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The map label for this gene is dxs

Identifier: 119717083

GI number: 119717083

Start: 3033169

End: 3035073

Strand: Reverse

Name: dxs

Synonym: Noca_2859

Alternate gene names: 119717083

Gene position: 3035073-3033169 (Counterclockwise)

Preceding gene: 119717084

Following gene: 119717082

Centisome position: 60.87

GC content: 71.34

Gene sequence:

>1905_bases
ATGGGCCTCCTCGACTCGATCGCGTCCCCGGCCGACCTGCGCGGGCTGAGCGACGCCCAGCTGGAGCAGCTCGCGAGCGA
GATCCGCGATCTCCTGATCCGCACTGTCGCGACCAACACCGGTCACCTCGGCCCCAACCTCGGCGTGGTGGAGCTGACCC
TCGCGATCCACCGGGTCTTCGACTCCCCGCGCGACCGGGTGGTGTTCGACACCGGCCACCAGGCGTACGTGCACAAGCTG
GTGTGCGGACGGGCGGCGAGCTTCGGCACCCTGCGCCGCGAGGGCGGCGTGAGCGGCTACCCGAGCCAGGCGGAGTCCCC
CCACGACATCGTCGAGAACTCCCACGCGTCCACGGCGCTCAGCTACGCCGACGGGCTCGCGAAGGCCTACACGATCCGCG
GCGAGGACCGCCACGTCATCGCGGTCATCGGCGACGGCGCGCTCACCGGGGGGATGGCCTGGGAGGCGCTCAACAACATC
GCGATCGCCAAGGCCAGCAAGCTGGTGATCGTCGTCAACGACAACGGCCGCTCCTACACGCCGACGATCGGCGGCCTCGC
GACCGCGCTCACCTCGCTGCGCACCAACCCGCGCTACGAGAACGTCCTCGACCTGGTCAAGCGCCGGCTCAATGCCGTCC
CGGGTGTCGGGCCGGCGGCGTACGACGCGCTGCACGCCATGAAGAAGGGGCTCAAGGACGCGCTCGCCCCCCAGGGCCTC
TTCGAGGACCTCGGGCTCAAGTACGTCGGCCCCGTCGACGGCCACGACCGCGCCGCGATGGAGCAGGTGCTCGCCCAGGC
CAAGCGGTTCAACGGCCCGGTGATCGTGCACGCGATCACCCGCAAGGGCTACGGCTACGACCCGGCCGAGCGGCACGAGG
CCGACCAGTTCCACGCGCCGGGCCCGTTCGACGTGCAGACCGGCGCGGAGAAGCCCAAGGGCCGGATCTGGACCGACGTC
TTCTCCGAGGAGATCGTCCACCTCGGGCACCGCCGCAAGGACCTGGTCGGCATCACCGCGGCGATGATGCACCCGGTCGG
CCTGGACGCCTTCCAGAAGCACTTCCCCGAGCGGACCTTCGACGTGGGGATCGCCGAGCAGCACGCCGCGACCTCGGCGG
CCGGCCTCGCCATGGGCGGCATGCACCCGGTCGTGGCGCTGTATGGCACCTTCCTCAACCGGGCCTTCGACCAGGTGCTG
ATGGACGTCGCGCTGCACAAGTGCGGCGTCACCTTCGTGCTCGACCGCTCGGGGGTCACCGGCGACGACGGCGCGAGCCA
CAACGGCATGTGGGACATGTCGATCCTCCAGGTCGTGCCGGGCCTGCGGCTGGCCGCGCCGCGCGACCCCGCCCGACTCC
GTGAGCTGCTCAACGAGGCCGTCGAGGTCGACGACGCCCCGACCGTCGTGCGCTTCCCGAAGGGCTCGCCGCCCGAGGAC
ATCGAGGCCGTCGACCGGGCCGGCGGGGCCGACATCCTGGTCCGCAACGGCACCAAGGACGTGCTGGTGGTCGCGGTCGG
CGCGATGGGCACGACCGCGGTCGACGTGGCGCAGCGGCTGACCGCGCAGGGCATCGGTGTGACCGTCGTCGACCCGCGCT
GGGTCAAGCCCGTCGACCCGGCGATCGTCGAGCTCGCGCGCGAGCACCGCCTCGTGGTCAGCATCGAGGACAACGGCGAG
ACCGGCGGCTGCGGAGCGGTGCTGCTGCAGACGCTCAACGCAGCCGGCGTGCACACACCGTTCCGCCTGCACGGGATCCC
GCAGCAGTTCCTCGGCCACGCGAAGCGCGCCGCGATCCTCGAGCGGATCGGCCTGACCCCGCAGGCGATCGCGCTCCGCA
TCGTGGAGGACATGACCTCGCTGACCGAAGGTCGTTCTCCTCTCGATGTCGAGCAGGCGACCTAG

Upstream 100 bases:

>100_bases
GTCACCGGCGTCCGCGAGCACGACGGCCGGCTCTGGCTCGGCAGCCTGCACGAGCCGGCGGTCGCGGTCGTGGATATCTA
GAGTCGTAGACTCGAGCGCT

Downstream 100 bases:

>100_bases
GCTCCTCCTCGCCGCCGTGCTGGTCGCGGCGGCGCTCGCCGGCTGCTCCGGGTCCGACGACGAGCCCGCACCGCCCGCCA
CCGCGGCGGTGCCGCGGGAC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MGLLDSIASPADLRGLSDAQLEQLASEIRDLLIRTVATNTGHLGPNLGVVELTLAIHRVFDSPRDRVVFDTGHQAYVHKL
VCGRAASFGTLRREGGVSGYPSQAESPHDIVENSHASTALSYADGLAKAYTIRGEDRHVIAVIGDGALTGGMAWEALNNI
AIAKASKLVIVVNDNGRSYTPTIGGLATALTSLRTNPRYENVLDLVKRRLNAVPGVGPAAYDALHAMKKGLKDALAPQGL
FEDLGLKYVGPVDGHDRAAMEQVLAQAKRFNGPVIVHAITRKGYGYDPAERHEADQFHAPGPFDVQTGAEKPKGRIWTDV
FSEEIVHLGHRRKDLVGITAAMMHPVGLDAFQKHFPERTFDVGIAEQHAATSAAGLAMGGMHPVVALYGTFLNRAFDQVL
MDVALHKCGVTFVLDRSGVTGDDGASHNGMWDMSILQVVPGLRLAAPRDPARLRELLNEAVEVDDAPTVVRFPKGSPPED
IEAVDRAGGADILVRNGTKDVLVVAVGAMGTTAVDVAQRLTAQGIGVTVVDPRWVKPVDPAIVELAREHRLVVSIEDNGE
TGGCGAVLLQTLNAAGVHTPFRLHGIPQQFLGHAKRAAILERIGLTPQAIALRIVEDMTSLTEGRSPLDVEQAT

Sequences:

>Translated_634_residues
MGLLDSIASPADLRGLSDAQLEQLASEIRDLLIRTVATNTGHLGPNLGVVELTLAIHRVFDSPRDRVVFDTGHQAYVHKL
VCGRAASFGTLRREGGVSGYPSQAESPHDIVENSHASTALSYADGLAKAYTIRGEDRHVIAVIGDGALTGGMAWEALNNI
AIAKASKLVIVVNDNGRSYTPTIGGLATALTSLRTNPRYENVLDLVKRRLNAVPGVGPAAYDALHAMKKGLKDALAPQGL
FEDLGLKYVGPVDGHDRAAMEQVLAQAKRFNGPVIVHAITRKGYGYDPAERHEADQFHAPGPFDVQTGAEKPKGRIWTDV
FSEEIVHLGHRRKDLVGITAAMMHPVGLDAFQKHFPERTFDVGIAEQHAATSAAGLAMGGMHPVVALYGTFLNRAFDQVL
MDVALHKCGVTFVLDRSGVTGDDGASHNGMWDMSILQVVPGLRLAAPRDPARLRELLNEAVEVDDAPTVVRFPKGSPPED
IEAVDRAGGADILVRNGTKDVLVVAVGAMGTTAVDVAQRLTAQGIGVTVVDPRWVKPVDPAIVELAREHRLVVSIEDNGE
TGGCGAVLLQTLNAAGVHTPFRLHGIPQQFLGHAKRAAILERIGLTPQAIALRIVEDMTSLTEGRSPLDVEQAT
>Mature_633_residues
GLLDSIASPADLRGLSDAQLEQLASEIRDLLIRTVATNTGHLGPNLGVVELTLAIHRVFDSPRDRVVFDTGHQAYVHKLV
CGRAASFGTLRREGGVSGYPSQAESPHDIVENSHASTALSYADGLAKAYTIRGEDRHVIAVIGDGALTGGMAWEALNNIA
IAKASKLVIVVNDNGRSYTPTIGGLATALTSLRTNPRYENVLDLVKRRLNAVPGVGPAAYDALHAMKKGLKDALAPQGLF
EDLGLKYVGPVDGHDRAAMEQVLAQAKRFNGPVIVHAITRKGYGYDPAERHEADQFHAPGPFDVQTGAEKPKGRIWTDVF
SEEIVHLGHRRKDLVGITAAMMHPVGLDAFQKHFPERTFDVGIAEQHAATSAAGLAMGGMHPVVALYGTFLNRAFDQVLM
DVALHKCGVTFVLDRSGVTGDDGASHNGMWDMSILQVVPGLRLAAPRDPARLRELLNEAVEVDDAPTVVRFPKGSPPEDI
EAVDRAGGADILVRNGTKDVLVVAVGAMGTTAVDVAQRLTAQGIGVTVVDPRWVKPVDPAIVELAREHRLVVSIEDNGET
GGCGAVLLQTLNAAGVHTPFRLHGIPQQFLGHAKRAAILERIGLTPQAIALRIVEDMTSLTEGRSPLDVEQAT

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=302, Percent_Identity=25.1655629139073, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4507521, Length=302, Percent_Identity=25.1655629139073, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI225637461, Length=543, Percent_Identity=23.0202578268877, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI225637459, Length=543, Percent_Identity=23.0202578268877, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI225637463, Length=543, Percent_Identity=23.0202578268877, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI133778974, Length=415, Percent_Identity=25.3012048192771, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1786622, Length=619, Percent_Identity=36.3489499192246, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17539652, Length=606, Percent_Identity=23.2673267326733, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24666278, Length=554, Percent_Identity=23.1046931407942, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45551847, Length=631, Percent_Identity=23.6133122028526, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550715, Length=631, Percent_Identity=23.6133122028526, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24645119, Length=591, Percent_Identity=23.5194585448393, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_NOCSJ (A1SKM6)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924048.1
- STRING:   A1SKM6
- GeneID:   4598458
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2859
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   NSP35761:NOCA_2859-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67661; Mature: 67530

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLDSIASPADLRGLSDAQLEQLASEIRDLLIRTVATNTGHLGPNLGVVELTLAIHRVF
CCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
DSPRDRVVFDTGHQAYVHKLVCGRAASFGTLRREGGVSGYPSQAESPHDIVENSHASTAL
CCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHHH
SYADGLAKAYTIRGEDRHVIAVIGDGALTGGMAWEALNNIAIAKASKLVIVVNDNGRSYT
HHHHHHHHEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHEEEECCEEEEEEECCCCEEC
PTIGGLATALTSLRTNPRYENVLDLVKRRLNAVPGVGPAAYDALHAMKKGLKDALAPQGL
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHH
FEDLGLKYVGPVDGHDRAAMEQVLAQAKRFNGPVIVHAITRKGYGYDPAERHEADQFHAP
HHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCCCCCCCCC
GPFDVQTGAEKPKGRIWTDVFSEEIVHLGHRRKDLVGITAAMMHPVGLDAFQKHFPERTF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCE
DVGIAEQHAATSAAGLAMGGMHPVVALYGTFLNRAFDQVLMDVALHKCGVTFVLDRSGVT
ECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
GDDGASHNGMWDMSILQVVPGLRLAAPRDPARLRELLNEAVEVDDAPTVVRFPKGSPPED
CCCCCCCCCCCHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCHH
IEAVDRAGGADILVRNGTKDVLVVAVGAMGTTAVDVAQRLTAQGIGVTVVDPRWVKPVDP
HHHHHCCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCH
AIVELAREHRLVVSIEDNGETGGCGAVLLQTLNAAGVHTPFRLHGIPQQFLGHAKRAAIL
HHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHH
ERIGLTPQAIALRIVEDMTSLTEGRSPLDVEQAT
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
GLLDSIASPADLRGLSDAQLEQLASEIRDLLIRTVATNTGHLGPNLGVVELTLAIHRVF
CCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
DSPRDRVVFDTGHQAYVHKLVCGRAASFGTLRREGGVSGYPSQAESPHDIVENSHASTAL
CCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHHHH
SYADGLAKAYTIRGEDRHVIAVIGDGALTGGMAWEALNNIAIAKASKLVIVVNDNGRSYT
HHHHHHHHEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHEEEECCEEEEEEECCCCEEC
PTIGGLATALTSLRTNPRYENVLDLVKRRLNAVPGVGPAAYDALHAMKKGLKDALAPQGL
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHH
FEDLGLKYVGPVDGHDRAAMEQVLAQAKRFNGPVIVHAITRKGYGYDPAERHEADQFHAP
HHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCCCCCCCCC
GPFDVQTGAEKPKGRIWTDVFSEEIVHLGHRRKDLVGITAAMMHPVGLDAFQKHFPERTF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCE
DVGIAEQHAATSAAGLAMGGMHPVVALYGTFLNRAFDQVLMDVALHKCGVTFVLDRSGVT
ECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
GDDGASHNGMWDMSILQVVPGLRLAAPRDPARLRELLNEAVEVDDAPTVVRFPKGSPPED
CCCCCCCCCCCHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCHH
IEAVDRAGGADILVRNGTKDVLVVAVGAMGTTAVDVAQRLTAQGIGVTVVDPRWVKPVDP
HHHHHCCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCH
AIVELAREHRLVVSIEDNGETGGCGAVLLQTLNAAGVHTPFRLHGIPQQFLGHAKRAAIL
HHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHH
ERIGLTPQAIALRIVEDMTSLTEGRSPLDVEQAT
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA