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The map label for this gene is add

Identifier: 119773227

GI number: 119773227

Start: 95910

End: 96908

Strand: Direct

Name: add

Synonym: Sama_0085

Alternate gene names: 119773227

Gene position: 95910-96908 (Clockwise)

Preceding gene: 119773224

Following gene: 119773229

Centisome position: 2.23

GC content: 56.56

Gene sequence:

>999_bases
ATGATTGATAACAAGATTCCACTGGTGGACCTCCACCGGCATCTTGACGGCAATGTCAGGGTGCAAACCATTTGGGAGCT
GGGTCATCAGCACGGTATCGCCTTACCGGCGGACTCGCTGGAGACGTTGGCGCCTTTCGTTCAAATTCAGGGTAAGGAAA
CCAGCCTGGTCGCGTTTTTGAAAAAGCTCGACTGGATGGTGGCCGTGCTCGCAGATCTGGATGCAGTGCAGCGGGTGGCC
CGTGAAAACGTGGCCGATGCAGCGCTGTCAGGCCTCGATTATGCCGAGCTGCGTTTCAGCCCTTACTACATGGCGATGAA
CCACAAGCTGCCGATTGAAGGTGTGGTGGAGGCCGTGATTGACGGTGTGAATCAGGGATTGAAAGCGCATCCCCAGGTGA
AGATTAACCTGATTGGCATCATGTCCCGCTCTTTTGGCGTGGATGCCTGCACCGCTGAGCTGAATGGCCTTTTGGCCCAC
CGCGACAAGCTGGTGGCCATCGACCTGGCCGGTGACGAACTGGGTTTCCCCGGCAGCCTGTTTAACGATCACTTCAAGCG
GGTGCGTGACTCGGGGCTGAATATTACAGTACACGCAGGTGAAGCCGCTGGCGCCGAGAGCATGTGGCAGGCGATTCAGG
AACTGGGTGCCACCCGTATCGGTCATGGCGTGAAGGCGGTACAGGATCCCAAGCTGATGGAGTATCTCGCCAAGCACCGC
ATTGGAATCGAGTCATGCCCCACTTCTAATCTGCAAACCTCCACCGTGAAGTCGCTGGCTGAGCATCCGCTGCGCACCTT
CGTGGATGCCGGTGTGTTGGTGTGTCTGAATACCGACGACCCGGGCGTGAGCAATATCGACATCAAGCACGAGTACAGAC
TTGCCCATAACGAGATGGGTTTCAGTGCTGCCGAGCTTGCCAAACTGCAGGCCAATGGTGTGGAGATGGCATTTATCTCT
GATTCAGACCGAAAAGCGCTTTACGCCGCCAAAGCCTGA

Upstream 100 bases:

>100_bases
ATTACTCAGATTTAAGCCTGCAATTGCGTGTTAAACTTCATCGCAGCCCAAGACCAGGAATAAAAACACAATTGGCGGGG
CTTTCAAACAGGGGTTAACT

Downstream 100 bases:

>100_bases
CTCAGCGAACATTGTAGATAAAAAAACCGGCCCAGTGGCCGGTTTTTTTGTTGGCTGAATCGGACTGGAACGCCCTTTTC
CAAGCCTTAAATTACCCGTG

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MIDNKIPLVDLHRHLDGNVRVQTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVAVLADLDAVQRVA
RENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVIDGVNQGLKAHPQVKINLIGIMSRSFGVDACTAELNGLLAH
RDKLVAIDLAGDELGFPGSLFNDHFKRVRDSGLNITVHAGEAAGAESMWQAIQELGATRIGHGVKAVQDPKLMEYLAKHR
IGIESCPTSNLQTSTVKSLAEHPLRTFVDAGVLVCLNTDDPGVSNIDIKHEYRLAHNEMGFSAAELAKLQANGVEMAFIS
DSDRKALYAAKA

Sequences:

>Translated_332_residues
MIDNKIPLVDLHRHLDGNVRVQTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVAVLADLDAVQRVA
RENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVIDGVNQGLKAHPQVKINLIGIMSRSFGVDACTAELNGLLAH
RDKLVAIDLAGDELGFPGSLFNDHFKRVRDSGLNITVHAGEAAGAESMWQAIQELGATRIGHGVKAVQDPKLMEYLAKHR
IGIESCPTSNLQTSTVKSLAEHPLRTFVDAGVLVCLNTDDPGVSNIDIKHEYRLAHNEMGFSAAELAKLQANGVEMAFIS
DSDRKALYAAKA
>Mature_332_residues
MIDNKIPLVDLHRHLDGNVRVQTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFLKKLDWMVAVLADLDAVQRVA
RENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVIDGVNQGLKAHPQVKINLIGIMSRSFGVDACTAELNGLLAH
RDKLVAIDLAGDELGFPGSLFNDHFKRVRDSGLNITVHAGEAAGAESMWQAIQELGATRIGHGVKAVQDPKLMEYLAKHR
IGIESCPTSNLQTSTVKSLAEHPLRTFVDAGVLVCLNTDDPGVSNIDIKHEYRLAHNEMGFSAAELAKLQANGVEMAFIS
DSDRKALYAAKA

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=337, Percent_Identity=32.0474777448071, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1787910, Length=327, Percent_Identity=62.3853211009174, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI32565969, Length=337, Percent_Identity=30.8605341246291, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17538512, Length=337, Percent_Identity=30.8605341246291, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI115537133, Length=322, Percent_Identity=24.8447204968944, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324188, Length=283, Percent_Identity=25.0883392226148, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645260, Length=323, Percent_Identity=24.4582043343653, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_SHEAM (A1S1P1)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_925967.1
- ProteinModelPortal:   A1S1P1
- SMR:   A1S1P1
- STRING:   A1S1P1
- GeneID:   4602342
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0085
- NMPDR:   fig|326297.7.peg.79
- eggNOG:   COG1816
- HOGENOM:   HBG630382
- OMA:   PYYMAMN
- PhylomeDB:   A1S1P1
- ProtClustDB:   PRK09358
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 36096; Mature: 36096

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 201-201 BINDING 14-14 BINDING 16-16 BINDING 171-171 BINDING 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDNKIPLVDLHRHLDGNVRVQTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFL
CCCCCCCHHHHHHCCCCCEEEEEHHHHHHHCCCCCCCHHHHHHHHHHEECCCCHHHHHHH
KKLDWMVAVLADLDAVQRVARENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCCCHHHHHHHHH
DGVNQGLKAHPQVKINLIGIMSRSFGVDACTAELNGLLAHRDKLVAIDLAGDELGFPGSL
HHHHCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHH
FNDHFKRVRDSGLNITVHAGEAAGAESMWQAIQELGATRIGHGVKAVQDPKLMEYLAKHR
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHC
IGIESCPTSNLQTSTVKSLAEHPLRTFVDAGVLVCLNTDDPGVSNIDIKHEYRLAHNEMG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEHHHHHHHHCC
FSAAELAKLQANGVEMAFISDSDRKALYAAKA
CCHHHHHHHHCCCEEEEEECCCCCCEEEEECC
>Mature Secondary Structure
MIDNKIPLVDLHRHLDGNVRVQTIWELGHQHGIALPADSLETLAPFVQIQGKETSLVAFL
CCCCCCCHHHHHHCCCCCEEEEEHHHHHHHCCCCCCCHHHHHHHHHHEECCCCHHHHHHH
KKLDWMVAVLADLDAVQRVARENVADAALSGLDYAELRFSPYYMAMNHKLPIEGVVEAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCCCHHHHHHHHH
DGVNQGLKAHPQVKINLIGIMSRSFGVDACTAELNGLLAHRDKLVAIDLAGDELGFPGSL
HHHHCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHH
FNDHFKRVRDSGLNITVHAGEAAGAESMWQAIQELGATRIGHGVKAVQDPKLMEYLAKHR
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHC
IGIESCPTSNLQTSTVKSLAEHPLRTFVDAGVLVCLNTDDPGVSNIDIKHEYRLAHNEMG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEHHHHHHHHCC
FSAAELAKLQANGVEMAFISDSDRKALYAAKA
CCHHHHHHHHCCCEEEEEECCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA