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The map label for this gene is pyrD

Identifier: 119716659

GI number: 119716659

Start: 2595122

End: 2596189

Strand: Direct

Name: pyrD

Synonym: Noca_2432

Alternate gene names: 119716659

Gene position: 2595122-2596189 (Clockwise)

Preceding gene: 119716658

Following gene: 119716660

Centisome position: 52.05

GC content: 73.41

Gene sequence:

>1068_bases
GTGCGAGGGGAGCGAGGCTCGAAGCCATCGGTGTACTCGCTGTTCTTCGACGGGGTCCTGACCCGCACCGACCCGGAGCG
CGCCCACCACGGCGCGTTCCGGGCGATCCGGGCAGCCCGGCCGGTGCTCGCCTCCCGGCGTACGCCGGGCGAGCAGGTCA
CGGCGCTCGGCCTCACGTTCCCCAACGTCTTGGGGCTGGCCGCCGGCTTCGACAAGAACGCCGTCGGCATCGACGCCCTC
GCGGCTCTCGGCTTCGGGCACGTCGAGATCGGCACCGTCACCGGCGAGCCCCAACCCGGCAACCCGAAGCCGCGGCTGTT
CCGGCTCCCCGAGGACCGTGCGATCGTCAACCGGATGGGCTTCAACAACGACGGCGCGGAGGTCGTCGCCCGACGTCTCG
CGGAGCGCTCCCGGGGCCGCGACAGGCTCGGCCACCGCAGTCGGCCGGTGCTCGGCGTGAACATCGGCAAGTCGAAGGTG
GTGCCGGACGACGACCAGGCCGCCGTCGAGGCGGACTACGAGAAGAGCGCCCGGCTGCTGGCGCCGTACGCCGACTACCT
CGTCGTGAACGTGAGCTCGCCGAACACGCCCGGGCTGCGCAACCTGCAGGCCGTCGAGAAGCTCCGGCCGCTGCTCGAGC
ACGTCCGCCGCACCGCCGACGCGGTCACCCGGACGCGGGTGCCGCTCCTGGTGAAGATCGCCCCCGACCTCGCCGACGAG
GACGTGCTCGGTGTGGCCGACCTGGCGCTCGCCATCGGGCTGGACGGGATCATCGCCACCAACACCACGATCTCCCGTGC
CGGCCTGCGCACGCCGGCCGACCGGGTCGGGGAGATCGGCGCCGGCGGGCTCTCCGGGCGACCGCTCACCGGGCGTGCAC
TCGAGGTGCTGCGGCTGCTGCGCGAGCGGGTCGGACCGGACCTGACCCTGGTCGGGGTCGGCGGCATCAGCACCGTGCAG
GACGCTCGCGACCGGCTGACCGCCGGCGCCGACCTGCTCCAGGCCTACAGCGCGTTCGTCTACGAGGGCCCGCTGTGGCC
CCGCCGCATCGTCAGGGGAGTCGCATGA

Upstream 100 bases:

>100_bases
ATCCAGGGACTGGGCGCGGCGGTGCAGGGGATCGAGGCGGTCCGGCGCGGCGAGATCGGGGTCCGGTCCCTCCAGGACTG
GGCGCGCAACGGTGGTTGAG

Downstream 100 bases:

>100_bases
TCCCGTTCGGCAGCCGCCTGCACGCCGCGATCGCGGATCGCGGTCCGCTCTGCGTCGGCATCGACCCGCACGCCGGGCTG
CTGAGCGACTGGGGCCTGGG

Product: dihydroorotate oxidase A

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MRGERGSKPSVYSLFFDGVLTRTDPERAHHGAFRAIRAARPVLASRRTPGEQVTALGLTFPNVLGLAAGFDKNAVGIDAL
AALGFGHVEIGTVTGEPQPGNPKPRLFRLPEDRAIVNRMGFNNDGAEVVARRLAERSRGRDRLGHRSRPVLGVNIGKSKV
VPDDDQAAVEADYEKSARLLAPYADYLVVNVSSPNTPGLRNLQAVEKLRPLLEHVRRTADAVTRTRVPLLVKIAPDLADE
DVLGVADLALAIGLDGIIATNTTISRAGLRTPADRVGEIGAGGLSGRPLTGRALEVLRLLRERVGPDLTLVGVGGISTVQ
DARDRLTAGADLLQAYSAFVYEGPLWPRRIVRGVA

Sequences:

