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The map label for this gene is mutA [H]

Identifier: 119717767

GI number: 119717767

Start: 3757951

End: 3759660

Strand: Reverse

Name: mutA [H]

Synonym: Noca_3545

Alternate gene names: 119717767

Gene position: 3759660-3757951 (Counterclockwise)

Preceding gene: 119717768

Following gene: 119717766

Centisome position: 75.41

GC content: 75.61

Gene sequence:

>1710_bases
GTGGACGGTGGAGTGGAAGGCGGCCTCGACGAGCCGGCACGGCTCGAGCCTGAGCAGGGGTCGCTGGACCTCGCCTCCCC
CGAGGACGCGTGGACGATCGCGGACTGGGAGAGGGGCGCGGCCGCCGTCCTGCGCAAGGCCCGCCGGTTGACCGACGAGG
ACCCCGACGACCTGGTCTGGGAGAAGCTCACCCGGTCCACGCTGGACGGGATCGGGGTCACGCCGCTCGGGACCCGCGCC
CTGCTCGACGAGGTGACGACGGTCGGACGCCCGACCCGCCAGGGCGACTGGGACGTGCGGGTGCAGGTCGACGGCGCCGA
CGCGAAGACCGCGAACGAGGAGGTCCTCGTCGACCTCGAGGGCGGCGCCACCTCACTGTGGCTCCGGGGCGGGGCCGACC
TGGGCACGCTCCTGGGGGGCGTCCGCCTCGACCTCGCGCCGGTGGTCCTCGACGGCGTCGACCCCACCGCCCTGCTCGCG
TACGCCGAGGGTCGCGAGCTGCACCCGCTGACCAACCTCGGCGTCGCCGCGCAGGACGCCACCGCCGAGGCCGCCCGCCG
CGCCGCCGACCGCGGGGTGCTCGGCTTCGTCGTCGACGCGACCACCGTCCACGACCGGGGCGGCTCGGACGTCCAGGAGC
TCGCCTGGTCGATCGCCATCGGCGCGGCGTACCTGCGCACGCTCACGGACGAAGGCCTCCCGGTCGAGCAGGCGGCCGGC
CTGGTCGAGTTCCGCTACGCGGCGACCGACGAGCAGTTCCCGACCATCGCGAAGCTCCGCGCGGCCCGCCGACTGTGGGC
CCGGGTGCTCGAGCTCAGCGGGGCCGGCGACCTGTCCCAGCGCCAGCACGCGGTCACCAGCCGGCCGATGATGACGCGCT
ACGACCCGTACGTGAACATGCTCCGCACCACGGTCGCGGCCTTCGCCGCCGGCGTGGGCGGCGCGGACGCCGTCACGGTG
CTGCCCTTCGACGGCCCGCTGGGTCGCCCCGAGCAGCTCGGGCGCCGGATCGCGCGCAACACCTCGCACCTGCTGATCGA
CGAGGCACACGTCGCGCACGTCGCGGACCCGGCCGGCGGCGCGTACGCCGTCGAGAAGCTCACCGACGACCTGGCGCTGG
CGGCGTGGGATCTGTTCGGGCAGCTGGACGACGGTGCGCCGCTGGACGGCGCCATCGCCGAGACCGTCGCCCGGCGCGCG
GCCGAGATCGCCCGGCGCAAGCGGCCGATCACCGGGCTGAGCGAGTTCCCGAACGCCGCCGAGGTGCTGCCCGAGCGGGC
GCCGTACGACGGCTGGGACGGGGTGGCCTCCTACGGCGCCCCGTTCGAGGCACTGCGCGACGACCCGTCACCGACGCCGG
TCTTCCTGGCCACGCTGGGCACCATCGCCGCCCACACGGCGCGGGCGACGTTCGCCACCAACCTGTTCGCCGCCGGCGGG
ATCGGCGTCGAGGTTTCCGGTCCGACGGCCGACCCCGGTGAGGTGGTCGCGGCGTACGCCGGGCAGCCGGTGGTCTGCCT
GGCCGGCTCGGACCCGACCTACGCCGAGTGGGGCGCCGAGGCGGCCGCGGCTCTGCGCGCCGCCGGCGCCCGGCACCTGA
TCCTCGCCGGCAAGCCCGCCGGCCCGCTCGGCGAGGCGGTGGACGACTCCTGTGCACTCGGGGTCGACGCCTTGGACTTC
CTGACCCGGACGAGGGAGAAGCTGTCGTGA

Upstream 100 bases:

>100_bases
TGGGCCTGCGGCCGCGGGACCTAGGTCGTGACCTGCTCTCGAAAACGTCACATCGCGTGGCCCCGCGGTGTGCCGCACAC
CTATCGTTCGGGGCATGAGT

Downstream 100 bases:

>100_bases
CCGTCCCCAAGACCTTCCGCGGGCTGCCGCTCACCGGCGGCGCGGCGGGCGCCGCCGACGAGGGGGCCGACCGCACCTGG
CTGGCCCCCGAAGGCATCGA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MDGGVEGGLDEPARLEPEQGSLDLASPEDAWTIADWERGAAAVLRKARRLTDEDPDDLVWEKLTRSTLDGIGVTPLGTRA
LLDEVTTVGRPTRQGDWDVRVQVDGADAKTANEEVLVDLEGGATSLWLRGGADLGTLLGGVRLDLAPVVLDGVDPTALLA
YAEGRELHPLTNLGVAAQDATAEAARRAADRGVLGFVVDATTVHDRGGSDVQELAWSIAIGAAYLRTLTDEGLPVEQAAG
LVEFRYAATDEQFPTIAKLRAARRLWARVLELSGAGDLSQRQHAVTSRPMMTRYDPYVNMLRTTVAAFAAGVGGADAVTV
LPFDGPLGRPEQLGRRIARNTSHLLIDEAHVAHVADPAGGAYAVEKLTDDLALAAWDLFGQLDDGAPLDGAIAETVARRA
AEIARRKRPITGLSEFPNAAEVLPERAPYDGWDGVASYGAPFEALRDDPSPTPVFLATLGTIAAHTARATFATNLFAAGG
IGVEVSGPTADPGEVVAAYAGQPVVCLAGSDPTYAEWGAEAAAALRAAGARHLILAGKPAGPLGEAVDDSCALGVDALDF
LTRTREKLS

Sequences:

>Translated_569_residues
MDGGVEGGLDEPARLEPEQGSLDLASPEDAWTIADWERGAAAVLRKARRLTDEDPDDLVWEKLTRSTLDGIGVTPLGTRA
LLDEVTTVGRPTRQGDWDVRVQVDGADAKTANEEVLVDLEGGATSLWLRGGADLGTLLGGVRLDLAPVVLDGVDPTALLA
YAEGRELHPLTNLGVAAQDATAEAARRAADRGVLGFVVDATTVHDRGGSDVQELAWSIAIGAAYLRTLTDEGLPVEQAAG
LVEFRYAATDEQFPTIAKLRAARRLWARVLELSGAGDLSQRQHAVTSRPMMTRYDPYVNMLRTTVAAFAAGVGGADAVTV
LPFDGPLGRPEQLGRRIARNTSHLLIDEAHVAHVADPAGGAYAVEKLTDDLALAAWDLFGQLDDGAPLDGAIAETVARRA
AEIARRKRPITGLSEFPNAAEVLPERAPYDGWDGVASYGAPFEALRDDPSPTPVFLATLGTIAAHTARATFATNLFAAGG
IGVEVSGPTADPGEVVAAYAGQPVVCLAGSDPTYAEWGAEAAAALRAAGARHLILAGKPAGPLGEAVDDSCALGVDALDF
LTRTREKLS
>Mature_569_residues
MDGGVEGGLDEPARLEPEQGSLDLASPEDAWTIADWERGAAAVLRKARRLTDEDPDDLVWEKLTRSTLDGIGVTPLGTRA
LLDEVTTVGRPTRQGDWDVRVQVDGADAKTANEEVLVDLEGGATSLWLRGGADLGTLLGGVRLDLAPVVLDGVDPTALLA
YAEGRELHPLTNLGVAAQDATAEAARRAADRGVLGFVVDATTVHDRGGSDVQELAWSIAIGAAYLRTLTDEGLPVEQAAG
LVEFRYAATDEQFPTIAKLRAARRLWARVLELSGAGDLSQRQHAVTSRPMMTRYDPYVNMLRTTVAAFAAGVGGADAVTV
LPFDGPLGRPEQLGRRIARNTSHLLIDEAHVAHVADPAGGAYAVEKLTDDLALAAWDLFGQLDDGAPLDGAIAETVARRA
AEIARRKRPITGLSEFPNAAEVLPERAPYDGWDGVASYGAPFEALRDDPSPTPVFLATLGTIAAHTARATFATNLFAAGG
IGVEVSGPTADPGEVVAAYAGQPVVCLAGSDPTYAEWGAEAAAALRAAGARHLILAGKPAGPLGEAVDDSCALGVDALDF
LTRTREKLS

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=243, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1789284, Length=222, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI25144500, Length=232, Percent_Identity=33.1896551724138, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 59595; Mature: 59595

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGGVEGGLDEPARLEPEQGSLDLASPEDAWTIADWERGAAAVLRKARRLTDEDPDDLVW
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEECCHHCCHHHHHHHHHHCCCCCCHHHHH
EKLTRSTLDGIGVTPLGTRALLDEVTTVGRPTRQGDWDVRVQVDGADAKTANEEVLVDLE
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEC
GGATSLWLRGGADLGTLLGGVRLDLAPVVLDGVDPTALLAYAEGRELHPLTNLGVAAQDA
CCCEEEEEECCCCHHHHHCCHHEEEEHEEECCCCHHHEEEECCCCCCCCHHCCCCCCCHH
TAEAARRAADRGVLGFVVDATTVHDRGGSDVQELAWSIAIGAAYLRTLTDEGLPVEQAAG
HHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
LVEFRYAATDEQFPTIAKLRAARRLWARVLELSGAGDLSQRQHAVTSRPMMTRYDPYVNM
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHH
LRTTVAAFAAGVGGADAVTVLPFDGPLGRPEQLGRRIARNTSHLLIDEAHVAHVADPAGG
HHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCHHHEECCCCCC
AYAVEKLTDDLALAAWDLFGQLDDGAPLDGAIAETVARRAAEIARRKRPITGLSEFPNAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHH
EVLPERAPYDGWDGVASYGAPFEALRDDPSPTPVFLATLGTIAAHTARATFATNLFAAGG
HHCCCCCCCCCCCCHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
IGVEVSGPTADPGEVVAAYAGQPVVCLAGSDPTYAEWGAEAAAALRAAGARHLILAGKPA
CEEEECCCCCCHHHHHHEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCC
GPLGEAVDDSCALGVDALDFLTRTREKLS
CCCCHHCCCHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDGGVEGGLDEPARLEPEQGSLDLASPEDAWTIADWERGAAAVLRKARRLTDEDPDDLVW
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEECCHHCCHHHHHHHHHHCCCCCCHHHHH
EKLTRSTLDGIGVTPLGTRALLDEVTTVGRPTRQGDWDVRVQVDGADAKTANEEVLVDLE
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEC
GGATSLWLRGGADLGTLLGGVRLDLAPVVLDGVDPTALLAYAEGRELHPLTNLGVAAQDA
CCCEEEEEECCCCHHHHHCCHHEEEEHEEECCCCHHHEEEECCCCCCCCHHCCCCCCCHH
TAEAARRAADRGVLGFVVDATTVHDRGGSDVQELAWSIAIGAAYLRTLTDEGLPVEQAAG
HHHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
LVEFRYAATDEQFPTIAKLRAARRLWARVLELSGAGDLSQRQHAVTSRPMMTRYDPYVNM
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHH
LRTTVAAFAAGVGGADAVTVLPFDGPLGRPEQLGRRIARNTSHLLIDEAHVAHVADPAGG
HHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCHHHEECCCCCC
AYAVEKLTDDLALAAWDLFGQLDDGAPLDGAIAETVARRAAEIARRKRPITGLSEFPNAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHH
EVLPERAPYDGWDGVASYGAPFEALRDDPSPTPVFLATLGTIAAHTARATFATNLFAAGG
HHCCCCCCCCCCCCHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
IGVEVSGPTADPGEVVAAYAGQPVVCLAGSDPTYAEWGAEAAAALRAAGARHLILAGKPA
CEEEECCCCCCHHHHHHEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCC
GPLGEAVDDSCALGVDALDFLTRTREKLS
CCCCHHCCCHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]