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The map label for this gene is dapE [H]

Identifier: 119718538

GI number: 119718538

Start: 4568701

End: 4570038

Strand: Reverse

Name: dapE [H]

Synonym: Noca_4319

Alternate gene names: 119718538

Gene position: 4570038-4568701 (Counterclockwise)

Preceding gene: 119718539

Following gene: 119718535

Centisome position: 91.66

GC content: 74.74

Gene sequence:

>1338_bases
ATGACCGACGACATCCGCGCCCGCGTCCAGGCCGTCCTCCCCGGGGTGCGCAGGGACCTGGAGGACCTGGTGCGGATCGA
GTCGGTCAGCGCCGACCCGGAGCGGGCCGCGGAGGTGCAGCGATCGGCCGAGGCGGTGGCCCGGCTGTTCCGCGACGAGG
CCTTCGACGAGGTCGACATCGTCAGCGCCGACGGTGGGGCGCCGGCGGTGATCGCCCGCAAGCGCGGCCCCGAGGGGGCA
CCGACGGTCCTGCTGTACGCCCACCACGACGTCCAGCCCGAGAACGACCACGCCGACTGGGACTCCCCGCCCTTCGAGCC
CACCGAGCGCGACGGGCGCCTCTACGCCCGCGGCGCCGCCGACGACAAGGCCGGCATCGCGGCCCACCTCGGCGCCCTGC
GGGTGTACGGCGCCGACGTGCCGGTCAGCGTCACGATGTTCATCGAGGGTGAGGAGGAGGTGGGGTCCGAGACGCTTCCC
GCGCTGCTCCGCGAGCACCAGGACCGGCTGCGCGCCGACGTGATCGTGATCGCCGACTCCGGCAACTGGGACATCGGCGT
GCCCGCCCTCACCACGAGCCTGCGCGGCCTGGTGCGCGTCGACGTCGAGGTGCGGACACTCACCCACGCGGTGCACTCGG
GCATGTGGGGCGGCCTGGTGCCCGACGCGCTGATGACCCTCGCCCGGCTGATCGCCACCCTGCACGACGACCGCGGCGAC
GTCGCGATCGAGGGGCTGCACGCCGGCCCGGCGGCCGACGTGGACTACCCCGAGGAGCGGCTCCGGGCCGAGTCGGGTGC
GGCGCCCGGCCTCGAGTGGATCGGCACCGGCTCGAGCGTCGAGCGGCTCTGGACCAAGCCCGCGCTCAGCATCACCGGCC
TGGACGCCCCGAAGGTCGCCGGCGCCAGCAACACCCTGGTCCCGGCCGCCCGGGCCCGGATCTCGATGCGCGTCGCTCCC
GGCGACACCACCGAGAACGCGCTGGCCTGCCTGGTGCGTCACCTCGAGGCGCACGTGCCCTGGGGCGCCACCCTCACCCA
CACGGTCGTCGACACCGGCGAGGCGACCCGGATCGACGCGACCGGGCCGGCGTACGACGCCGCGCGTGCCGCGTTCACCG
AGGCCTGGGACGGCACCGCGCCCGTCGACATGGGCGTGGGCGGCTCGATCCCCTTCATCGCGGAGTTCCTGGACGCCTTC
CCCGAGGCGAGCGTGCTGGTCACCGGTGTCGAGGACCCGGACACCCGCGCCCACGGCGCCAACGAGGGGCTGCACCTCGC
GGAGTTCGAGCGGGTCGTCCTTGCCGAGGCGCTGCTGCTCGGCAAGCTCGGCGGCTGA

Upstream 100 bases:

>100_bases
CCGTACCTCCCGTTGGGATAGTCCCTGACGATTGCGCTGTCCCGCCCGCGGATCCGCCCCGCAAGCGTCAGGGACTACCG
GACTGATTAGGTTGAGACCC

Downstream 100 bases:

>100_bases
CGGGGCGCCTAGCTCGCTGTAACGCCCGTTTACCCCTCCTTCCCCCCATGCTGCAACACCCGGGGCAGACGGGGTAACAC
GGCGTTACAGCAGATGGGGG

Product: hypothetical protein

Products: NA

Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTDDIRARVQAVLPGVRRDLEDLVRIESVSADPERAAEVQRSAEAVARLFRDEAFDEVDIVSADGGAPAVIARKRGPEGA
PTVLLYAHHDVQPENDHADWDSPPFEPTERDGRLYARGAADDKAGIAAHLGALRVYGADVPVSVTMFIEGEEEVGSETLP
ALLREHQDRLRADVIVIADSGNWDIGVPALTTSLRGLVRVDVEVRTLTHAVHSGMWGGLVPDALMTLARLIATLHDDRGD
VAIEGLHAGPAADVDYPEERLRAESGAAPGLEWIGTGSSVERLWTKPALSITGLDAPKVAGASNTLVPAARARISMRVAP
GDTTENALACLVRHLEAHVPWGATLTHTVVDTGEATRIDATGPAYDAARAAFTEAWDGTAPVDMGVGGSIPFIAEFLDAF
PEASVLVTGVEDPDTRAHGANEGLHLAEFERVVLAEALLLGKLGG

Sequences:

>Translated_445_residues
MTDDIRARVQAVLPGVRRDLEDLVRIESVSADPERAAEVQRSAEAVARLFRDEAFDEVDIVSADGGAPAVIARKRGPEGA
PTVLLYAHHDVQPENDHADWDSPPFEPTERDGRLYARGAADDKAGIAAHLGALRVYGADVPVSVTMFIEGEEEVGSETLP
ALLREHQDRLRADVIVIADSGNWDIGVPALTTSLRGLVRVDVEVRTLTHAVHSGMWGGLVPDALMTLARLIATLHDDRGD
VAIEGLHAGPAADVDYPEERLRAESGAAPGLEWIGTGSSVERLWTKPALSITGLDAPKVAGASNTLVPAARARISMRVAP
GDTTENALACLVRHLEAHVPWGATLTHTVVDTGEATRIDATGPAYDAARAAFTEAWDGTAPVDMGVGGSIPFIAEFLDAF
PEASVLVTGVEDPDTRAHGANEGLHLAEFERVVLAEALLLGKLGG
>Mature_444_residues
TDDIRARVQAVLPGVRRDLEDLVRIESVSADPERAAEVQRSAEAVARLFRDEAFDEVDIVSADGGAPAVIARKRGPEGAP
TVLLYAHHDVQPENDHADWDSPPFEPTERDGRLYARGAADDKAGIAAHLGALRVYGADVPVSVTMFIEGEEEVGSETLPA
LLREHQDRLRADVIVIADSGNWDIGVPALTTSLRGLVRVDVEVRTLTHAVHSGMWGGLVPDALMTLARLIATLHDDRGDV
AIEGLHAGPAADVDYPEERLRAESGAAPGLEWIGTGSSVERLWTKPALSITGLDAPKVAGASNTLVPAARARISMRVAPG
DTTENALACLVRHLEAHVPWGATLTHTVVDTGEATRIDATGPAYDAARAAFTEAWDGTAPVDMGVGGSIPFIAEFLDAFP
EASVLVTGVEDPDTRAHGANEGLHLAEFERVVLAEALLLGKLGG

Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]

Homologues:

Organism=Homo sapiens, GI271398239, Length=440, Percent_Identity=30.9090909090909, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI21071039, Length=381, Percent_Identity=29.1338582677165, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI271398277, Length=307, Percent_Identity=28.3387622149837, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17563146, Length=482, Percent_Identity=26.7634854771784, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI193211059, Length=450, Percent_Identity=28.2222222222222, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6321159, Length=457, Percent_Identity=25.601750547046, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319758, Length=436, Percent_Identity=26.605504587156, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585880, Length=440, Percent_Identity=29.7727272727273, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005941
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 47133; Mature: 47002

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDIRARVQAVLPGVRRDLEDLVRIESVSADPERAAEVQRSAEAVARLFRDEAFDEVDI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VSADGGAPAVIARKRGPEGAPTVLLYAHHDVQPENDHADWDSPPFEPTERDGRLYARGAA
EECCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
DDKAGIAAHLGALRVYGADVPVSVTMFIEGEEEVGSETLPALLREHQDRLRADVIVIADS
CCCCHHHHHHHHHEEECCCCCEEEEEEEECHHHHCHHHHHHHHHHHHHHHCEEEEEEECC
GNWDIGVPALTTSLRGLVRVDVEVRTLTHAVHSGMWGGLVPDALMTLARLIATLHDDRGD
CCCCCCCHHHHHHHCCEEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC
VAIEGLHAGPAADVDYPEERLRAESGAAPGLEWIGTGSSVERLWTKPALSITGLDAPKVA
EEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCEECCCCHHHHHHCCCCCEEECCCCCCCC
GASNTLVPAARARISMRVAPGDTTENALACLVRHLEAHVPWGATLTHTVVDTGEATRIDA
CCCCCCCHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECC
TGPAYDAARAAFTEAWDGTAPVDMGVGGSIPFIAEFLDAFPEASVLVTGVEDPDTRAHGA
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
NEGLHLAEFERVVLAEALLLGKLGG
CCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDDIRARVQAVLPGVRRDLEDLVRIESVSADPERAAEVQRSAEAVARLFRDEAFDEVDI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VSADGGAPAVIARKRGPEGAPTVLLYAHHDVQPENDHADWDSPPFEPTERDGRLYARGAA
EECCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
DDKAGIAAHLGALRVYGADVPVSVTMFIEGEEEVGSETLPALLREHQDRLRADVIVIADS
CCCCHHHHHHHHHEEECCCCCEEEEEEEECHHHHCHHHHHHHHHHHHHHHCEEEEEEECC
GNWDIGVPALTTSLRGLVRVDVEVRTLTHAVHSGMWGGLVPDALMTLARLIATLHDDRGD
CCCCCCCHHHHHHHCCEEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC
VAIEGLHAGPAADVDYPEERLRAESGAAPGLEWIGTGSSVERLWTKPALSITGLDAPKVA
EEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCEECCCCHHHHHHCCCCCEEECCCCCCCC
GASNTLVPAARARISMRVAPGDTTENALACLVRHLEAHVPWGATLTHTVVDTGEATRIDA
CCCCCCCHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEECC
TGPAYDAARAAFTEAWDGTAPVDMGVGGSIPFIAEFLDAFPEASVLVTGVEDPDTRAHGA
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
NEGLHLAEFERVVLAEALLLGKLGG
CCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA