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The map label for this gene is prlC [H]

Identifier: 119718830

GI number: 119718830

Start: 4887395

End: 4889320

Strand: Reverse

Name: prlC [H]

Synonym: Noca_4613

Alternate gene names: 119718830

Gene position: 4889320-4887395 (Counterclockwise)

Preceding gene: 119718831

Following gene: 119718829

Centisome position: 98.06

GC content: 72.79

Gene sequence:

>1926_bases
ATGAGCCTCGCCCCTCTCGCGCTCCCGTTGCCCGACGACGCCCAGGAGTGGGTCGAGTCCCTGACCCGCGACGGACTCGC
GACCGCCCGCGAGCGCGCCGAGCGGCTGCGCACGTCCCCGCCGGCCGACCCGCTGGACCTGCTCCGCGAGTGGGACGAGG
TGGCCCGCGCGCTGTCCGGCGTCGCGGCGGCCGCCTCGCTGCTCGCGAACGTGCACCCGCTGGAGCCGGTGCGGACCGCG
TGCGAGGCGGCCGACCGGGAGGTGGACCGGCTGCTCACCGAGCTGCGCCAGGACCGCGGGCTGTACGACGTCTTCGCGGC
CGCCGACCCGGCCGGCCTGGACCCCGCGGCAGCACGCCTGCTCGACAAGACCCTCGAGGACTTCCGGCGCGCCGGCGTCG
ACCTCGACGACGCGACCCGGGCCCGGCTCGCCGAGATCAACGAGCGGCTGACCCAGGTCGGTCAGGAGTTCAGTCGCACC
ATCCGCGACGACGTGCGCACCGTCCGGGTCCCGGCCGAGCGCCTCGCCGGCCTGCCGCAGGACTGGCTCGACGCCCATCC
CGTCGATGCCGACGGGCTGGTCACGGTCACCACCGACTACCCGGACGCGGTGCCGGTCCGGATGTTCGTCCACGACGCGG
GCGTCCGGCGCCAGGTCACGGTCGCGTTCCTGGAGCGTGGCTGGCCGCAGAACGAGCCGCTGCTGCGCGAGATGTTCGCA
CTGCGGCACGAGCTCGCCACCCTGGTCGGCTACGCCGACTGGGCGTCGTACGACGCCGGCGTGAAGATGATCGGCGACGG
ACCGGCGATCCCGGCGTTCATCGACCGGATCGCGGCCGCCGCGGACGCGCCCATGCGGCGCGACCTCGACCAGCTGCTCG
AGCGCTACCGGCGCGATGTCCCGGACGCGACCGCGATCGACACCGCGGACTCGCTGTACTACGAGGAGCTGGTCCGCCAG
GAGCGGCACGACGTCGACGCGCAGCGGGTCCGGGCGTACTTCGACTTCACCAAGGTCCGCCGTGGCCTGCTCGAGGTCAC
CGGCCGGCTGTTCGGGCTGCGCTACGAGCCGGTCCCCGACGCGACGGTCTGGCACGAGGACGTCGCGGCGTACGACGTGC
TTCGCGACGCCCCCGACGGCCCGGTCCCCGTCGGGCGGATCTACCTGGACCTGCACCCGCGCGAGGGCAAGTACAAGCAC
GCGGCGCAGTTCACCCTCGTCGACGGGCTCGCCGGGCGGCAGCTGCCCGAGGGCGTGCTGGTGTGCAACTTCTCGCGCGG
CCTGATGGAGCACGACCATGTGGTCACGCTGTTCCACGAGTTCGGGCATCTGGTCCACCACGTGCTCGGCGGCCACGGCG
GGTGGACCCGCTTCTCCGGGGTCGCGACCGAGTGGGACTTCGTCGAGGCGCCCAGCCAGCTGCTCGAGGAGTGGGCGTGG
GACCCCGAGGTGCTGCGCACCTTCGCCGCCGACGCCGACGGCGAGCCGATCCCGGAGGACCTGGTGGAGCGGATGCGGGC
CGCCGACGAGTTCGGCAAGGGCTACCACGCGCGCACCCAGATGTTCTACGCGGCGATGTCGTACTGGTTCCACACGTCGC
GTCCCGACGACCTGACCGCGGCGATGCGCGAGCTGCAGGAGCGCTACTCGCCGTTCCCCTACATCGACGGCACCCACATG
TTCGCGAGCTTCGGCCACCTCGGCGGCTACTCCTCGGCGTACTACACCTACATGTGGTCGCTGGTGATCGCGAAGGACCT
GTTCTCCGCCTTCGACCCCGCCGATCTCTTCGACCCGGTCGTCGCCGGTCGCTACCGCGACCGCGTGCTCGCCCTCGGCG
GCTCCCGGGACGCCGCCGACCTGGTCACCGACTTCCTCGGCCGCCCCTACACCTTCGACGCGTACGCCGCCTGGCTCGCT
CGCTAG

