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The map label for this gene is adhC [C]

Identifier: 119717873

GI number: 119717873

Start: 3875558

End: 3876655

Strand: Reverse

Name: adhC [C]

Synonym: Noca_3651

Alternate gene names: 119717873

Gene position: 3876655-3875558 (Counterclockwise)

Preceding gene: 119717874

Following gene: 119717872

Centisome position: 77.75

GC content: 73.22

Gene sequence:

>1098_bases
ATGCAGCAGGTCAAGGCCGTGATCGCCCGCGGCAAGGGGCAACCCGTCGAGGTGACCACCATCAACGTGCCCGACCCGGG
CCCGGGCGAGGCACTCGTCCAGGTGCAGGCCTGCGGGGTCTGCCACACCGACCTGCACTACCGCGAGGGCGGCATCAACG
ACGACTTCCCGTTCCTCCTCGGTCACGAGGCCGCCGGCGTCGTCGAGGCGGTCGGCCCGGACGTGACGGCCATCGCCCCG
GGCGACTTCGTGATCCTGAACTGGCGGGCCGTGTGCGGCGAGTGCCGGGCCTGCGAGCGCGGCGAGCCGTGGTACTGCTT
CGCGACCCACAACGCCACCCAGCGGATGACCCTCGCCGAGGGTCCCGACGCCGGCACCGAGCTCGCGCCGGCCCTCGGGA
TCGGCGCGTTCGCCGAGAAGACCCTGGTCGCGGCCGGCCAGTGCACGAAGGTCGACCCGTCGGCCCGGCCGGCCGCCGTC
GGGCTGCTCGGCTGCGGGGTGATGGCGGGGATCGGAGCCGCGATCAACACCGGCGCGGTCACCCGCGGGAAGTCCGTCGC
GGTCATCGGCTGCGGCGGCGTCGGCGTGGCCGCGATCGCCGGCTCGGCGCTCGCCGGGGCCTCGCCGATCATCGCGGTCG
ACATCGACGCCCAGAAGCTGGAGGCCGCGCGCCGGATGGGCGCCACCCACGTCGTCGACTCCAGCCGGACCGACCCGGTC
GCGGCGATCCAGGAGCTCACCGGCGGCTTCGGCGCGGACGTCGTCATCGAGGCCGTCGGCCGCCCGGAGACCTGGAAGCA
GGCGTTCTACGCCCGCGACCTGGCCGGCACGGTGGTGCTGGTCGGCGTACCGACGCCCGAGATGAAGGTCCCGGACCTCC
CGCTCATCGACGTCTTCGGCCGGGGCGGGTCGCTGAAGTCGAGCTGGTACGGCGACTGCCTGCCCAGCCGCGACTTCCCG
ATGCTCGTCGACCTCTACCAGCAGGGCCGGCTGGACCTGGACGCCTTCGTCAGCGAGGAGATCGGCATCGGCGACGTCGA
GGCGGCGTTCGAGCGGATGCACGAGGGCGGCGTGTTGCGCTCGGTGGTGATCCTCTGA

Upstream 100 bases:

>100_bases
CGACCAGGAGTAGCAGCACATCGGTGCGCCCGGCCCTGCGCGCACCGGCCCGGATGCGGTTGCATGGTCCCTCACACGCC
GTCCGCGGAGAGGGAGCAGC

Downstream 100 bases:

>100_bases
TGGCCGGGCCGGGCCCGGCGCGGGTCGACCACGCGGTGTCCTCCGGAACGTTCAGCCTCGACGGGGAGACGTTCGAGGTC
GAGAACAACATCTGGGTCGT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MQQVKAVIARGKGQPVEVTTINVPDPGPGEALVQVQACGVCHTDLHYREGGINDDFPFLLGHEAAGVVEAVGPDVTAIAP
GDFVILNWRAVCGECRACERGEPWYCFATHNATQRMTLAEGPDAGTELAPALGIGAFAEKTLVAAGQCTKVDPSARPAAV
GLLGCGVMAGIGAAINTGAVTRGKSVAVIGCGGVGVAAIAGSALAGASPIIAVDIDAQKLEAARRMGATHVVDSSRTDPV
AAIQELTGGFGADVVIEAVGRPETWKQAFYARDLAGTVVLVGVPTPEMKVPDLPLIDVFGRGGSLKSSWYGDCLPSRDFP
MLVDLYQQGRLDLDAFVSEEIGIGDVEAAFERMHEGGVLRSVVIL

Sequences:

>Translated_365_residues
MQQVKAVIARGKGQPVEVTTINVPDPGPGEALVQVQACGVCHTDLHYREGGINDDFPFLLGHEAAGVVEAVGPDVTAIAP
GDFVILNWRAVCGECRACERGEPWYCFATHNATQRMTLAEGPDAGTELAPALGIGAFAEKTLVAAGQCTKVDPSARPAAV
GLLGCGVMAGIGAAINTGAVTRGKSVAVIGCGGVGVAAIAGSALAGASPIIAVDIDAQKLEAARRMGATHVVDSSRTDPV
AAIQELTGGFGADVVIEAVGRPETWKQAFYARDLAGTVVLVGVPTPEMKVPDLPLIDVFGRGGSLKSSWYGDCLPSRDFP
MLVDLYQQGRLDLDAFVSEEIGIGDVEAAFERMHEGGVLRSVVIL
>Mature_365_residues
MQQVKAVIARGKGQPVEVTTINVPDPGPGEALVQVQACGVCHTDLHYREGGINDDFPFLLGHEAAGVVEAVGPDVTAIAP
GDFVILNWRAVCGECRACERGEPWYCFATHNATQRMTLAEGPDAGTELAPALGIGAFAEKTLVAAGQCTKVDPSARPAAV
GLLGCGVMAGIGAAINTGAVTRGKSVAVIGCGGVGVAAIAGSALAGASPIIAVDIDAQKLEAARRMGATHVVDSSRTDPV
AAIQELTGGFGADVVIEAVGRPETWKQAFYARDLAGTVVLVGVPTPEMKVPDLPLIDVFGRGGSLKSSWYGDCLPSRDFP
MLVDLYQQGRLDLDAFVSEEIGIGDVEAAFERMHEGGVLRSVVIL

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=32.972972972973, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=32.4324324324324, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=31.0810810810811, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=31.9783197831978, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=31.9783197831978, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI71565154, Length=377, Percent_Identity=33.6870026525199, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI71565152, Length=380, Percent_Identity=31.8421052631579, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI156523966, Length=373, Percent_Identity=31.0991957104558, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4501939, Length=364, Percent_Identity=31.3186813186813, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI156627571, Length=374, Percent_Identity=25.1336898395722, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=35.3099730458221, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1788073, Length=357, Percent_Identity=27.1708683473389, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081918, Length=288, Percent_Identity=31.5972222222222, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790045, Length=369, Percent_Identity=24.390243902439, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1786518, Length=373, Percent_Identity=28.1501340482574, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788075, Length=357, Percent_Identity=27.7310924369748, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786825, Length=273, Percent_Identity=32.2344322344322, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787863, Length=341, Percent_Identity=25.8064516129032, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790718, Length=355, Percent_Identity=25.6338028169014, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082125, Length=280, Percent_Identity=28.9285714285714, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788407, Length=315, Percent_Identity=23.1746031746032, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI226510992, Length=347, Percent_Identity=24.4956772334294, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=379, Percent_Identity=33.245382585752, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71997431, Length=381, Percent_Identity=33.3333333333333, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17565904, Length=351, Percent_Identity=33.3333333333333, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17562876, Length=364, Percent_Identity=24.1758241758242, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=354, Percent_Identity=25.1412429378531, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=367, Percent_Identity=28.8828337874659, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=365, Percent_Identity=28.2191780821918, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=357, Percent_Identity=27.1708683473389, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=374, Percent_Identity=33.6898395721925, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319621, Length=370, Percent_Identity=29.4594594594595, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6323099, Length=355, Percent_Identity=26.1971830985915, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=365, Percent_Identity=26.3013698630137, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=380, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319955, Length=349, Percent_Identity=26.647564469914, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=349, Percent_Identity=26.647564469914, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=380, Percent_Identity=26.0526315789474, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=297, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=366, Percent_Identity=25.4098360655738, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17737895, Length=376, Percent_Identity=34.5744680851064, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI17137530, Length=342, Percent_Identity=26.6081871345029, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17737897, Length=351, Percent_Identity=27.0655270655271, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 37682; Mature: 37682

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQVKAVIARGKGQPVEVTTINVPDPGPGEALVQVQACGVCHTDLHYREGGINDDFPFLL
CCHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEECCEEECCCEECCCCCCCCCCEEE
GHEAAGVVEAVGPDVTAIAPGDFVILNWRAVCGECRACERGEPWYCFATHNATQRMTLAE
CCCCCCHHHHCCCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCEEEEEECCCCEEEEECC
GPDAGTELAPALGIGAFAEKTLVAAGQCTKVDPSARPAAVGLLGCGVMAGIGAAINTGAV
CCCCCCHHHHHHCCCHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCE
TRGKSVAVIGCGGVGVAAIAGSALAGASPIIAVDIDAQKLEAARRMGATHVVDSSRTDPV
ECCCEEEEEEECCCHHHHHHCCHHCCCCCEEEEECCHHHHHHHHHCCCEEEECCCCCCHH
AAIQELTGGFGADVVIEAVGRPETWKQAFYARDLAGTVVLVGVPTPEMKVPDLPLIDVFG
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEEC
RGGSLKSSWYGDCLPSRDFPMLVDLYQQGRLDLDAFVSEEIGIGDVEAAFERMHEGGVLR
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCE
SVVIL
EEEEC
>Mature Secondary Structure
MQQVKAVIARGKGQPVEVTTINVPDPGPGEALVQVQACGVCHTDLHYREGGINDDFPFLL
CCHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEECCEEECCCEECCCCCCCCCCEEE
GHEAAGVVEAVGPDVTAIAPGDFVILNWRAVCGECRACERGEPWYCFATHNATQRMTLAE
CCCCCCHHHHCCCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCEEEEEECCCCEEEEECC
GPDAGTELAPALGIGAFAEKTLVAAGQCTKVDPSARPAAVGLLGCGVMAGIGAAINTGAV
CCCCCCHHHHHHCCCHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCE
TRGKSVAVIGCGGVGVAAIAGSALAGASPIIAVDIDAQKLEAARRMGATHVVDSSRTDPV
ECCCEEEEEEECCCHHHHHHCCHHCCCCCEEEEECCHHHHHHHHHCCCEEEECCCCCCHH
AAIQELTGGFGADVVIEAVGRPETWKQAFYARDLAGTVVLVGVPTPEMKVPDLPLIDVFG
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEEC
RGGSLKSSWYGDCLPSRDFPMLVDLYQQGRLDLDAFVSEEIGIGDVEAAFERMHEGGVLR
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCE
SVVIL
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]