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The map label for this gene is tktB [C]

Identifier: 119718441

GI number: 119718441

Start: 4462968

End: 4463780

Strand: Reverse

Name: tktB [C]

Synonym: Noca_4222

Alternate gene names: 119718441

Gene position: 4463780-4462968 (Counterclockwise)

Preceding gene: 119718442

Following gene: 119718440

Centisome position: 89.53

GC content: 62.24

Gene sequence:

>813_bases
ATGGACGAGGTGACTGCTCCCGAGCTGGCTCGGCGGATCAGAGAGCATGTCCTCCGGATGACCAGTCGCGGGCGCAGCTC
CCACGTCGCCTCCGGCCTATCGGTCGCCGACATCCTCGCGGTTCTGTACGGCGACGTTCTCCGCGTCGATCCGGCAGACC
CCGAGGCGAACGATCGCGATCGATTCGTGATGAGTAAGGGACATGCCGGCGCTGCCGTATATGCAGTGCTCGCCGAGCGT
GGCTTTCTTGAGCGCGAGTCTTTGTTGAGTCACTACCAGAACGGGTCGACATTTTCCGGTCACGTGAGCCATGTCGACGT
ACCGGGGGTCGAGGTGTCGACCGGTTCCCTTGGGCACGGGTTGTCGATCGCAACCGGAATGGCCTGGCGAGCCCGTTCAA
CGGGCGCGACGTGGCGGGCTTACGCCCTACTGAGCGATGGGGAGTGCGACGAAGGGAGTACTTGGGAGGCAGCGCTTTTC
GCCGGTCACCATGGGCTTTCGAACCTTGTGGCCGTGATCGACTACAACAAGTACCAATCGCTCGCGACGACTGACGAGAC
GCTCACCCTCGAGCCATTCGCCGACAAATGGGTTGCGTTCGGCTGGGATGTGGTCGAGGTCGATGGACATGACACGGTGG
AACTGTTCGCTGCTCTGTCGGTCGACCCGAGTCGGCATACTCGCCCTCGGTGCGTACTTGCCCACACGATCAAGGGCAAA
GGCGTGTCGTTCATGGAGAACAACGTGCTCTGGCACTACCGGCCGCCGTCTGAGGATGAGTTGGCGTTGGCGTTGACGGA
GATCGCGACGTGA

Upstream 100 bases:

>100_bases
GCGAGACTATCGCGGTTCTCGAGGAGGTCGGTTTGCGTGATCTCGAATTGCGCCGTTTCGACTTCGACCCGTATATCGGC
TACGCCGTCCTCTGACAGTT

Downstream 100 bases:

>100_bases
GGACGCGGTTCTTCGCTGACCTGCTCGAGGCCGCGCGACTCAATCCCGACATAGTCTTGATTACGGGTGACCTCGGGTTC
GGCGTTGTCGAGCCCTTTGT

Product: transketolase subunit A

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MDEVTAPELARRIREHVLRMTSRGRSSHVASGLSVADILAVLYGDVLRVDPADPEANDRDRFVMSKGHAGAAVYAVLAER
GFLERESLLSHYQNGSTFSGHVSHVDVPGVEVSTGSLGHGLSIATGMAWRARSTGATWRAYALLSDGECDEGSTWEAALF
AGHHGLSNLVAVIDYNKYQSLATTDETLTLEPFADKWVAFGWDVVEVDGHDTVELFAALSVDPSRHTRPRCVLAHTIKGK
GVSFMENNVLWHYRPPSEDELALALTEIAT

Sequences:

>Translated_270_residues
MDEVTAPELARRIREHVLRMTSRGRSSHVASGLSVADILAVLYGDVLRVDPADPEANDRDRFVMSKGHAGAAVYAVLAER
GFLERESLLSHYQNGSTFSGHVSHVDVPGVEVSTGSLGHGLSIATGMAWRARSTGATWRAYALLSDGECDEGSTWEAALF
AGHHGLSNLVAVIDYNKYQSLATTDETLTLEPFADKWVAFGWDVVEVDGHDTVELFAALSVDPSRHTRPRCVLAHTIKGK
GVSFMENNVLWHYRPPSEDELALALTEIAT
>Mature_270_residues
MDEVTAPELARRIREHVLRMTSRGRSSHVASGLSVADILAVLYGDVLRVDPADPEANDRDRFVMSKGHAGAAVYAVLAER
GFLERESLLSHYQNGSTFSGHVSHVDVPGVEVSTGSLGHGLSIATGMAWRARSTGATWRAYALLSDGECDEGSTWEAALF
AGHHGLSNLVAVIDYNKYQSLATTDETLTLEPFADKWVAFGWDVVEVDGHDTVELFAALSVDPSRHTRPRCVLAHTIKGK
GVSFMENNVLWHYRPPSEDELALALTEIAT

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=265, Percent_Identity=37.3584905660377, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI4507521, Length=265, Percent_Identity=37.3584905660377, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI133778974, Length=253, Percent_Identity=35.9683794466403, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI225637459, Length=253, Percent_Identity=32.0158102766798, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI225637461, Length=253, Percent_Identity=31.2252964426877, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI225637463, Length=222, Percent_Identity=31.5315315315315, Blast_Score=108, Evalue=4e-24,
Organism=Escherichia coli, GI1788808, Length=273, Percent_Identity=31.8681318681319, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI48994911, Length=273, Percent_Identity=30.7692307692308, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17539652, Length=250, Percent_Identity=38.8, Blast_Score=177, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6325331, Length=242, Percent_Identity=34.297520661157, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319593, Length=230, Percent_Identity=31.304347826087, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45551847, Length=249, Percent_Identity=34.9397590361446, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45550715, Length=249, Percent_Identity=34.9397590361446, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24666278, Length=249, Percent_Identity=35.7429718875502, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24645119, Length=218, Percent_Identity=34.8623853211009, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 29384; Mature: 29384

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEVTAPELARRIREHVLRMTSRGRSSHVASGLSVADILAVLYGDVLRVDPADPEANDRD
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCEEEECCCCCCCCCCC
RFVMSKGHAGAAVYAVLAERGFLERESLLSHYQNGSTFSGHVSHVDVPGVEVSTGSLGHG
EEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCEEEEECCCEEEECCCCCCC
LSIATGMAWRARSTGATWRAYALLSDGECDEGSTWEAALFAGHHGLSNLVAVIDYNKYQS
CCHHCCCEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCCEEEEEECCHHHC
LATTDETLTLEPFADKWVAFGWDVVEVDGHDTVELFAALSVDPSRHTRPRCVLAHTIKGK
CCCCCCEEEECCCCCCHHHCCCEEEEECCCCCEEEEEEECCCCCCCCCCEEEEEEEECCC
GVSFMENNVLWHYRPPSEDELALALTEIAT
CCEEEECCEEEEECCCCCCHHEEEEHHHCC
>Mature Secondary Structure
MDEVTAPELARRIREHVLRMTSRGRSSHVASGLSVADILAVLYGDVLRVDPADPEANDRD
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCEEEECCCCCCCCCCC
RFVMSKGHAGAAVYAVLAERGFLERESLLSHYQNGSTFSGHVSHVDVPGVEVSTGSLGHG
EEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEECCEEEEECCCEEEECCCCCCC
LSIATGMAWRARSTGATWRAYALLSDGECDEGSTWEAALFAGHHGLSNLVAVIDYNKYQS
CCHHCCCEEECCCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCCEEEEEECCHHHC
LATTDETLTLEPFADKWVAFGWDVVEVDGHDTVELFAALSVDPSRHTRPRCVLAHTIKGK
CCCCCCEEEECCCCCCHHHCCCEEEEECCCCCEEEEEEECCCCCCCCCCEEEEEEEECCC
GVSFMENNVLWHYRPPSEDELALALTEIAT
CCEEEECCEEEEECCCCCCHHEEEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]