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The map label for this gene is thrS

Identifier: 119716597

GI number: 119716597

Start: 2525866

End: 2527872

Strand: Direct

Name: thrS

Synonym: Noca_2370

Alternate gene names: 119716597

Gene position: 2525866-2527872 (Clockwise)

Preceding gene: 119716594

Following gene: 119716599

Centisome position: 50.66

GC content: 68.41

Gene sequence:

>2007_bases
GTGTCCGACCTGAAGATCGCCCTCACCCACGCCGACGCGCGTGAGGAGCGGACGGTCACGACGGGCACCAAGGCATGGGA
GCTCTTCCAGGACGACCCGTCGGTGATCGCGGCCCGGGTGAACGGCGCGTTGCGAGACCTCGCCCACGAGCTCGCCGACG
GCGACCAGGTCGAGCCCGTGGCCATCGACAGCCCCGACGGGCACGACATCCTGCGCCACTCCACCGCGCACGTCATGGCC
CAGGCGGTCCAGCAGCTGTTCCCGGACGCCAAGCTCGGTATCGGCCCGCCGGTCGAGAACGGCTTCTACTACGACTTCGA
CGTCGATACCCCCTTCAACCCTGCGGACCTCGACAAGATCGAGACCGCGATGCGCAAGATCATCAAGGAGGGCCAGCGGT
TCTCCCGCCGGGTCACCACCGACGCCGACGCGATCAGCGAGCTGCGGGACGAGCCCTACAAGATCGAGCTGATCGGCCTG
AAGGGGTCCGGCGCCTCGACCGGCTCGACCACAGAGGCCGTCGAGGGTGCGAGCGTCGAGGTCGGTGCCGGCGAGCTGAC
GATCTACGACAACATCCGCCGCAACGGCGACGTCGCGTGGAGCGACCTGTGCCGTGGCCCGCACCTGCCCACCACCAAGC
GGATCCCGGCGTTCAAGCTGATGCGCACCGCCGCGGCGTACTGGCGCGGGAACGAGAAGAACAAGCAGCTCCAGCGCATC
TACGGCACCGCCTGGGAGTCCAAGGACGCCCTCGAGGAGCACCTGCACCGGATCGAGGAGGCCGAGCGGCGCGACCACCG
CAAGCTCGGGCGCGACCTCGACCTGTTCAGCTTCCCGGACGAGATCGGGTCCGGTCTCCCCGTGTTCCACCCCAAGGGCG
GGGTGATCAAGCGGGTGATGGAGGACTACGTCCGCCAGCGCCACGTCGAGGAGGGCTTCGAGTACGTCGGGACCCCGCAC
ATCGCCAAGGAGGGCCTGTTCTACACCTCCGGGCACCTGCCGTACTACGGGGAGGCGATGTTCCCGCCCCTCGACGTCGA
CGGCATGGACTACCGGCTCAAGGCGATGAACTGCCCGATGCACAACCTGATCTTCCGGTCGCGGCAGCGCTCCTACCGCG
AGCTGCCGCTGCGGCTGTTCGAGTTCGGACACGTCTACCGGCACGAGAAGTCCGGCGTGATCCACGGGCTGACCCGCGTC
CGGGGGTTCGCCCAGGATGACTCGCACTCGTACGTCACCAAGGAGCAGGCGCCGGCGGAGATCAAGCACCTCCTCGACTT
CTGCCTCGGGCTGTTCCGCGATTTCGGCCTGGACGACTTCTACCTCGAGCTGTCCACCCGGGACGACTCCAAGCCCGACA
AGTTCATCGGGTCGGACGAGGACTGGGCGGTCGCGACCAAGGTGCTCGAGGACGTCTGCATCGCCTCGGGCCTGGAGCTG
GTCCCCGACCCGGGCGGGGCGGCGTACTACGGGCCGAAGGTCTCCGTGCAGGCGCGTGACGCGATCGGCCGGACCTGGCA
GATGTCGACGATCCAGTACGACTTCAACCAGCCCTCGGCGGACCGGTTCGACCTCCACTACACCGCCGCCGACGGCTCGC
GTCAGCAGCCGGTGATGATCCACTCCGCCAAGTTCGGCTCGATCGAGCGGTTCATCGGCGTGCTCGTGGAGCACTACGCC
GGCGCCTTTCCTCCGTGGCTGGCGCCCGTGCAGGTGCAGGCGATCCCGATCGCCGAGCGGCACAACGACTACCTCTACGA
CGTGGCCAAGCGGATGCAGGCCCAGGGGCTGCGGGTCGAGGTCGACGACTCCGACGACCGGATGCAGAAGAAGATCCGCA
ACGCCCAGCTCCTGAAGGTGCCGTTCATGATGATCGCCGGCGACGACGACGTCGCGGCCGGCGCGGTCTCCTTCCGCTAC
CGCGACGGGCGCCAGGACAACGGCGTTCCCCTCGACGAGGCGATCCGCCGGGTCGCCGACGCGGTCGCGAGCCGCGAGCA
GGTGTAG

Upstream 100 bases:

>100_bases
CCGGTCGGCCCACCTGACCCATCGGAAACCGGAGCGCGCTCGCCTGAGACGCCCCGATACGATCGGTGGGTCCGTCTCGT
CTGCCGCCCCAGGAGTCACC

Downstream 100 bases:

>100_bases
CGGCAGGCGGCTACGCCCGGAGGCTCTTCACGTAGCGGCGGCACGGCGAGACGTACGTCGTGCCGCCGGCGGTGACCTCG
TAGGGCAGGTCGCCACCGTC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MSDLKIALTHADAREERTVTTGTKAWELFQDDPSVIAARVNGALRDLAHELADGDQVEPVAIDSPDGHDILRHSTAHVMA
QAVQQLFPDAKLGIGPPVENGFYYDFDVDTPFNPADLDKIETAMRKIIKEGQRFSRRVTTDADAISELRDEPYKIELIGL
KGSGASTGSTTEAVEGASVEVGAGELTIYDNIRRNGDVAWSDLCRGPHLPTTKRIPAFKLMRTAAAYWRGNEKNKQLQRI
YGTAWESKDALEEHLHRIEEAERRDHRKLGRDLDLFSFPDEIGSGLPVFHPKGGVIKRVMEDYVRQRHVEEGFEYVGTPH
IAKEGLFYTSGHLPYYGEAMFPPLDVDGMDYRLKAMNCPMHNLIFRSRQRSYRELPLRLFEFGHVYRHEKSGVIHGLTRV
RGFAQDDSHSYVTKEQAPAEIKHLLDFCLGLFRDFGLDDFYLELSTRDDSKPDKFIGSDEDWAVATKVLEDVCIASGLEL
VPDPGGAAYYGPKVSVQARDAIGRTWQMSTIQYDFNQPSADRFDLHYTAADGSRQQPVMIHSAKFGSIERFIGVLVEHYA
GAFPPWLAPVQVQAIPIAERHNDYLYDVAKRMQAQGLRVEVDDSDDRMQKKIRNAQLLKVPFMMIAGDDDVAAGAVSFRY
RDGRQDNGVPLDEAIRRVADAVASREQV

Sequences:

>Translated_668_residues
MSDLKIALTHADAREERTVTTGTKAWELFQDDPSVIAARVNGALRDLAHELADGDQVEPVAIDSPDGHDILRHSTAHVMA
QAVQQLFPDAKLGIGPPVENGFYYDFDVDTPFNPADLDKIETAMRKIIKEGQRFSRRVTTDADAISELRDEPYKIELIGL
KGSGASTGSTTEAVEGASVEVGAGELTIYDNIRRNGDVAWSDLCRGPHLPTTKRIPAFKLMRTAAAYWRGNEKNKQLQRI
YGTAWESKDALEEHLHRIEEAERRDHRKLGRDLDLFSFPDEIGSGLPVFHPKGGVIKRVMEDYVRQRHVEEGFEYVGTPH
IAKEGLFYTSGHLPYYGEAMFPPLDVDGMDYRLKAMNCPMHNLIFRSRQRSYRELPLRLFEFGHVYRHEKSGVIHGLTRV
RGFAQDDSHSYVTKEQAPAEIKHLLDFCLGLFRDFGLDDFYLELSTRDDSKPDKFIGSDEDWAVATKVLEDVCIASGLEL
VPDPGGAAYYGPKVSVQARDAIGRTWQMSTIQYDFNQPSADRFDLHYTAADGSRQQPVMIHSAKFGSIERFIGVLVEHYA
GAFPPWLAPVQVQAIPIAERHNDYLYDVAKRMQAQGLRVEVDDSDDRMQKKIRNAQLLKVPFMMIAGDDDVAAGAVSFRY
RDGRQDNGVPLDEAIRRVADAVASREQV
>Mature_667_residues
SDLKIALTHADAREERTVTTGTKAWELFQDDPSVIAARVNGALRDLAHELADGDQVEPVAIDSPDGHDILRHSTAHVMAQ
AVQQLFPDAKLGIGPPVENGFYYDFDVDTPFNPADLDKIETAMRKIIKEGQRFSRRVTTDADAISELRDEPYKIELIGLK
GSGASTGSTTEAVEGASVEVGAGELTIYDNIRRNGDVAWSDLCRGPHLPTTKRIPAFKLMRTAAAYWRGNEKNKQLQRIY
GTAWESKDALEEHLHRIEEAERRDHRKLGRDLDLFSFPDEIGSGLPVFHPKGGVIKRVMEDYVRQRHVEEGFEYVGTPHI
AKEGLFYTSGHLPYYGEAMFPPLDVDGMDYRLKAMNCPMHNLIFRSRQRSYRELPLRLFEFGHVYRHEKSGVIHGLTRVR
GFAQDDSHSYVTKEQAPAEIKHLLDFCLGLFRDFGLDDFYLELSTRDDSKPDKFIGSDEDWAVATKVLEDVCIASGLELV
PDPGGAAYYGPKVSVQARDAIGRTWQMSTIQYDFNQPSADRFDLHYTAADGSRQQPVMIHSAKFGSIERFIGVLVEHYAG
AFPPWLAPVQVQAIPIAERHNDYLYDVAKRMQAQGLRVEVDDSDDRMQKKIRNAQLLKVPFMMIAGDDDVAAGAVSFRYR
DGRQDNGVPLDEAIRRVADAVASREQV

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=628, Percent_Identity=36.624203821656, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI38570111, Length=635, Percent_Identity=35.5905511811024, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI20070344, Length=653, Percent_Identity=34.9157733537519, Blast_Score=339, Evalue=5e-93,
Organism=Escherichia coli, GI1788013, Length=634, Percent_Identity=36.9085173501577, Blast_Score=439, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71984192, Length=633, Percent_Identity=35.7030015797788, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71984184, Length=633, Percent_Identity=35.7030015797788, Blast_Score=392, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322112, Length=648, Percent_Identity=35.0308641975309, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322654, Length=402, Percent_Identity=34.5771144278607, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24583842, Length=627, Percent_Identity=35.5661881977671, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI28574141, Length=627, Percent_Identity=35.5661881977671, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24583839, Length=627, Percent_Identity=35.5661881977671, Blast_Score=408, Evalue=1e-114,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_NOCSJ (A1SJ90)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923562.1
- ProteinModelPortal:   A1SJ90
- SMR:   A1SJ90
- STRING:   A1SJ90
- GeneID:   4599470
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2370
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- ProtClustDB:   PRK12305
- BioCyc:   NSP35761:NOCA_2370-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 75111; Mature: 74980

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLKIALTHADAREERTVTTGTKAWELFQDDPSVIAARVNGALRDLAHELADGDQVEPV
CCCCEEEEEECCCCCCCEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEE
AIDSPDGHDILRHSTAHVMAQAVQQLFPDAKLGIGPPVENGFYYDFDVDTPFNPADLDKI
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHH
ETAMRKIIKEGQRFSRRVTTDADAISELRDEPYKIELIGLKGSGASTGSTTEAVEGASVE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHCCCCEEE
VGAGELTIYDNIRRNGDVAWSDLCRGPHLPTTKRIPAFKLMRTAAAYWRGNEKNKQLQRI
ECCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
YGTAWESKDALEEHLHRIEEAERRDHRKLGRDLDLFSFPDEIGSGLPVFHPKGGVIKRVM
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHH
EDYVRQRHVEEGFEYVGTPHIAKEGLFYTSGHLPYYGEAMFPPLDVDGMDYRLKAMNCPM
HHHHHHHHHHHHHHHCCCCCHHHCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCH
HNLIFRSRQRSYRELPLRLFEFGHVYRHEKSGVIHGLTRVRGFAQDDSHSYVTKEQAPAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHH
IKHLLDFCLGLFRDFGLDDFYLELSTRDDSKPDKFIGSDEDWAVATKVLEDVCIASGLEL
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
VPDPGGAAYYGPKVSVQARDAIGRTWQMSTIQYDFNQPSADRFDLHYTAADGSRQQPVMI
CCCCCCCCEECCEEEEEEHHHCCCEEEEEEEEEECCCCCCCCEEEEEEECCCCCCCCEEE
HSAKFGSIERFIGVLVEHYAGAFPPWLAPVQVQAIPIAERHNDYLYDVAKRMQAQGLRVE
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECHHHCCHHHHHHHHHHHHCCCEEE
VDDSDDRMQKKIRNAQLLKVPFMMIAGDDDVAAGAVSFRYRDGRQDNGVPLDEAIRRVAD
ECCCHHHHHHHHCCCEEEEECEEEEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
AVASREQV
HHHHCCCC
>Mature Secondary Structure 
SDLKIALTHADAREERTVTTGTKAWELFQDDPSVIAARVNGALRDLAHELADGDQVEPV
CCCEEEEEECCCCCCCEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEE
AIDSPDGHDILRHSTAHVMAQAVQQLFPDAKLGIGPPVENGFYYDFDVDTPFNPADLDKI
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHH
ETAMRKIIKEGQRFSRRVTTDADAISELRDEPYKIELIGLKGSGASTGSTTEAVEGASVE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHCCCCEEE
VGAGELTIYDNIRRNGDVAWSDLCRGPHLPTTKRIPAFKLMRTAAAYWRGNEKNKQLQRI
ECCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
YGTAWESKDALEEHLHRIEEAERRDHRKLGRDLDLFSFPDEIGSGLPVFHPKGGVIKRVM
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHH
EDYVRQRHVEEGFEYVGTPHIAKEGLFYTSGHLPYYGEAMFPPLDVDGMDYRLKAMNCPM
HHHHHHHHHHHHHHHCCCCCHHHCCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCH
HNLIFRSRQRSYRELPLRLFEFGHVYRHEKSGVIHGLTRVRGFAQDDSHSYVTKEQAPAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHH
IKHLLDFCLGLFRDFGLDDFYLELSTRDDSKPDKFIGSDEDWAVATKVLEDVCIASGLEL
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
VPDPGGAAYYGPKVSVQARDAIGRTWQMSTIQYDFNQPSADRFDLHYTAADGSRQQPVMI
CCCCCCCCEECCEEEEEEHHHCCCEEEEEEEEEECCCCCCCCEEEEEEECCCCCCCCEEE
HSAKFGSIERFIGVLVEHYAGAFPPWLAPVQVQAIPIAERHNDYLYDVAKRMQAQGLRVE
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECHHHCCHHHHHHHHHHHHCCCEEE
VDDSDDRMQKKIRNAQLLKVPFMMIAGDDDVAAGAVSFRYRDGRQDNGVPLDEAIRRVAD
ECCCHHHHHHHHCCCEEEEECEEEEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
AVASREQV
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA