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The map label for this gene is purM [H]

Identifier: 119718534

GI number: 119718534

Start: 4562133

End: 4563221

Strand: Reverse

Name: purM [H]

Synonym: Noca_4315

Alternate gene names: 119718534

Gene position: 4563221-4562133 (Counterclockwise)

Preceding gene: 119718535

Following gene: 119718533

Centisome position: 91.52

GC content: 73.92

Gene sequence:

>1089_bases
GTGTCCGAGCCCGTTCCTGGCAACGCCTACGCCGCCGCCGGCGTGTCCATCGAGGCCGGTGACAAGGCCGTCGAGCTGAT
GAAGGTGTGGGTCGAGAAGGCTCGGCGGCCGGAGATGATCGGCGGGATCGGTGGGTTCGCGGGCCTGTTCGACGCCTCGG
CCCTGAAGTCCTACACCCGGCCCCTGCTCGCCACGTCCGCCGACGGCGTCGGCACCAAGGTCGCGATCGCCCAGGCTCTC
GACAAGCACGACTCGATCGGCTTCGACCTGGTCGGGATGCTGGTCGACGACCTGGTCGTCTGCGGGGCCGAGCCGCTGTT
CCTCACCGACTACATCGCGACCGGCCGGGTGCTCCCCGAGCGGATCGCCGCGATCGTGAAGGGCATCGCCGAGGCCTGCA
TCGAGGCCGGCTGTGCGCTGCTCGGCGGCGAGACCGCCGAGCATCCCGGGCTGCTCGGACCGGACGAGTACGACGTCGCG
GGCTCGACCACGGGCGTCGTCGACGCGGACGACCTGCTCGGCCCCGGCCGGGTGCGTCCGGGCGACGCGGTCATCGCGAT
GGAGTCCTCCGGGCTGCACTCCAACGGCTACTCGCTGGTGCGGCACGTGCTGCTCGCCCCGACCGACGCCGGCGGCGCCG
GATGGACCCTCGACCGGCAGGTCGACGAGCTCGGTCGCACCCTCGGGGAGGAGCTGCTCGAGCCGACCCGGATCTACACC
CGGGCGTGCCTGGCCCTGGCCCGCGGGACCCGCACCCACGCGATGTCACACATCACCGGCGGCGGCCTGGCCGCCAACCT
CGAGCGGGTGCTCCCCGTGGAGCTCGCCGCGACCCTGGACCGCCGTACCTGGACGCCCGCGCCGGTCTTCGACCTGGTCC
GCCGGGTCGGCGCCGTCCCCCAGCCCGACCTGGAGATGACGCTGAACTGCGGCGTCGGCATGGTCGCGCTCGTCGATCCC
GCGGACGCCGACGCGGCCGTCGCCGTCCTCGGCGAGCACGGCGTGCGCGCCTGGGTGGCCGGGGAGGTCATCGCCGACGC
CGAGCGCGGCGGCCGGGTCGAGCTGGTCGGCCAGCACCCCGGCTGGTGA

Upstream 100 bases:

>100_bases
CCCGACGAGAGCCTGCTCGGCAAGCACCTGCTCGAGTCCTCGATCCAGGCGCCGTCGTACGGCAAGGCGCTGCCCGTCCT
CAACAACCCGTAGGAGCCCC

Downstream 100 bases:

>100_bases
CCCCGCGCCCGGGCCGGTTCTGGTCCGGTTCTGGTCCGGTTCTGGGCCGGTGGGTGACCCCGGCCACGTGAAATGTCGTC
GCGCGGTGTCGAAAGCGCGA

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSEPVPGNAYAAAGVSIEAGDKAVELMKVWVEKARRPEMIGGIGGFAGLFDASALKSYTRPLLATSADGVGTKVAIAQAL
DKHDSIGFDLVGMLVDDLVVCGAEPLFLTDYIATGRVLPERIAAIVKGIAEACIEAGCALLGGETAEHPGLLGPDEYDVA
GSTTGVVDADDLLGPGRVRPGDAVIAMESSGLHSNGYSLVRHVLLAPTDAGGAGWTLDRQVDELGRTLGEELLEPTRIYT
RACLALARGTRTHAMSHITGGGLAANLERVLPVELAATLDRRTWTPAPVFDLVRRVGAVPQPDLEMTLNCGVGMVALVDP
ADADAAVAVLGEHGVRAWVAGEVIADAERGGRVELVGQHPGW

Sequences:

>Translated_362_residues
MSEPVPGNAYAAAGVSIEAGDKAVELMKVWVEKARRPEMIGGIGGFAGLFDASALKSYTRPLLATSADGVGTKVAIAQAL
DKHDSIGFDLVGMLVDDLVVCGAEPLFLTDYIATGRVLPERIAAIVKGIAEACIEAGCALLGGETAEHPGLLGPDEYDVA
GSTTGVVDADDLLGPGRVRPGDAVIAMESSGLHSNGYSLVRHVLLAPTDAGGAGWTLDRQVDELGRTLGEELLEPTRIYT
RACLALARGTRTHAMSHITGGGLAANLERVLPVELAATLDRRTWTPAPVFDLVRRVGAVPQPDLEMTLNCGVGMVALVDP
ADADAAVAVLGEHGVRAWVAGEVIADAERGGRVELVGQHPGW
>Mature_361_residues
SEPVPGNAYAAAGVSIEAGDKAVELMKVWVEKARRPEMIGGIGGFAGLFDASALKSYTRPLLATSADGVGTKVAIAQALD
KHDSIGFDLVGMLVDDLVVCGAEPLFLTDYIATGRVLPERIAAIVKGIAEACIEAGCALLGGETAEHPGLLGPDEYDVAG
STTGVVDADDLLGPGRVRPGDAVIAMESSGLHSNGYSLVRHVLLAPTDAGGAGWTLDRQVDELGRTLGEELLEPTRIYTR
ACLALARGTRTHAMSHITGGGLAANLERVLPVELAATLDRRTWTPAPVFDLVRRVGAVPQPDLEMTLNCGVGMVALVDPA
DADAAVAVLGEHGVRAWVAGEVIADAERGGRVELVGQHPGW

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=347, Percent_Identity=43.2276657060519, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI209869995, Length=347, Percent_Identity=43.2276657060519, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI209869993, Length=347, Percent_Identity=43.2276657060519, Blast_Score=259, Evalue=4e-69,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=44.3148688046647, Blast_Score=279, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17567511, Length=357, Percent_Identity=31.9327731092437, Blast_Score=187, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321203, Length=341, Percent_Identity=42.8152492668622, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24582400, Length=292, Percent_Identity=38.3561643835616, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37545; Mature: 37414

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPVPGNAYAAAGVSIEAGDKAVELMKVWVEKARRPEMIGGIGGFAGLFDASALKSYTR
CCCCCCCCCEEECCCEEECCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHH
PLLATSADGVGTKVAIAQALDKHDSIGFDLVGMLVDDLVVCGAEPLFLTDYIATGRVLPE
HHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHH
RIAAIVKGIAEACIEAGCALLGGETAEHPGLLGPDEYDVAGSTTGVVDADDLLGPGRVRP
HHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCCCCCCC
GDAVIAMESSGLHSNGYSLVRHVLLAPTDAGGAGWTLDRQVDELGRTLGEELLEPTRIYT
CCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RACLALARGTRTHAMSHITGGGLAANLERVLPVELAATLDRRTWTPAPVFDLVRRVGAVP
HHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
QPDLEMTLNCGVGMVALVDPADADAAVAVLGEHGVRAWVAGEVIADAERGGRVELVGQHP
CCCCEEEEECCCCEEEEECCCCCCHHEEECCCCCCEEHHHHHHHHHHCCCCEEEEECCCC
GW
CC
>Mature Secondary Structure 
SEPVPGNAYAAAGVSIEAGDKAVELMKVWVEKARRPEMIGGIGGFAGLFDASALKSYTR
CCCCCCCCEEECCCEEECCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHH
PLLATSADGVGTKVAIAQALDKHDSIGFDLVGMLVDDLVVCGAEPLFLTDYIATGRVLPE
HHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHH
RIAAIVKGIAEACIEAGCALLGGETAEHPGLLGPDEYDVAGSTTGVVDADDLLGPGRVRP
HHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCCCCCCC
GDAVIAMESSGLHSNGYSLVRHVLLAPTDAGGAGWTLDRQVDELGRTLGEELLEPTRIYT
CCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RACLALARGTRTHAMSHITGGGLAANLERVLPVELAATLDRRTWTPAPVFDLVRRVGAVP
HHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
QPDLEMTLNCGVGMVALVDPADADAAVAVLGEHGVRAWVAGEVIADAERGGRVELVGQHP
CCCCEEEEECCCCEEEEECCCCCCHHEEECCCCCCEEHHHHHHHHHHCCCCEEEEECCCC
GW
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA