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The map label for this gene is pyrC [H]

Identifier: 119716656

GI number: 119716656

Start: 2589258

End: 2590556

Strand: Direct

Name: pyrC [H]

Synonym: Noca_2429

Alternate gene names: 119716656

Gene position: 2589258-2590556 (Clockwise)

Preceding gene: 119716655

Following gene: 119716657

Centisome position: 51.93

GC content: 73.44

Gene sequence:

>1299_bases
GTGAGCACCAGCTACCTGATCAAGAACGTCTCCGTCCTGGGCGGCACGCCGACCGACCTGCTGCTCGAGGACGGGGTGAT
CCGCGAGGCCGCGGACCGGCCCGACGCCGAGGTGATCGATGCGACCGGCCTGATCGCACTGCCCGGGCTGGTCGACCTGC
ACACCCACCTGCGCGAGCCCGGTCGCGAGGACGCCGAGACCGTCGAGACCGGTACGCACGCCGCCGCGATGGGCGGCTTC
ACCGCCGTGCACGCGATGGCCAACACCGAGCCGGTGGCCGACACCGCCGGCGTCGTCGAGCAGGTCTGGCGGCTGGGCCG
CGAGGCCGGCTACTGCGACGTGTTCCCGGTCGGCGCCGTCACCGTGGGCCTCCAGGGCGAGCGCCTCGCCGAGCTCGGTG
CGATGGCGGACTCGGCCGCCCGGGTGCGGGTGTTCTCCGACGACGGGAAGTGCGTCAGCGACGCGGTGCTGATGCGCCGC
GCGCTGGAGTACGTCAAGGCGTTCGACGGCGTCGTCGCGCAGCACGCCCAGGAGCCACGGCTGACCGAGGGCGCCCAGAT
GAACGAGGGCGAGCTGTCCGGCCGGCTCGGACTGGCCGGCTGGCCGGCGGTCGCCGAGGAGGCGATCATCGCCCGCGACC
TGCTGCTCGCCGAGCACGTCGGGTCCCGGCTGCACGTCTGCCACGTGTCGACGGCCGGCTCGGTCGAGCTGATCCGCTGG
GCCAAGGCGAAGGCCGAGAAGGACGGGCACTGGGAGGTCACGGCCGAGGCGTGCCCCCACCACCTGCTGCTGACCGACGA
GCTGGCGGCGACCTACGACCCGATCTACAAGGTGAACCCCCCGCTGCGCACCGCGGCGGACGCCCAGGCGCTCCGTGCCG
GGCTGGCCGACGGCACGATCGACATCGTCGCCACCGACCACGCGCCGCACCCCCACGAGGACAAGGACTGCGAGTGGGCG
GCCGCCGCGTTCGGCATGCTCGGCCTGGAGACGGCGCTCTCGGTGGTCCAGCAGACGATGGTGGACACCGGGCTGCTCGA
CTGGGCCGGCCTGGCCGAGCGGATGTCCTACGCCCCGGCCCGGATCGGCCGGGTCTCCGACCAGCACGGGCGCCCGGTCG
CGATCGGTGAGCCCGCGAACATGGTGCTCTACGACCCCGGAGCCACCCGCACGATCGACCCGTCGGAGTCGGCCAGCCTG
AGCCGCAACACGCCGTACCGCGGCATGGAGCTGCCCGGCCGGGTGGTCGCGACATTCCTGCGTGGCCGCGCCACGGTGCT
CGACGGGAAGCTGCAGTGA

Upstream 100 bases:

>100_bases
AGGTCACCAACGGCGTCGCCGTGCGGATGGCCGTCCTGTACCTGCTGCTGGGCGGCTCCGAGCCCGCGGTTTCGACCAGC
TCAACCAACGAGGCGGAAGA

Downstream 100 bases:

>100_bases
CGAGGGCGATCCTCGTCCTGGAGGACGGCCGCAGCTTCCAGGGCGAGTCGTACGGCGCCGAGGGGGAGACCTTCGGCGAG
GCGGTCTTCAACACCGGCAT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSTSYLIKNVSVLGGTPTDLLLEDGVIREAADRPDAEVIDATGLIALPGLVDLHTHLREPGREDAETVETGTHAAAMGGF
TAVHAMANTEPVADTAGVVEQVWRLGREAGYCDVFPVGAVTVGLQGERLAELGAMADSAARVRVFSDDGKCVSDAVLMRR
ALEYVKAFDGVVAQHAQEPRLTEGAQMNEGELSGRLGLAGWPAVAEEAIIARDLLLAEHVGSRLHVCHVSTAGSVELIRW
AKAKAEKDGHWEVTAEACPHHLLLTDELAATYDPIYKVNPPLRTAADAQALRAGLADGTIDIVATDHAPHPHEDKDCEWA
AAAFGMLGLETALSVVQQTMVDTGLLDWAGLAERMSYAPARIGRVSDQHGRPVAIGEPANMVLYDPGATRTIDPSESASL
SRNTPYRGMELPGRVVATFLRGRATVLDGKLQ

Sequences:

>Translated_432_residues
MSTSYLIKNVSVLGGTPTDLLLEDGVIREAADRPDAEVIDATGLIALPGLVDLHTHLREPGREDAETVETGTHAAAMGGF
TAVHAMANTEPVADTAGVVEQVWRLGREAGYCDVFPVGAVTVGLQGERLAELGAMADSAARVRVFSDDGKCVSDAVLMRR
ALEYVKAFDGVVAQHAQEPRLTEGAQMNEGELSGRLGLAGWPAVAEEAIIARDLLLAEHVGSRLHVCHVSTAGSVELIRW
AKAKAEKDGHWEVTAEACPHHLLLTDELAATYDPIYKVNPPLRTAADAQALRAGLADGTIDIVATDHAPHPHEDKDCEWA
AAAFGMLGLETALSVVQQTMVDTGLLDWAGLAERMSYAPARIGRVSDQHGRPVAIGEPANMVLYDPGATRTIDPSESASL
SRNTPYRGMELPGRVVATFLRGRATVLDGKLQ
>Mature_431_residues
STSYLIKNVSVLGGTPTDLLLEDGVIREAADRPDAEVIDATGLIALPGLVDLHTHLREPGREDAETVETGTHAAAMGGFT
AVHAMANTEPVADTAGVVEQVWRLGREAGYCDVFPVGAVTVGLQGERLAELGAMADSAARVRVFSDDGKCVSDAVLMRRA
LEYVKAFDGVVAQHAQEPRLTEGAQMNEGELSGRLGLAGWPAVAEEAIIARDLLLAEHVGSRLHVCHVSTAGSVELIRWA
KAKAEKDGHWEVTAEACPHHLLLTDELAATYDPIYKVNPPLRTAADAQALRAGLADGTIDIVATDHAPHPHEDKDCEWAA
AAFGMLGLETALSVVQQTMVDTGLLDWAGLAERMSYAPARIGRVSDQHGRPVAIGEPANMVLYDPGATRTIDPSESASLS
RNTPYRGMELPGRVVATFLRGRATVLDGKLQ

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=402, Percent_Identity=28.8557213930348, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI190194363, Length=434, Percent_Identity=25.1152073732719, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786722, Length=439, Percent_Identity=29.3849658314351, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI87082175, Length=453, Percent_Identity=25.60706401766, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193204318, Length=426, Percent_Identity=27.6995305164319, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71989490, Length=468, Percent_Identity=26.4957264957265, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17539558, Length=461, Percent_Identity=27.3318872017354, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI86575075, Length=444, Percent_Identity=23.1981981981982, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322218, Length=439, Percent_Identity=29.6127562642369, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642586, Length=395, Percent_Identity=29.3670886075949, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17137462, Length=444, Percent_Identity=24.3243243243243, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221377917, Length=451, Percent_Identity=24.1685144124169, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI18859883, Length=455, Percent_Identity=27.4725274725275, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45915; Mature: 45784

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSYLIKNVSVLGGTPTDLLLEDGVIREAADRPDAEVIDATGLIALPGLVDLHTHLREP
CCCCCEEEEEHCCCCCCHHHHHCCCHHHHHCCCCCCCEECCCCCEECCCHHHHHHHHCCC
GREDAETVETGTHAAAMGGFTAVHAMANTEPVADTAGVVEQVWRLGREAGYCDVFPVGAV
CCCHHHHHHCCCHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCEE
TVGLQGERLAELGAMADSAARVRVFSDDGKCVSDAVLMRRALEYVKAFDGVVAQHAQEPR
EECCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LTEGAQMNEGELSGRLGLAGWPAVAEEAIIARDLLLAEHVGSRLHVCHVSTAGSVELIRW
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHH
AKAKAEKDGHWEVTAEACPHHLLLTDELAATYDPIYKVNPPLRTAADAQALRAGLADGTI
HHHHCCCCCCEEEEHHHCCCEEEEEHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCCCEE
DIVATDHAPHPHEDKDCEWAAAAFGMLGLETALSVVQQTMVDTGLLDWAGLAERMSYAPA
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHH
RIGRVSDQHGRPVAIGEPANMVLYDPGATRTIDPSESASLSRNTPYRGMELPGRVVATFL
HHCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
RGRATVLDGKLQ
CCCEEEECCCCC
>Mature Secondary Structure 
STSYLIKNVSVLGGTPTDLLLEDGVIREAADRPDAEVIDATGLIALPGLVDLHTHLREP
CCCCEEEEEHCCCCCCHHHHHCCCHHHHHCCCCCCCEECCCCCEECCCHHHHHHHHCCC
GREDAETVETGTHAAAMGGFTAVHAMANTEPVADTAGVVEQVWRLGREAGYCDVFPVGAV
CCCHHHHHHCCCHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCEE
TVGLQGERLAELGAMADSAARVRVFSDDGKCVSDAVLMRRALEYVKAFDGVVAQHAQEPR
EECCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LTEGAQMNEGELSGRLGLAGWPAVAEEAIIARDLLLAEHVGSRLHVCHVSTAGSVELIRW
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHH
AKAKAEKDGHWEVTAEACPHHLLLTDELAATYDPIYKVNPPLRTAADAQALRAGLADGTI
HHHHCCCCCCEEEEHHHCCCEEEEEHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCCCEE
DIVATDHAPHPHEDKDCEWAAAAFGMLGLETALSVVQQTMVDTGLLDWAGLAERMSYAPA
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHH
RIGRVSDQHGRPVAIGEPANMVLYDPGATRTIDPSESASLSRNTPYRGMELPGRVVATFL
HHCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
RGRATVLDGKLQ
CCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]