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The map label for this gene is moeB [H]

Identifier: 119773279

GI number: 119773279

Start: 153990

End: 154754

Strand: Reverse

Name: moeB [H]

Synonym: Sama_0137

Alternate gene names: 119773279

Gene position: 154754-153990 (Counterclockwise)

Preceding gene: 119773280

Following gene: 119773272

Centisome position: 3.59

GC content: 57.12

Gene sequence:

>765_bases
ATGACCGACGACATACTCTCTGACACAGAGCTGCTACGCTACAGTCGCCAGATTTCCATAAAATCCATGGATATAGAGGG
TCAGGAAAAGCTCAAACAGGCTCGGGTGCTGGTGATAGGCGCCGGCGGCCTTGGCTGCGCCGCCGCCCAGTATCTGGGCG
TTGCCGGTGTTGGTGCAATGACTCTGGTGGACTTTGACACTGTGGAGCTGTCGAACCTGCAACGCCAGGTGCTACACCGG
GACAATCGCATCGGCATGCTCAAGGTGGAATCGGCCAGGCTGGCTCTCAATGAGCTTAATCCCCATGTGCAGATAAATCC
CATTGGCCGGGTACTGGACGACCCCGAAATGGATGCGTTGGTCGCAGACCATTCCCTGGTGCTGGACTGTACCGACAATG
TGGCGGTGCGTCAGCAACTGAACCGGGCATGCTTTGCCCATAAGGTACCGCTGGTATCGGCCGCGGCGATTCGCATGGAA
GGCATGATTACCGTGTTTGACTATGCCGGAGACAGCCCCTGTTATCAGTGCTTCGCCAGCCTGTTTGGTGAGCAGCAGCT
GACCTGTGTTGAGTCGGGTATTCTGGCCCCGGTGGTGGGGTTGATGGGGTGCTTACAGGCAGTTGAGGCCATTAAATTGA
TTGCCGGCATGGGCAAACCTTTGCTGGGGCGCCTGCTGATGGTGGATGCCATGACGATGGAGATGCGCCAGATGATACTG
CCACGCCAGCCCAATTGCCCTGTTTGCGGTGGTGCCACAGTTTAA

Upstream 100 bases:

>100_bases
TCGCCAACTGCTTTATCCATCTGCCTCAATTTCAGGGCAGCCTGGAAGCGGGCGAGACTATTCTGGTTGAACCCTTCGAT
AGCATTTTGGACTAAGCCCA

Downstream 100 bases:

>100_bases
ACTCTGGGTTGGGCGGCTTCGATTCTCAGTAAAATGGCTTGGGGTCTACATCCAGGCTGGATGGGGAGACGCCCCGCTCT
ATGTTCAGATCTGACTTGAG

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MTDDILSDTELLRYSRQISIKSMDIEGQEKLKQARVLVIGAGGLGCAAAQYLGVAGVGAMTLVDFDTVELSNLQRQVLHR
DNRIGMLKVESARLALNELNPHVQINPIGRVLDDPEMDALVADHSLVLDCTDNVAVRQQLNRACFAHKVPLVSAAAIRME
GMITVFDYAGDSPCYQCFASLFGEQQLTCVESGILAPVVGLMGCLQAVEAIKLIAGMGKPLLGRLLMVDAMTMEMRQMIL
PRQPNCPVCGGATV

Sequences:

>Translated_254_residues
MTDDILSDTELLRYSRQISIKSMDIEGQEKLKQARVLVIGAGGLGCAAAQYLGVAGVGAMTLVDFDTVELSNLQRQVLHR
DNRIGMLKVESARLALNELNPHVQINPIGRVLDDPEMDALVADHSLVLDCTDNVAVRQQLNRACFAHKVPLVSAAAIRME
GMITVFDYAGDSPCYQCFASLFGEQQLTCVESGILAPVVGLMGCLQAVEAIKLIAGMGKPLLGRLLMVDAMTMEMRQMIL
PRQPNCPVCGGATV
>Mature_253_residues
TDDILSDTELLRYSRQISIKSMDIEGQEKLKQARVLVIGAGGLGCAAAQYLGVAGVGAMTLVDFDTVELSNLQRQVLHRD
NRIGMLKVESARLALNELNPHVQINPIGRVLDDPEMDALVADHSLVLDCTDNVAVRQQLNRACFAHKVPLVSAAAIRMEG
MITVFDYAGDSPCYQCFASLFGEQQLTCVESGILAPVVGLMGCLQAVEAIKLIAGMGKPLLGRLLMVDAMTMEMRQMILP
RQPNCPVCGGATV

