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The map label for this gene is hemN [H]

Identifier: 119773228

GI number: 119773228

Start: 96995

End: 98335

Strand: Reverse

Name: hemN [H]

Synonym: Sama_0086

Alternate gene names: 119773228

Gene position: 98335-96995 (Counterclockwise)

Preceding gene: 119773230

Following gene: 119773226

Centisome position: 2.28

GC content: 52.72

Gene sequence:

>1341_bases
ATGATCGAGAAATACAACTACAGCGGTCCCCGTTATACCTCTTATCCGACGGCGCTGGAGTTCAACGACGGCTTTACAGA
GCAGGATTTGCTGAGTGCCATTGAGCACAGCAAGAGCGATAAGTTGTCACTTTATATTCACATCCCCTTCTGTGCCAAGC
TTTGTTATTACTGCGGCTGCAACAAGGTCATCACCCGCCACGCCCATAAGGCCGATCAGTACATTGAGTATCTGGCGAGT
GAAATCTTAAACCGTGCCCCACTGTTCAAGGGCTACACGGTTACTCAGATGCACTGGGGCGGTGGTACCCCTACTTTCCT
GAGCCCTGAGCAAATTCTGCGGCTGACCAAGCTTTTAAAGGACAACTTCAACTTCGCCGATGAAGGTGAATTCTCCATTG
AAGTTGACCCGCGCGAAATTGAGCTGACCATGCTCGACACCCTCAAGGAAGCCGGTTTCAACCGTATTTCTATTGGGGTG
CAGGACTTCAACAAGCAGGTTCAGGAAGCGGTAAACCGTCCACAGGACGAGCAGTTTATTTTCGACCTGATTGGCAAGGC
CAAGGCCATGGGCTTTGAGTCCACCAACGTGGATTTGATTTACGGCCTGCCCCATCAGACACCGGAAACCTTCGCTGAAA
CCATCCAGCGCATTCTGGACCTGTCGCCTGACCGTCTGTCGGTGTTCAACTACGCCCACCTGCCTGCGCGCTTTGCCGCC
CAGCGCAAGATCAAGGACGAAGATCTGCCATCACCGCAGCAGAAGCTGGAAATCCTGCACCAGACCATCGAGACCCTGGT
GGACGCCGGATATCAGTACATCGGCATGGATCACTTCGCCAAGCCCGATGACGAGCTGGCGCGCCTGCAACGCGAAGGCA
AGCTGCACCGCAACTTCCAAGGCTATACTACCCAGGAAGAATGTGACCTGCTGGGTCTGGGTGTATCGTCCATCAGCCAG
ATTGGCGATTGCTACGCCCAAAACCAGAAAGATATCCGCCCATACTACGAAGCCATAGACGACCATGGCCATGCGCTGTG
GAAGGGTTGCAAACTGAACCACGACGACGAAATCCGCCGGGTGGTCATCAAGCAGCTGATCTGTCATTTCGACCTGGATA
TGGCTGTTATCGATGAGAAGTTTGGCTTCACCTTCGAAGACTACTTCGCTCAGGATTTGAAACTGCTGCAGACCTTTATC
GACGACAAGCTGGTGACCATTGAGAACCGTCGTATTCATGTGTCTGATACCGGCCGTCTGCTTATCCGTAATATCTGTAT
GTGCTTTGACGTGTACTTCCGCGAGAAGGCCCGTCAGCAGCAGTTCTCACGGGTAATTTAA

Upstream 100 bases:

>100_bases
TCAAGGTTATTTGATCTTAAAGCCTTCATACTTCGCCCATTGCTAAATTACCGGAGGACACGACTTGAAGCAGCCAACTC
AAATCAGCTGGGATCAGTCG

Downstream 100 bases:

>100_bases
GGCTTGGAAAAGGGCGTTCCAGTCCGATTCAGCCAACAAAAAAACCGGCCACTGGGCCGGTTTTTTTATCTACAATGTTC
GCTGAGTCAGGCTTTGGCGG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MIEKYNYSGPRYTSYPTALEFNDGFTEQDLLSAIEHSKSDKLSLYIHIPFCAKLCYYCGCNKVITRHAHKADQYIEYLAS
EILNRAPLFKGYTVTQMHWGGGTPTFLSPEQILRLTKLLKDNFNFADEGEFSIEVDPREIELTMLDTLKEAGFNRISIGV
QDFNKQVQEAVNRPQDEQFIFDLIGKAKAMGFESTNVDLIYGLPHQTPETFAETIQRILDLSPDRLSVFNYAHLPARFAA
QRKIKDEDLPSPQQKLEILHQTIETLVDAGYQYIGMDHFAKPDDELARLQREGKLHRNFQGYTTQEECDLLGLGVSSISQ
IGDCYAQNQKDIRPYYEAIDDHGHALWKGCKLNHDDEIRRVVIKQLICHFDLDMAVIDEKFGFTFEDYFAQDLKLLQTFI
DDKLVTIENRRIHVSDTGRLLIRNICMCFDVYFREKARQQQFSRVI

Sequences:

>Translated_446_residues
MIEKYNYSGPRYTSYPTALEFNDGFTEQDLLSAIEHSKSDKLSLYIHIPFCAKLCYYCGCNKVITRHAHKADQYIEYLAS
EILNRAPLFKGYTVTQMHWGGGTPTFLSPEQILRLTKLLKDNFNFADEGEFSIEVDPREIELTMLDTLKEAGFNRISIGV
QDFNKQVQEAVNRPQDEQFIFDLIGKAKAMGFESTNVDLIYGLPHQTPETFAETIQRILDLSPDRLSVFNYAHLPARFAA
QRKIKDEDLPSPQQKLEILHQTIETLVDAGYQYIGMDHFAKPDDELARLQREGKLHRNFQGYTTQEECDLLGLGVSSISQ
IGDCYAQNQKDIRPYYEAIDDHGHALWKGCKLNHDDEIRRVVIKQLICHFDLDMAVIDEKFGFTFEDYFAQDLKLLQTFI
DDKLVTIENRRIHVSDTGRLLIRNICMCFDVYFREKARQQQFSRVI
>Mature_446_residues
MIEKYNYSGPRYTSYPTALEFNDGFTEQDLLSAIEHSKSDKLSLYIHIPFCAKLCYYCGCNKVITRHAHKADQYIEYLAS
EILNRAPLFKGYTVTQMHWGGGTPTFLSPEQILRLTKLLKDNFNFADEGEFSIEVDPREIELTMLDTLKEAGFNRISIGV
QDFNKQVQEAVNRPQDEQFIFDLIGKAKAMGFESTNVDLIYGLPHQTPETFAETIQRILDLSPDRLSVFNYAHLPARFAA
QRKIKDEDLPSPQQKLEILHQTIETLVDAGYQYIGMDHFAKPDDELARLQREGKLHRNFQGYTTQEECDLLGLGVSSISQ
IGDCYAQNQKDIRPYYEAIDDHGHALWKGCKLNHDDEIRRVVIKQLICHFDLDMAVIDEKFGFTFEDYFAQDLKLLQTFI
DDKLVTIENRRIHVSDTGRLLIRNICMCFDVYFREKARQQQFSRVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=243, Percent_Identity=25.9259259259259, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI87082341, Length=446, Percent_Identity=65.4708520179372, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1789325, Length=245, Percent_Identity=30.6122448979592, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51651; Mature: 51651

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKYNYSGPRYTSYPTALEFNDGFTEQDLLSAIEHSKSDKLSLYIHIPFCAKLCYYCGC
CCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHCC
NKVITRHAHKADQYIEYLASEILNRAPLFKGYTVTQMHWGGGTPTFLSPEQILRLTKLLK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
DNFNFADEGEFSIEVDPREIELTMLDTLKEAGFNRISIGVQDFNKQVQEAVNRPQDEQFI
HCCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCHHHHH
FDLIGKAKAMGFESTNVDLIYGLPHQTPETFAETIQRILDLSPDRLSVFNYAHLPARFAA
HHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QRKIKDEDLPSPQQKLEILHQTIETLVDAGYQYIGMDHFAKPDDELARLQREGKLHRNFQ
HHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHCCHHCCCC
GYTTQEECDLLGLGVSSISQIGDCYAQNQKDIRPYYEAIDDHGHALWKGCKLNHDDEIRR
CCCCHHHHHEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHCCCCCCHHHHHH
VVIKQLICHFDLDMAVIDEKFGFTFEDYFAQDLKLLQTFIDDKLVTIENRRIHVSDTGRL
HHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCHHH
LIRNICMCFDVYFREKARQQQFSRVI
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIEKYNYSGPRYTSYPTALEFNDGFTEQDLLSAIEHSKSDKLSLYIHIPFCAKLCYYCGC
CCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHCC
NKVITRHAHKADQYIEYLASEILNRAPLFKGYTVTQMHWGGGTPTFLSPEQILRLTKLLK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
DNFNFADEGEFSIEVDPREIELTMLDTLKEAGFNRISIGVQDFNKQVQEAVNRPQDEQFI
HCCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCEEEECHHHHHHHHHHHHCCCCHHHHH
FDLIGKAKAMGFESTNVDLIYGLPHQTPETFAETIQRILDLSPDRLSVFNYAHLPARFAA
HHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QRKIKDEDLPSPQQKLEILHQTIETLVDAGYQYIGMDHFAKPDDELARLQREGKLHRNFQ
HHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHCCHHCCCC
GYTTQEECDLLGLGVSSISQIGDCYAQNQKDIRPYYEAIDDHGHALWKGCKLNHDDEIRR
CCCCHHHHHEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHCCCCCCHHHHHH
VVIKQLICHFDLDMAVIDEKFGFTFEDYFAQDLKLLQTFIDDKLVTIENRRIHVSDTGRL
HHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCEEEECCCHHH
LIRNICMCFDVYFREKARQQQFSRVI
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7768836; 8346018; 9278503 [H]