Upstream 100 bases:

>100_bases
GTCGTCGCGGCAGCCTGGCCCCCGGCCCTCGTCCCTAGCCCGCGTTCCTGGTCGGCGTCCCTGGTCTGCGTCCCTCCTCT
GCATCCCTACTCTGGGCGAC

Downstream 100 bases:

>100_bases
GTCCAGCCGGTTCGTGACGGTTTCCCCGGTTAGCCGGGGAAGTTGCCACTGTTGGGCCGAAACTTCGGCCGATAAGTTCC
GGTTTCCCCGGTTCACCGGG

Product: thimet oligopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MSLAPLALPLPDDAQEWVESLTRDGLATARERAERLRTSPPADPLDLLREWDEVARALSGVAAAASLLANVHPLEPVRTA
CEAADREVDRLLTELRQDRGLYDVFAAADPAGLDPAAARLLDKTLEDFRRAGVDLDDATRARLAEINERLTQVGQEFSRT
IRDDVRTVRVPAERLAGLPQDWLDAHPVDADGLVTVTTDYPDAVPVRMFVHDAGVRRQVTVAFLERGWPQNEPLLREMFA
LRHELATLVGYADWASYDAGVKMIGDGPAIPAFIDRIAAAADAPMRRDLDQLLERYRRDVPDATAIDTADSLYYEELVRQ
ERHDVDAQRVRAYFDFTKVRRGLLEVTGRLFGLRYEPVPDATVWHEDVAAYDVLRDAPDGPVPVGRIYLDLHPREGKYKH
AAQFTLVDGLAGRQLPEGVLVCNFSRGLMEHDHVVTLFHEFGHLVHHVLGGHGGWTRFSGVATEWDFVEAPSQLLEEWAW
DPEVLRTFAADADGEPIPEDLVERMRAADEFGKGYHARTQMFYAAMSYWFHTSRPDDLTAAMRELQERYSPFPYIDGTHM
FASFGHLGGYSSAYYTYMWSLVIAKDLFSAFDPADLFDPVVAGRYRDRVLALGGSRDAADLVTDFLGRPYTFDAYAAWLA
R

Sequences:

>Translated_641_residues
MSLAPLALPLPDDAQEWVESLTRDGLATARERAERLRTSPPADPLDLLREWDEVARALSGVAAAASLLANVHPLEPVRTA
CEAADREVDRLLTELRQDRGLYDVFAAADPAGLDPAAARLLDKTLEDFRRAGVDLDDATRARLAEINERLTQVGQEFSRT
IRDDVRTVRVPAERLAGLPQDWLDAHPVDADGLVTVTTDYPDAVPVRMFVHDAGVRRQVTVAFLERGWPQNEPLLREMFA
LRHELATLVGYADWASYDAGVKMIGDGPAIPAFIDRIAAAADAPMRRDLDQLLERYRRDVPDATAIDTADSLYYEELVRQ
ERHDVDAQRVRAYFDFTKVRRGLLEVTGRLFGLRYEPVPDATVWHEDVAAYDVLRDAPDGPVPVGRIYLDLHPREGKYKH
AAQFTLVDGLAGRQLPEGVLVCNFSRGLMEHDHVVTLFHEFGHLVHHVLGGHGGWTRFSGVATEWDFVEAPSQLLEEWAW
DPEVLRTFAADADGEPIPEDLVERMRAADEFGKGYHARTQMFYAAMSYWFHTSRPDDLTAAMRELQERYSPFPYIDGTHM
FASFGHLGGYSSAYYTYMWSLVIAKDLFSAFDPADLFDPVVAGRYRDRVLALGGSRDAADLVTDFLGRPYTFDAYAAWLA
R
>Mature_640_residues
SLAPLALPLPDDAQEWVESLTRDGLATARERAERLRTSPPADPLDLLREWDEVARALSGVAAAASLLANVHPLEPVRTAC
EAADREVDRLLTELRQDRGLYDVFAAADPAGLDPAAARLLDKTLEDFRRAGVDLDDATRARLAEINERLTQVGQEFSRTI
RDDVRTVRVPAERLAGLPQDWLDAHPVDADGLVTVTTDYPDAVPVRMFVHDAGVRRQVTVAFLERGWPQNEPLLREMFAL
RHELATLVGYADWASYDAGVKMIGDGPAIPAFIDRIAAAADAPMRRDLDQLLERYRRDVPDATAIDTADSLYYEELVRQE
RHDVDAQRVRAYFDFTKVRRGLLEVTGRLFGLRYEPVPDATVWHEDVAAYDVLRDAPDGPVPVGRIYLDLHPREGKYKHA
AQFTLVDGLAGRQLPEGVLVCNFSRGLMEHDHVVTLFHEFGHLVHHVLGGHGGWTRFSGVATEWDFVEAPSQLLEEWAWD
PEVLRTFAADADGEPIPEDLVERMRAADEFGKGYHARTQMFYAAMSYWFHTSRPDDLTAAMRELQERYSPFPYIDGTHMF
ASFGHLGGYSSAYYTYMWSLVIAKDLFSAFDPADLFDPVVAGRYRDRVLALGGSRDAADLVTDFLGRPYTFDAYAAWLAR