>Translated_355_residues
MRGERGSKPSVYSLFFDGVLTRTDPERAHHGAFRAIRAARPVLASRRTPGEQVTALGLTFPNVLGLAAGFDKNAVGIDAL
AALGFGHVEIGTVTGEPQPGNPKPRLFRLPEDRAIVNRMGFNNDGAEVVARRLAERSRGRDRLGHRSRPVLGVNIGKSKV
VPDDDQAAVEADYEKSARLLAPYADYLVVNVSSPNTPGLRNLQAVEKLRPLLEHVRRTADAVTRTRVPLLVKIAPDLADE
DVLGVADLALAIGLDGIIATNTTISRAGLRTPADRVGEIGAGGLSGRPLTGRALEVLRLLRERVGPDLTLVGVGGISTVQ
DARDRLTAGADLLQAYSAFVYEGPLWPRRIVRGVA
>Mature_355_residues
MRGERGSKPSVYSLFFDGVLTRTDPERAHHGAFRAIRAARPVLASRRTPGEQVTALGLTFPNVLGLAAGFDKNAVGIDAL
AALGFGHVEIGTVTGEPQPGNPKPRLFRLPEDRAIVNRMGFNNDGAEVVARRLAERSRGRDRLGHRSRPVLGVNIGKSKV
VPDDDQAAVEADYEKSARLLAPYADYLVVNVSSPNTPGLRNLQAVEKLRPLLEHVRRTADAVTRTRVPLLVKIAPDLADE
DVLGVADLALAIGLDGIIATNTTISRAGLRTPADRVGEIGAGGLSGRPLTGRALEVLRLLRERVGPDLTLVGVGGISTVQ
DARDRLTAGADLLQAYSAFVYEGPLWPRRIVRGVA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=325, Percent_Identity=44.6153846153846, Blast_Score=242, Evalue=4e-64,
Organism=Escherichia coli, GI1787177, Length=354, Percent_Identity=42.6553672316384, Blast_Score=254, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17509475, Length=327, Percent_Identity=40.0611620795107, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI281361352, Length=326, Percent_Identity=41.1042944785276, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI17137316, Length=326, Percent_Identity=41.1042944785276, Blast_Score=232, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_NOCSJ (A1SJF2)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923624.1
- ProteinModelPortal:   A1SJF2
- SMR:   A1SJF2
- STRING:   A1SJF2
- GeneID:   4598268
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2432
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- PhylomeDB:   A1SJF2
- BioCyc:   NSP35761:NOCA_2432-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 37972; Mature: 37972

Theoretical pI: Translated: 10.58; Mature: 10.58

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 193-193

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGERGSKPSVYSLFFDGVLTRTDPERAHHGAFRAIRAARPVLASRRTPGEQVTALGLTF
CCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCH
PNVLGLAAGFDKNAVGIDALAALGFGHVEIGTVTGEPQPGNPKPRLFRLPEDRAIVNRMG
HHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEECCCHHHHHHHCC
FNNDGAEVVARRLAERSRGRDRLGHRSRPVLGVNIGKSKVVPDDDQAAVEADYEKSARLL
CCCCHHHHHHHHHHHHHCCHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHCCHHHCCCEE
APYADYLVVNVSSPNTPGLRNLQAVEKLRPLLEHVRRTADAVTRTRVPLLVKIAPDLADE
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
DVLGVADLALAIGLDGIIATNTTISRAGLRTPADRVGEIGAGGLSGRPLTGRALEVLRLL
CHHHHHHHHHHHCCCCEEECCCCHHHCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHH
RERVGPDLTLVGVGGISTVQDARDRLTAGADLLQAYSAFVYEGPLWPRRIVRGVA
HHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
>Mature Secondary Structure
MRGERGSKPSVYSLFFDGVLTRTDPERAHHGAFRAIRAARPVLASRRTPGEQVTALGLTF
CCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCH
PNVLGLAAGFDKNAVGIDALAALGFGHVEIGTVTGEPQPGNPKPRLFRLPEDRAIVNRMG
HHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEECCCHHHHHHHCC
FNNDGAEVVARRLAERSRGRDRLGHRSRPVLGVNIGKSKVVPDDDQAAVEADYEKSARLL
CCCCHHHHHHHHHHHHHCCHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHCCHHHCCCEE
APYADYLVVNVSSPNTPGLRNLQAVEKLRPLLEHVRRTADAVTRTRVPLLVKIAPDLADE
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
DVLGVADLALAIGLDGIIATNTTISRAGLRTPADRVGEIGAGGLSGRPLTGRALEVLRLL
CHHHHHHHHHHHCCCCEEECCCCHHHCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHH
RERVGPDLTLVGVGGISTVQDARDRLTAGADLLQAYSAFVYEGPLWPRRIVRGVA
HHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA