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The map label for this gene is livH [H]

Identifier: 119718661

GI number: 119718661

Start: 4695949

End: 4696833

Strand: Reverse

Name: livH [H]

Synonym: Noca_4442

Alternate gene names: 119718661

Gene position: 4696833-4695949 (Counterclockwise)

Preceding gene: 119718662

Following gene: 119718660

Centisome position: 94.2

GC content: 68.59

Gene sequence:

>885_bases
ATGACCGAGCTGCTCCAGAACCTCCTCCTCGGCCTGCTGCTGGGCGGCGTGTACGCCCTCGCGGCGAGTGGGTTGACCCT
GATCTTCGGTGTCATGCGGGTGATCAACATCGCCCACGGCGCGTTCCTGATCCTGGCCTCGTTCATCACCTACTGGCTGT
GGGACGCGTTCGGCATCGACCCGTTGCTCGCGATCGTGATCACGACCCCGATCGTGTTCGCGCTCGGGTGGGTCACCTAC
AAGGTCGTCGTGTCCCCGATCCGCACGGCGCCGATGGCGTCGACGGTGCTGCTCACCTTCGGGCTGGCGCTGGTGGTCGA
GGGTGCGATGGGGGAGATCTGGGGCAACAACTCGACGGCGGTCCGGCCGTCGTACGCCGATGAGTCCTTCATCTTCGGGG
GTCTGTTCCTCCCGAAGGCCCAGGTGTACGGCGGCCTGATCGCGGTCGTGGTCCTCGTCCTGCTGTGGGGCGTGCTGACC
AAGACGTGGCTGGGCCGGGCGATCCGCGCGGCGGCGACGAACCCGTCGTCCGCAGAGCTGGTCGGCATCAAGGTGAGCGC
GGTCGCGGCTCTCGTGTTCGCGCTCGGGATCGCGGCCGCCGGTGCCGGCGGTGCGATCACCGGGGTGCTCTACCCGTTCG
TCCCCGGCTCGCACTACCAGTGGATCGCGCGGTTGCTCGCGATCGTGGTGCTCGGCGGCCTCGGGAGCCTCAACGGCGCG
GTCCTCGGCGCGCTCATCTTCGGCATCGCCGAGACGCTGACCGCCGCCTACGTGTCGCCCTCCTGGGCAACCGCCGTCCC
GTACGCCATCGTGTTCCTGGTGCTGCTGATCCGCCCGCAGGGACTGCTCGGCACCCGACTCCGAGAGGATGCAGTAGCAG
CATGA

Upstream 100 bases:

>100_bases
TGATCGGCCAGTGGCAGAACGGCAAGCCCGAGATCGTGCTGCCGGCCGACGTGTCCACCGCGGACATCGAGCCCGGCTGG
CACCCGGGGGCCGGTGGCTG

Downstream 100 bases:

>100_bases
AACCGATCTGGCTGGGCCGGGCGGTCGCCCTCGCCGCGGGCGTCCTGCTCGTCGCCTACCCGATGCTCAGCGACGACATC
TACTACCAGAACATGATCAT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTELLQNLLLGLLLGGVYALAASGLTLIFGVMRVINIAHGAFLILASFITYWLWDAFGIDPLLAIVITTPIVFALGWVTY
KVVVSPIRTAPMASTVLLTFGLALVVEGAMGEIWGNNSTAVRPSYADESFIFGGLFLPKAQVYGGLIAVVVLVLLWGVLT
KTWLGRAIRAAATNPSSAELVGIKVSAVAALVFALGIAAAGAGGAITGVLYPFVPGSHYQWIARLLAIVVLGGLGSLNGA
VLGALIFGIAETLTAAYVSPSWATAVPYAIVFLVLLIRPQGLLGTRLREDAVAA

Sequences:

>Translated_294_residues
MTELLQNLLLGLLLGGVYALAASGLTLIFGVMRVINIAHGAFLILASFITYWLWDAFGIDPLLAIVITTPIVFALGWVTY
KVVVSPIRTAPMASTVLLTFGLALVVEGAMGEIWGNNSTAVRPSYADESFIFGGLFLPKAQVYGGLIAVVVLVLLWGVLT
KTWLGRAIRAAATNPSSAELVGIKVSAVAALVFALGIAAAGAGGAITGVLYPFVPGSHYQWIARLLAIVVLGGLGSLNGA
VLGALIFGIAETLTAAYVSPSWATAVPYAIVFLVLLIRPQGLLGTRLREDAVAA
>Mature_293_residues
TELLQNLLLGLLLGGVYALAASGLTLIFGVMRVINIAHGAFLILASFITYWLWDAFGIDPLLAIVITTPIVFALGWVTYK
VVVSPIRTAPMASTVLLTFGLALVVEGAMGEIWGNNSTAVRPSYADESFIFGGLFLPKAQVYGGLIAVVVLVLLWGVLTK
TWLGRAIRAAATNPSSAELVGIKVSAVAALVFALGIAAAGAGGAITGVLYPFVPGSHYQWIARLLAIVVLGGLGSLNGAV
LGALIFGIAETLTAAYVSPSWATAVPYAIVFLVLLIRPQGLLGTRLREDAVAA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=303, Percent_Identity=31.6831683168317, Blast_Score=108, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30576; Mature: 30445

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELLQNLLLGLLLGGVYALAASGLTLIFGVMRVINIAHGAFLILASFITYWLWDAFGID
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
PLLAIVITTPIVFALGWVTYKVVVSPIRTAPMASTVLLTFGLALVVEGAMGEIWGNNSTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VRPSYADESFIFGGLFLPKAQVYGGLIAVVVLVLLWGVLTKTWLGRAIRAAATNPSSAEL
ECCCCCCCCCEECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
VGIKVSAVAALVFALGIAAAGAGGAITGVLYPFVPGSHYQWIARLLAIVVLGGLGSLNGA
EEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
VLGALIFGIAETLTAAYVSPSWATAVPYAIVFLVLLIRPQGLLGTRLREDAVAA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TELLQNLLLGLLLGGVYALAASGLTLIFGVMRVINIAHGAFLILASFITYWLWDAFGID
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
PLLAIVITTPIVFALGWVTYKVVVSPIRTAPMASTVLLTFGLALVVEGAMGEIWGNNSTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VRPSYADESFIFGGLFLPKAQVYGGLIAVVVLVLLWGVLTKTWLGRAIRAAATNPSSAEL
ECCCCCCCCCEECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
VGIKVSAVAALVFALGIAAAGAGGAITGVLYPFVPGSHYQWIARLLAIVVLGGLGSLNGA
EEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
VLGALIFGIAETLTAAYVSPSWATAVPYAIVFLVLLIRPQGLLGTRLREDAVAA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]