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The map label for this gene is clpP4 [H]

Identifier: 119717698

GI number: 119717698

Start: 3686518

End: 3687138

Strand: Reverse

Name: clpP4 [H]

Synonym: Noca_3476

Alternate gene names: 119717698

Gene position: 3687138-3686518 (Counterclockwise)

Preceding gene: 119717699

Following gene: 119717697

Centisome position: 73.95

GC content: 65.7

Gene sequence:

>621_bases
ATGTCTGAGATGAACTACTACATCCCGCAGTGGGAAGAGCGCACGTCGTACGGCTTCCGGCGCATCGACCCCTACGCCAA
GCTGTTCGAGGACCGGATCATCTACCTCGGCACGCCGATCTCCGACGACGTCGCGAACGCGGTGATCGCCCAGCTGCTCT
GCCTGCAGTCGATGAACCCCGACCAGGACATCAGCATCTACATCAACAGCCCCGGCGGCTCGTTCACCGCGCTGACCGCG
ATCTACGACACGATGAAGTTCATCAAGCCCGACGTGCAGACCGTGTGCATCGGGCAGGCCGCGTCCGCGGCGGCGATCCT
GCTGGCGGCCGGCACCCCCGGCAAGCGGCTGGCGCTGCCGAACAGCCGGATCCTGATCCACCAGCCCTACACCGAGGGCA
CCTTCGGCCAGACCTCCGACATCGAGATCCAGGCCAACGAGATCCTGCGGATGCGCGAGCTGCTCGAGAAGATGATCAGC
GACCACAGCGGCCGCTCCATCGAGGAGGTCAGCCACGACATCGAGCGGGACAAGATCCTCACCGCCGAGGGCGCGGTCGA
GTACGGCCTGATCGACGCCGTGCTCGAGTCGCTCAAGGGCACTCCCGCGGTGGCCGGCTGA

Upstream 100 bases:

>100_bases
CCGACCAGGCCAAGGAGTACGGCCTGGTCGACCAGGTCATCAAGAGCGCTCGCGAGGCCGCCGACGACGGCCGCCCGGCC
CGGCAGAAGGACTGACCCGA

Downstream 100 bases:

>100_bases
CCCGTCCGGAGTGTTCCTCGTGTCCGGCCCCCGGCAGGGGGCGGCAGGAGGTACCGTCGGAGAGGGCCTCGGCCCACCCA
TCGGCACCAGGATCGACCGC

Product: ClpP2 peptidase

Products: NA

Alternate protein names: Endopeptidase Clp 4 [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSEMNYYIPQWEERTSYGFRRIDPYAKLFEDRIIYLGTPISDDVANAVIAQLLCLQSMNPDQDISIYINSPGGSFTALTA
IYDTMKFIKPDVQTVCIGQAASAAAILLAAGTPGKRLALPNSRILIHQPYTEGTFGQTSDIEIQANEILRMRELLEKMIS
DHSGRSIEEVSHDIERDKILTAEGAVEYGLIDAVLESLKGTPAVAG

Sequences:

>Translated_206_residues
MSEMNYYIPQWEERTSYGFRRIDPYAKLFEDRIIYLGTPISDDVANAVIAQLLCLQSMNPDQDISIYINSPGGSFTALTA
IYDTMKFIKPDVQTVCIGQAASAAAILLAAGTPGKRLALPNSRILIHQPYTEGTFGQTSDIEIQANEILRMRELLEKMIS
DHSGRSIEEVSHDIERDKILTAEGAVEYGLIDAVLESLKGTPAVAG
>Mature_205_residues
SEMNYYIPQWEERTSYGFRRIDPYAKLFEDRIIYLGTPISDDVANAVIAQLLCLQSMNPDQDISIYINSPGGSFTALTAI
YDTMKFIKPDVQTVCIGQAASAAAILLAAGTPGKRLALPNSRILIHQPYTEGTFGQTSDIEIQANEILRMRELLEKMISD
HSGRSIEEVSHDIERDKILTAEGAVEYGLIDAVLESLKGTPAVAG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=47.8723404255319, Blast_Score=172, Evalue=2e-43,
Organism=Escherichia coli, GI1786641, Length=188, Percent_Identity=51.063829787234, Blast_Score=208, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17538017, Length=187, Percent_Identity=45.9893048128342, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI20129427, Length=189, Percent_Identity=48.1481481481481, Blast_Score=177, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22687; Mature: 22556

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEMNYYIPQWEERTSYGFRRIDPYAKLFEDRIIYLGTPISDDVANAVIAQLLCLQSMNP
CCCCCCCCCCCCCHHHCCCHHCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
DQDISIYINSPGGSFTALTAIYDTMKFIKPDVQTVCIGQAASAAAILLAAGTPGKRLALP
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCCCCEEECC
NSRILIHQPYTEGTFGQTSDIEIQANEILRMRELLEKMISDHSGRSIEEVSHDIERDKIL
CCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEE
TAEGAVEYGLIDAVLESLKGTPAVAG
ECCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SEMNYYIPQWEERTSYGFRRIDPYAKLFEDRIIYLGTPISDDVANAVIAQLLCLQSMNP
CCCCCCCCCCCCHHHCCCHHCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
DQDISIYINSPGGSFTALTAIYDTMKFIKPDVQTVCIGQAASAAAILLAAGTPGKRLALP
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCCCCEEECC
NSRILIHQPYTEGTFGQTSDIEIQANEILRMRELLEKMISDHSGRSIEEVSHDIERDKIL
CCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEE
TAEGAVEYGLIDAVLESLKGTPAVAG
ECCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]