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The map label for this gene is livM [H]

Identifier: 119718333

GI number: 119718333

Start: 4344709

End: 4345674

Strand: Reverse

Name: livM [H]

Synonym: Noca_4114

Alternate gene names: 119718333

Gene position: 4345674-4344709 (Counterclockwise)

Preceding gene: 119718334

Following gene: 119718332

Centisome position: 87.16

GC content: 69.77

Gene sequence:

>966_bases
ATGAGAGCCATCGCCCTGCGCCGTTCCGCGCTCGCCTTCGCCTGCGCCGTGGTGCTCCTGGTCCTCGCGTTCAACGTCCC
CGACAACCGGGTCGTCCTGTTCAACACCTTCCTGGCGTACGGCGCCCTGGTGCTGAGCCTCGACCTCATGGTCGGCAACC
TCAACCTGCTGCCCGCCGGTCACGCGGCGTTCTTCGGAGCCGGCGCGTACGCCTCGGTCGTGCTGAACCAGACCGCGGGC
TGGCCGCTCCCGATCGCCGGCCTGGTGGCCATGGTCGGTTGCGGTCTGTTCGCGGCCGTGATCGGCCTGCCCGTGGTCGG
GCGGACGGCCGGGATGTCGTTCGCGATCGTCACGTTCGCGATCGGCGAGCTGATGGTGCGCGTCGTCGCCAAGTCACCGG
ATCTCCTGGGCGGCACGGAGGGGCTGACGGTCTCGTGGGGAGTAGGCGAGGACATGCCGTTCGGCTTCACCATCTACCGC
TACTTCTCGCTGTGGCTCGTCGCCGTCTTCGTCCTCGTGCTGCTGGTCGTGATCTGGATCCGGAGCTCCCACCTGGGGCT
CCGCCTCACCGCGATCCGCGACGACGAGAACGCCACCCGCGGCCTCGGCATCAACCCGGTCGCCTACAAGACCGTGGTCT
TCGGCATCAGCTCCGGACTGGCGGCCGCCGTCGGTGTCGCGTGGGCACCGATGGTCGGCTACATCGGACCGGACTCCATG
GCGACCGGCGAGTCGATCTTCCTGCTCAGCCTGCTCATCGTCGGCGGCATCCGGTCGGTCGGCGGTGCGCTGGCCGGCGT
CCTGCTGCTGATGATCCTGCCGCTCTACCTCGAGATCGAGCCGGCGGCACGGATCGCCTTCGTCGGCGGCGCTCTCGCCC
TGATCGCGCTGATCGAGCCCGGCGGCATCGCCGGCCTCGCCCGACGGGCCCGTGCCCTCCTCGCCCGTCCCAGGATTCCC
GCATGA

Upstream 100 bases:

>100_bases
CCGACCCGTCGATGACCAGCGTCTACACGTTCACGGCGATGATCGTCGTGCTGCTCCTGATGCCGCAGGGCATCTTCAAC
CGGAAGCAGGTCCGAGCCGG

Downstream 100 bases:

>100_bases
GTACGTCCACCACCGGCCCGGTCGTCGAGCCCTCCGTCGTACCCTCCGTCGAGCCCGTCCTCGAGCTGCACGGCATCACC
GTTCGACTCGGCGGCGTCGA

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MRAIALRRSALAFACAVVLLVLAFNVPDNRVVLFNTFLAYGALVLSLDLMVGNLNLLPAGHAAFFGAGAYASVVLNQTAG
WPLPIAGLVAMVGCGLFAAVIGLPVVGRTAGMSFAIVTFAIGELMVRVVAKSPDLLGGTEGLTVSWGVGEDMPFGFTIYR
YFSLWLVAVFVLVLLVVIWIRSSHLGLRLTAIRDDENATRGLGINPVAYKTVVFGISSGLAAAVGVAWAPMVGYIGPDSM
ATGESIFLLSLLIVGGIRSVGGALAGVLLLMILPLYLEIEPAARIAFVGGALALIALIEPGGIAGLARRARALLARPRIP
A

Sequences:

>Translated_321_residues
MRAIALRRSALAFACAVVLLVLAFNVPDNRVVLFNTFLAYGALVLSLDLMVGNLNLLPAGHAAFFGAGAYASVVLNQTAG
WPLPIAGLVAMVGCGLFAAVIGLPVVGRTAGMSFAIVTFAIGELMVRVVAKSPDLLGGTEGLTVSWGVGEDMPFGFTIYR
YFSLWLVAVFVLVLLVVIWIRSSHLGLRLTAIRDDENATRGLGINPVAYKTVVFGISSGLAAAVGVAWAPMVGYIGPDSM
ATGESIFLLSLLIVGGIRSVGGALAGVLLLMILPLYLEIEPAARIAFVGGALALIALIEPGGIAGLARRARALLARPRIP
A
>Mature_321_residues
MRAIALRRSALAFACAVVLLVLAFNVPDNRVVLFNTFLAYGALVLSLDLMVGNLNLLPAGHAAFFGAGAYASVVLNQTAG
WPLPIAGLVAMVGCGLFAAVIGLPVVGRTAGMSFAIVTFAIGELMVRVVAKSPDLLGGTEGLTVSWGVGEDMPFGFTIYR
YFSLWLVAVFVLVLLVVIWIRSSHLGLRLTAIRDDENATRGLGINPVAYKTVVFGISSGLAAAVGVAWAPMVGYIGPDSM
ATGESIFLLSLLIVGGIRSVGGALAGVLLLMILPLYLEIEPAARIAFVGGALALIALIEPGGIAGLARRARALLARPRIP
A

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=298, Percent_Identity=28.1879194630872, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 33325; Mature: 33325

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAIALRRSALAFACAVVLLVLAFNVPDNRVVLFNTFLAYGALVLSLDLMVGNLNLLPAG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEECCCC
HAAFFGAGAYASVVLNQTAGWPLPIAGLVAMVGCGLFAAVIGLPVVGRTAGMSFAIVTFA
CHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
IGELMVRVVAKSPDLLGGTEGLTVSWGVGEDMPFGFTIYRYFSLWLVAVFVLVLLVVIWI
HHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RSSHLGLRLTAIRDDENATRGLGINPVAYKTVVFGISSGLAAAVGVAWAPMVGYIGPDSM
CCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
ATGESIFLLSLLIVGGIRSVGGALAGVLLLMILPLYLEIEPAARIAFVGGALALIALIEP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHCCC
GGIAGLARRARALLARPRIPA
CCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRAIALRRSALAFACAVVLLVLAFNVPDNRVVLFNTFLAYGALVLSLDLMVGNLNLLPAG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEECCCC
HAAFFGAGAYASVVLNQTAGWPLPIAGLVAMVGCGLFAAVIGLPVVGRTAGMSFAIVTFA
CHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
IGELMVRVVAKSPDLLGGTEGLTVSWGVGEDMPFGFTIYRYFSLWLVAVFVLVLLVVIWI
HHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RSSHLGLRLTAIRDDENATRGLGINPVAYKTVVFGISSGLAAAVGVAWAPMVGYIGPDSM
CCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
ATGESIFLLSLLIVGGIRSVGGALAGVLLLMILPLYLEIEPAARIAFVGGALALIALIEP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHCCC
GGIAGLARRARALLARPRIPA
CCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]