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=614, Percent_Identity=32.0846905537459, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI14149738, Length=579, Percent_Identity=30.7426597582038, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI156105687, Length=656, Percent_Identity=25.9146341463415, Blast_Score=182, Evalue=1e-45,
Organism=Escherichia coli, GI1789913, Length=677, Percent_Identity=29.5420974889217, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1787819, Length=588, Percent_Identity=25, Blast_Score=135, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI32565901, Length=479, Percent_Identity=21.294363256785, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319793, Length=621, Percent_Identity=30.4347826086957, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322715, Length=672, Percent_Identity=22.172619047619, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI20129717, Length=605, Percent_Identity=26.1157024793388, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21356111, Length=424, Percent_Identity=25, Blast_Score=132, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 71981; Mature: 71850

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAPLALPLPDDAQEWVESLTRDGLATARERAERLRTSPPADPLDLLREWDEVARALSG
CCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VAAAASLLANVHPLEPVRTACEAADREVDRLLTELRQDRGLYDVFAAADPAGLDPAAARL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHH
LDKTLEDFRRAGVDLDDATRARLAEINERLTQVGQEFSRTIRDDVRTVRVPAERLAGLPQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHCCCCH
DWLDAHPVDADGLVTVTTDYPDAVPVRMFVHDAGVRRQVTVAFLERGWPQNEPLLREMFA
HHHCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
LRHELATLVGYADWASYDAGVKMIGDGPAIPAFIDRIAAAADAPMRRDLDQLLERYRRDV
HHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
PDATAIDTADSLYYEELVRQERHDVDAQRVRAYFDFTKVRRGLLEVTGRLFGLRYEPVPD
CCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ATVWHEDVAAYDVLRDAPDGPVPVGRIYLDLHPREGKYKHAAQFTLVDGLAGRQLPEGVL
CHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCEE
VCNFSRGLMEHDHVVTLFHEFGHLVHHVLGGHGGWTRFSGVATEWDFVEAPSQLLEEWAW
EEECHHCCHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCC
DPEVLRTFAADADGEPIPEDLVERMRAADEFGKGYHARTQMFYAAMSYWFHTSRPDDLTA
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
AMRELQERYSPFPYIDGTHMFASFGHLGGYSSAYYTYMWSLVIAKDLFSAFDPADLFDPV
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VAGRYRDRVLALGGSRDAADLVTDFLGRPYTFDAYAAWLAR
HHCHHHCCEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SLAPLALPLPDDAQEWVESLTRDGLATARERAERLRTSPPADPLDLLREWDEVARALSG
CCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VAAAASLLANVHPLEPVRTACEAADREVDRLLTELRQDRGLYDVFAAADPAGLDPAAARL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHH
LDKTLEDFRRAGVDLDDATRARLAEINERLTQVGQEFSRTIRDDVRTVRVPAERLAGLPQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHCCCCH
DWLDAHPVDADGLVTVTTDYPDAVPVRMFVHDAGVRRQVTVAFLERGWPQNEPLLREMFA
HHHCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
LRHELATLVGYADWASYDAGVKMIGDGPAIPAFIDRIAAAADAPMRRDLDQLLERYRRDV
HHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
PDATAIDTADSLYYEELVRQERHDVDAQRVRAYFDFTKVRRGLLEVTGRLFGLRYEPVPD
CCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ATVWHEDVAAYDVLRDAPDGPVPVGRIYLDLHPREGKYKHAAQFTLVDGLAGRQLPEGVL
CHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCEE
VCNFSRGLMEHDHVVTLFHEFGHLVHHVLGGHGGWTRFSGVATEWDFVEAPSQLLEEWAW
EEECHHCCHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCC
DPEVLRTFAADADGEPIPEDLVERMRAADEFGKGYHARTQMFYAAMSYWFHTSRPDDLTA
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
AMRELQERYSPFPYIDGTHMFASFGHLGGYSSAYYTYMWSLVIAKDLFSAFDPADLFDPV
HHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VAGRYRDRVLALGGSRDAADLVTDFLGRPYTFDAYAAWLAR
HHCHHHCCEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]