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The map label for this gene is tdh [H]

Identifier: 119716413

GI number: 119716413

Start: 2335788

End: 2336723

Strand: Reverse

Name: tdh [H]

Synonym: Noca_2183

Alternate gene names: 119716413

Gene position: 2336723-2335788 (Counterclockwise)

Preceding gene: 119716414

Following gene: 119716412

Centisome position: 46.87

GC content: 73.29

Gene sequence:

>936_bases
ATGAAGGCATTCGCCATCACCGCCCGCGACACCCAGCCCACCGTCCAGGACCTGCCGACTCCCGAGCCCACCGCCGGCGA
GGTCCTCGTCGAGGTCGAGGCGGCCTCGGTCAACGGATTCGACCTGTCGGTCACCGCCGGCTACGTCTGGGACATGATCC
CCGGCATCGAGTTCCCCGTCGTGCTCGGCCGCGACCTCGTCGGCACCGTCACCGCCCTCGGTGAGGGCGTCGAAGGCGTC
GCGGTCGGCGACCGGGTCACCGCCGTCTTCCCCGGCATGGCGCTCGGCCCCAGGACCGGCAGCTTCACCGAGTACGTCGC
GCTGCCCGCCACCGCCGTCACCGCTGTCCCGTCCGGAGTCGACTCCCAGCAGGCTGCCGTCATCGGCCTGGCCGGCGTCG
CCGCCTCAGACGCGCTCGAGGCACTCGACATCCAGGCCGGTGAGACGGTGCTCGTCTCCGGAGCCACCGGGGGCGTCGGC
TCCATCGCCACCCAGCTCGCAGCGGCAGCCGGTGCCACTGTCATCGGGACCGCCCAGCCCGGTCAGGAGGAGGCCTACGT
CCGCAGCCTCGGCGCGGCGCACACCCTCGACTACACCGGCGACGTCGCCGCCGCCATCGAGGCCATCGCGCCGCAGGGCG
TCGACAAGATCGTGCACGCCGCCGGCGACCCCAGCGCGCTCGCCACCGTCCTCAAGCCCGGCGGCGCCGCAGCCTCGACC
CTCGGTGCGAGCGCCGAGCAGTTCGGCCGCGACGACGTCACCGTCGCCACGATCATGGCCGACGCCACCGCCGAGAAGCT
CGCGGCGCTGCTCGAGCGGGTAGCCAGGGGTGAGCTCCGCGTCAACGTTGAGACCGCCATCCCCTTGGGGCGCGCGCCCG
AGGCGTTCGCGGCCTTCGCCGACGGCACCCTCGGCAAGGTCCTCATCACCCGCTGA

Upstream 100 bases:

>100_bases
GTGCTGTCGGTCGCAGTCCTGGTGCTGCGCATCGTCACCGCCTGAACATCCATCCCTGCCCGACCCACCACCCGATCCAC
CCATCCACAGGAGGAACACC

Downstream 100 bases:

>100_bases
ACACCTACACGAAACCAGGAGCTCCAACTCATGAACGTGACCGTCTTCGGCGCCACCGGCGCCATCGGATCACTCACCGT
CACTGAGCTGCTCGACCGAG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKAFAITARDTQPTVQDLPTPEPTAGEVLVEVEAASVNGFDLSVTAGYVWDMIPGIEFPVVLGRDLVGTVTALGEGVEGV
AVGDRVTAVFPGMALGPRTGSFTEYVALPATAVTAVPSGVDSQQAAVIGLAGVAASDALEALDIQAGETVLVSGATGGVG
SIATQLAAAAGATVIGTAQPGQEEAYVRSLGAAHTLDYTGDVAAAIEAIAPQGVDKIVHAAGDPSALATVLKPGGAAAST
LGASAEQFGRDDVTVATIMADATAEKLAALLERVARGELRVNVETAIPLGRAPEAFAAFADGTLGKVLITR

Sequences:

>Translated_311_residues
MKAFAITARDTQPTVQDLPTPEPTAGEVLVEVEAASVNGFDLSVTAGYVWDMIPGIEFPVVLGRDLVGTVTALGEGVEGV
AVGDRVTAVFPGMALGPRTGSFTEYVALPATAVTAVPSGVDSQQAAVIGLAGVAASDALEALDIQAGETVLVSGATGGVG
SIATQLAAAAGATVIGTAQPGQEEAYVRSLGAAHTLDYTGDVAAAIEAIAPQGVDKIVHAAGDPSALATVLKPGGAAAST
LGASAEQFGRDDVTVATIMADATAEKLAALLERVARGELRVNVETAIPLGRAPEAFAAFADGTLGKVLITR
>Mature_311_residues
MKAFAITARDTQPTVQDLPTPEPTAGEVLVEVEAASVNGFDLSVTAGYVWDMIPGIEFPVVLGRDLVGTVTALGEGVEGV
AVGDRVTAVFPGMALGPRTGSFTEYVALPATAVTAVPSGVDSQQAAVIGLAGVAASDALEALDIQAGETVLVSGATGGVG
SIATQLAAAAGATVIGTAQPGQEEAYVRSLGAAHTLDYTGDVAAAIEAIAPQGVDKIVHAAGDPSALATVLKPGGAAAST
LGASAEQFGRDDVTVATIMADATAEKLAALLERVARGELRVNVETAIPLGRAPEAFAAFADGTLGKVLITR

Specific function: Threonine catabolism; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=330, Percent_Identity=28.4848484848485, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI24308257, Length=219, Percent_Identity=32.8767123287671, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI28557745, Length=210, Percent_Identity=32.8571428571429, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI18379349, Length=214, Percent_Identity=33.1775700934579, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI194239674, Length=205, Percent_Identity=29.7560975609756, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI13236495, Length=205, Percent_Identity=29.7560975609756, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI194239676, Length=183, Percent_Identity=31.6939890710383, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI22538446, Length=189, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI22538444, Length=189, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790045, Length=258, Percent_Identity=28.6821705426357, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790485, Length=181, Percent_Identity=31.4917127071823, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787863, Length=187, Percent_Identity=31.0160427807487, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=207, Percent_Identity=33.8164251207729, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71987554, Length=220, Percent_Identity=30, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=206, Percent_Identity=32.5242718446602, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=229, Percent_Identity=30.5676855895196, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=205, Percent_Identity=32.1951219512195, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=338, Percent_Identity=25.7396449704142, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=187, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24581339, Length=219, Percent_Identity=28.310502283105, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581341, Length=219, Percent_Identity=28.310502283105, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 30899; Mature: 30899

Theoretical pI: Translated: 4.02; Mature: 4.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFAITARDTQPTVQDLPTPEPTAGEVLVEVEAASVNGFDLSVTAGYVWDMIPGIEFPV
CCEEEEEECCCCCHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEECCHHHHHCCCCCCCC
VLGRDLVGTVTALGEGVEGVAVGDRVTAVFPGMALGPRTGSFTEYVALPATAVTAVPSGV
EECCHHHHHHHHHCCCCCCEEECCEEEEECCCCEECCCCCCCHHEEECCHHHHHHCCCCC
DSQQAAVIGLAGVAASDALEALDIQAGETVLVSGATGGVGSIATQLAAAAGATVIGTAQP
CCCCEEEEEEECHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCC
GQEEAYVRSLGAAHTLDYTGDVAAAIEAIAPQGVDKIVHAAGDPSALATVLKPGGAAAST
CHHHHHHHHHCCHHCCCCCCHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCCCHHHH
LGASAEQFGRDDVTVATIMADATAEKLAALLERVARGELRVNVETAIPLGRAPEAFAAFA
HCCCHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHC
DGTLGKVLITR
CCCCCEEEEEC
>Mature Secondary Structure
MKAFAITARDTQPTVQDLPTPEPTAGEVLVEVEAASVNGFDLSVTAGYVWDMIPGIEFPV
CCEEEEEECCCCCHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEECCHHHHHCCCCCCCC
VLGRDLVGTVTALGEGVEGVAVGDRVTAVFPGMALGPRTGSFTEYVALPATAVTAVPSGV
EECCHHHHHHHHHCCCCCCEEECCEEEEECCCCEECCCCCCCHHEEECCHHHHHHCCCCC
DSQQAAVIGLAGVAASDALEALDIQAGETVLVSGATGGVGSIATQLAAAAGATVIGTAQP
CCCCEEEEEEECHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCC
GQEEAYVRSLGAAHTLDYTGDVAAAIEAIAPQGVDKIVHAAGDPSALATVLKPGGAAAST
CHHHHHHHHHCCHHCCCCCCHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCCCHHHH
LGASAEQFGRDDVTVATIMADATAEKLAALLERVARGELRVNVETAIPLGRAPEAFAAFA
HCCCHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHC
DGTLGKVLITR
CCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA