLERGIDVFLDIDWQGAQQVKKLMPEAMGIFILPPSREELERRLIGRGQDSDEVIASRMAQAVSEMSHYT
EYEYVIVNDNFDEALADLQAIIRAGRLTCAGQARTHGDMLKGLLAD

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=41.7142857142857, Blast_Score=133, Evalue=9e-32,
Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=41.7142857142857, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=41.7142857142857, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI14780902, Length=201, Percent_Identity=29.8507462686567, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI262118259, Length=177, Percent_Identity=31.638418079096, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4505237, Length=177, Percent_Identity=31.638418079096, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI262118255, Length=177, Percent_Identity=31.638418079096, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI262118263, Length=177, Percent_Identity=31.638418079096, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI21361598, Length=197, Percent_Identity=28.9340101522843, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI38570142, Length=186, Percent_Identity=30.1075268817204, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI186700629, Length=190, Percent_Identity=25.7894736842105, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI186700627, Length=190, Percent_Identity=25.7894736842105, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI186972120, Length=190, Percent_Identity=25.7894736842105, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI111154074, Length=160, Percent_Identity=28.75, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI21536464, Length=127, Percent_Identity=29.9212598425197, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790080, Length=205, Percent_Identity=66.8292682926829, Blast_Score=284, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=36.1111111111111, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=36.1111111111111, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17557440, Length=179, Percent_Identity=27.3743016759777, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988041, Length=181, Percent_Identity=23.2044198895028, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=44.5652173913043, Blast_Score=151, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21356141, Length=179, Percent_Identity=39.6648044692737, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22922; Mature: 22791

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRGNLFIVSAPSGAGKSSLISALLKDKPADKQVSVSHTTRKPRPGEENGVHYHFVSVD
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEEEEEECHH
EFKALIAQDAFFEWAEVFGNFYGTSRLTVQATLERGIDVFLDIDWQGAQQVKKLMPEAMG
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCEEEEEECCCCHHHHHHHHHHHCC
IFILPPSREELERRLIGRGQDSDEVIASRMAQAVSEMSHYTEYEYVIVNDNFDEALADLQ
EEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHH
AIIRAGRLTCAGQARTHGDMLKGLLAD
HHHHHCCCEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
STRGNLFIVSAPSGAGKSSLISALLKDKPADKQVSVSHTTRKPRPGEENGVHYHFVSVD
CCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEEEEEECHH
EFKALIAQDAFFEWAEVFGNFYGTSRLTVQATLERGIDVFLDIDWQGAQQVKKLMPEAMG
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCEEEEEECCCCHHHHHHHHHHHCC
IFILPPSREELERRLIGRGQDSDEVIASRMAQAVSEMSHYTEYEYVIVNDNFDEALADLQ
EEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHH
AIIRAGRLTCAGQARTHGDMLKGLLAD
HHHHHCCCEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA