Click here to switch to the map view.

The map label for this gene is ethA [H]

Identifier: 119718787

GI number: 119718787

Start: 4836251

End: 4837690

Strand: Reverse

Name: ethA [H]

Synonym: Noca_4569

Alternate gene names: 119718787

Gene position: 4837690-4836251 (Counterclockwise)

Preceding gene: 119718788

Following gene: 119718786

Centisome position: 97.03

GC content: 70.49

Gene sequence:

>1440_bases
ATGACCGAGCACGTGGACGTCCTCATCATCGGCGCCGGACTGTCCGGGATCGGCGCCGCCTGCCGGCTGCGCACCGAGCA
CCCCGGCCGCAGTGTCGCCGTGCTCGAGGCGCGCGAGGCCAGTGGCGGTACCTGGGACCTGTTCCGCTACCCCGGCATCC
GCTCGGACTCCGACATGTTCACCTTCGGCTTCAAGTGGCGGCCGTGGCCCGGTGACACCGCGCTCGCCGACGGCGCCTCG
ATCCTGGAGTACCTGCGCACCGTCGCCCGGGAGTACGCCGTCGACGAGCTGATCCGCTACCGGCACCGGGTCGTCAGCGC
GAGCTGGGACTCCGGGACCGACCTCTGGACGGTCGAGGTCGACCACGACGGCGAGGTGCGCACCTTCACGACCAACCTGC
TCTGGGCCTGCGGCGGCTACTACGACTACGACCGGGGCTTCGCCCCGGAGCTGCCCGGCCAGGAGCGGTTCCACGGCCCT
GTCGTGCACCCCCAGCACTGGCCGGACGACCTCGACTACGCGGGCAAGAAGGTCGTCGTGATCGGGTCCGGGGCGACCGC
GGTGACCCTCGTCCCGGCGCTGGCCGAGGCCGGCGCCGGTCACGTCACGATGCTCCAACGGTCCCCGACCTACATCCTCT
CGCTGCCCGGCCGCGACCCGCTCGCGACCCGGCTGCGCCGGCTGCCCACCCGCGTCAGCTACCCGATCGTGCGGTGGAAG
GCGATCCTGCTCGCGGTCACGACGTACCAGCTCGCCCAGCGGCGTCCCGAGCTCGTGAAGAGCCTGCTCCGCAAGATGAC
CGCCAAGCAGCTGCCCGCCGGGGTCGACGTCGACGTGCACTTCAAGCCGGCGTACGACCCGTGGGACCAGCGGCTGTGCT
TCGTCCCGGACGGCGACCTCTTCAAGGCGATGCGCGCCGGCCGCGCGTCCGTGGTCACCGACCACATCGACACCTTCACC
GAGACGGGGATCCGGCTGCGCTCCGGGGAGGAGCTCGAGGCCGACGTCGTGGTGACCGCCACCGGCCTGACCCTCAAGGC
GATGGGCGGCGTCGAGCTGGTCGTCGACGGGGTGCCGGTGAAGATGCAGGACACGATGACCTACAAGGCGCTGATGCTCA
GCGACGTGCCCAACTTCGTCTTCACGATCGGCTACACCAACGCCTCCTGGACGCTGAAGGCCGACCTGGTGGCCGACTTC
GTGTGCCGGCTGCTGACCTACCTCGACGAGCACGGCGTACGTCGCGCCGTGGCGCCGCGCGACCCGTCGGTCGGCGAGCA
GCGGCTGATCGACTTCAGCTCGGGCTACATCCTCCGGGCGCTGGACGAGCTCCCCAAGCAGGGTGACCGCGAGCCGTGGA
AGCTGCGGCAGAACTACCTGCGCGACGTGCGCTCGATCAACCACGACCGCATCGACGACGGGGTCCTCACGTTTCGCTGA

Upstream 100 bases:

>100_bases
GCAGCACCGTGGAGCACCCCCCGCGGCTGCTCGCCCGGTTCGTCGCGCTCTACGCTCGTTGACGCAAGACTCATTGACAC
GGATTCAGTAGGGTCTGCCC

Downstream 100 bases:

>100_bases
GGCCCGGAACGGTCACCGCTCCCCTTGTCACGACGAAGGAGCCACGAGGAGGCAGCCATGGGAATCGGTGACAAGGCCAA
GCACAAGCTCGAAGAGGCCG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTEHVDVLIIGAGLSGIGAACRLRTEHPGRSVAVLEAREASGGTWDLFRYPGIRSDSDMFTFGFKWRPWPGDTALADGAS
ILEYLRTVAREYAVDELIRYRHRVVSASWDSGTDLWTVEVDHDGEVRTFTTNLLWACGGYYDYDRGFAPELPGQERFHGP
VVHPQHWPDDLDYAGKKVVVIGSGATAVTLVPALAEAGAGHVTMLQRSPTYILSLPGRDPLATRLRRLPTRVSYPIVRWK
AILLAVTTYQLAQRRPELVKSLLRKMTAKQLPAGVDVDVHFKPAYDPWDQRLCFVPDGDLFKAMRAGRASVVTDHIDTFT
ETGIRLRSGEELEADVVVTATGLTLKAMGGVELVVDGVPVKMQDTMTYKALMLSDVPNFVFTIGYTNASWTLKADLVADF
VCRLLTYLDEHGVRRAVAPRDPSVGEQRLIDFSSGYILRALDELPKQGDREPWKLRQNYLRDVRSINHDRIDDGVLTFR

Sequences:

>Translated_479_residues
MTEHVDVLIIGAGLSGIGAACRLRTEHPGRSVAVLEAREASGGTWDLFRYPGIRSDSDMFTFGFKWRPWPGDTALADGAS
ILEYLRTVAREYAVDELIRYRHRVVSASWDSGTDLWTVEVDHDGEVRTFTTNLLWACGGYYDYDRGFAPELPGQERFHGP
VVHPQHWPDDLDYAGKKVVVIGSGATAVTLVPALAEAGAGHVTMLQRSPTYILSLPGRDPLATRLRRLPTRVSYPIVRWK
AILLAVTTYQLAQRRPELVKSLLRKMTAKQLPAGVDVDVHFKPAYDPWDQRLCFVPDGDLFKAMRAGRASVVTDHIDTFT
ETGIRLRSGEELEADVVVTATGLTLKAMGGVELVVDGVPVKMQDTMTYKALMLSDVPNFVFTIGYTNASWTLKADLVADF
VCRLLTYLDEHGVRRAVAPRDPSVGEQRLIDFSSGYILRALDELPKQGDREPWKLRQNYLRDVRSINHDRIDDGVLTFR
>Mature_478_residues
TEHVDVLIIGAGLSGIGAACRLRTEHPGRSVAVLEAREASGGTWDLFRYPGIRSDSDMFTFGFKWRPWPGDTALADGASI
LEYLRTVAREYAVDELIRYRHRVVSASWDSGTDLWTVEVDHDGEVRTFTTNLLWACGGYYDYDRGFAPELPGQERFHGPV
VHPQHWPDDLDYAGKKVVVIGSGATAVTLVPALAEAGAGHVTMLQRSPTYILSLPGRDPLATRLRRLPTRVSYPIVRWKA
ILLAVTTYQLAQRRPELVKSLLRKMTAKQLPAGVDVDVHFKPAYDPWDQRLCFVPDGDLFKAMRAGRASVVTDHIDTFTE
TGIRLRSGEELEADVVVTATGLTLKAMGGVELVVDGVPVKMQDTMTYKALMLSDVPNFVFTIGYTNASWTLKADLVADFV
CRLLTYLDEHGVRRAVAPRDPSVGEQRLIDFSSGYILRALDELPKQGDREPWKLRQNYLRDVRSINHDRIDDGVLTFR

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 53501; Mature: 53369

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHVDVLIIGAGLSGIGAACRLRTEHPGRSVAVLEAREASGGTWDLFRYPGIRSDSDMF
CCCCEEEEEEECCCCCCCCEEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCEE
TFGFKWRPWPGDTALADGASILEYLRTVAREYAVDELIRYRHRVVSASWDSGTDLWTVEV
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEE
DHDGEVRTFTTNLLWACGGYYDYDRGFAPELPGQERFHGPVVHPQHWPDDLDYAGKKVVV
CCCCCEEEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
IGSGATAVTLVPALAEAGAGHVTMLQRSPTYILSLPGRDPLATRLRRLPTRVSYPIVRWK
EECCCCHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCHHHHHHHHCCCCCCCHHHHHH
AILLAVTTYQLAQRRPELVKSLLRKMTAKQLPAGVDVDVHFKPAYDPWDQRLCFVPDGDL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHCEEEECCCCHH
FKAMRAGRASVVTDHIDTFTETGIRLRSGEELEADVVVTATGLTLKAMGGVELVVDGVPV
HHHHHCCCCCEEHHHHHHHHHCCEEEECCCCCCCEEEEEECCEEEEECCCEEEEECCCCE
KMQDTMTYKALMLSDVPNFVFTIGYTNASWTLKADLVADFVCRLLTYLDEHGVRRAVAPR
EEECCHHHHHHHHHCCCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCCEECCCCC
DPSVGEQRLIDFSSGYILRALDELPKQGDREPWKLRQNYLRDVRSINHDRIDDGVLTFR
CCCCCHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECC
>Mature Secondary Structure 
TEHVDVLIIGAGLSGIGAACRLRTEHPGRSVAVLEAREASGGTWDLFRYPGIRSDSDMF
CCCEEEEEEECCCCCCCCEEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCEE
TFGFKWRPWPGDTALADGASILEYLRTVAREYAVDELIRYRHRVVSASWDSGTDLWTVEV
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEE
DHDGEVRTFTTNLLWACGGYYDYDRGFAPELPGQERFHGPVVHPQHWPDDLDYAGKKVVV
CCCCCEEEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
IGSGATAVTLVPALAEAGAGHVTMLQRSPTYILSLPGRDPLATRLRRLPTRVSYPIVRWK
EECCCCHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCHHHHHHHHCCCCCCCHHHHHH
AILLAVTTYQLAQRRPELVKSLLRKMTAKQLPAGVDVDVHFKPAYDPWDQRLCFVPDGDL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHCEEEECCCCHH
FKAMRAGRASVVTDHIDTFTETGIRLRSGEELEADVVVTATGLTLKAMGGVELVVDGVPV
HHHHHCCCCCEEHHHHHHHHHCCEEEECCCCCCCEEEEEECCEEEEECCCEEEEECCCCE
KMQDTMTYKALMLSDVPNFVFTIGYTNASWTLKADLVADFVCRLLTYLDEHGVRRAVAPR
EEECCHHHHHHHHHCCCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHCCCEECCCCC
DPSVGEQRLIDFSSGYILRALDELPKQGDREPWKLRQNYLRDVRSINHDRIDDGVLTFR
CCCCCHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]