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The map label for this gene is gmd [H]

Identifier: 119718422

GI number: 119718422

Start: 4441847

End: 4442869

Strand: Reverse

Name: gmd [H]

Synonym: Noca_4203

Alternate gene names: 119718422

Gene position: 4442869-4441847 (Counterclockwise)

Preceding gene: 119718423

Following gene: 119718420

Centisome position: 89.11

GC content: 69.5

Gene sequence:

>1023_bases
GTGGCGAAGACGGCGTTGATCACGGGGATCACGGGGCAGGACGGGTCCTACCTGGCCGAGCTGTTGCTGGCCAAGGGCTA
CGTGGTGCACGGGCTGCGGCGGCGGTCGTCGACGTTCAACAGCTCGCGGATCGAGCATCTCTACCAGGACCCGCACGACC
CGGACACGCGGTTGTTCCTGCACTACGCGGACCTCACGGATGCCGCGAACCTGATCCGGCTGCTGCACCGGATCCAACCG
GACGAGGTCTACAACCTCGCCGGGCAGTCGCACGTGGGCGCCAGCTTCGACGAGCCCGAGCACACGGCGATCACGACGGG
CGTCGGCCCGCTGACGCTGCTGGAGGCGATCCGCACGGTCGGGATCGACTGCCGCTTCTACCAGGCATCCAGCTCGGCGA
TGTACGGCGCCGCGACCGGGGCGCAGGACGAGTGCTCGCCGTTCCGTCCGCTCTCGCCCTACGGCGCCGCGAAGCTGCAC
GCGTACTGGTCGACGGTGACCTATCGCGAGGGCTACGGGATGTTCGCGGTCAGCGGCATCCTCTTCAACCACGAGTCGCC
CCGGCGCGGAGAGACCTTCCTGACCCGGAAGGTGACCCGTGCAGTGGCACGGATCCAGGCGGGGCTCGATGACTTCCTCT
ATCTCGGGAACCTCGAGCCCACCCGCGACTGGGGCTACGCCCCGGAGTACGTCGAGGGGATGTGGCGGATGCTGCAGGCC
GACGAGCCGGACGACTACGTGCTGGCGACCGGCACGTCGTACAGCGTCCGCGACTTCGTGGTCGCGGCCTTCGAGCACGC
CGGCCTCGACTGGGAGAAGCACGTGCGACGCGACGAGCGCTACGTGCGGCCGAACGAGAACCCGTCGCTGGTCGGCGACG
CGTCCAAGGCCGAGGCGAGACTCGGCTGGAAGGCGCACGTGAACGCGGACGAGCTCGTGCGGCTGATGGTCGACGCCGAC
GTCCAGGCAGTGGCCAGCGAGGGCCGGCCCTGGATCGACACCCCGCCGCCGAGCGTGGGCTGA

Upstream 100 bases:

>100_bases
CCAGAGGTGGATGCTCGTCGCTGGCGCTCCTCGCACCTCAAGCACCGCGGTTCGCTCGCACCTCACCCACCGTGAACGCC
GGTGTGGAACGATTCTGGGC

Downstream 100 bases:

>100_bases
GCTACGCCGGCACCGCACCGATCGCGACGCGGCCGTCGCCGCCAATCCGCAGCGGGCCGGCGTCGTGGGGCACGAACAGC
GCCTCCCCCTGCACGAGGCG

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAKTALITGITGQDGSYLAELLLAKGYVVHGLRRRSSTFNSSRIEHLYQDPHDPDTRLFLHYADLTDAANLIRLLHRIQP
DEVYNLAGQSHVGASFDEPEHTAITTGVGPLTLLEAIRTVGIDCRFYQASSSAMYGAATGAQDECSPFRPLSPYGAAKLH
AYWSTVTYREGYGMFAVSGILFNHESPRRGETFLTRKVTRAVARIQAGLDDFLYLGNLEPTRDWGYAPEYVEGMWRMLQA
DEPDDYVLATGTSYSVRDFVVAAFEHAGLDWEKHVRRDERYVRPNENPSLVGDASKAEARLGWKAHVNADELVRLMVDAD
VQAVASEGRPWIDTPPPSVG

Sequences:

>Translated_340_residues
MAKTALITGITGQDGSYLAELLLAKGYVVHGLRRRSSTFNSSRIEHLYQDPHDPDTRLFLHYADLTDAANLIRLLHRIQP
DEVYNLAGQSHVGASFDEPEHTAITTGVGPLTLLEAIRTVGIDCRFYQASSSAMYGAATGAQDECSPFRPLSPYGAAKLH
AYWSTVTYREGYGMFAVSGILFNHESPRRGETFLTRKVTRAVARIQAGLDDFLYLGNLEPTRDWGYAPEYVEGMWRMLQA
DEPDDYVLATGTSYSVRDFVVAAFEHAGLDWEKHVRRDERYVRPNENPSLVGDASKAEARLGWKAHVNADELVRLMVDAD
VQAVASEGRPWIDTPPPSVG
>Mature_339_residues
AKTALITGITGQDGSYLAELLLAKGYVVHGLRRRSSTFNSSRIEHLYQDPHDPDTRLFLHYADLTDAANLIRLLHRIQPD
EVYNLAGQSHVGASFDEPEHTAITTGVGPLTLLEAIRTVGIDCRFYQASSSAMYGAATGAQDECSPFRPLSPYGAAKLHA
YWSTVTYREGYGMFAVSGILFNHESPRRGETFLTRKVTRAVARIQAGLDDFLYLGNLEPTRDWGYAPEYVEGMWRMLQAD
EPDDYVLATGTSYSVRDFVVAAFEHAGLDWEKHVRRDERYVRPNENPSLVGDASKAEARLGWKAHVNADELVRLMVDADV
QAVASEGRPWIDTPPPSVG

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=340, Percent_Identity=53.5294117647059, Blast_Score=358, Evalue=5e-99,
Organism=Escherichia coli, GI1788366, Length=353, Percent_Identity=52.1246458923513, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI48994969, Length=190, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539424, Length=345, Percent_Identity=53.6231884057971, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133901788, Length=345, Percent_Identity=53.6231884057971, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133901790, Length=345, Percent_Identity=53.6231884057971, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17539422, Length=345, Percent_Identity=53.6231884057971, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133901786, Length=345, Percent_Identity=53.6231884057971, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17507723, Length=340, Percent_Identity=52.6470588235294, Blast_Score=353, Evalue=7e-98,
Organism=Drosophila melanogaster, GI24158427, Length=341, Percent_Identity=51.3196480938416, Blast_Score=348, Evalue=3e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 37781; Mature: 37649

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTALITGITGQDGSYLAELLLAKGYVVHGLRRRSSTFNSSRIEHLYQDPHDPDTRLFL
CCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEE
HYADLTDAANLIRLLHRIQPDEVYNLAGQSHVGASFDEPEHTAITTGVGPLTLLEAIRTV
EECCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHH
GIDCRFYQASSSAMYGAATGAQDECSPFRPLSPYGAAKLHAYWSTVTYREGYGMFAVSGI
CCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEECCCCEEEEEEE
LFNHESPRRGETFLTRKVTRAVARIQAGLDDFLYLGNLEPTRDWGYAPEYVEGMWRMLQA
EECCCCCCCCHHHHHHHHHHHHHHHHHCHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHC
DEPDDYVLATGTSYSVRDFVVAAFEHAGLDWEKHVRRDERYVRPNENPSLVGDASKAEAR
CCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEECCCCHHHHH
LGWKAHVNADELVRLMVDADVQAVASEGRPWIDTPPPSVG
CCEEEECCHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKTALITGITGQDGSYLAELLLAKGYVVHGLRRRSSTFNSSRIEHLYQDPHDPDTRLFL
CCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEE
HYADLTDAANLIRLLHRIQPDEVYNLAGQSHVGASFDEPEHTAITTGVGPLTLLEAIRTV
EECCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHH
GIDCRFYQASSSAMYGAATGAQDECSPFRPLSPYGAAKLHAYWSTVTYREGYGMFAVSGI
CCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEECCCCEEEEEEE
LFNHESPRRGETFLTRKVTRAVARIQAGLDDFLYLGNLEPTRDWGYAPEYVEGMWRMLQA
EECCCCCCCCHHHHHHHHHHHHHHHHHCHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHC
DEPDDYVLATGTSYSVRDFVVAAFEHAGLDWEKHVRRDERYVRPNENPSLVGDASKAEAR
CCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEECCCCHHHHH
LGWKAHVNADELVRLMVDADVQAVASEGRPWIDTPPPSVG
CCEEEECCHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]