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The map label for this gene is pat [H]

Identifier: 119718733

GI number: 119718733

Start: 4774595

End: 4775665

Strand: Reverse

Name: pat [H]

Synonym: Noca_4514

Alternate gene names: 119718733

Gene position: 4775665-4774595 (Counterclockwise)

Preceding gene: 119718734

Following gene: 119718732

Centisome position: 95.78

GC content: 73.86

Gene sequence:

>1071_bases
ATGACCAGCCCCCAGCCCCGGCGCACGGTCGCTGCGATCCCGCCGTACGTCGCCGGGAAGCCGCCGACGGTCCGACCCGG
GATGACGTCGTACAAGCTCTCCTCGAACGAGAACCCCTACCCGCCGCTGCCCGGCGTCATCGAGGCCGTCCAGGCGGGCG
TCGCCGCCATGAACCGGTACCCCGACATGGGCAGCGCCGCGCTCTACGCCGCCCTGTCGGAGAAGTTCGCGGTGCCGTCC
GACCACCTCTCGGTGGCCACCGGGTCGGTCGGGCTGATCTACCAGCTGGTGCAGGCGTTCTGCGAGCCCGGCGACGAGGT
CGTGTTCGCCTGGCGCTCGTTCGAGGCGTACCCGATCGCGGTGACGGCCGCGGCCGCGACCGCAGTCAAGGTCCCGGTGC
TCGCCGACGGCCGGCACGACCTGGACGCGATGGCGGCCGCCGTCACCGACCGCACCAAGGTGGTGCTGGTCTGCACCCCC
AACAACCCGACCGGCCCGGCGGTCACCCAGGCCGAGCTGGACGACTTCCTCGAGAAGGTGCCGCCGCACGTGCTCGTCGT
CGTGGACGAGGCCTACCTGGAGTTCGTGCGGATGGCCGATCCGGTCGACGGTCTCGCGACGTACCGCGCCCGGGAGAACG
TCGTGCTCACCCGCACCTTCTCCAAGGCCTACGGGCTGGCGGGCTTCCGGGTCGGGTACGCCGTCGCGCCTGCCCCGATC
GCGGCCGCGCTGCGCGCCGTGTCGCTGCCGTTCGGGGTCTCGACCGTCGCCCAGGCCGCGGCCATCGCGTCGCTCGAGCG
CCAGGCCGAGCTGCTCGAGCGGGTCGAGGCGCTGGTCGTCGAGCGGGCCCGCGTCGTCGCGGGCCTGGCCGAGGCGGGGT
GGGACGTCCCGGCCGCCCAGGGCAACTTCGTGTGGTTCGAGCTCGGCGAGCGGACCGCCGACTTCGCCGCGGCCGCGGAC
GAGGCCGGGATCGTGGTCCGGCCGTTCGCCGGGGAGGGCGCCCGGGTCTCGATCGGGGAGACCGAGGCCAACGGCCGGCT
GCTTCAGGTGGCCGCAGCCTTCAGCCGCTGA

Upstream 100 bases:

>100_bases
CGGGGTCGGGATCGGGATCGTGCTGGCGGTGCTGCTGCGGCCCTGGCGGCGGCGTCCCCATCGACCCGCGGCCCGAGAAG
TGCGTCACTAGGGTGAGCCC

Downstream 100 bases:

>100_bases
CGCGGTAGCGTGCCGACGCATGTCGTCGTCGCCTCGTCCCGTCCTGGTCGCGGTCGCGGCCGCTGCCCTGGGGGCCGGGC
TGCTGGCGCCCGCCAGCGGG

Product: aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTSPQPRRTVAAIPPYVAGKPPTVRPGMTSYKLSSNENPYPPLPGVIEAVQAGVAAMNRYPDMGSAALYAALSEKFAVPS
DHLSVATGSVGLIYQLVQAFCEPGDEVVFAWRSFEAYPIAVTAAAATAVKVPVLADGRHDLDAMAAAVTDRTKVVLVCTP
NNPTGPAVTQAELDDFLEKVPPHVLVVVDEAYLEFVRMADPVDGLATYRARENVVLTRTFSKAYGLAGFRVGYAVAPAPI
AAALRAVSLPFGVSTVAQAAAIASLERQAELLERVEALVVERARVVAGLAEAGWDVPAAQGNFVWFELGERTADFAAAAD
EAGIVVRPFAGEGARVSIGETEANGRLLQVAAAFSR

Sequences:

>Translated_356_residues
MTSPQPRRTVAAIPPYVAGKPPTVRPGMTSYKLSSNENPYPPLPGVIEAVQAGVAAMNRYPDMGSAALYAALSEKFAVPS
DHLSVATGSVGLIYQLVQAFCEPGDEVVFAWRSFEAYPIAVTAAAATAVKVPVLADGRHDLDAMAAAVTDRTKVVLVCTP
NNPTGPAVTQAELDDFLEKVPPHVLVVVDEAYLEFVRMADPVDGLATYRARENVVLTRTFSKAYGLAGFRVGYAVAPAPI
AAALRAVSLPFGVSTVAQAAAIASLERQAELLERVEALVVERARVVAGLAEAGWDVPAAQGNFVWFELGERTADFAAAAD
EAGIVVRPFAGEGARVSIGETEANGRLLQVAAAFSR
>Mature_355_residues
TSPQPRRTVAAIPPYVAGKPPTVRPGMTSYKLSSNENPYPPLPGVIEAVQAGVAAMNRYPDMGSAALYAALSEKFAVPSD
HLSVATGSVGLIYQLVQAFCEPGDEVVFAWRSFEAYPIAVTAAAATAVKVPVLADGRHDLDAMAAAVTDRTKVVLVCTPN
NPTGPAVTQAELDDFLEKVPPHVLVVVDEAYLEFVRMADPVDGLATYRARENVVLTRTFSKAYGLAGFRVGYAVAPAPIA
AALRAVSLPFGVSTVAQAAAIASLERQAELLERVEALVVERARVVAGLAEAGWDVPAAQGNFVWFELGERTADFAAAADE
AGIVVRPFAGEGARVSIGETEANGRLLQVAAAFSR

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=321, Percent_Identity=23.98753894081, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI169881279, Length=321, Percent_Identity=23.98753894081, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788332, Length=323, Percent_Identity=29.4117647058824, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786816, Length=261, Percent_Identity=28.735632183908, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788722, Length=295, Percent_Identity=29.4915254237288, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788627, Length=169, Percent_Identity=27.810650887574, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=354, Percent_Identity=25.9887005649718, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9

Molecular weight: Translated: 37420; Mature: 37289

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPQPRRTVAAIPPYVAGKPPTVRPGMTSYKLSSNENPYPPLPGVIEAVQAGVAAMNRY
CCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
PDMGSAALYAALSEKFAVPSDHLSVATGSVGLIYQLVQAFCEPGDEVVFAWRSFEAYPIA
CCCCHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
VTAAAATAVKVPVLADGRHDLDAMAAAVTDRTKVVLVCTPNNPTGPAVTQAELDDFLEKV
EEEHHHHHEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHC
PPHVLVVVDEAYLEFVRMADPVDGLATYRARENVVLTRTFSKAYGLAGFRVGYAVAPAPI
CCEEEEEECHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEHHHHHCCCCEECCEEECCHHH
AAALRAVSLPFGVSTVAQAAAIASLERQAELLERVEALVVERARVVAGLAEAGWDVPAAQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GNFVWFELGERTADFAAAADEAGIVVRPFAGEGARVSIGETEANGRLLQVAAAFSR
CCEEEEECCCCCHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCEEEEEEHHCC
>Mature Secondary Structure 
TSPQPRRTVAAIPPYVAGKPPTVRPGMTSYKLSSNENPYPPLPGVIEAVQAGVAAMNRY
CCCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCC
PDMGSAALYAALSEKFAVPSDHLSVATGSVGLIYQLVQAFCEPGDEVVFAWRSFEAYPIA
CCCCHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
VTAAAATAVKVPVLADGRHDLDAMAAAVTDRTKVVLVCTPNNPTGPAVTQAELDDFLEKV
EEEHHHHHEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHC
PPHVLVVVDEAYLEFVRMADPVDGLATYRARENVVLTRTFSKAYGLAGFRVGYAVAPAPI
CCEEEEEECHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEHHHHHCCCCEECCEEECCHHH
AAALRAVSLPFGVSTVAQAAAIASLERQAELLERVEALVVERARVVAGLAEAGWDVPAAQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GNFVWFELGERTADFAAAADEAGIVVRPFAGEGARVSIGETEANGRLLQVAAAFSR
CCEEEEECCCCCHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCEEEEEEHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]