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=228, Percent_Identity=46.0526315789474, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI4885649, Length=144, Percent_Identity=32.6388888888889, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI23510338, Length=166, Percent_Identity=30.1204819277108, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI23510340, Length=166, Percent_Identity=30.1204819277108, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI38045948, Length=164, Percent_Identity=32.9268292682927, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI38045944, Length=111, Percent_Identity=34.2342342342342, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI38045942, Length=111, Percent_Identity=34.2342342342342, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787048, Length=245, Percent_Identity=62.8571428571429, Blast_Score=329, Evalue=1e-91,
Organism=Escherichia coli, GI87082356, Length=248, Percent_Identity=41.5322580645161, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI1789177, Length=124, Percent_Identity=30.6451612903226, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=248, Percent_Identity=38.3064516129032, Blast_Score=186, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI193203301, Length=153, Percent_Identity=30.718954248366, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI86565433, Length=155, Percent_Identity=31.6129032258064, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI86565431, Length=155, Percent_Identity=31.6129032258064, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71984476, Length=67, Percent_Identity=43.2835820895522, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=259, Percent_Identity=37.8378378378378, Blast_Score=162, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6322639, Length=164, Percent_Identity=27.4390243902439, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320598, Length=153, Percent_Identity=26.797385620915, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24582879, Length=249, Percent_Identity=45.3815261044177, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24660640, Length=151, Percent_Identity=32.4503311258278, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28573937, Length=161, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI20129973, Length=109, Percent_Identity=35.7798165137615, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24641311, Length=255, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27429; Mature: 27297

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
9.1 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
8.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDILSDTELLRYSRQISIKSMDIEGQEKLKQARVLVIGAGGLGCAAAQYLGVAGVGAM
CCCCCCCHHHHHHHHHHCEEEEECCCCHHHHHHCEEEEEECCCHHHHHHHHHHHCCCCEE
TLVDFDTVELSNLQRQVLHRDNRIGMLKVESARLALNELNPHVQINPIGRVLDDPEMDAL
EEEECCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCEEECCCCCCCCCCCHHHE
VADHSLVLDCTDNVAVRQQLNRACFAHKVPLVSAAAIRMEGMITVFDYAGDSPCYQCFAS
EECCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHH
LFGEQQLTCVESGILAPVVGLMGCLQAVEAIKLIAGMGKPLLGRLLMVDAMTMEMRQMIL
HHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
PRQPNCPVCGGATV
CCCCCCCCCCCCCC
>Mature Secondary Structure 
TDDILSDTELLRYSRQISIKSMDIEGQEKLKQARVLVIGAGGLGCAAAQYLGVAGVGAM
CCCCCCHHHHHHHHHHCEEEEECCCCHHHHHHCEEEEEECCCHHHHHHHHHHHCCCCEE
TLVDFDTVELSNLQRQVLHRDNRIGMLKVESARLALNELNPHVQINPIGRVLDDPEMDAL
EEEECCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCEEECCCCCCCCCCCHHHE
VADHSLVLDCTDNVAVRQQLNRACFAHKVPLVSAAAIRMEGMITVFDYAGDSPCYQCFAS
EECCEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHH
LFGEQQLTCVESGILAPVVGLMGCLQAVEAIKLIAGMGKPLLGRLLMVDAMTMEMRQMIL
HHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
PRQPNCPVCGGATV
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]