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The map label for this gene is cysS

Identifier: 119718240

GI number: 119718240

Start: 4246125

End: 4247540

Strand: Reverse

Name: cysS

Synonym: Noca_4021

Alternate gene names: 119718240

Gene position: 4247540-4246125 (Counterclockwise)

Preceding gene: 119718242

Following gene: 119718239

Centisome position: 85.19

GC content: 70.41

Gene sequence:

>1416_bases
GTGACCTTCCGGCTGTACGACACCGCGACCCGCGAAGTCCGTGACTTCGTCCCCCTCGAGGAGGGGAAGGCGGGTCTCTA
CGTCTGCGGTCTCACCGTGCAGTCCGAGCCGCACGTCGGGCACGTCCGCTCGGGCGTGAACTTCGACGTGCTGCAGCGCT
GGCTGCGCCACCTCGGCTACGACGTCACGTTCATCCGCAACGTGACCGACATCGACGACAAGATCCTGGTCAAGTCGGCC
GAGCAGGGCCTGGCGTGGTACCAGCTGGCCTACCGGATGAAGCGCCAGCTCGACCGGGCGTACGACGACCTCAACGTGGC
GCCGCCGACCTACGAGCCGGCCGCCACCGGGCACGTGCCCGAGATGATCGTGCTGATCCAGGAGCTGATCGCCAAGGGGC
ACGCGTACGCCGCCGAGGACGGCTCGGGCGACGTCTACTTCGACGTGCGGTCCTGGCCGCAATACGGCGAGCTGACCCGG
CAGGGCATCGACGACATGGAGGCGGCCGAGGACGCCGACCCCCGTGGCAAGCGCGACCCGCGCGACTTCGCGCTGTGGAA
GGGCTGGAAGAAGGACTCGGAGCCGGAGACAGCCGCCTGGCCGAGCCCGTGGGGCCCGGGACGCCCGGGCTGGCACATCG
AGTGCTCGGCGATGGCGGGCAAGTACCTCGGCCCCGCCTTCGACATCCACGGCGGCGGCGTCGACCTGCGGTTCCCGCAC
CACGAGAACGAGCAGGCCCAGTCGCGCGCGGCCGGCCGGCCGTTCGCGACGTACTGGATGCACAACGCGTGGATCACCAC
GGCGGGCGAGAAGATGAGCAAGTCGCTCGGCAACTCGCTGACGATCCCGGCCGTGCTCCAGAAGTACCGCGGCATCGAGC
TGCGCTACTACCTGGTCGCCGCGCACTACCGCAGCCACGTGGAGTTCAGCTTCGAGGCGCTCGACGAGGCCGCCACGGGG
TTCCGCCGGATCGAGAACTTCCTCGACCGCGCCGCCGACGTGCTCGGCGGGATCGGCGGCGGCATCGCCTGCGCCGACTT
CCTCAACGCGATGAACGACGACCTCGGCACCCCCGCAGCCGTCGCCGCGATCCACGAGGTGGTGCGCGAGGGCAACAAGC
TCCTGGCCGCGGGGGACTCGCCCGCGCTGCGCGGCAACGCCGCGTCGGTGGTCGCGATGCTCGACGTGCTCGGCCTGGAC
CCGGCCGACCCGGCATGGAGCTCCCCAGGAGGCGGCCGGACGGCCGAACGTCTCGAGACCGTGGTCGAGGGGCTGGTCTC
GGACTTGCTCACCCAACGGGAGAAGGCCCGTGCCGACCGAGACTTCGTGTCGGCGGATGCGATCCGGGACCGACTGCATG
CGGTCGGCGTCCAGCTCGAAGACACCCCCGACGGACCGAAGTGGAGCCTCTCCTAG

Upstream 100 bases:

>100_bases
TGCCGCGTCGGCGGGTGGGAGTGCCACGCCGGGCAGGAGCGCCGCAGCGAGCGCGATCACGGATGTCAGTCGGCGCACCC
ACAAACCCTAGACTTCCTGG

Downstream 100 bases:

>100_bases
TCATGGCAGGCAACAGCCAGCGCAAGGGCGCGATCAAGAAGTCCGGCAAGGGCAACCCCACCGCCGGCTCCGGCGGCCGG
GTCCGCCGCGGCCTGGAGGG

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTFRLYDTATREVRDFVPLEEGKAGLYVCGLTVQSEPHVGHVRSGVNFDVLQRWLRHLGYDVTFIRNVTDIDDKILVKSA
EQGLAWYQLAYRMKRQLDRAYDDLNVAPPTYEPAATGHVPEMIVLIQELIAKGHAYAAEDGSGDVYFDVRSWPQYGELTR
QGIDDMEAAEDADPRGKRDPRDFALWKGWKKDSEPETAAWPSPWGPGRPGWHIECSAMAGKYLGPAFDIHGGGVDLRFPH
HENEQAQSRAAGRPFATYWMHNAWITTAGEKMSKSLGNSLTIPAVLQKYRGIELRYYLVAAHYRSHVEFSFEALDEAATG
FRRIENFLDRAADVLGGIGGGIACADFLNAMNDDLGTPAAVAAIHEVVREGNKLLAAGDSPALRGNAASVVAMLDVLGLD
PADPAWSSPGGGRTAERLETVVEGLVSDLLTQREKARADRDFVSADAIRDRLHAVGVQLEDTPDGPKWSLS

Sequences:

>Translated_471_residues
MTFRLYDTATREVRDFVPLEEGKAGLYVCGLTVQSEPHVGHVRSGVNFDVLQRWLRHLGYDVTFIRNVTDIDDKILVKSA
EQGLAWYQLAYRMKRQLDRAYDDLNVAPPTYEPAATGHVPEMIVLIQELIAKGHAYAAEDGSGDVYFDVRSWPQYGELTR
QGIDDMEAAEDADPRGKRDPRDFALWKGWKKDSEPETAAWPSPWGPGRPGWHIECSAMAGKYLGPAFDIHGGGVDLRFPH
HENEQAQSRAAGRPFATYWMHNAWITTAGEKMSKSLGNSLTIPAVLQKYRGIELRYYLVAAHYRSHVEFSFEALDEAATG
FRRIENFLDRAADVLGGIGGGIACADFLNAMNDDLGTPAAVAAIHEVVREGNKLLAAGDSPALRGNAASVVAMLDVLGLD
PADPAWSSPGGGRTAERLETVVEGLVSDLLTQREKARADRDFVSADAIRDRLHAVGVQLEDTPDGPKWSLS
>Mature_470_residues
TFRLYDTATREVRDFVPLEEGKAGLYVCGLTVQSEPHVGHVRSGVNFDVLQRWLRHLGYDVTFIRNVTDIDDKILVKSAE
QGLAWYQLAYRMKRQLDRAYDDLNVAPPTYEPAATGHVPEMIVLIQELIAKGHAYAAEDGSGDVYFDVRSWPQYGELTRQ
GIDDMEAAEDADPRGKRDPRDFALWKGWKKDSEPETAAWPSPWGPGRPGWHIECSAMAGKYLGPAFDIHGGGVDLRFPHH
ENEQAQSRAAGRPFATYWMHNAWITTAGEKMSKSLGNSLTIPAVLQKYRGIELRYYLVAAHYRSHVEFSFEALDEAATGF
RRIENFLDRAADVLGGIGGGIACADFLNAMNDDLGTPAAVAAIHEVVREGNKLLAAGDSPALRGNAASVVAMLDVLGLDP
ADPAWSSPGGGRTAERLETVVEGLVSDLLTQREKARADRDFVSADAIRDRLHAVGVQLEDTPDGPKWSLS

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=464, Percent_Identity=33.4051724137931, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI10835051, Length=414, Percent_Identity=32.1256038647343, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI21269877, Length=465, Percent_Identity=31.3978494623656, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI62240992, Length=465, Percent_Identity=31.3978494623656, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI303304987, Length=465, Percent_Identity=31.3978494623656, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1786737, Length=468, Percent_Identity=43.5897435897436, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17509795, Length=480, Percent_Identity=31.875, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17509797, Length=480, Percent_Identity=31.875, Blast_Score=182, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324082, Length=408, Percent_Identity=33.3333333333333, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI19922218, Length=357, Percent_Identity=37.5350140056022, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI19922364, Length=426, Percent_Identity=34.9765258215962, Blast_Score=182, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_NOCSJ (A1SNY3)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_925205.1
- ProteinModelPortal:   A1SNY3
- SMR:   A1SNY3
- STRING:   A1SNY3
- GeneID:   4598157
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_4021
- eggNOG:   COG0215
- HOGENOM:   HBG327651
- OMA:   DFDALNM
- PhylomeDB:   A1SNY3
- ProtClustDB:   PRK00260
- BioCyc:   NSP35761:NOCA_4021-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 51888; Mature: 51756

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFRLYDTATREVRDFVPLEEGKAGLYVCGLTVQSEPHVGHVRSGVNFDVLQRWLRHLGY
CEEEEECHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCHHHHCCCCHHHHHHHHHHCCC
DVTFIRNVTDIDDKILVKSAEQGLAWYQLAYRMKRQLDRAYDDLNVAPPTYEPAATGHVP
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
EMIVLIQELIAKGHAYAAEDGSGDVYFDVRSWPQYGELTRQGIDDMEAAEDADPRGKRDP
HHHHHHHHHHHCCCCEECCCCCCCEEEEECCCCCHHHHHHHCCCHHHHHCCCCCCCCCCC
RDFALWKGWKKDSEPETAAWPSPWGPGRPGWHIECSAMAGKYLGPAFDIHGGGVDLRFPH
CHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCCEEECCCCEEEECCC
HENEQAQSRAAGRPFATYWMHNAWITTAGEKMSKSLGNSLTIPAVLQKYRGIELRYYLVA
CCCHHHHHHHCCCCHHHHHEECCEEECCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEEE
AHYRSHVEFSFEALDEAATGFRRIENFLDRAADVLGGIGGGIACADFLNAMNDDLGTPAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHH
VAAIHEVVREGNKLLAAGDSPALRGNAASVVAMLDVLGLDPADPAWSSPGGGRTAERLET
HHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
VVEGLVSDLLTQREKARADRDFVSADAIRDRLHAVGVQLEDTPDGPKWSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCC
>Mature Secondary Structure 
TFRLYDTATREVRDFVPLEEGKAGLYVCGLTVQSEPHVGHVRSGVNFDVLQRWLRHLGY
EEEEECHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCHHHHCCCCHHHHHHHHHHCCC
DVTFIRNVTDIDDKILVKSAEQGLAWYQLAYRMKRQLDRAYDDLNVAPPTYEPAATGHVP
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
EMIVLIQELIAKGHAYAAEDGSGDVYFDVRSWPQYGELTRQGIDDMEAAEDADPRGKRDP
HHHHHHHHHHHCCCCEECCCCCCCEEEEECCCCCHHHHHHHCCCHHHHHCCCCCCCCCCC
RDFALWKGWKKDSEPETAAWPSPWGPGRPGWHIECSAMAGKYLGPAFDIHGGGVDLRFPH
CHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCCEEECCCCEEEECCC
HENEQAQSRAAGRPFATYWMHNAWITTAGEKMSKSLGNSLTIPAVLQKYRGIELRYYLVA
CCCHHHHHHHCCCCHHHHHEECCEEECCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEEE
AHYRSHVEFSFEALDEAATGFRRIENFLDRAADVLGGIGGGIACADFLNAMNDDLGTPAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHH
VAAIHEVVREGNKLLAAGDSPALRGNAASVVAMLDVLGLDPADPAWSSPGGGRTAERLET
HHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
VVEGLVSDLLTQREKARADRDFVSADAIRDRLHAVGVQLEDTPDGPKWSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA