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The map label for this gene is guaB [C]

Identifier: 119717862

GI number: 119717862

Start: 3862277

End: 3863383

Strand: Reverse

Name: guaB [C]

Synonym: Noca_3640

Alternate gene names: 119717862

Gene position: 3863383-3862277 (Counterclockwise)

Preceding gene: 119717863

Following gene: 119717861

Centisome position: 77.49

GC content: 72.09

Gene sequence:

>1107_bases
GTGACCGACATCGAGATCGGCCGGGCCAAGCGGGCCCGGCATGCGTACTCCTTCGACGACATCGCGATCGTGCCGTCCCG
GCGCACCCGCGACCCGGAGGAGGTGAGCACCGCCTGGCAGATCGACGCCTACCGCTTCGACATCCCGGTGCTCGCGGCGC
CGATGGACTCGGTGATGTCGCCCGGGACGGCGATCGCACTGGGTCGCTTCGGTGGGCTCGGCGTGCTCAACCTCGAGGGC
CTGTGGACGCGCTACGAGGACCCGGACCCGCTGCTCGAGGAGGTCGCCGCGCTCGAGGGCAGCGAGGGCACCCGCCGGCT
CCAGCAGATGTACACCGAGCCGATCAAGGCCGAGCTGATCACCGAGCGGCTGCGCGAGATCCGCGACGCGGGGGTCACCG
TCGCCGGGTCGCTCTCGCCCGGGCGCACCAAGGACTTCGCGAAGGCGGTCGTCGACGCCGGCGTCGACATGTTCGTGATC
AGGGGTACGACGGTGTCCGCGGAGCACGTGTCCTCCCAGGCCGAGCCGTTGAACCTCAAGGAGTTCATCTACGAGCTCGA
CGTGCCGGTGGTCGTCGGCGGCTGCGCGACCCACCAGGCCGCGCTGCACCTGATGCGCACGGGCGCGGCCGGCGTCCTGG
TCGGCTTCGGCGGAGGAGCCGCGCACACGACCCGGACCGTGCTCGGGGTCGCGGTGCCGATGGCGTCCGCGGTCGCCGAC
GTCGCCGCCGCGCGCCGCGACTACCTCGACGAGTCCGGCGGCCGCTACGTCCACGTGATCGCGGACGGCTCGATCGGCAA
GTCCGGCGACGTCGCGAAGGCGATCGCCTGCGGCGCCGACGCCGTGATGGTCGGCTCACCGTTCGCGCGGGCCACCGACG
CCCCCGGACGCGGGTTCCACTGGGGCACCGAGGCCCACCACCACGACCTGCCCCGCGGCCAGCGGGTGCAGTTCGAGACC
GTCGGGACGATCGAGGAGATCCTGTTCGGCCCGTCCCGGGTCGCCGACGGCACGATGAACCTGATGGGCGCGCTGCGCCG
CTCGATGGCGACCACCGGCTACACCGAGCTCAAGGAGTTCCAGCGCGTCGAGATCGTCGTCGAGTGA

Upstream 100 bases:

>100_bases
GACGATGGCCCGGCGCGTCGCCGCTCGCGACGGTTGACCTACCAGATCCGAGGATCTGGGCCCCGCGACCGGTTGCCGCC
GGTCTCGATAGAGTTGATCG

Downstream 100 bases:

>100_bases
GGCCGGCGTGAGGGTCGCGGCCGGGCAGGCGGTCTCGGTCAGCGGCGACCTCGACGCGAACGTGCGCACGGCCGCGCGGC
TCACCCGGCTCGCCGCGACC

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MTDIEIGRAKRARHAYSFDDIAIVPSRRTRDPEEVSTAWQIDAYRFDIPVLAAPMDSVMSPGTAIALGRFGGLGVLNLEG
LWTRYEDPDPLLEEVAALEGSEGTRRLQQMYTEPIKAELITERLREIRDAGVTVAGSLSPGRTKDFAKAVVDAGVDMFVI
RGTTVSAEHVSSQAEPLNLKEFIYELDVPVVVGGCATHQAALHLMRTGAAGVLVGFGGGAAHTTRTVLGVAVPMASAVAD
VAAARRDYLDESGGRYVHVIADGSIGKSGDVAKAIACGADAVMVGSPFARATDAPGRGFHWGTEAHHHDLPRGQRVQFET
VGTIEEILFGPSRVADGTMNLMGALRRSMATTGYTELKEFQRVEIVVE

Sequences:

>Translated_368_residues
MTDIEIGRAKRARHAYSFDDIAIVPSRRTRDPEEVSTAWQIDAYRFDIPVLAAPMDSVMSPGTAIALGRFGGLGVLNLEG
LWTRYEDPDPLLEEVAALEGSEGTRRLQQMYTEPIKAELITERLREIRDAGVTVAGSLSPGRTKDFAKAVVDAGVDMFVI
RGTTVSAEHVSSQAEPLNLKEFIYELDVPVVVGGCATHQAALHLMRTGAAGVLVGFGGGAAHTTRTVLGVAVPMASAVAD
VAAARRDYLDESGGRYVHVIADGSIGKSGDVAKAIACGADAVMVGSPFARATDAPGRGFHWGTEAHHHDLPRGQRVQFET
VGTIEEILFGPSRVADGTMNLMGALRRSMATTGYTELKEFQRVEIVVE
>Mature_367_residues
TDIEIGRAKRARHAYSFDDIAIVPSRRTRDPEEVSTAWQIDAYRFDIPVLAAPMDSVMSPGTAIALGRFGGLGVLNLEGL
WTRYEDPDPLLEEVAALEGSEGTRRLQQMYTEPIKAELITERLREIRDAGVTVAGSLSPGRTKDFAKAVVDAGVDMFVIR
GTTVSAEHVSSQAEPLNLKEFIYELDVPVVVGGCATHQAALHLMRTGAAGVLVGFGGGAAHTTRTVLGVAVPMASAVADV
AAARRDYLDESGGRYVHVIADGSIGKSGDVAKAIACGADAVMVGSPFARATDAPGRGFHWGTEAHHHDLPRGQRVQFETV
GTIEEILFGPSRVADGTMNLMGALRRSMATTGYTELKEFQRVEIVVE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI156104880, Length=194, Percent_Identity=29.3814432989691, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI66933016, Length=152, Percent_Identity=34.8684210526316, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71994385, Length=179, Percent_Identity=32.9608938547486, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71994389, Length=177, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323464, Length=162, Percent_Identity=29.0123456790123, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323585, Length=162, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322012, Length=162, Percent_Identity=28.3950617283951, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24641071, Length=161, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641073, Length=161, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571163, Length=161, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 39358; Mature: 39227

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIEIGRAKRARHAYSFDDIAIVPSRRTRDPEEVSTAWQIDAYRFDIPVLAAPMDSVMS
CCCCCCCCHHHHHHCCCCCCEEEECCCCCCCHHHHHHEEEEEEEEECCCEEECCHHHHHC
PGTAIALGRFGGLGVLNLEGLWTRYEDPDPLLEEVAALEGSEGTRRLQQMYTEPIKAELI
CCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHH
TERLREIRDAGVTVAGSLSPGRTKDFAKAVVDAGVDMFVIRGTTVSAEHVSSQAEPLNLK
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCEECHHHHCCCCCCCCHH
EFIYELDVPVVVGGCATHQAALHLMRTGAAGVLVGFGGGAAHTTRTVLGVAVPMASAVAD
HHHHHCCCCEEEECCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VAAARRDYLDESGGRYVHVIADGSIGKSGDVAKAIACGADAVMVGSPFARATDAPGRGFH
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEECCCCHHCCCCCCCCCC
WGTEAHHHDLPRGQRVQFETVGTIEEILFGPSRVADGTMNLMGALRRSMATTGYTELKEF
CCCCCCCCCCCCCCEEEEEEHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHH
QRVEIVVE
CCEEEEEC
>Mature Secondary Structure 
TDIEIGRAKRARHAYSFDDIAIVPSRRTRDPEEVSTAWQIDAYRFDIPVLAAPMDSVMS
CCCCCCCHHHHHHCCCCCCEEEECCCCCCCHHHHHHEEEEEEEEECCCEEECCHHHHHC
PGTAIALGRFGGLGVLNLEGLWTRYEDPDPLLEEVAALEGSEGTRRLQQMYTEPIKAELI
CCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHH
TERLREIRDAGVTVAGSLSPGRTKDFAKAVVDAGVDMFVIRGTTVSAEHVSSQAEPLNLK
HHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCEECHHHHCCCCCCCCHH
EFIYELDVPVVVGGCATHQAALHLMRTGAAGVLVGFGGGAAHTTRTVLGVAVPMASAVAD
HHHHHCCCCEEEECCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VAAARRDYLDESGGRYVHVIADGSIGKSGDVAKAIACGADAVMVGSPFARATDAPGRGFH
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEECCCCHHCCCCCCCCCC
WGTEAHHHDLPRGQRVQFETVGTIEEILFGPSRVADGTMNLMGALRRSMATTGYTELKEF
CCCCCCCCCCCCCCEEEEEEHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHH
QRVEIVVE
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA