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The map label for this gene is merR1 [H]

Identifier: 119716427

GI number: 119716427

Start: 2347243

End: 2347650

Strand: Reverse

Name: merR1 [H]

Synonym: Noca_2198

Alternate gene names: 119716427

Gene position: 2347650-2347243 (Counterclockwise)

Preceding gene: 119716428

Following gene: 119716426

Centisome position: 47.09

GC content: 64.71

Gene sequence:

>408_bases
ATGCGGACCAAGGAACTGGCGGATCGAGCCGGCGTGAACAGCGAGACCCTGCGCTACTACGAACGCCGCGGCCTGTTGTC
TGAACCACCACGCACTCCGGGCGGCTATCGCGACTACCCGTCCTCGACCGTTGGCCTGCTGCTGTTCATCAAGCGCGCCC
AAGAGCTGGGATTCAGGCTGGATGAGGTGGATGAACTGCTTCATCTCGATGCCGGTGGCCCGGAAAGCTGCGATGCGGCT
CGTGGGCTGGCCGAGCAGCGCAGGGCCGACCTGCAGCGGAGGATCTCCGATCTCCAACGGATGCACGACTCGCTGACCGC
CCTGGTGGACACCTGCGAACTTCCCCGGGCTGACCGCACATGCGCTCTGCTCGACGCTCTGACAGTCACACGAGAGGTGG
TCCGATGA

Upstream 100 bases:

>100_bases
CGCAGTGGAAACGAGACCACGAGCCGTCCTGATAGTCGGCTGGGCGGTTCCCCGGGTCGGGATTGACTTCGTAGTTGGGT
ACAGGGTTCACGATGGAGTC

Downstream 100 bases:

>100_bases
AGCTCGAGGTGCTGCACGTGACCGACTGCCCGAACGTGCGGCCGATGCTGGACCGGCTGGCCGAGGCCACCGACCTCCCG
GTCGCCACACGAGAGGTCAC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MRTKELADRAGVNSETLRYYERRGLLSEPPRTPGGYRDYPSSTVGLLLFIKRAQELGFRLDEVDELLHLDAGGPESCDAA
RGLAEQRRADLQRRISDLQRMHDSLTALVDTCELPRADRTCALLDALTVTREVVR

Sequences:

>Translated_135_residues
MRTKELADRAGVNSETLRYYERRGLLSEPPRTPGGYRDYPSSTVGLLLFIKRAQELGFRLDEVDELLHLDAGGPESCDAA
RGLAEQRRADLQRRISDLQRMHDSLTALVDTCELPRADRTCALLDALTVTREVVR
>Mature_135_residues
MRTKELADRAGVNSETLRYYERRGLLSEPPRTPGGYRDYPSSTVGLLLFIKRAQELGFRLDEVDELLHLDAGGPESCDAA
RGLAEQRRADLQRRISDLQRMHDSLTALVDTCELPRADRTCALLDALTVTREVVR

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=129, Percent_Identity=37.2093023255814, Blast_Score=84, Evalue=3e-18,
Organism=Escherichia coli, GI1786695, Length=131, Percent_Identity=33.587786259542, Blast_Score=73, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15228; Mature: 15228

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTKELADRAGVNSETLRYYERRGLLSEPPRTPGGYRDYPSSTVGLLLFIKRAQELGFRL
CCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCH
DEVDELLHLDAGGPESCDAARGLAEQRRADLQRRISDLQRMHDSLTALVDTCELPRADRT
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
CALLDALTVTREVVR
HHHHHHHHHHHHHHC
>Mature Secondary Structure
MRTKELADRAGVNSETLRYYERRGLLSEPPRTPGGYRDYPSSTVGLLLFIKRAQELGFRL
CCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCH
DEVDELLHLDAGGPESCDAARGLAEQRRADLQRRISDLQRMHDSLTALVDTCELPRADRT
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
CALLDALTVTREVVR
HHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]