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The map label for this gene is mutB [H]

Identifier: 119717766

GI number: 119717766

Start: 3755792

End: 3757954

Strand: Reverse

Name: mutB [H]

Synonym: Noca_3544

Alternate gene names: 119717766

Gene position: 3757954-3755792 (Counterclockwise)

Preceding gene: 119717767

Following gene: 119717765

Centisome position: 75.37

GC content: 70.83

Gene sequence:

>2163_bases
GTGACCGTCCCCAAGACCTTCCGCGGGCTGCCGCTCACCGGCGGCGCGGCGGGCGCCGCCGACGAGGGGGCCGACCGCAC
CTGGCTGGCCCCCGAAGGCATCGACATCAAGGGGCTCTACACGCCCGCCGACCTCGAGGGCCTCGACGCCCTCGACACGC
TGCCGGGCCTGAGCCCGTTCCTGCGCGGCCCCTACCCGACGATGTACACCACCCAGCCGTGGACCATCCGGCAGTACGCC
GGCTTCTCCACCGCGGAGGAGTCCAACGCGTTCTACCGCCGCAACCTCGCGGCCGGCCAGAAGGGCCTCAGCGTCGCGTT
CGACCTGGCCACCCACCGCGGCTACGACTCCGACCACCCGCGGGTCCGCGGCGACGTCGGCATGGCCGGTGTCGCCATCG
ACTCGATCTACGACGCCCGCACGCTGTTCGACGGCATCCCGCTCGACGCGATGTCGGTCTCGATGACCATGAACGGCGCG
GTGCTGCCGATCATGGCGCTCTACATCGCGGCGGCCGAGGAGCAGGGGGTGAAGCCTTCGCTGCTCGCGGGGACCATCCA
GAACGACATCCTCAAGGAGTTCATGGTCCGCAACACCTACATCTACCCGCCGGCCCCGAGCATGCGGATCATCAGCGACA
TCTTCCGGTACACCGCCGAGCGGATGCCGCGCTTCAACTCGATCTCGATCTCCGGGTACCACATGCAGGAGGCGGGGGCC
ACCAACGACCTGGAGCTGGCCTACACGCTGGCCGACGGTGTCGAGTACATCCGGGCCGGCCTGTCCGCGGGGCTCGACAT
CGACCGGTTCGCGCCGCGGCTGTCGTTCTTCTGGGCGATCGGCATGAACTTCTTCATGGAGGTCGCGAAGATGCGCGCCG
CGCGGGCCCTGTGGGCCCGGCTGGTGCGCCAGTTCGACCCGCAGAACCCCAAGTCGCTCAGCCTGCGCACCCACAGCCAG
ACCTCCGGCTGGTCGCTGACCGCGCAGGACGTCTTCAACAACGTCGGACGCACCTGCATCGAGGCGATGGCGGCGACCCA
GGGACACACCCAGTCGCTGCACACCAACGCACTGGACGAGGCGATCGCGCTGCCGACCGACTTCTCGGCCCGGATCGCCC
GCAACACCCAGCTGCTGCTCCAGCAGGAGAGCGGCACCACCGGCACCATCGACCCGTGGGCCGGCTCCTACTACGTGGAG
CGGCTGACCCACGATCTCGCCGAGCGGGCCTGGGCGCACATCCTCGAGGCCGAGGAAGCCGGTGGCATGGCGGCCGCGAT
CGAGCAGGGCATCCCGAAGATGCGCATCGAGGAGGCTGCCGCCCGCACGCAGGCGCGGATCGACGCAGGCAGCCAGAAGG
TGATCGGCGTCAACACCTACCGGCTGGCGGCCGAGGACAAGCTGGACGTGCTCAAGGTCGACAACGACGACGTCTATCGC
CAGCAGATCGCCAAGCTCGAGCGGCTCCGGGCCGAGCGCGACGACCACGAGGTCGAGCGCACCCTCGAGGCGCTGACCAA
CGCCGCCGACCAGGGCCCCTCGAGCAGCCTCGACGGGAACCTGCTCGCGCTCGCGGTCGACGCCGCCCGCGCGAAGGCGA
CCGTGGGGGAGATCTCCGCAGCGCTGGAGAAGGTGTACGGGCGGCACCAGGCCGTGATCCGTACCATCAGCGGCGTGTAC
AGGGCCGAGGCGGACCGGGCCGGCGACGCGGTCGTCGCCCAGGTGCTGGAGGAGACCGAGCGGTTCGAGGAGGCCGAGGG
CCGGCGCCCGCGGATCCTCGTCGCGAAGATGGGCCAGGACGGCCACGACCGCGGCCAGAAGGTCGTGGTCAGCGCGTTCG
CCGACCTGGGCTTCGACGTGGACGTGGGGCCGCTGTTCTCCACGCCCGAGGAGGTCGCCCAGCAGGCGGTGGACGCGGAC
GTCCACATCGTGGGGGTCTCCTCGCTCGCGGCCGGCCACCTGACGCTGCTGCCCGCGCTGAAGAAGGCGCTGGCCGACCA
GGGCCGGCCGGACATCATGATCGTGATCGGCGGGGTGATCCCGCCCGACGACGTGGCGACGCTGATGGAGATGGGCGCCG
CCGCGGTGTTCCTGCCCGGCACGGTCATCGCCGGGTCCGCCCTCGACCTGCTGGCCCGGCTGCGCGAGCAGCTCGGCCAC
TGA

Upstream 100 bases:

>100_bases
CCGGCAAGCCCGCCGGCCCGCTCGGCGAGGCGGTGGACGACTCCTGTGCACTCGGGGTCGACGCCTTGGACTTCCTGACC
CGGACGAGGGAGAAGCTGTC

Downstream 100 bases:

>100_bases
TGCCGGACGTTCCCGGCCTCGTCGAGGGGCTCGTCGAGGGCATCCGCGAGGGCCGGCGTGCCGCGGTGTCGCGGGCGATC
ACCCTGGTCGAGTCGACCCG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 720; Mature: 719

Protein sequence:

>720_residues
MTVPKTFRGLPLTGGAAGAADEGADRTWLAPEGIDIKGLYTPADLEGLDALDTLPGLSPFLRGPYPTMYTTQPWTIRQYA
GFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVRGDVGMAGVAIDSIYDARTLFDGIPLDAMSVSMTMNGA
VLPIMALYIAAAEEQGVKPSLLAGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFRYTAERMPRFNSISISGYHMQEAGA
TNDLELAYTLADGVEYIRAGLSAGLDIDRFAPRLSFFWAIGMNFFMEVAKMRAARALWARLVRQFDPQNPKSLSLRTHSQ
TSGWSLTAQDVFNNVGRTCIEAMAATQGHTQSLHTNALDEAIALPTDFSARIARNTQLLLQQESGTTGTIDPWAGSYYVE
RLTHDLAERAWAHILEAEEAGGMAAAIEQGIPKMRIEEAAARTQARIDAGSQKVIGVNTYRLAAEDKLDVLKVDNDDVYR
QQIAKLERLRAERDDHEVERTLEALTNAADQGPSSSLDGNLLALAVDAARAKATVGEISAALEKVYGRHQAVIRTISGVY
RAEADRAGDAVVAQVLEETERFEEAEGRRPRILVAKMGQDGHDRGQKVVVSAFADLGFDVDVGPLFSTPEEVAQQAVDAD
VHIVGVSSLAAGHLTLLPALKKALADQGRPDIMIVIGGVIPPDDVATLMEMGAAAVFLPGTVIAGSALDLLARLREQLGH

Sequences:

>Translated_720_residues
MTVPKTFRGLPLTGGAAGAADEGADRTWLAPEGIDIKGLYTPADLEGLDALDTLPGLSPFLRGPYPTMYTTQPWTIRQYA
GFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVRGDVGMAGVAIDSIYDARTLFDGIPLDAMSVSMTMNGA
VLPIMALYIAAAEEQGVKPSLLAGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFRYTAERMPRFNSISISGYHMQEAGA
TNDLELAYTLADGVEYIRAGLSAGLDIDRFAPRLSFFWAIGMNFFMEVAKMRAARALWARLVRQFDPQNPKSLSLRTHSQ
TSGWSLTAQDVFNNVGRTCIEAMAATQGHTQSLHTNALDEAIALPTDFSARIARNTQLLLQQESGTTGTIDPWAGSYYVE
RLTHDLAERAWAHILEAEEAGGMAAAIEQGIPKMRIEEAAARTQARIDAGSQKVIGVNTYRLAAEDKLDVLKVDNDDVYR
QQIAKLERLRAERDDHEVERTLEALTNAADQGPSSSLDGNLLALAVDAARAKATVGEISAALEKVYGRHQAVIRTISGVY
RAEADRAGDAVVAQVLEETERFEEAEGRRPRILVAKMGQDGHDRGQKVVVSAFADLGFDVDVGPLFSTPEEVAQQAVDAD
VHIVGVSSLAAGHLTLLPALKKALADQGRPDIMIVIGGVIPPDDVATLMEMGAAAVFLPGTVIAGSALDLLARLREQLGH
>Mature_719_residues
TVPKTFRGLPLTGGAAGAADEGADRTWLAPEGIDIKGLYTPADLEGLDALDTLPGLSPFLRGPYPTMYTTQPWTIRQYAG
FSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVRGDVGMAGVAIDSIYDARTLFDGIPLDAMSVSMTMNGAV
LPIMALYIAAAEEQGVKPSLLAGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFRYTAERMPRFNSISISGYHMQEAGAT
NDLELAYTLADGVEYIRAGLSAGLDIDRFAPRLSFFWAIGMNFFMEVAKMRAARALWARLVRQFDPQNPKSLSLRTHSQT
SGWSLTAQDVFNNVGRTCIEAMAATQGHTQSLHTNALDEAIALPTDFSARIARNTQLLLQQESGTTGTIDPWAGSYYVER
LTHDLAERAWAHILEAEEAGGMAAAIEQGIPKMRIEEAAARTQARIDAGSQKVIGVNTYRLAAEDKLDVLKVDNDDVYRQ
QIAKLERLRAERDDHEVERTLEALTNAADQGPSSSLDGNLLALAVDAARAKATVGEISAALEKVYGRHQAVIRTISGVYR
AEADRAGDAVVAQVLEETERFEEAEGRRPRILVAKMGQDGHDRGQKVVVSAFADLGFDVDVGPLFSTPEEVAQQAVDADV
HIVGVSSLAAGHLTLLPALKKALADQGRPDIMIVIGGVIPPDDVATLMEMGAAAVFLPGTVIAGSALDLLARLREQLGH

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=695, Percent_Identity=63.4532374100719, Blast_Score=907, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=686, Percent_Identity=63.4110787172012, Blast_Score=842, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=695, Percent_Identity=62.7338129496403, Blast_Score=893, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 77868; Mature: 77737

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPKTFRGLPLTGGAAGAADEGADRTWLAPEGIDIKGLYTPADLEGLDALDTLPGLSPF
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCCCCCCCHHHHCCCCCHH
LRGPYPTMYTTQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHP
HCCCCCCCCCCCCCCHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCC
RVRGDVGMAGVAIDSIYDARTLFDGIPLDAMSVSMTMNGAVLPIMALYIAAAEEQGVKPS
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCHH
LLAGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFRYTAERMPRFNSISISGYHMQEAGA
HHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCEEECCCCC
TNDLELAYTLADGVEYIRAGLSAGLDIDRFAPRLSFFWAIGMNFFMEVAKMRAARALWAR
CCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVRQFDPQNPKSLSLRTHSQTSGWSLTAQDVFNNVGRTCIEAMAATQGHTQSLHTNALDE
HHHHCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AIALPTDFSARIARNTQLLLQQESGTTGTIDPWAGSYYVERLTHDLAERAWAHILEAEEA
HHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GGMAAAIEQGIPKMRIEEAAARTQARIDAGSQKVIGVNTYRLAAEDKLDVLKVDNDDVYR
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCEEEEECCCHHHH
QQIAKLERLRAERDDHEVERTLEALTNAADQGPSSSLDGNLLALAVDAARAKATVGEISA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
ALEKVYGRHQAVIRTISGVYRAEADRAGDAVVAQVLEETERFEEAEGRRPRILVAKMGQD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
GHDRGQKVVVSAFADLGFDVDVGPLFSTPEEVAQQAVDADVHIVGVSSLAAGHLTLLPAL
CCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHH
KKALADQGRPDIMIVIGGVIPPDDVATLMEMGAAAVFLPGTVIAGSALDLLARLREQLGH
HHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEECCHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVPKTFRGLPLTGGAAGAADEGADRTWLAPEGIDIKGLYTPADLEGLDALDTLPGLSPF
CCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCCCCCCCHHHHCCCCCHH
LRGPYPTMYTTQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHP
HCCCCCCCCCCCCCCHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCC
RVRGDVGMAGVAIDSIYDARTLFDGIPLDAMSVSMTMNGAVLPIMALYIAAAEEQGVKPS
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCHH
LLAGTIQNDILKEFMVRNTYIYPPAPSMRIISDIFRYTAERMPRFNSISISGYHMQEAGA
HHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCEEECCCCC
TNDLELAYTLADGVEYIRAGLSAGLDIDRFAPRLSFFWAIGMNFFMEVAKMRAARALWAR
CCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVRQFDPQNPKSLSLRTHSQTSGWSLTAQDVFNNVGRTCIEAMAATQGHTQSLHTNALDE
HHHHCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AIALPTDFSARIARNTQLLLQQESGTTGTIDPWAGSYYVERLTHDLAERAWAHILEAEEA
HHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GGMAAAIEQGIPKMRIEEAAARTQARIDAGSQKVIGVNTYRLAAEDKLDVLKVDNDDVYR
CCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCEEEEECCCHHHH
QQIAKLERLRAERDDHEVERTLEALTNAADQGPSSSLDGNLLALAVDAARAKATVGEISA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
ALEKVYGRHQAVIRTISGVYRAEADRAGDAVVAQVLEETERFEEAEGRRPRILVAKMGQD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
GHDRGQKVVVSAFADLGFDVDVGPLFSTPEEVAQQAVDADVHIVGVSSLAAGHLTLLPAL
CCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHH
KKALADQGRPDIMIVIGGVIPPDDVATLMEMGAAAVFLPGTVIAGSALDLLARLREQLGH
HHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEECCHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]