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The map label for this gene is nagB [H]

Identifier: 119718702

GI number: 119718702

Start: 4740064

End: 4740849

Strand: Reverse

Name: nagB [H]

Synonym: Noca_4483

Alternate gene names: 119718702

Gene position: 4740849-4740064 (Counterclockwise)

Preceding gene: 119718703

Following gene: 119718700

Centisome position: 95.09

GC content: 74.43

Gene sequence:

>786_bases
ATGGAGATCGTCCCGCTCGCCACCGAGCCCGAGGTCGCCGGGCTCGCCGCGGACGCGATCGAGGCCCTGGTCCGCGCGCA
CCCCGAGTCCGTGCTCGGTCTGGCCACCGGTTCGAGCCCGCTGCCGGCGTACCAGGAGCTGATCCGCCGGCGGCGCGCCG
GCAGCGGTCCGTCATACGCCGGCGTCCGGGCCTTCCTGCTCGACGAGTACGTCGGGCTGCCGCCCGGCCATCCGCAGTCC
TACCGGGAGACGATCTTCCGCGAGCTCACCGACGCGCTCGACATCGACCGGGACCGGGTCGCGAGCCCGGACCCGACCCC
GGACCTGCTGTCCACGGCAGGCGAGCGCTACGAGGACGCGATCCGCGCGGCCGGCGGGGTGGACCTGCAGGTGCTCGGCA
TCGGCGCCGACGGCCACCTCGCGTTCAACGAGCCCGGCTCCTCGCTCGGGTCGCTGACCCGGCTCAAGACGCTCACCGGG
GAGACCCGCGCCGACAACGCCCGGTTCTTCGACTCCGTCGACCAGGTGCCCCGGCACGTGCTCACCCAGGGTCTCGGGAC
GATCCTGCGGGCCGGCCGCCTGCTGCTGGTCGCCACCGGGGCCGGCAAGGCGGCCGCGATCGCCGCGGCCGTCGAGGGCC
CGGTCTCCGCATCCTGCCCCGCGTCCGTGCTCCAGCTGCACCCACACGTCACGGTCCTGCTCGACGAGGCCGCCGCGGCG
CAGCTGACCCGTACCGCGTACTACCGCGAGGTCTTCGACGACAAGCCGGACTGGCAGCGTCCGTGA

Upstream 100 bases:

>100_bases
CCGTGGCCACGGCCACCTCGACGCCGCTGCGGCTGCTCGGCCTGCCGCCCCGCGAGGAGCGGATCCGGCTCACCGACGAC
CTGCGCCTGGAGGTGCACTG

Downstream 100 bases:

>100_bases
GTCGCCGCTGACGGGTCGTGTGTCCCACGACGCGCTATGGCGCGTTCTCAGGCACACGACCCGGAGCCGTCACCCCAGCG
CCACCACCAGGGCGAGCACC

Product: glucosamine-6-phosphate isomerase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MEIVPLATEPEVAGLAADAIEALVRAHPESVLGLATGSSPLPAYQELIRRRRAGSGPSYAGVRAFLLDEYVGLPPGHPQS
YRETIFRELTDALDIDRDRVASPDPTPDLLSTAGERYEDAIRAAGGVDLQVLGIGADGHLAFNEPGSSLGSLTRLKTLTG
ETRADNARFFDSVDQVPRHVLTQGLGTILRAGRLLLVATGAGKAAAIAAAVEGPVSASCPASVLQLHPHVTVLLDEAAAA
QLTRTAYYREVFDDKPDWQRP

Sequences:

>Translated_261_residues
MEIVPLATEPEVAGLAADAIEALVRAHPESVLGLATGSSPLPAYQELIRRRRAGSGPSYAGVRAFLLDEYVGLPPGHPQS
YRETIFRELTDALDIDRDRVASPDPTPDLLSTAGERYEDAIRAAGGVDLQVLGIGADGHLAFNEPGSSLGSLTRLKTLTG
ETRADNARFFDSVDQVPRHVLTQGLGTILRAGRLLLVATGAGKAAAIAAAVEGPVSASCPASVLQLHPHVTVLLDEAAAA
QLTRTAYYREVFDDKPDWQRP
>Mature_261_residues
MEIVPLATEPEVAGLAADAIEALVRAHPESVLGLATGSSPLPAYQELIRRRRAGSGPSYAGVRAFLLDEYVGLPPGHPQS
YRETIFRELTDALDIDRDRVASPDPTPDLLSTAGERYEDAIRAAGGVDLQVLGIGADGHLAFNEPGSSLGSLTRLKTLTG
ETRADNARFFDSVDQVPRHVLTQGLGTILRAGRLLLVATGAGKAAAIAAAVEGPVSASCPASVLQLHPHVTVLLDEAAAA
QLTRTAYYREVFDDKPDWQRP

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923881, Length=219, Percent_Identity=42.4657534246575, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI13027378, Length=255, Percent_Identity=38.8235294117647, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1786893, Length=259, Percent_Identity=39.7683397683398, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1789530, Length=220, Percent_Identity=30.9090909090909, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI48994958, Length=112, Percent_Identity=39.2857142857143, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554876, Length=254, Percent_Identity=38.5826771653543, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24581960, Length=262, Percent_Identity=38.5496183206107, Blast_Score=171, Evalue=4e-43,
Organism=Drosophila melanogaster, GI19920764, Length=262, Percent_Identity=38.5496183206107, Blast_Score=171, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.5.99.6 [H]

Molecular weight: Translated: 27647; Mature: 27647

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVPLATEPEVAGLAADAIEALVRAHPESVLGLATGSSPLPAYQELIRRRRAGSGPSYA
CCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHHCCCCCCHH
GVRAFLLDEYVGLPPGHPQSYRETIFRELTDALDIDRDRVASPDPTPDLLSTAGERYEDA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHH
IRAAGGVDLQVLGIGADGHLAFNEPGSSLGSLTRLKTLTGETRADNARFFDSVDQVPRHV
HHHCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LTQGLGTILRAGRLLLVATGAGKAAAIAAAVEGPVSASCPASVLQLHPHVTVLLDEAAAA
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEECHHHHH
QLTRTAYYREVFDDKPDWQRP
HHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEIVPLATEPEVAGLAADAIEALVRAHPESVLGLATGSSPLPAYQELIRRRRAGSGPSYA
CCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHHCCCCCCHH
GVRAFLLDEYVGLPPGHPQSYRETIFRELTDALDIDRDRVASPDPTPDLLSTAGERYEDA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHH
IRAAGGVDLQVLGIGADGHLAFNEPGSSLGSLTRLKTLTGETRADNARFFDSVDQVPRHV
HHHCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LTQGLGTILRAGRLLLVATGAGKAAAIAAAVEGPVSASCPASVLQLHPHVTVLLDEAAAA
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEECHHHHH
QLTRTAYYREVFDDKPDWQRP
HHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA