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The map label for this gene is hisS [H]

Identifier: 119716624

GI number: 119716624

Start: 2554390

End: 2555745

Strand: Direct

Name: hisS [H]

Synonym: Noca_2397

Alternate gene names: 119716624

Gene position: 2554390-2555745 (Clockwise)

Preceding gene: 119716623

Following gene: 119716625

Centisome position: 51.23

GC content: 70.65

Gene sequence:

>1356_bases
ATGGCCAAACCCACCCCGCTGAGCGGGTTCCCCGAGCTGCTGCCCGAGCAGCGGGTCGTCGAGCAGCAGGTCGTCGACAC
CCTCCGGCACACGTTCGAGCTCTACGGCTTCGCGGGCATCGAGACCCGGGCCGTCGAACCGCTCGACCAGCTGCTGCGCA
AGGGCGACACCTCCAAGGAGGTCTACCTCCTGCGCCGGCTGCACGAGGAGTCGGCGGAGGGGCACTCCGGCATCGGGCTG
CACTTCGACCTGACCGTGCCGTTCGCGCGCTACGTGCTCGAGAACGCCGGCAGGCTGGAGTTTCCGTTCCGCCGCTACCA
GATCCAGAAGGCGTGGCGCGGCGAGCGGCCGCAGGAGGGCCGCTACCGCGAGTTCACCCAGGCCGACATCGACGTCATCG
GCCGCGACGAGCTGCCCTTCCACCACGACGTCGAGGTCACCCGGGTGATGGTCGACGCACTGAACCGGCTCGACTTCTTG
CCGGCGTTCCGGCTCCAGGTGAACAACCGCAAGCTGATCCAGGGTTTCTACGCCGGCCTGGGCGTCGCCGACACCGACGA
GGCGATGCGGATCGTCGACAAGCTCGACAAGCTCCCGGTCGAGAAGGTGCGCGCGATGCTGGTCGCCGAGGCCGGCGTCG
ACGAGGCGACCGCCGACCGCGTGCTGTCGCTGGCGACGATCCGCGCCACCGACGACTCCTTCGTCGACGCCGTCCGGGCG
CTGGGCGTCGAACACCCGCTGCTCGACGAGGGCCTGGCCGAGCTCGGTGCACTGGTGCGGGCGTGTGCCGATCTCGTCAG
CGACCGGGTGCAGGTCGTCGCGGACCTCTCGATCGCGCGCGGCCTCGACTACTACACCGGCACGGTCTTCGAGACCCGGC
TCGACGGCTACGAGTCGCTGGGATCGATCTGCTCCGGCGGTCGCTACGACGCGCTCGCGTCCGACGGCCGCACGACGTAC
CCCGGCGTCGGCATCTCGCTCGGCGTCAGCCGGGTCGTCGTGCCGCTGATGGCGCGCACCGGCCTGGCGGCCAGCCGCAA
GGTGCCGAGCGCCGTCGTGGTCGCGGTCGTCTCCGAGGAGTCGCGACCCGAGAGCGAGGCGGTCGCCGCCGCCCTGCGTG
CCCGCAACATCCCCTGCGAGGTCGCGGCGAGCGCGCAGAAGTTCGGCAAGCAGATCCGGTACGCCGAGCGGCGGGGCATC
CCGTACGTCTGGTTCCCGGACCAGGCCGAGGTGAAGGACATCCGGTTGGGGGAGCAGGTGGCGGCCGACCCCGCCTCCTG
GACCCCACCCATCGAGGACCTGCGACCGCAGGTCGTTGCGACGAGCCCGACAAGCGAGATGGAGAGTACGAAGTGA

Upstream 100 bases:

>100_bases
GACGTCGTCGTCCTGCCGGGCCACGGCGAGCAGACGTCCATCGGTCGCGAGCGTGCGACCAACCCCTACCTGATTCCGTT
GAGTCTCCAGGATCTGTGAC

Downstream 100 bases:

>100_bases
TTCGCACCCAGGACGCCGGCGCACTGCGCGCCGAGAACGTCGGCCAGACCGTGACTCTCGCGGGGTGGGTGGCCAACCGG
CGCGATCACGGTGGGGTCGC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MAKPTPLSGFPELLPEQRVVEQQVVDTLRHTFELYGFAGIETRAVEPLDQLLRKGDTSKEVYLLRRLHEESAEGHSGIGL
HFDLTVPFARYVLENAGRLEFPFRRYQIQKAWRGERPQEGRYREFTQADIDVIGRDELPFHHDVEVTRVMVDALNRLDFL
PAFRLQVNNRKLIQGFYAGLGVADTDEAMRIVDKLDKLPVEKVRAMLVAEAGVDEATADRVLSLATIRATDDSFVDAVRA
LGVEHPLLDEGLAELGALVRACADLVSDRVQVVADLSIARGLDYYTGTVFETRLDGYESLGSICSGGRYDALASDGRTTY
PGVGISLGVSRVVVPLMARTGLAASRKVPSAVVVAVVSEESRPESEAVAAALRARNIPCEVAASAQKFGKQIRYAERRGI
PYVWFPDQAEVKDIRLGEQVAADPASWTPPIEDLRPQVVATSPTSEMESTK

Sequences:

>Translated_451_residues
MAKPTPLSGFPELLPEQRVVEQQVVDTLRHTFELYGFAGIETRAVEPLDQLLRKGDTSKEVYLLRRLHEESAEGHSGIGL
HFDLTVPFARYVLENAGRLEFPFRRYQIQKAWRGERPQEGRYREFTQADIDVIGRDELPFHHDVEVTRVMVDALNRLDFL
PAFRLQVNNRKLIQGFYAGLGVADTDEAMRIVDKLDKLPVEKVRAMLVAEAGVDEATADRVLSLATIRATDDSFVDAVRA
LGVEHPLLDEGLAELGALVRACADLVSDRVQVVADLSIARGLDYYTGTVFETRLDGYESLGSICSGGRYDALASDGRTTY
PGVGISLGVSRVVVPLMARTGLAASRKVPSAVVVAVVSEESRPESEAVAAALRARNIPCEVAASAQKFGKQIRYAERRGI
PYVWFPDQAEVKDIRLGEQVAADPASWTPPIEDLRPQVVATSPTSEMESTK
>Mature_450_residues
AKPTPLSGFPELLPEQRVVEQQVVDTLRHTFELYGFAGIETRAVEPLDQLLRKGDTSKEVYLLRRLHEESAEGHSGIGLH
FDLTVPFARYVLENAGRLEFPFRRYQIQKAWRGERPQEGRYREFTQADIDVIGRDELPFHHDVEVTRVMVDALNRLDFLP
AFRLQVNNRKLIQGFYAGLGVADTDEAMRIVDKLDKLPVEKVRAMLVAEAGVDEATADRVLSLATIRATDDSFVDAVRAL
GVEHPLLDEGLAELGALVRACADLVSDRVQVVADLSIARGLDYYTGTVFETRLDGYESLGSICSGGRYDALASDGRTTYP
GVGISLGVSRVVVPLMARTGLAASRKVPSAVVVAVVSEESRPESEAVAAALRARNIPCEVAASAQKFGKQIRYAERRGIP
YVWFPDQAEVKDIRLGEQVAADPASWTPPIEDLRPQVVATSPTSEMESTK

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI15029520, Length=439, Percent_Identity=32.1184510250569, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI6996014, Length=429, Percent_Identity=32.4009324009324, Blast_Score=162, Evalue=9e-40,
Organism=Escherichia coli, GI1788861, Length=451, Percent_Identity=26.3858093126386, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71993693, Length=432, Percent_Identity=29.8611111111111, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71993686, Length=432, Percent_Identity=29.8611111111111, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6325290, Length=376, Percent_Identity=31.6489361702128, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24643061, Length=443, Percent_Identity=30.9255079006772, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24643059, Length=453, Percent_Identity=29.3598233995585, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 49760; Mature: 49629

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPTPLSGFPELLPEQRVVEQQVVDTLRHTFELYGFAGIETRAVEPLDQLLRKGDTSKE
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHH
VYLLRRLHEESAEGHSGIGLHFDLTVPFARYVLENAGRLEFPFRRYQIQKAWRGERPQEG
HHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCC
RYREFTQADIDVIGRDELPFHHDVEVTRVMVDALNRLDFLPAFRLQVNNRKLIQGFYAGL
CHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEECCHHHHHHHHHCC
GVADTDEAMRIVDKLDKLPVEKVRAMLVAEAGVDEATADRVLSLATIRATDDSFVDAVRA
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCHHHHHHHHH
LGVEHPLLDEGLAELGALVRACADLVSDRVQVVADLSIARGLDYYTGTVFETRLDGYESL
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHCCHHHH
GSICSGGRYDALASDGRTTYPGVGISLGVSRVVVPLMARTGLAASRKVPSAVVVAVVSEE
HHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCC
SRPESEAVAAALRARNIPCEVAASAQKFGKQIRYAERRGIPYVWFPDQAEVKDIRLGEQV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHCCHHH
AADPASWTPPIEDLRPQVVATSPTSEMESTK
HCCCCCCCCCHHHCCCCEEECCCCHHHCCCC
>Mature Secondary Structure 
AKPTPLSGFPELLPEQRVVEQQVVDTLRHTFELYGFAGIETRAVEPLDQLLRKGDTSKE
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHH
VYLLRRLHEESAEGHSGIGLHFDLTVPFARYVLENAGRLEFPFRRYQIQKAWRGERPQEG
HHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCC
RYREFTQADIDVIGRDELPFHHDVEVTRVMVDALNRLDFLPAFRLQVNNRKLIQGFYAGL
CHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEECCHHHHHHHHHCC
GVADTDEAMRIVDKLDKLPVEKVRAMLVAEAGVDEATADRVLSLATIRATDDSFVDAVRA
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCHHHHHHHHH
LGVEHPLLDEGLAELGALVRACADLVSDRVQVVADLSIARGLDYYTGTVFETRLDGYESL
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHCCHHHH
GSICSGGRYDALASDGRTTYPGVGISLGVSRVVVPLMARTGLAASRKVPSAVVVAVVSEE
HHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECCC
SRPESEAVAAALRARNIPCEVAASAQKFGKQIRYAERRGIPYVWFPDQAEVKDIRLGEQV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHCCHHH
AADPASWTPPIEDLRPQVVATSPTSEMESTK
HCCCCCCCCCHHHCCCCEEECCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA